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Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

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Bioactive Materials 2021年第5期6卷 1255-1266页

作者： Limei Li Mali Yu Yao Li Qing Li Hongcai Yang Meng Zheng Yi Han di lu Sheng lu Li Gui Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of Stomatology The First People’s Hospital of Yunnan ProvinceKunming650032China Department of Neurology The First Affiliated HospitalKunming Medical UniversityKunming650000China Yunnan Key Laboratory of digital Orthopaedics Department of OrthopaedicsThe First People’s Hospital of Yunnan ProvinceKunming650032China Department of Endocrinology The Third People’s Hospital of Yunnan ProvinceKunming650011China

The development of functional materials for osteoporosis is ultimately required for bone ***,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone *** this work,nano-hydroxyapatite(n-HA)/resveratrol(Res)/chitosan(CS)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of *** of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res ***,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α,IL-1βand iNOS in RAW264.7 cells in a dose dependent ***,enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell *** ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCN,and substantial mineralization in osteogenic *** implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture *** results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

关键词： n-HA/Res/CS microsphere Anti-inflammation Osteo-differentiation Osteoporotic bone regeneration

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SOPA-GA-CNN: Synchronous optimisation of parameters and architectures by genetic algorithms with convolutional neural network blocks for securing Industrial Internet-of-Things

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IET Cyber-Systems and Robotics 2023年第1期5卷 51-66页

作者： Jia-Cheng Huang Guo-Qiang Zeng Guang-Gang Geng Jian Weng Kang-di lu College of Cyber Security and the National Joint Engineering Research Center of Network Security Detection and Protection Technology Jinan UniversityGuangzhouChina National-Local Joint Engineering Research Center of digitalize Electrical Design Technology Wenzhou UniversityWenzhouChina National Laboratory of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhouChina

In recent years,deep learning has been applied to a variety of scenarios in Industrial Internet of Things(IIoT),including enhancing the security of ***,the existing deep learning methods utilised in IIoT security are manually designed by heavily relying on the experience of the *** authors have made the first contribution concerning the joint optimisation of neural architecture search and hyper-parameters optimisation for securing IIoT.A novel automated deep learning method called synchronous optimisation of parameters and architectures by GA with CNN blocks(SOPA-GA-CNN)is proposed to synchronously optimise the hyperparameters and block-based architectures in convolutional neural networks(CNNs)by genetic algorithms(GA)for the intrusion detection issue of *** efficient hybrid encoding strategy and the corresponding GA-based evolutionary operations are designed to characterise and evolve both the hyperparameters,including batch size,learning rate,weight optimiser and weight regularisation,and the architectures,such as the block-based network topology and the parameters of each CNN *** experimental results on five intrusion detection datasets in IIoT,including secure water treatment,water distribution,Gas Pipeline,Botnet in Internet of Things and Power System Attack Dataset,have demonstrated the superiority of the proposed SOPA-GA-CNN to the state-of-the-art manually designed models and neuron-evolutionary methods in terms of accuracy,precision,recall,F1-score,and the number of parameters of the deep learning models.

关键词： cyber-systems deep learning deep neural network Internet of things swarm intelligence

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Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis:A population-based study

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World Journal of Clinical Cases 2022年第30期10卷 10882-10895页

作者： Jun-Feng Wang Hong-di lu Ying Wang Rui Zhang Xiang Li Sheng Wang The First Department of Thoracic Oncology Jilin Province Tumor HospitalChangchun 130021Jilin ProvinceChina Big Data Center for Clinical Research Jilin Province Tumor HospitalChangchun 130021Jilin ProvinceChina

BACKGROUND The presence of liver metastasis(LM) is an independent prognostic factor for shorter survival in non-small cell lung cancer(NSCLC) *** median overall survival of patients with involvement of the liver is less than 5 *** present,identifying prognostic factors and constructing survival prediction nomogram for NSCLC patients with LM(NSCLC-LM) are highly *** To build a forecasting model to predict the survival time of NSCLC-LM *** Data on NSCLC-LM patients were collected from the Surveillance,Epidemiology,and End Results database between 2010 and *** analysis was used to estimate the incidence trend of ***-Meier curves were constructed to assess survival *** regression was applied to select the independent prognostic predictors of cancer-specific survival(CSS).A nomogram was established and its prognostic performance was *** The age-adjusted incidence of NSCLC-LM increased from 22.7 per 1000000 in 2010to 25.2 in 2013,and then declined to 22.1 in *** to the multivariable Cox regression analysis of the training set,age,marital status,sex,race,histological type,T stage,metastatic pattern,and whether the patient received chemotherapy or not were identified as independent prognostic factors for CSS(P dices of the training and validation sets were 0.726 and 0.722,*** results of decision curve analyses(DCAs) and calibration curves showed that the nomogram was well-discriminated and had great clinical *** We designed a nomogram model and further constructed a novel risk classification system based on easily accessible clinical factors which demonstrated excellent performance to predict the individual CSS of NSCLC-LM patients.

