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Goncrete block pavements in urban and local roads:Analysis of stress-strain condition and proposal for a catalogue

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 557-566页

作者： Paola di mascio Laura Moretti Americo Capannolo Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00184Italy

Although the construction of block pavements has grown fast in the last decades,there is still a need for simple tools that could be applied to design *** paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces(no interlocking effect).The examined blocks were laid on a bedding sand layer,a cement treated base layer and a granular unbound foundation *** commercial finite element(FE)software ANSYS?was used to calculate the response of the pavement when subjected to different loading,construction *** wheel positions,five blocks patterns,three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement *** and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the *** the end of this study,a proposal for a catalogue is *** has nine pavement sets,because it takes into account three values of subgrade capacity(30,90,and 150 MPa of resilient modulus)and three levels of traffic(400,000,1,500,000,and 4,000,000 passages of commercial vehicles during the service life).The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.

关键词： Block pavement Finite element model Concrete pavers Local roads Urban roads

Methodology and evidence from a case study in Rome to increase pedestrian safety along home-to-school routes

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 715-727页

作者： Maria Vittoria Corazza Daniela D'Alessandro Paola di mascio Laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00185Italy

Home-to-school routes are very sensitive areas: they represent, for children, a learning tool for their everyday activities, but if poorly designed, maintained and equipped they can expose them to traffic risks. Sidewalks' inappropriate level of service and poor maintenance, especially, are main factors contributing to walking unsuitability, thus to poor comfort and safety levels for young pedestrians, and more in general for all the vulnerable non-motorized road users. This paper deals with a methodology specifically developed to highlight the quality of the urban environment where the home-to-school routes are located, according to four main criteria: wellbeing, usage, appearance, and safety and security. Each criterion is associated with a checklist including the most relevant features to assess, with a focus on maintenance as a key parameter to create safe and comfortable routes to school. An application, a case study in Rome, where the lack of regular maintenance results into a network of unsafe sidewalks, is also presented, analyzing three different areas where a number of schools are located. Detours when approaching school premises were surveyed, due to the levels of distresses and linked to the poor comfort and safety levels. As the mutual influence of built environment over road safety and maintenance requirements for home-to-school paths is not largely investigated thus far, the paper's goal is to provide advanced knowledge for studies and applications further afield.

关键词： Traffic engineering Road safety Pedestrians Home-to-school routes Sidewalks

Managing sidewalk pavement maintenance:A case study to increase pedestrian safety

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 203-214页

作者： Maria Vittoria Corazza Paola di mascio Laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of Rome

Comfort is a major requirement in planning pedestrian facilities. Pedestrians walk where they feel comfortable and when they do not feel at ease, they walk elsewhere. A typical example is that filthy, distressed, or too narrow sidewalks induce pedestrians to walk on carriageways. This behaviour jeopardizes road safety and highly dangerous to most users, leave them vulnerable. Unsuitable pavements can be the result of irregular maintenance operations to restore evenness after shock damage, weather phenomena, installation of equipment （e.g., posts, fences, urban furniture） with a reduction of walkable surface, or substandard repair work on pavements and patches due to emergency operations. These problems can be solved with an appropriate maintenance management system, which optimizes financial resources to make smart decisions about how to intervene with an adequate and lasting maintenance operation. This paper defines an evaluation index for sidewalk conditions as a part of an efficient set-up of a Sidewalk Management System, which is similar to the better known Road Management System. The study relies on sur- veys, as well as the classification and analysis of sidewalk distresses. The authors adapted an index already standardized by ASTM for roads and airports： the Pavement Condition Index （PCI）. PCI has been modified to consider the specific types on the sidewalks studied within this paper. To validate the method, a case study of a residential district in Rome, Italy, was carried out. The chosen area lacks regular maintenance and has therefore resulted in a network of unsafe sidewalks. Frequent detour routes were surveyed and related to the level of distresses within a general assessment of safety. This study con- centrates on sidewalks with flexible pavements because this type of pavement is the only one adopted in the survey areas and, in general, throughout Italy.

关键词： Sidewalks Maintenance Condition index Pedestrians Safety Asphalt pavements

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Safety ranking definition for infrastructures with high PTW flow

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第5期5卷 406-416页

作者： Antonella Ragnoli Maria Vittoria Corazza Paola di mascio Department of Civil Building and Environmental Engineering Sapienza University of Rome

Powered two-wheelers （PTWs） provide a suitable mode for a large portion of population in many cities due to rider＇s personal convenience and the vehicle supposed easiness of manoeuvring. At the same time PTWs present serious safety issues compared to other motorized vehicles. This paper reports the main outcome of study carried out in Rome, where this mode is very popular and assesses the economic efforts to make infrastructure safer for PTWs. The methodology, extensively described in the paper, includes three steps： the accident analysis, the development of economic indicators of accidents costs, the maintenance priority. In the first step the location of the PTWs local accidents are iden- tified, then the accidents are analyzed by means of the suitable indicators and, among these the safety potential （SAPO）. Lastly, according to the results of the analyzed indicators the need of infrastructure maintenance will be defined. Usually SAPO is applied to rural areas, but here it has been adapted to describe the phenomena of the urban area in hand. As a result, the estimation of the saving potential to improve the infrastructure safety levels, thus reducing the amount of accidents, is presented, along with recommendations on how to upscale the SAPO at city level.

