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Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

Neural Regeneration Research 2022年第1期17卷 59-64页

作者： M.Ángeles García-Pallero diana cardona Lola Rueda-Ruzafa Miguel Rodriguez-Arrastia Pablo Roman Hospital Universitario Central de Asturias AsturiasSpain Department of Nursing Science Physiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health Sciences Faculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health Sciences Pre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYS Faculty of Health SciencesJaume I UniversityCastello de la PlanaSpain

Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDLINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.

关键词： central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review

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Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps

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World Journal of Gastroenterology 2012年第41期18卷 5905-5911页

作者： Johanna L Chan Li Lin Michael Feiler Andrew I Wolf diana M cardona Ziad F Gellad Department of Medicine Duke University Medical CenterDurham NC 27705 United States Duke Clinical Research Institute DurhamNC 27705 United States Department of Pathology Duke UniversityMedical Center Durham NC 27705 United States Durham VA Medical Center Durham NC 27705United States

AIM： To evaluate accuracy of in vivo diagnosis of ad- enomatous vs non-adenomatous polyps using/-SCAN digital chromoendoscopy compared with high-definition white light. METHODS： This is a single-center comparative effec- tiveness pilot study. Polyps （n = 103） from 75 average- risk adult outpatients undergoing screening or surveil- lance colonoscopy between December 1, 2010 and April 1, 2011 were evaluated by two participating en- doscopists in an academic outpatient endoscopy center. Polyps were evaluated both with high-definition white light and with/-SCAN to make an/n vivo prediction of adenomatous vs non-adenomatous pathology. We de- termined diagnostic characteristics of/-SCAN and high- definition white light, including sensitivity, specificity, and accuracy, with regards to identifying adenomatous vs non-adenomatous polyps. Histopathologic diagnosis was the gold standard comparison. RESULTS： One hundred and three small polyps, de- tected from forty-three patients, were included in the analysis. The average size of the polyps evaluated in the analysis was 3.7 mm （SD 1.3 mm, range 2 mm to 8 mm）. Formal histopathology revealed that 54/103 （52.4%） were adenomas, 26/103 （25.2%） were hyper- plastic, and 23/103 （22.3%） were other diagnoses in- clude ＂lymphoid aggregates＂, ＂non-specific colitis,＂ and ＂no pathologic diagnosis.＂ Overall, the combined accu- racy of endoscopists for predicting adenomas was iden- tical between/-SCAN （71.8%, 95%CI： 62.1%-80.3%） and high-definition white light （71.8%, 95%CI： 62.1%-80.3%）. However, the accuracy of each endosco- pist differed substantially, where endoscopist A demon- strated 63.0% overall accuracy （95%CI： 50.9%-74.0%） as compared with endoscopist B demonstrating 93.3% overall accuracy （95%CI： 77.9%-99.2%）, irrespective of imaging modality. Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study. Though endoscopist A increased accuracy using/-SCAN from 59% （95%CI： 42.1%-74.4%） in the first hal

关键词： Colonoscopy Adenoma Virtual chromoendoscopy Colonic polyps Comparative effectiveness

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Integration of Probabilistic and Multi-Hazard Risk Assessment Within Urban Development Planning and Emergency Preparedness and Response: Application to Manizales,Colombia

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International Journal of Disaster Risk Science 2017年第3期8卷 270-283页

作者： Gabriel A.Bernal Mario A.Salgado-Gálvez Daniela Zuloaga Julián Tristancho diana González Omar-Darío cardona INGENIAR Ltda Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) Universidad Distrital Francisco Joséde Caldas Instituto de Estudios Ambientales(IDEA) Universidad Nacional de Colombia Sede Manizales

The details of a multi-hazard and probabilistic risk assessment, developed for urban planning and emergency response activities in Manizales, Colombia, are presented in this article. This risk assessment effort was developed under the framework of an integral disaster risk management project whose goal was to connect risk reduction activities by using open access and state-of-theart risk models. A probabilistic approach was used for the analysis of seismic, landslide, and volcanic hazards to obtain stochastic event sets suitable for probabilistic loss estimation and to generate risk results in different metrics after aggregating in a rigorous way the losses associated to the different hazards. Detailed and high resolution exposure databases were used for the building stock and infrastructure of the city together with a set of vulnerability functions for each of the perils considered. The urban and territorial ordering plan of the city was updated for socioeconomic development and land use using the hazard and risk inputs and determinants, which cover not only the current urban area but also those adjacent areas where the expansion of Manizales is expected to occur. The emergency response capabilities of the city were improved by taking into account risk scenarios and after updating anautomatic and real-time post-earthquake damage assessment.

