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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling Carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.< 80 years) at *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P < 0.001) and HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P < 0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates

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World Journal of Gastroenterology 2009年第2期15卷 204-210页

作者： Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín hernández Ludisleydis Bermúdez Boris L Rodríguez Department of Microbiology and Immunology Biotechnology Division National Centre for Scientif ic Research Ciudad de La Habana Cuba Department of Gastroenterology Medical and Chirurgic Research Centre (CIMEQ) Ciudad de La Habana Cuba Anatomopathology Department Medical and Chirurgic Research Centre (CIMEQ) Ciudad de La Habana Cuba

AIM： To investigate the prevalence of vacuolating cytotoxin （vacA）, cytotoxin associated gene A （cagA） and blood adhesion binding antigen （babA2） genotypes of Helicobacter pylori （H pylori） isolates from Cuban dyspeptic patients. METHODS： DNA was extracted from Hpylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specific primers for vacA （s1, s2, m1, m2）, cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS： vacA alleles s1, s2, m1 and m2 were detected in 96 （73.8%）, 34 （26.2%）, 75 （57.7%） and 52 isolates （40%）, respectively, while the cagA gene was detected in 95 isolates （73.2%）. One hundred and seven isolates （82.3%） were babA2-positive. A significant correlation was observed between vacAs1m1 and cagA and between vacAs1ml and babA2 genotypes （P 〈 0.001 and P 〈 0.05, respectively） and between babA2 genotype and cagA status （P 〈 0.05）; but, no correlation was observed between vacAsl and babA2 genotypes. Eighty five （65.4%） and 73 （56.2%） strains were type 1 （vacAsl-cagA-positive） and ＂triplepositive＂（vacAs1-cagA-babA2-positive）, respectively, and their presence was significantly associated with duodenal ulcer （P 〈 0.01 and P 〈 0.001, respectively）. CONCLUSION： The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were significantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied.

关键词： Cuban dyspeptic patients He/icobacterpylori vacA, cagA and babA

Mitochondrial genotyping of cultured Piaractus brachypomus revealed low diversity and mutations in regions involved in metabolisms and proliferation

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Aquaculture and Fisheries 2023年第3期8卷 239-243页

作者： Alexis Felipe Rojas-Cruz Carlos Ciceri-Coronado Alejandro Reyes-Bermúdez Programa de Biología Facultad de Ciencias B´asicasUniversidad de la AmazoniaFlorencia180001Colombia

In Amazonia,small-oriented family businesses or communities cultivate freshwater organisms as a source of *** effective management is fundamental for optimizing cultivated stocks,Amazonian aquaculture belittles the importance of genetic diversity,relying primarily on phenotypical characteristics during breeders’*** provide a“proof of concept”built on the premise that implementing modern technologies is crucial to optimizing fish stocks in rural Amazonian fish farms,we conducted a pilot study assessing genetic diversity on cultivated Piaractus brachypomus from Caquet´a,*** used mitochondrial control region(CR)sequences to evaluate *** data revealed low genetic diversity and suggested that most sampled individuals probably originated from a single maternal *** diversification resulted from discrete point mutations not associated with geographical *** accumulate in non-conserved CR regions,yet the most divergent haplotypes display mutations in conserved CR sequences with roles in mitochondrial metabolisms and ***,our results indicate a need in the local industry to design breeding strategies to enhance diversity to avoid deleterious effects caused by inbreeding and domestication.

关键词： Mitochondrial control region Amazonian fish farming Genetic diversity Freshwater

GSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm

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Journal of Animal Science and Biotechnology 2019年第4期10卷 931-941页

作者： Marc Llavanera Ariadna Delgado-Bermúdez Beatriz Fernandez-Fuertes Sandra Recuero Yentel Mateo Sergi Bonet Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction (Techno Sperm) Unit of Cell Biology Department of Biology Institute of Food and Agricultural Technology University of Girona

