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集成技术 2024年第3期13卷 128-142页

作者：史越贾李佳刘翟中国科学院武汉病毒研究所武汉430207

自人类进入信息时代以来,全球信息总量飞速膨胀,为数据存储行业带来极大挑战。当前的信息存储工具存在许多缺陷,如信息密度低、使用寿命短、环境污染等,而脱氧核糖核酸(DNA)作为天然的遗传信息载体,具有信息密度高、稳定性高、保存时间... 详细信息

自人类进入信息时代以来,全球信息总量飞速膨胀,为数据存储行业带来极大挑战。当前的信息存储工具存在许多缺陷,如信息密度低、使用寿命短、环境污染等,而脱氧核糖核酸(DNA)作为天然的遗传信息载体,具有信息密度高、稳定性高、保存时间长、维护成本低等优点,可能成为信息存储领域的卓越选择。尽管DNA存储目前面临读写成本高、速度慢、错误率高等挑战,但在某些领域也有着独特的优势,如“冷”数据存储和军事加密存储等。目前,DNA存储的潜在发展方向主要包括在军事、航空航天等特殊场景下的应用,高容错的编解码方案,生物活体存储体系,脱离测序的信息读取方法,以及集成化的存储系统和统一行业标准等。希望在不久的将来,DNA存储能够实现规模化应用,迎来数据存储的新纪元。

关键词： DNA存储合成生物学生物技术-信息技术交叉数字信息存储

SARS-like virus in the Middle East:A truly bat-related coronavirus causing human diseases

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Protein & Cell 2012年第11期3卷 803-805页

作者： Guangwen Lu di liu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Network Information Center Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

On September 23rd,the United Kingdom Health Protection Agency(HPA)reported the diagnostic confirmation of a human infection case by a new type of coronavirus(http://***/NewsCentre/NationalPressReleases/2012PressReleases/120923acuterespiratoryillnessidentified/).The patient is a 49-year-old Qatari who suffered from an acute,serious respiratory illness.

关键词： acute respiratory diseases

New Developments in the Pharmacodynamics and Pharmacokinetics of Combination of Chinese Medicine and Western Medicine

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Chinese Journal of Integrative Medicine 2017年第4期23卷 312-319页

作者： liu di LIANG Xiao-chun Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical CollegeTranslational Medicine Center Chinese Academy of Medical Sciences Beijing 100730 China

It is very common to use Chinese medicine (CM) combined with Western medicine (WM) in clinical practice. The appropriate combination of CM with WM can reduce toxicity and enhance effects in order to make the best use of advantages and bypass the disadvantages. However, an inappropriate combination can not only affect the curative effect but even cause death. Therefore, strengthening the complementary advantages of the CM and WM to improve the therapeutic efficacy and reduce side effects has become an important research topic of clinical medicine and pharmacy. Many researchers try to clarify the effects of combining CM with WM on therapeutic efficacy and absorption, distribution, metabolism and excretion by pharmacodynamics and pharmacokinetics studies, providing evidence for clinical application. This review focuses on the new developments in the pharmacodynamics and pharmacokinetics of the combination of CM with WM in order to give references for clinical treatment.

关键词： combination of Chinese and Western medicine pharmacodynamics pharmacokinetics

OTFS-Based Efficient Handover Authentication Scheme with Privacy-Preserving for High Mobility Scenarios

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China Communications 2023年第1期20卷 36-49页

作者： Dawei Li di liu Yu Sun Jianwei liu School of Cyber Science and Technology Beihang UniversityBeijing 100191China

Handover authentication in high mobility scenarios is characterized by frequent and shortterm parallel ***,the penetration loss and Doppler frequency shift caused by high speed also lead to the deterioration of network link ***,high mobility scenarios require handover schemes with less handover ***,some existing schemes that meet this requirement cannot provide strong security guarantees,while some schemes that can provide strong security guarantees have large handover *** solve this dilemma,we propose a privacy-preserving handover authentication scheme that can provide strong security guarantees with less computational *** on Orthogonal Time Frequency Space(OTFS)link and Key Encapsulation Mechanism(KEM),we establish the shared key between protocol entities in the initial authentication phase,thereby reducing the overhead in the handover *** proposed scheme can achieve mutual authentication and key agreement among the user equipment,relay node,and authentication *** demonstrate that our proposed scheme can achieve user anonymity,unlinkability,perfect forward secrecy,and resistance to various attacks through security analysis including the *** performance evaluation results show that our scheme has a small computational cost compared with other schemes and can also provide a strong guarantee of security properties.

