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Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

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Traditional Medicine Research 2024年第10期9卷 1-9页

作者： Bo-Wen Zhang di yang Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi yang Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:Luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

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An adaptive fuel cell hybrid vehicle propulsion sizing model

iEnergy

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iEnergy 2024年第1期3卷 59-72页

作者： Jia di yang Paul R.Shearing Jason Millichamp Theo Suter Dan J.L.Brett James B.Robinson Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUK Advanced Propulsion Lab MarshgateUniversity College LondonLondon E202AEUK ZERO Institute Holywell HouseOsney MeadUniversity of OxfordOxfordOX20ES The Faraday Institution Quad OneBecquerel AvenueHarwell Science and Innovation CampusDidcot OX110RAUK

As we enter the age of electrochemical propulsion,there is an increasing tendency to discuss the viability or otherwise of different electrochemical propulsion systems in zero-sum *** discussions are often grounded in a specific use case;however,given the need to electrify the wider transport sector it is evident that we must consider systems in a holistic *** designed adequately,the hybridisation of power sources within automotive applications has been demonstrated to positively impact fuel cell efficiency,durability,and cost,while having potential benefits for the safety of *** this paper,the impact of the fuel cell to battery hybridisation degree is explored through the key design parameter of system *** fuel cell electric hybrid vehicle(FCHEV)scenarios of various hydridisation degrees,including light-duty vehicles(LDVs),Class 8 heavy goods vehicles(HGVs),and buses are modelled to enable the appropriate sizing of the proton exchange membrane(PEMFC)stack and lithium-ion battery(LiB)pack and additional balance of *** operating conditions of the modelled PEMFC stack and battery pack are then varied under a range of relevant drive cycles to identify the relative performance of the *** extending the model further and incorporating a feedback loop,we are able to remove the need to include estimated vehicle masses a priori enabling improving the speed and accuracy of the model as an analysis tool for vehicle mass and performance estimation.

关键词： Proton exchange membrane(PEMFC) lithium-ion batteries fuel cell electric hybrid vehicle(FCHEV) electric propulsion powertrain modelling

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diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland-immunophenotypic and genetic features: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3895-3903页

作者： Chang-Song Wang Xia Chu di yang Lei Ren Nian-Long Meng Xue-Xia Lv Tian Yun Yan-Sha Cao Department of Pathology 989th Hospital of PLALuoyang 471000Henan ProvinceChina Department of Pathology 988^th Hospital of PLAZhengzhou 450042Henan ProvinceChina Department of Pathology Sanmenxia center HospitalSanmenxia 472000Henan ProvinceChina Department of Pathology Luoyang First People’s HospitalLuoyang 471000Henan ProvinceChina

BACKGROUND Warthin’s tumor(WT)is composed of several cysts that are lined with tall,bilayered oncocytic columnar cells and lymphoid *** WT,the two components rarely transform into carcinoma or lymphoma,and when it does,carcinoma is the most common *** 28 cases of lymphoma with WT have been reported,most of which were non-Hodgkin lymphomas,and only a few cases were Hodgkin *** the present report,we studied a case of diffuse large B cell lymphoma(DLBCL)arising from follicular lymphoma(FL)with WT in the parotid gland and its immunophenotypic and genetic *** SUMMARY A 67-year-old man presented with a slowly enlarging right cheek mass for 12 years,and the mass began to change in size over a 2-mo time *** time,the patient felt mild local pain and right cheek *** medical history included a hepatitis B virus infection for 20 years and 30 years of *** examination of the excised specimen showed a gray-red and gray-white appearance and a soft texture lobulated external surface neoplasm that measured 9 cm×8 cm×7 cm and was well circumscribed by relative normal parotid gland *** cross section,the cut surfaces of the neoplasm were multicystic and had a homogeneous scaly appearance.A small fluid was discovered in the *** oxyphilic,cuboidal or polygonal epithelium cells and lymphoid intraparenchymal components were *** medium-to large-sized lymphoid cells were observed diffusely in part of the neoplasm,and a few secondary lymphoid follicles were observed at the center or edge of the *** staining showed that the columnar oncocytic cells were positive for AE1/AE3;neoplastic cells located in coarctate follicular were positive for CD20,Pax-5,bcl-2 and bcl-6;and the adjacent diffusely medium-to large-sized lymphoid cells were positive for Pax-5,bcl-6,CD20,MUM-1,bcl-2 and *** bcl-6(3q27)break-apart rearrangement was observed,and an Epstein Barr virus test was