Background: Cryopreservation is currently the most efficient method for long-term preservation of mammalian gametes and is extensively used in swine artificial insemination(AI) centres. However, it is well-known that cryopreservation procedures induce changes in the water phase in both intra and extracellular compartments,which alter the content and localisation of several proteins and ends up curtailing the structural integrity of functional sperm(i.e., cryoinjuries). Alterations and deficiencies of sperm-oocyte binding proteins during gamete recognition are one of the causes of reproductive failure both in vitro and in vivo. In this sense, characterisation of cryopreservation effects upon oocyte-binding proteins of sperm, such as IZUMO1 and GSTM3, is essential when assessing the impact of this technique in swine ***: Cryopreservation was found to induce changes in the localisation of IZUMO1 and GSTM3 in boar ***, the relative content of both proteins was not altered after thawing. Furthermore, whereas IZUMO1 content was found not to be related to the cryotolerance of boar sperm, GSTM3 content was observed to be higher in poor(PFE) than in good(GFE) freezability ejaculates in both pre-frozen(1.00 INT·mm^2± 0.14 INT·mm^2 vs.0.72 INT·mm^2± 0.15 INT·mm^2;P < 0.05) and post-thawed(0.96 INT·mm^2± 0.20 INT·mm^2 vs. 70 INT·mm^2± 0.19 INT·mm^2;P < 0.05) samples. Moreover, GSTM3 levels were found to be higher in those spermatozoa that exhibited low mitochondrial activity, high reactive oxygen species(ROS) production, and high membrane lipid disorder postthaw(P < 0.05).Conclusions: The difference in GSTM3 content between GFE and PFE, together with this protein having been found to be related to poor sperm quality post-thaw, suggests that it could be used as a cryotolerance marker of boar spermatozoa. Furthermore, both IZUMO1 and GSTM3 relocate during cryopreservation, which could contribute to the reduced fertilising capacity of frozen-thawed boar

关键词： Boar Cryopreservation GSTM3 IZUMO1 ROS Sperm

Determination of double-and single-stranded DNA breaks in bovine sperm is predictive of their fertilizing capacity

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Journal of Animal Science and Biotechnology 2023年第1期14卷 134-151页

作者： Jordi Ribas‑Maynou Ariadna Delgado‑Bermúdez Yentel Mateo‑Otero Estel Vinolas Carlos O.Hidalgo WSteven Ward Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Faculty of SciencesInstitute of Food and Agricultural TechnologyUniversity of GironaC/Maria Aurèlia Campany69ES‑17003 GironaSpain. Unit of Cell Biology Department of BiologyFaculty of SciencesUniversity of GironaES‑17003 GironaSpain. Institute for Biogenesis Research Department of AnatomyBiochemistry&PhysiologyJohn A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHI 96822USA. Department of Animal Selection and Reproduction The Regional Agri-Food Research and Development Service of Asturias(SERIDA)ES‑33394 GijónSpain. Catalan Institution for Research and Advanced Studies(ICREA) ES‑08010 BarcelonaSpain.

Background:The analysis of chromatin integrity has become an important determinant of sperm *** frozenthawed bovine sperm,neither the sequence of post-thaw injury events nor the dynamics of different types of sperm DNA breaks are well *** aim of the present work was to describe such sperm degradation aftermath focusing on DNA damage dynamics,and to assess if this parameter can predict pregnancy rates in ***:A total of 75 cryopreserved ejaculates from 25 Holstein bulls were evaluated at two post-thawing periods(0-2 h and 2-4 h),analyzing global and double-stranded DNA damage through alkaline and neutral Comet assays,chromatin deprotamination and decondensation,sperm motility,viability,acrosomal status,and intracellular levels of total ROS,superoxides and *** of 59,605 females was conducted using sperm from the same bulls,thus obtaining the non-return to estrus rates after 90 d(NRR).Results showed an increased rate of double-stranded breaks in the first period(0-2 h:1.29±1.01%/h vs.2-4 h:0.13±1.37%/h;P0.05).Finally,whereas no correlations between bull fertility and any dynamic parameter were found,there were correlations between the NRR and the basal percentage of highly-damaged sperm assessed with the alkaline Comet(Rs=-0.563,P=0.003),between NRR and basal progressive motility(Rs=0.511,P=0.009),and between NRR and sperm with high ROS at 4 h post-thaw(Rs=0.564,P=0.003).Conclusion:The statistically significant correlations found between intracellular ROS,sperm viability,sperm motility,DNA damage

关键词： Cattle Chromatin Comet test DNA damage Fertility Sperm Sperm quality

Metabolomic fingerprinting of pig seminal plasma identifies in vivo fertility biomarkers

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Journal of Animal Science and Biotechnology 2022年第2期13卷 473-487页

作者： Yentel Mateo-Otero Pol Fernández-López Ariadna Delgado-Bermúdez Pau Nolis Jordi Roca Jordi Miró Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaES-17003 GironaSpain Department of Biology Unit of Cell BiologyFaculty of SciencesUniversity of GironaES-17003 GironaSpain Centre d’Estudis Avançats de Blanes(CEAB) Spanish Research Council(CSIC)ES-17300 GironaSpain Magnetic Nuclear Resonance Facility Autonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Animal Medicine and Surgery Faculty of Veterinary MedicineUniversity of MurciaES-30100 MurciaSpain Equine Reproduction Service Department of Animal Medicine and SurgeryFaculty of Veterinary MedicineAutonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Veterinary Medical Sciences University of BolognaIT-40064 Ozzano dell’EmiliaBolognaItaly