关键词： high mobility condition handover authentication privacy-preserving Tamarin OTFS

Linking deep CO2 outgassing to cratonic destruction

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National Science Review 2022年第6期9卷 12-22页

作者： Zhao-Xue Wang Sheng-Ao liu Shuguang Li di liu Jingao liu State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences

Outgassing of carbon dioxide from the Earth's interior regulates the surface climate through deep *** we examine the role of cratonic destruction in mantle CO2outgassing via collating and presenting new data for Paleozoic kimberlites, Mesozoic basaltic rocks and their mantle xenoliths from the eastern North China Craton（NCC）, which underwent extensive destruction in the early Cretaceous. High Ca/Al and low Ti/Eu and δ26Mg are widely observed in lamprophyres and mantle xenoliths, which demonstrates that the cratonic lithospheric mantle（CLM） was pervasively metasomatized by recycled *** analysis of bubble-bearing melt inclusions shows that redox melting of the C-rich CLM produced carbonated silicate melts with high CO2content. The enormous quantities of CO2in these magmas,together with substantial CO2degassing from the carbonated melt–CLM reaction and crustal heating,indicate that destruction of the eastern NCC resulted in rapid and extensive mantle CO2emission, which partly contributed to the early Cretaceous greenhouse climate episode.

关键词： carbonate metasomatism lithospheric mantle CO2 outgassing deep carbon cycling cratonic destruction North China Craton

Al和Cr协同作用提高核用高强钢耐水蒸气氧化性能

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金属学报 2024年第3期60卷 357-366页

作者：彭祥阳张乐李聪聪侯硕刘迪周建明路广遥蒋虽合中广核研究院有限公司设备研究所深圳518000 北京科技大学新金属材料国家重点实验室北京100083

前期研发的Fe-Ni-Al基超高强度马氏体时效钢表现出了良好的力学和抗辐照性能,然而典型Cr_(2)O_(3)氧化保护膜的耐热钢在轻水反应堆高温高压含水蒸气的服役环境中极易失效,亟待研发兼具抗高温水蒸气氧化、优异力学和抗辐照性能的先进材... 详细信息

前期研发的Fe-Ni-Al基超高强度马氏体时效钢表现出了良好的力学和抗辐照性能,然而典型Cr_(2)O_(3)氧化保护膜的耐热钢在轻水反应堆高温高压含水蒸气的服役环境中极易失效,亟待研发兼具抗高温水蒸气氧化、优异力学和抗辐照性能的先进材料。本工作在前期研发的Fe-Ni-Al系超高强度马氏体时效钢基础上添加不同含量的Cr元素,在保持新型马氏体钢优异力学性能的同时,对其在干燥空气和含水蒸气环境中的氧化性能进行研究。采用非自耗真空电弧炉制备合金铸锭,并对时效处理后的高强钢进行600℃干燥空气和潮湿空气2种环境中的抗氧化性能测试,对氧化后样品的表面和截面形貌进行微观组织表征。结果表明,添加9%Cr后的Fe-13Ni-2.3Al高强钢在600℃空气+10%水蒸气的气氛中氧化100 h的平均单位面积增重仅为0.1 mg/cm^(2),是添加5%Cr的Fe-13Ni-2.3Al高强钢和Fe-18Ni-3Al马氏体时效钢的1/50。对氧化后高强钢微观组织表征分析表明,在Al和Cr元素协同作用下,Fe-13Ni-9Cr-2.3Al高强钢在600℃空气+10%水蒸气条件下表面自发形成了富Fe、Cr、Al的复合氧化膜,提高了抗高温水蒸气氧化性能,其中Cr通过第三组元效应降低氧化物膜-基体界面氧分压,从而促进在高温水蒸气条件下在基体表面形成致密连续的富Al氧化膜。

关键词：超高强度钢水蒸气氧化氧化膜第三组元效应协同效应

三七根腐病菌茄腐镰刀菌的实时荧光LAMP快速检测方法的建立与应用

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农业生物技术学报 2024年第4期32卷 939-948页

作者：车晓莉梁婷婷曲媛刘迪秋昆明理工大学生命科学与技术学院云南省三七资源可持续利用重点实验室

根腐病是我国三七(Panax notoginseng)种植区高发的一种严重病害，茄腐镰刀菌(Fusarium solani)是引起三七根腐病的重要病原菌。本研究建立了一套对三七根腐病菌茄腐镰刀菌进行现场快速检测的实时荧光环介导等温扩增(loop-mediated isot... 详细信息