关键词： diffuse large B cell lymphoma Warthin’s tumor Parotid gland Follicularlymphoma Case report Genetic feature

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Longitudinal observation of intraocular pressure variations with acute altitude changes

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World Journal of Clinical Cases 2019年第20期7卷 3226-3236页

作者： Yuan Xie Yun-Xiao Sun Ying Han di-Ya yang Yi-Quan yang Kai Cao Shu-Ning Li Xue Li Xin-Xin Lu Shi-Zheng Wu Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Ophthalmology University of CaliforniaSan FranciscoCA 94143United States Department of Laboratory Medicine Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Departments of Neurology the Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Higher intraocular pressure(IOP)is a major risk factor for developing glaucoma,and the leading cause of irreversible blindness *** altitude(HA)may be involved in IOP,but the reported results were *** to HA directly by plane from low altitude regions is an acute,effortless ***,the effects of such exposure to different altitudes on IOP have rarely been *** To investigate changes in IOP after rapid effortless exposure to HA in stages and compare it with systemic *** Fifty-eight healthy subjects(116 eyes)were divided into three groups:17 lowaltitude(LA)residents[44 m above sea level(ASL)],22 HA residents(2261 m ASL)and 19 very HA(VHA)residents(3750 m ASL).The LA group flew to HA *** days later,they flew with the HA group to VHA where both groups stayed for 2 ***,the LA group flew back to HA and stayed for 1 d before flying back to 44 ***,oxygen saturation(SpO2)and pulse rate were *** linear mixed model was used to compare repeated *** IOP in the LA group significantly decreased from 18.41±2.40 mmHg at 44 m to 13.60±3.68 mmHg at 2261 m ASL(P<0.001),and then to 11.85±2.48 mmHg at 3750 m ASL(P=0.036 compared to IOP at 2261 m ASL)and partially recovered to 13.47±2.57 mmHg upon return to 44 *** in the LA group at HA and VHA was comparable to that in the local residents(12.2±2.4 mmHg for HA,11.5±1.8 mmHg for VHA).IOP was positively associated with SpO2 while negatively associated with pulse *** IOP in the LA group gradually reduced as altitude elevated in stages and became comparable to IOP in local *** may be associated with IOP,which deserves further study.

关键词： Intraocular pressure High altitude Hypoxia Glaucoma Lowlanders Erythrocyte

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Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

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Neural Regeneration Research 2022年第8期17卷 1761-1768页

作者： Wei-Tao Yan Yan-di yang Xi-Min Hu Wen-Ya Ning Lyu-Shuang Liao Shuang Lu Wen-Juan Zhao Qi Zhang Kun Xiong Department of Neurobiology and Human Anatomy School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Human Resources Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis,apoptosis and necroptosis act in consort in a multimeric protein complex,*** allows all the components of PANoptosis to be regulated *** provides a new way to study the regulation of cell death,in that different types of cell death may be regulated at the same *** test whether PANoptosis exists in diseases other than infectious diseases,we chose cerebral ischemia/reperfusion injury as the research model,collected articles researching cerebral ischemia/reperfusion from three major databases,obtained the original research data from these articles by bibliometrics,data mining and other methods,then integrated and analyzed these *** selected papers that investigated at least two of the components of PANoptosis to check its occurrence in ischemia/*** the cell model simulating ischemic brain injury,pyroptosis,apoptosis and necroptosis occur together and this phenomenon exists widely in different passage cell lines or primary ***,apoptosis and necroptosis also occurred in rat and mouse models of ischemia/reperfusion *** confirms that PANoptosis is observed in ischemic brain injury and indicates that PANoptosis can be a target in the regulation of various central nervous system diseases.