关键词： Non-small cell lung cancer Liver metastasis Nomogram Risk classification system

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Construction and Implementation of CNOOC's Green Supply China

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China Oil & Gas 2018年第3期25卷 52-57页

作者： lu di China National Offshore Oil Corporation

Firstly, the construction background and basic connotations of CNOOC's Green Supply Chain was presented in this paper. Then, a detailed introduction to CNOOC's good practices for building green oil and gas fields, green power plants, green refineries and green chemical plants was given with respect to the establishment of a green production construction and assessment system as well as green exploration, green manufacturing,green products, green sales, green recovery and other aspects. Finally, the effects of the Green Supply Chain established by CNOOC were summarized.

关键词： Green supply chain Energy conservation and emission reduction Low carbon

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A solution-processed nanoscale COF-like material towards optoelectronic applications

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Science China Chemistry 2021年第1期64卷 82-91页

作者： Qiang Fu Ting Wang Yanna Sun Nan Zheng Zengqi Xie di lu Zhiyuan Xu Xiangjian Wan Yamin Zhang Yongsheng Liu The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China Renewable Energy Conversion and Storage Center Nankai UniversityTianjin 300071China

Two-dimensional(2 D)covalent organic frameworks(COFs)with periodic functionalπ-electron systems are an emerging class of optoelectronic ***,almost all conjugated COFs so far are insoluble and hard to process,which hampers severely their optoelectronic ***,a solution-processable,nanoscale and sp2 carbon-conjugated COF-like material,PDPP-C20 was successfully designed and *** solution-processed PDPP-C20 films exhibit high crystallinity and excellent charge transport properties along out-of-plane directions,combined with the highest occupied molecular orbital(HOMO)/lowest unoccupied molecular orbital(luMO)levels of-5.36/-3.75 e V,making PDPP-C20 suitable for electronic device *** efficiency as high as 21.92%has been demonstrated when it was used as a functional interfacial layer in perovskite solar cells,coupled with dramatically improved stability in comparison with the control device due to the superior hydrophobicity of PDPP-C20 layer as well as its passivation effect on perovskite ***,the soluble PDPP-C20 could also be used as donor in bulk-heterojunction organic solar cells and an initial efficiency of 2.46%has been *** results indicate that this new class of soluble and nanoscale COF-like materials should offer a new arena of functional materials for optoelectronic devices.

关键词： solution-processable covalent organic frameworks perovskite solar cells mobility passivation

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The ongoing trends of patient-derived xenograft models in oncology

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Cancer Communications 2020年第11期40卷 559-563页

作者： Jianyong Zhuo Renyi Su Winyen Tan Zhengxing Lian di lu Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310003P.R.China Department of Hepatobiliary and Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003P.R.China National Health Commission Key Laboratory of Combined Multi-organ Transplantation Institute of Organ TransplantationZhejiang UniversityHangzhouZhejiang 310003P.R.China Department of Hepatobiliary and Pancreatic Surgery Li Shui HospitalZhejiang University School of MedicineLishuiZhejiang 323000P.R.China

1 MAIN TEXT Patient-derived xenograft(PDX)models have garnered increasing attention since the last *** models are typically characterized by the implantation of fresh patient-derived tumor tissues into immunodeficient *** models are well recognized in academic laboratories,pharmaceutical institutions,and specialized commercial organizations as having the ability to recapitulate genomics,transcriptomics,proteomics,and metabolomics of the parental tumor tissue[1,2].Recently,these models have been successfully used in preclinical studies to identify potential biomarkers for drug response and resistance,and to measure tumor evolution in response to treatment[3,4].Favorable outcomes demonstrated using PDX models could be used as ideal models for preclinical research and clinical translation studies.

关键词： clinical specialized implantation

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孔隙结构对黏土持水性及抗剪强度的影响

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中国科技论文 2024年第5期19卷 557-565页

作者：陈芸颜荣涛张芹陈柏莹蔡煜陆地桂林理工大学土木工程学院广西桂林541004

为研究双峰孔隙结构对非饱和土力学特性的影响,以广西南宁和桂林2种典型双峰孔隙结构黏土为研究对象,分析了其在不同饱和度情况下的抗剪强度特性;辅以滤纸法及核磁共振(nuclear magnetic resonance,NMR)技术探究了2种土体在双峰孔隙结... 详细信息