关键词： Safety Accident costsl Powered two-wheeler (PTW) Maintenance

Sedation and analgesia in children with cerebral palsy:a narrative review

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World Journal of Pediatrics 2019年第5期15卷 432-440页

作者： Ingrid Rabach Francesca Peri Marta Minute Emanuela Aru Marianna Lucafò Alberto di mascio Giorgio Cozzi Egidio Barbi Institute for Maternal and Child Health IRCCS'Burlo Garofolo'Via dell'Istria 65/134100 TriesteItaly University of Trieste TriesteItaly Department of Medicine Surgery and Health SciencesUniversity of TriesteTriesteItaly

Background Patients with cognitive impairment due to cerebral palsy experience pain more often than healthy peers and frequently require diagnostic and therapeutic painful *** and procedural sedation outside the operating room are often required,but they may not adequately be provided because of the inability to accurately recognize and classify the state of pain and for the perceived higher risk of *** sources We reviewed the available literature to highlight the specific risk factors and area of criticism,that should be further *** searched the Cochrane Library,Medline,Pubmed from 1987 to September 2018 using key words such as'cerebral palsy and children and pain'or'sedation and cerebral palsy and children'.Results While different pain scales are useful in recognizing pain expressions,anxiety scales are not ***,studies on non-pharmacological techniques do not always have comparable *** risk factors,from anatomic abnormalities to liver and kidney functioning,should be kept in mind before proceeding with *** Large trials are needed to assess the impact of non-pharmacological techniques and to evaluate which pain control strategy(pharmacological and non-pharmacological)should be used in different settings.

关键词： Analgesia Cerebral palsy Intellectual disability Pain Procedural sedation

Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo andrea Maria Morace Francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

Interactional behaviors of the parasitic beetle Paussus favieri with its ant host Pheidole pallidula:the mimetic role of the acoustical signals

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Insect Science 2021年第2期28卷 548-554页

作者： Simone Fattorini Emanuela Maurizi andrea di Giulio Department of Life Health and Environmental SciencesUniversity of L'AquilaL'AquilaItaly Research Centre for Plant Protection and Certification Council for Agricultural Research and Economics(CREA-DC)FlorenceItaly Department of Science LIMERoma Tre UniversityRomeItaly

The social parasitic beetle Puussus favieri(Coleoptera,Carabidae,Paussini)performs different types of stridulations,which sclectively mimic those emitted by dif-ferent ant castes of its host Pheidole pallidula(Hymenoptera,Formicidae,Myrmicinae).However,the significance of this acoustical mimicry for the success of the parasitic strat-egy and the behaviors elicited in the host ants by stridulations was *** reared Paussus favieri in Pheidole pallidula colonies and filmed their interacting *** analyzed in slow motion the behavior of ants near a stridulating *** analyzed sep-arately trains of pulse(Pa+Pb,produced by repeated rubbings)and single pulse(Pc,produced by a single rubbing)of stridulations,clearly recognizable from the shaking up and down of the beetle hind *** associated them with differcent ant *** full repertoire of sounds produced by P:favieri elicited benevolent responses both in workers and *** found that different signals elicit different(sometimes multiplc)bchaviors in ants,with different frequency in the two ant ***,Pc(alone or in conjunction with other types of pulses)appears to be the type of acoustic signal mostly responsible for all recorded *** results indicate that the acoustic channel plays a pivotal role in the host-parasite *** that a parasite uses the acoustical channel so intensively,and in such a complicated way to trigger ant bchaviors,indicates that acoustic signals may be more important in ant societies than commonly recognized.

关键词： acoustical channel ant castes beetle-ant interactions behavioral repertoire social parasites stridulation

Simplified Wave Models Applicability to Shallow Mud Flows Modeled as Power-Law Fluids

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Journal of Mountain Science 2014年第6期11卷 1454-1465页

作者： Cristiana di CRISTO Michele IERVOLINO andrea VACCA diCeM Università di Cassino e del Lazio Meridionale diCDEA Seconda Università di Napoli

Simplified wave models- such as kinematic,diffusion and quasi-steady- are widely employed as a convenient replacement of the full dynamic one in the analysis of unsteady open-channel flows,and especially for flood *** their use may guarantee a significant reduction of the computational effort,it is mandatory to define the conditions in which they may be confidently *** present paper investigates the applicability conditions of the kinematic,diffusion and quasisteady dynamic shallow wave models for mud flows of power-law *** power-law model describes in an adequate and convenient way fluids that at low shear rates fluids do not posses yield stress,such as clay or kaolin suspensions,which are frequently encountered in Chinese *** the framework of a linear analysis,the propagation characteristics of a periodic perturbation of an initial steady uniform flow predicted by the simplified models are compared with those of the full dynamic *** on this comparison,applicability criteria for the different wave approximations for mud flood of power-law fluids are *** presented results provide guidelines for selecting the appropriate approximation for a given flow problem,and therefore they may represent a useful tool for engineering predictions.

关键词： Power-law fluid Unsteady flows Shallow flows Simplified wave models