关键词： apoptosis brain central nervous system ischemia/reperfusion middle cerebral artery occlusion necroptosis oxygen and glucose deprivation PANoptosis pyroptosis regulated cell death

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Effects of keV protons irradiation on polyimide films

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Rare Metals 2007年第S1期26卷 124-128页

作者： LI Ruiqi,LI Chundong,HE Shiyu,di Mingwei,and yang Dezhuang Space Materials & Environment Engineering Laboratory,Harbin Institute of Technology,Harbin 150001,China Harbin Inst Technol Space Mat & Environm Engn Lab Harbin 150001 Peoples R China

Ground simulation tests of proton irradiation for Kapton films were conducted using the space synthesis irradiating facility,in which the energy of protons was chosen as 90 keV,and the flux was 5.0×1011 cm-2·*** proton irradiation some bulges like fingers appears on the surface of Kapton and the surface roughness increases ***/Vis analysis demonstrates that the irradiation leads to the red shifting in the edge of optical absorption and a strong increase in absorbance in the visible region.X-ray photoelectron spectroscopy(XPS) analysis indicates that the enrichment of carbon atom due to the bond breaking and reconstruction during the irradiation results in the degradation of the optical properties.

关键词： proton radiation kapton optical property chemical structure surface roughness

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Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2020年第5期32卷 547-563页

作者： Rui Liu Ruoxi Hong Yan Wang Ying Gong Danna Yeerken di yang Jinting Li Jiawen Fan Jie Chen Weimin Zhang Qimin Zhan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China

Objective: Solute carrier family 38(SLC38 s) transporters play important roles in amino acid transportation and signaling transduction. However, their genetic alterations and biological roles in tumors are still largely *** study aimed to elucidate the genetic signatures of SLC38 s transporters and their implications in esophageal squamous cell carcinoma(ESCC).Methods: Analyses on somatic mutation and copy number alterations(CNAs) of SLC38 A3 were performed as described. Immunohistochemistry(IHC) assay and Western blot assay were used to detect the protein expression level. MTS assay, colony formation assay, transwell assay and wound healing assay were used to explore the malignant phenotypes of ESCC cells. Immunofluorescence assay was used to verify the colocalization of two indicated proteins and immunopreciptation assay was performed to confirm the interaction of ***: Our findings revealed that SLC38 s family was significantly disrupted in ESCC, with high frequent CNAs and few somatic mutations. SLC38 A3 was the most frequent loss gene among them and was linked to poor survival and lymph node metastasis. The expression of SLC38 A3 was lower in tumor tissues compared to that in normal tissues, which was also significantly associated with worse clinical outcome. Further experiments revealed that depletion of SLC38 A3 could promote EMT in ESCC cell lines, and the interaction of SLC38 A3 and SETDB1 might lead to the reduced transcription of Snail. Pharmacogenomic analyses demonstrated that fifteen inhibitors were showed significantly correlated with SLC38 A3 ***: Our investigations have provided insights that SLC38 A3 could act as a suppressor in EMT pathway and serve as a prognostic factor and predictor of differential drug sensitivities in ESCC.

关键词： Amino acid transporter esophageal squamous cell carcinoma epithelial-mesenchymal transition genomic alterations SLC38A3 SETDB1 Snail

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磴口县地下水空间异质性分析及其对景观格局变化的响应

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农业机械学报 2019年第12期50卷 205-212页

作者：刘建华于强 yang di 岳德鹏张启斌武英达中国社会科学院数量经济与技术经济研究所北京100732 北京林业大学林学院北京100083 弗罗里达大学地理系盖恩斯维尔FL 326113 中国消防救援学院北京102200

应用地统计学和地理信息系统方法,分析内蒙古自治区巴彦淖尔市磴口县地下水埋深对景观格局演变的响应。首先,通过半变异函数模型分析了磴口县地下水埋深的空间异质性特征,进而利用克里金插值对研究区2008、2016年的地下水埋深空间分布... 详细信息