根腐病是我国三七(Panax notoginseng)种植区高发的一种严重病害，茄腐镰刀菌(Fusarium solani)是引起三七根腐病的重要病原菌。本研究建立了一套对三七根腐病菌茄腐镰刀菌进行现场快速检测的实时荧光环介导等温扩增(loop-mediated isothermal amplification, LAMP)体系。首先通过PCR反应筛选D-氨基酸氧化酶基因(D-amino acid oxidase gene, DAO)为特异性检测茄腐镰刀菌的基因位点，并对该基因设计LAMP反应的特异性引物组并优化其反应条件，其中65℃为最佳反应温度，MgSO4的最佳浓度为6 mmol/L;dNTPs的最佳浓度为0.6 mmol/L；有环引物存在的情况下，扩增效率更高。分析了LAMP法检测茄腐镰刀菌的灵敏度，模板浓度可低至0.009 pg/μL。最后结合DNA免提法以及钙黄绿素显色法建立了三七根腐病菌茄腐镰刀菌的LAMP现场快速检测技术。本研究为三七种植以及种子种苗交易过程中的根腐致病菌茄腐镰刀菌的快速检测提供技术支撑。

关键词：三七茄腐镰刀菌实时荧光LAMP 快速分子检测

Anabolic-androgenic steroids and cardiovascular risk

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Chinese Medical Journal 2019年第18期132卷 2229-2236页

作者： Jian-di liu Yan-Qing Wu Department of Cardiology The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Objective:Anabolic-androgenic steroids (AAS) represents a group of synthetic testosterone derivatives that play an important role in clinical *** drugs are widely abused among the general public to increase lean weight and improve athletic *** has been reported that AAS use can produce many adverse effects,especially the occurrence of cardiovascular *** there are many related studies,there has been no consensus on AAS use and cardiovascular *** present study was to review the effect of AAS on the cardiovascular *** sources:The data in this review were obtained from articles included in PubMed and the National Center for Biotechnology Information *** selection:Original articles,case reports,and systematic reviews about AAS were selected for the ***:The use/abuse of AAS is correlated with higher cardiovascular risks,and many AAS users/abusers had cardiovascular ***,there are many confounding factors in the studies that explored the causality between AAS intake and disease development,and additional studies are required to determine AAS ***:AAS produces toxic effects on the cardiovascular system,and it is necessary to ensure that more people know this about AAS,including medical personnel.

关键词： Anabolic-androgenic steroid Cardiovascular risk Toxicity effects

基于CP基因的中国云南省烟草TMV群体遗传多样性分析

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植物保护 2024年第4期50卷 48-60页

作者：赵正婷盖晓彤张俊蕾夏振远刘弟姜宁刘雅婷云南农业大学农学与生物技术学院昆明650201 云南省烟草农业科学研究院昆明650021 云南农业大学植物保护学院昆明650201 云南农业大学烟草学院昆明650201

为探明云南烟草上烟草花叶病毒(tobacco mosaic virus,TMV)的群体遗传多样性特征,本研究使用TMV外壳蛋白(coat protein,CP)基因的特异性引物对采自云南各烟区的疑似烟草花叶病样品进行检测,通过克隆测序获得138个TMV CP基因序列,对其进... 详细信息

为探明云南烟草上烟草花叶病毒(tobacco mosaic virus,TMV)的群体遗传多样性特征,本研究使用TMV外壳蛋白(coat protein,CP)基因的特异性引物对采自云南各烟区的疑似烟草花叶病样品进行检测,通过克隆测序获得138个TMV CP基因序列,对其进行了一致性比对,及系统发育、错配分布、遗传变异、群体多样性等分析。变异分析显示,138条CP基因序列共有变异位点数122个,占总位点数的25.42%,变异类型只有核苷酸替换,核酸多样性为0.018,单倍型多样性为0.970;一致性比对结果显示,138条序列的核苷酸和氨基酸序列一致性均为96%~100%;重组分析未检测到重组信号;对来自云南烟草,NCBI上其他地区烟草及云南地区其他寄主的TMV分离物的CP基因进行系统发育分析,结果显示,所有TMV分离物在进化上可分为4个组,本试验获得的分离物分布在1、2、3组,其中只有来源昭通地区的分离物倾向于聚成簇,表明云南烟草TMV分离物的适应性进化受地理适应性所驱动,与寄主适应性基本无关;错配分布分析显示,云南烟草TMV群体呈多峰分布,表明该群体近期未经历群体扩张事件;群体间遗传分化分析结果表明,除昭通和曲靖烟草TMV群体与其他TMV群体之间很容易发生遗传漂变促使群体发生遗传分化外,其余大部分TMV群体之间的基因流都可以抵制遗传漂变。本研究首次报道了云南各烟区TMV分离物群体遗传变异情况,研究结果可为TMV的抗病育种和制定更为有效的防治策略提供重要参考。

关键词：烟草云南烟草花叶病毒 CP基因遗传多样性

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