Background:Metabolomic approaches,which include the study of low molecular weight molecules,are an emerging-omics technology useful for identification of *** this field,nuclear magnetic resonance(NMR)spectroscopy has already been used to uncover(in)fertility biomarkers in the seminal plasma(SP)of several mammalian ***,NMR studies profiling the porcine SP metabolome to uncover in vivo fertility biomarkers are yet to be carried ***,this study aimed to evaluate the putative relationship between SPmetabolites and in vivo fertility *** this end,24 entire ejaculates(three ejaculates per boar)were collected from artificial insemination(AI)-boars throughout a year(one ejaculate every 4 months).Immediately after collection,ejaculates were centrifuged to obtain SP-samples,which were stored for subsequent metabolomic analysis by NMR *** outcomes from 1525 inseminations were recorded over a year,including farrowing rate,litter size,stillbirths per litter and the duration of ***:A total of 24 metabolites were identified and quantified in all *** operating characteristic(ROC)curve analysis showed that lactate levels in SP had discriminative capacity for farrowing rate(area under the curve[AUC]=0.764)while carnitine(AUC=0.847),hypotaurine(AUC=0.819),sn-glycero-3-phosphocholine(AUC=0.833),glutamate(AUC=0.799)and glucose(AUC=0.750)showed it for litter ***,citrate(AUC=0.743),creatine(AUC=0.812),phenylalanine(AUC=0.750),tyrosine(AUC=0.753)and malonate(AUC=0.868)levels had discriminative capacity for stillbirths per litter;and malonate(AUC=0.767)and fumarate(AUC=0.868)levels for gestation ***:The assessment of selected SP-metabolites in ejaculates through NMR spectroscopy could be considered as a promising non-invasive tool to predict in vivo fertility outcomes in ***,supplementing AI-doses with specific metabolites should also be envisaged as a way to improve their f

关键词： Artificial insemination in vivo fertility Metabolomics NMR Pregnancy outcomes Seminal plasma

Validation of kinetic modeling of progesterone release from polymeric membranes

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 54-62页

作者： Analia Irma Romero Mercedes Villegas Alicia Graciela Cid Mónica Liliana Parentis Elio Emilio Gonzo José María Bermúdez Instituto de Investigaciones para la Industria Química Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas Facultad de Ingeniería Universidad Nacional de Salta

Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone(Prg) controlled release from poly-3-hydroxybutyric acid(PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion(AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found,which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.

关键词： Mathematical models Model validation Drug delivery/release Mass transfer coefficient Equilibrium distribution constant

The 3x + 1 Conjecture, a Direct Path

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American Journal of Computational Mathematics 2023年第2期13卷 350-355页

作者： Salvador Bermúdez Gómez Instituto Politécnico Nacional SEPI-ESIME-Zacatenco Mexico City México

The 3x + 1 problem, is a math problem that has baffled mathematicians for over 50 years. It’s easy to explain: take any positive number, if it’s even, divide it by 2;if it’s odd, multiply it by 3 and add 1. Repeat this process with the resulting number, and the conjecture says that you will eventually reach 1. Despite testing all starting values up to an enormous number, no one has proved the conjecture is true for all possible starting values. The problem’s importance lies in its simplicity and difficulty, inspiring new ideas in mathematics and advancing fields like number theory, dynamical systems, and computer science. Proving or disproving the conjecture would revolutionize our understanding of math. The presence of infinite sequences is a matter of question. To investigate and solve this conjecture, we are utilizing a novel approach involving the fields of number theory and computer science.

关键词： 3x + 1 Collatz Solved Computer Science Number Theory New Algo-rithm

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用于橡胶胶料的一种新型二氧化硅填充剂

世界橡胶工业 1984年第4期 26-32页

作者： L.González hernàdez 金晟娟

一种新型的二氧化硅是从天然硅酸镁中(海泡石)经过酸处理后获得的。在酸处理过程中,八面体层中阳离子的移动速率要比那些在四面体层中的移功速率快。其形态和结晶随着X—射线的衍射和电子显微镜的衍射而发生变化。文中测定了在各种不同... 详细信息

一种新型的二氧化硅是从天然硅酸镁中(海泡石)经过酸处理后获得的。在酸处理过程中,八面体层中阳离子的移动速率要比那些在四面体层中的移功速率快。其形态和结晶随着X—射线的衍射和电子显微镜的衍射而发生变化。文中测定了在各种不同用量下,新型二氧化硅填充剂对以天然橡胶、丁苯橡胶以及丁腈橡胶为基础的硫化胶料的性能,同时还对硅烷偶联剂在胶料中的效应作了研究。

关键词：二氧化硅填充剂硅烷偶联剂酸处理海泡石蛸螵石粘土矿物天然胶料