关键词： Emergency response Manizales (Colombia) Multi-hazard risk assessment Probabilistic hazard analysis Probabilistic risk assessment Urban planning

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Exploring multifaceted factors in chronic kidney disease risk: A comprehensive analysis of biochemistry, lifestyle, and inflammation in elderly Chinese individuals

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World Journal of Clinical Cases 2024年第5期12卷 1033-1035页

作者： Fernando cardona Unitat de Genètica Molecular Instituto de Biomedicina de Valencia–CSICValencia 46010Spain Centro de investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud Carlos IIIMadrid 28029Spain Departamento de Biotecnología Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural(ETSIAMN)Univeristat Politècnica de ValenciaValencia 46022Spain

This letter praises a recent article in the World Journal of Clinical Cases(Roles of biochemistry data,lifestyle,and inflammation in identifying abnormal renal function in old Chinese),examining factors affecting abnormal renal function in elderly Chinese using advanced machine *** highlights the importance of uric acid,age,hemoglobin,body mass index,sport hours,and systolic blood *** study's holistic approach,integrating lifestyle and inflammation,offers a nuanced understanding of chronic kidney disease risk *** letter suggests exploring mechanistic pathways of hyperuricemia,the link between anemia and renal function,and the connection between body mass index and estimated glomerular filtration *** advocates investigating physical activity's impact on renal health and the independent effects of blood *** study significantly contributes to chronic kidney disease understanding,proposing avenues for further exploration and *** are extended to the authors and the journal.

关键词： Biochemistry data Lifestyle Machine learning Renal function

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Inverse methodology as applied to reconstruct local textile features from measured pressure field

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Journal of Materials Science & Technology 2021年第12期71卷 241-247页

作者： S.Bancora C.Binetruy S.Advani Comas-cardona Ecole Centrale de Nantes Research Institute in Civil Engineering and Mechanics(GeM)UMR CNRS 618344321 Nantes Cedex 3France Department of Mechanical Engineering University of DelawareNewarkDelaware 19716USA

One can compute the final deformation of a known geometry under specific boundary conditions using the constitutive laws of mechanics that describe their stress strain *** such cases the initial geometry is known,and all operators mapping the deformation are defined on the reference ***,there are situations in which the final configuration of a deformation might be known but not the *** inverse formulation allows one to determine the initial geometry of a domain,given its final deformation state,the material behavior law and a set of boundary *** the present work we propose a method to reconstruct the mesoscale geometry of a textile based on its mechanical response during *** do so,stress boundary conditions are acquired by means of a pressuresensitive *** adopting an appropriate material law,the thickness and width information of the yarns are deduced from the pressure field experienced by the compacted *** 3 D scanning techniques such as-CT,the proposed method can be applied on any domain size,allowing long-range variability to be *** the best of the authors’knowledge,there are no previous works that use a pressure-sensitive film on a large domain to capture the input data for a shape *** example application serves as a demonstration of a methodology which could be applied to other classes of materials.