应用地统计学和地理信息系统方法,分析内蒙古自治区巴彦淖尔市磴口县地下水埋深对景观格局演变的响应。首先,通过半变异函数模型分析了磴口县地下水埋深的空间异质性特征,进而利用克里金插值对研究区2008、2016年的地下水埋深空间分布进行了拟合;其次,基于磴口县2008年与2016年的景观格局分布数据,研究了其景观格局演变特点;最后利用GIS叠加分析手段,将地下水埋深变化与景观格局演变数据进行耦合,分析了地下水埋深对景观格局演变的响应机制。研究结果如下:①空间上,磴口县地下水埋深大体遵循由东北向西南逐渐加深的趋势,研究时段内其空间异质性呈上升趋势,空间异质性中的随机扰动增强。②县域主要景观类型为林地,其次为沙地、裸地与水体,研究时段内建筑用地与水体增加明显,耕地与沙地略有减少。③景观格局演变对地下水埋深有较明显的影响,建筑用地的扩张使其加深,地表灌溉系统的不断完善使其上升。总体来看,磴口县地下水资源利用效率有较明显的提高。

关键词：磴口县地统计学景观格局演变地下水埋深半变异函数

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Establishment of Comprehensive Evaluation Indicator System for Sustainable Development of Microcredit and Empirical Analysis

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Asian Agricultural Research 2012年第11期4卷 106-110,114页

作者： yang di-hang LUO He-hua School of Economics Hunan Agricultural University

We establish the comprehensive evaluation indicator system for sustainable development of micro-credit,constituted by the profitability ratio,financial constitution ratio,loan quality ratio and operating efficiency *** the case of micro-credit of China Foundation for Poverty Alleviation,we measure the current situation of sustainable development of *** far as we are concerned,the composite index of sustainable development of micro-credit shows the growth trend on the ***,in order to further improve the sustainable development of microcredit,provide farmers with better financial services and enable more farmers to benefit from micro-credit,we put forth the following recommendations:strengthening technological innovation to reduce costs and improve operating efficiency and profitability of the micro-credit;strengthening risk control to improve the quality of loans;providing all-around non-financial services to lay the foundation for the sustainable development of microcredit;setting an appropriate level of interest rates to improve the profitability of the institutions.

关键词： Micro-credit Sustainable development Indicator sys

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Some Analyses on Effects of Site Classification on Ground Motion Characteristics in the Chi-Chi,Taiwan Earthquake

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Earthquake Research in China 2006年第4期20卷 435-448页

作者： Dong di yang Jian Liu Rui Institute of Engineering Seismology of Qingdao City Qingdao 266003 China

According to the epicenter distance and the site classification, the 404 groups of earthquake recordings of the main shock of the Chi-Chi, Taiwan China earthquake in 1999 are catalogued. Based on these data, we analyze the statistical features of duration, PGA, envelopes and the response spectra ratio of the horizontal and vertical components of the acceleration recordings. The results of these analyses show that the effect of site classification on the acceleration of various components is obvious; furthermore, fault direction also has certain effects on the characteristics of the horizontal components of ground motion. The detailed research results are as follows：（ 1 ） the duration of the horizontal components of acceleration records increases with the softening of the site; （2） the direction of fault slip has some effects on PGA＇s attenuation features; （3） the average envelopes of acceleration records at different distances and site dames are basically single peak functions of time and the envelopes of horizontal and vertical components of ground motion are obviously different; （4） with the same epicenter distance, EW/NS response spectrum ratios tend to approximate 1.0 as the site becomes softer and the period shorter. V/H response spectrum ratios in short periods （〈 0. 1s） increase with the softening of site, however, V/H ratios within the long-period range （〉 characteristic period） decrease with the softening of the site, and the decrease of V/EW ratio speeds up relatively.

关键词： Site Duration Envelope Response spectrum ratio

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