为研究双峰孔隙结构对非饱和土力学特性的影响,以广西南宁和桂林2种典型双峰孔隙结构黏土为研究对象,分析了其在不同饱和度情况下的抗剪强度特性;辅以滤纸法及核磁共振(nuclear magnetic resonance,NMR)技术探究了2种土体在双峰孔隙结构情况下孔隙水分布状态对强度的影响机理。结果表明:饱和状态下,2种土体试样的T2分布曲线为双峰结构,且土样持水特性整体上均呈现双峰土水特征曲线;2种土体的应力-位移关系变化规律相似,抗剪强度与饱和度密切相关;在饱和度为40%前后土样黏聚力变化趋势发生改变,而内摩擦角则是在饱和度为80%时达到最小值。

关键词：双峰孔隙结构饱和度抗剪强度滤纸法核磁共振技术

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“一带一路”共建国家农业科技创新合作网络结构演化及影响因素探究

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科技管理研究 2024年第5期44卷 32-39页

作者：王丹邓灿辉赵新力卢頔郭翔宇东北农业大学经济管理学院黑龙江哈尔滨150030 东北农业大学现代农业发展研究中心黑龙江哈尔滨150030 中共河南省委党校经济管理教研部河南郑州451464 清华大学中国科技政策研究中心北京100084 中国国际工程咨询有限公司北京100089

基于WOS数据库中跨国农业科技论文合著数据,借助社会网络分析法和QAP回归模型,剖析2006—2020年“一带一路”共建国家农业科技创新合作网络结构演化特征及影响因素。研究发现:(1)“一带一路”共建国家农业科技创新合作网络整体结构指标... 详细信息

基于WOS数据库中跨国农业科技论文合著数据,借助社会网络分析法和QAP回归模型,剖析2006—2020年“一带一路”共建国家农业科技创新合作网络结构演化特征及影响因素。研究发现:(1)“一带一路”共建国家农业科技创新合作网络整体结构指标均得到了不同程度的优化,且各指标优化速度快于全球农业科技创新合作网络。(2)“一带一路”共建国家和全球国家农业科技创新合作网络去中心化趋势均较明显,多核共存特征更加突出。(3)中国和意大利在合作网络中同时扮演着核心者和中间人角色。(4)合作网络呈现出双向溢出、主受益、“经纪人”3种类型的块集聚特征,亚洲国家是推动农业科技创新合作的主引擎。(5)制度、经济、科研和认知邻近对3个阶段的合作网络都具有显著的正向影响,而空间邻近对合作的阻碍作用逐渐减弱。“一带一路”共建国家应进一步重视跨国农业科技创新合作,明确自身在合作网络中的地位与角色,充分借助网络核心国家的重要作用,加速融入农业科技创新国际合作核心网络.

关键词：农业科技创新合作网络 “一带一路” 社会网络分析 QAP回归模型

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全氟正丙基乙烯基醚的合成研究进展

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有机氟工业 2024年第1期 18-22页

作者：路迪董军涛孙冲凌永洪巫国雄浙江巨化股份有限公司氟聚合物事业部浙江衢州324000

对全氟正丙基乙烯基醚(PPVE)的合成和纯化专利和文献进行了总结。通过分析PPVE现有主要合成和纯化方法的特点,为氟化工和制药等行业在合成、纯化以及应用PPVE时提供技术参考。

关键词：全氟正丙基乙烯基醚脱羧还原法热解法

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Advanced therapies for congenital biliary tract malformation:From bench to bedside

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iLIVER 2022年第3期1卷 159-168页

作者： Yixuan Shao Xinyu Yang Hao Chen di lu Yonggang Huang Xiao Xu People's Hospital Zhejiang University School of MedicineHangzhou310006China Department of Hernia and Abdominal Wall Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina Institute of Organ Transplantation Zhejiang UniversityHangzhou310003China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou310024China

Congenital biliary tract malformations are a series of rare but extremely serious diseases that mainly include biliary atresia and biliary hypoplasia(referred to as Alagille syndrome).The rapid progression of biliary atresia and Alagille syndrome results in jaundice,cholestatic liver disease,cirrhosis,and even liver *** most cases,supportive or clinically specific therapies cannot achieve satisfactory ***,liver transplantation(especially living donor liver transplantation)may be *** many studies have elucidated the role of genetic factors and the molecular mechanism of congenital biliary tract malformations,experimental therapies such as organoid transplantation,cell therapy,and immunotherapy have been proved to be *** advanced methods have shown outstanding advantages,particularly in patients with end-stage biliary tract malformations,surgery failure,and other problems that cannot be solved by conventional *** review article discusses the potential pathogenesis of and promising therapeutic strategies for biliary tract malformations.

关键词： Biliary tract malformation Biliary atresia Alagille syndrome Pediatric liver transplantation Organoid Immunotherapy

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