关键词： Textiles Pressure sensors Inverse method Digital twin Geometry reconstruction Hyperelasticity

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Evaluation of biostimulation and Tween 80 addition for the bioremediation of long-term DDT-contaminated soil

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Journal of Environmental Sciences 2015年第2期27卷 101-109页

作者： Bibiana Betancur-Corredor Nancy J.Pino Santiago cardona Gustavo A.Peuela GDCON Research Group Faculty of Engineering University Research Headquarters (SIU) University of Antioquia School of Geosciences and Environment Faculty of Mines National University of Colombia School of Microbiology University of Antioquia

The bioremediation of a long-term contaminated soil through biostimulation and surfactant addition was evaluated. The concentrations of 1,1,1-trichloro-2,2-bis（4-chlorophenyl）ethane（DDT） and its metabolites 1,1-dichloro-2,2-bis（4-chlorophenyl） ethane（DDD） and1,1-dichloro-2,2-bis（4-chlorophenyl） ethylene（DDE） were monitored during an 8-week remediation process. Physicochemical characterization of the treated soil was performed before and after the bioremediation process. The isolation and identification of predominant microorganisms during the remediation process were also carried out. The efficiency of detoxification was evaluated after each bioremediation protocol. Humidity and p H and the heterotrophic microorganism count were monitored weekly. The DDT concentration was reduced by 79% after 8 weeks via biostimulation with surfactant addition（B ＋ S） and 94.3%via biostimulation alone（B）. Likewise, the concentrations of the metabolites DDE and DDD were reduced to levels below the quantification limits. The microorganisms isolated during bioremediation were identified as Bacillus thuringiensis, Flavobacterium sp., Cuprivadius sp.,Variovorax soli, Phenylobacterium sp. and Lysobacter sp., among others. Analysis with scanning electron microscopy（SEM） allowed visualization of the colonization patterns of soil particles. The toxicity of the soil before and after bioremediation was evaluated using Vibrio fischeri as a bioluminescent sensor. A decrease in the toxic potential of the soil was verified by the increase of the concentration/effect relationship EC50 to 26.9% and 27.2% for B ＋ S and B, respectively, compared to 0.4% obtained for the soil before treatment and 2.5%by natural attenuation after 8 weeks of treatment.

关键词： DDT Soil Bioremediation Biostimulation Surfactant Toxicity

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Features of the motion of gel particles in a three-phase bubble column under foaming and non-foaming conditions

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1370-1382页

作者： Gabriel Salierno Mauricio Maestri Stella Piovano Miryan Cassanello Maria Angelica cardona Daniel Hojman Hector Somacal Laboratorio de Reactores y Sistemas para la lndustria-LARSl Dep. lndustrias FCEyN Universidad de Buenos Aires Int. GiJiraldes 2620 CI428BGA Buenos Aires Argentina Laboratorio de Diagnóstico por Radiaciones-LADiR Dep. de Fisica Experimental. Comision National de Energia Atomica (CNEA) San Martin Buenos Aires Argentina Universidad de San Martin San Martin Buenos Aires Argentina

Features of the motion of gel particles in a three-phase bubble column with non-foaming and foaming gas–liquid systems,determined by using experiments of radioactive particle tracking(RPT),have been *** tracer used is a gel particle which resembles typical immobilized *** tracer trajectory is analyzed to extract relevant information for design *** solid velocity field,turbulence parameters,dispersion coefficients,mixing times and flow transitions are determined and *** presence of foam significantly affects many quantified parameters,especially within the heterogeneous flow *** hydrodynamic stresses are reduced in the presence of foam,especially close to the *** dispersion coefficients also decrease,and the solid mixing time is only slightly affected by the presence of *** holdup,inferred both from RPT experiments and from gamma ray scanning,is higher for foaming systems and leads to a shift in the transition gas velocity towards higher values.

关键词： Bubble columns Solid motion Gel beads Foaming Particle tracking Mixing

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The relationship between sexually transmitted microorganisms and seminal quality in asymptomatic men

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Asian Journal of Urology 2022年第4期9卷 473-479页

作者： Valentina Velasquez Rivera Walter D.cardona Maya Jenniffer Puerta-Suarez Department of Microbiology and Parasitology Medical SchoolUniversity of AntioquiaAntioquiaColombia

Objective:To detect DNA of different microorganisms,in semen samples from apparently healthy men and correlate their presence with seminal ***:Semensamples from 81 healthy volunteers were collected,and semen parameters were *** extraction was performed using the phenol-chloroform technique,and the micro-organisms were detected by the amplification of specific primers using polymerase chain ***:DNA from at least one of the microorganisms was detected in 78 *** most frequent microorganism found in semen were:Lactobacillus spp.(70%),Neisseria gonorrhoeae(***)(36%),Streptococcus epidermidis(64%),Klebsiella pneumoniae(56%),Staphylococcus aureus(32%),Chlamydia trachomatis(***)(28%),Pseudomonas aeru-ginosa(27%).The seminal parameters of all semen samples were over the lower reference values fornormal *** compare with negative samples,seminal volume was higher for the Escherichia coli positive samples and lower for Pseudomonas aeruginosa positive *** samples positive for Staphylococcus aureus had worse sperm *** frequency of progressive motility was higher in positive samples for *** and *** semen samples for *** had a higher concentration per ***:It is common to find microorganisms in semen of asymptomatic men,including those responsible for sexually transmitted *** treatment is recommended only in those individuals with a sexually transmitted infection(*** and ***)and always promote condom use.

关键词： Chlamydia trachomatis Neisseria gonorrhoeae Enterococcus faecalis Streptococcus agalactiae Staphylococcus spp. Seminal quality

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Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens

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Virologica Sinica 2016年第3期31卷 266-269页

作者： Flavia Adriana Zanetti Romina cardona Carlos Rodolfo Federico Silvina Chimeno-Zoth Gabriela Calamante Consejo Nacional de Investigaciones Cientificas y Tecnologicas(CONICET) Rivadavia 1917 (C 1033AAJ) Ciudad Autonoma de Buenos Aires Argentina Instituto de Biotecnologia Centro de Investigaciones en Ciencias Veterinarias y Agronomicas Instituto Nacional de Tecnologia Agropecuaria (INTA) Buenos Aires Argentina

Dear Editor,Infectious bursal disease virus（IBDV）causes infectious bursal disease,a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry *** replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius（BF）,leading to immunosuppression in affected flocks（Mahgoub et al.,2012）.Viral protein 2（VP2）,

关键词： bursal infectious contagious Recombinant expressing immunized vaccines affects vaccination chicken

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Validation of CFD-DEM simulation of a liquid-solid fluidized bed by dynamic analysis of time series

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Particuology 2022年第9期20卷 75-87页

作者： Julia Picabea Mauricio Maestri Miryan Cassanello Gabriel Salierno Cataldo De Blasio María Angélica cardona Daniel Hojman Héctor Somacal Departamento de Industrias Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaIntendente Güiraldes 2160C1428EGABuenos AiresArgentina CONICET-Universidad de Buenos Aires Instituto de Tecnología de Alimentos y Procesos Químicos-ITAPROQCiudad UniversitariaIntendente Güiraldes 2160 C1428EGABuenos AiresArgentina Faculty of Science and Engineering Abo Akademi UniversityRantakatu 265100 VaasaFinland Laboratorio de Diagnósticos por Radiaciones Dep.Física ExperimentalComisión Nacional de Energía AtómicaBKNA1650 San MartínBuenos AiresArgentina CONICET C1033AAJ Buenos AiresArgentina Escuela de Ciencia y Tecnología Universidad de San MartínBKNA 1650 San MartínBuenos AiresArgentina

Liquid-solid fluidized beds(LSFB)modeling validation is crucial for establishing design rules and monitor-ing ***,it generally relies on comparing global variables,which overlook dynamic features that influence reaction *** work aims to implement time series analysis tools to compare Radioactive Particle Tracking data with a simulation consisting of Computational Fluid Dynamics cou-pled with Discrete-Element *** have been performed in a pilot-scale LSFB of calcium alginate spheres fluidized with a calcium chloride *** Diks'test indicates that the simulation can capture the LSFB *** also allows diagnosing flow regime transitions from the *** of solid dispersion coefficients and mixing times predicted by the simulation are in good agreement with the experiments.

关键词： Liquid-solid fluidization CFD-DEM Dynamic comparison Radioactive particle tracking

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