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Recent Progress in Reinforcement learning and Adaptive Dynamic Programming for Advanced Control Applications

IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 18-36页

作者： Ding Wang Ning Gao derong l.u Jinna li Frank l.lewis IEEE the Faculty of Information Technology Beijing Key Laboratory of Computational Intelligence and Intelligent SystemBeijing Laboratory of Smart Environmental Protectionand Beijing Institute of Artificial IntelligenceBeijing University of TechnologyBeijing 100124China the School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen 518055China the Department of Electrical and Computer Engineering University of Illinois at ChicagoChicago IL 60607 USA the School of Information and Control Engineering Liaoning Petrochemical UniversityFushun 113001China the uTA Research Institute the University of Texas at ArlingtonArlington TX 76118 USA

Reinforcement learning(Rl) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with Rl and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, ***, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and Rl frameworks,showing how they promote ADP formulation ***, several typical control applications with respect to Rl and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and Rl for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence.

关键词： Adaptive dynamic programming(ADP) advanced control complex environment data-driven control event-triggered design intelligent control neural networks nonlinear systems optimal control reinforcement learning(Rl)

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Variational data encoding and correlations in quantum-enhanced machine learning

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Chinese Physics B 2024年第9期33卷 298-306页

作者： Ming-Hao Wang Hua l.u School of Physics Hubei UniversityWuhan 430062China School of Science Hubei University of TechnologyWuhan 430068China

leveraging the extraordinary phenomena of quantum superposition and quantum correlation,quantum computing offers unprecedented potential for addressing challenges beyond the reach of classical *** paper tackles two pivotal challenges in the realm of quantum computing:firstly,the development of an effective encoding protocol for translating classical data into quantum states,a critical step for any quantum *** encoding strategies can significantly influence quantum computer ***,we address the need to counteract the inevitable noise that can hinder quantum *** primary contribution is the introduction of a novel variational data encoding method,grounded in quantum regression algorithm *** adapting the learning concept from machine learning,we render data encoding a learnable *** allowed us to study the role of quantum correlation in data *** numerical simulations of various regression tasks,we demonstrate the efficacy of our variational data encoding,particularly post-learning from instructional ***,we delve into the role of quantum correlation in enhancing task performance,especially in noisy *** findings underscore the critical role of quantum correlation in not only bolstering performance but also in mitigating noise interference,thus advancing the frontier of quantum computing.

关键词： quantum machine learning variational data encoding quantum correlation

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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cel.ular & Molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael l.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-OC43,Nl63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

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Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha l.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

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Noncoding RNAs：＇our turn＇ to join the p53 networ

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Journal of Molecular Cell Biology 2014年第3期8卷 179-180页

作者： Yong li Hua l.u Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY40202 USA E-mail: yong.ti@louisviUe.edu Department of Biochemistry& Molecular Biology andTulane Cancer Center TulaneUniversity School ofMedicine New Orleans LA70112 USA

The p53 tumor suppressor is the guardian of the rrr- o human genome. Since ,ts discovery in pS3 has been the most studied molecule in the field of cancer. Recently, its role has also been extended to other biological and pathological processes, p53 functions primarily as a transcription factor to regulate target genes that encode proteins crucial for promot- ing apoptotic cell death, cell cycle arrest, senescence, and so on in response to diverse upstream stressors. Interestingly, some of the p53 targets are noncoding RNAs. Noncoding RNAs can be functional without being translated into proteins and are often independent RNA molecules or noncoding parts of messenger RNAs. The past decade has witnessed bur- geoning intensive investigation on the interplay of noncoding RNAs with p53, its regulators, and effectors during the development of cancer and/or other dis- eases. This issue of Journal of Molecular Cell Biology presents five essays to review the rapid progress in this area from five different angles and to offer new insight into the role of noncoding RNAs in the p53 signaling web with updated information.

关键词：非编码RNA BP网络分子细胞生物学 P53 编码蛋白质细胞周期阻滞 p53 人类基因组

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Childhood malaria in the Niger delta area of Nigeria:mothers/care givers'perception,definition and treatment practices

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 52-58页

作者： Idogun E.Sylvester Airauhi l.u Department of Chemical Pathology University of Benin Teaching HospitalBenin City Department of Medical Microbiology Biology University of Benin Teaching HospitalBenin City

Objective:The objective of the study was to evaluate mothers/care givers perception of malaria,their treatment practices and the effects on the outcome of ***:Four hundred and sixty children were enrolled and their mothers/care givers *** children were screened for malaria parasitaemia and there after,blood specimens were obtained for biochemical and haematological evaluation from those children who met the criteria and tested positive to *** *** cell volume,electrolytes,urea, creatinine,plasma glucose,and serum bilirubin were ***:A total of 460 children were studied, 233(50.7%) males and 227(49.3%) *** malaria cases were 112(24.3%) and severe malaria 348(75.7%).Those who presented early 106(23.0%) and those who presented late 354(77.0%).Perception and definition of malaria as well as the treatment seeking behaviors vary significantly with the level of education of the mothers and care *** without formal education 68(51.9%) wrongly perceived that the etiology of malaria can only be diagnosed by native doctors compared to those with primary six education 61 (26.5%) and junior secondary education 10(10.1%).Only 43(9.3%) gave the correct dose of chloroquine syrup to their sick children,while 32(7.0%) gave at sub optimal ***:Wrong perception of malaria especially the complicated malaria and wrong treatment practices are major contributory factors to the high mortality and morbidity of malaria in *** is therefore a need for health education to correct the wrong ideas about the cause and treatment practices of malaria as part of malaria control programme.

关键词： Childhood malaria Mothers/Caregivers Perception and treatment practices Nigeria

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-lobato Mariam Masmudi-Martín Manuel F.lópez-Aranda Juan F.lópez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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miR-26a-5p调控PTEN/PI3K/Akt信号通路对高糖诱导视网膜Müller细胞活化及凋亡的影响

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西安交通大学学报（医学版） 2024年第5期45卷 705-711页

作者：唐德荣杨雨雯石蕊刘丹丹安康市职业技术学院医学院/安康市中心医院眼科陕西安康725000 温州医科大学浙江温州325035 陕西省人民医院眼科陕西西安710068

目的检测微小RNA-26a-5p(microRNA-26a-5p,miR-26a-5p)对PTEN/PI3K/Akt信号通路及高糖刺激的视网膜Müller细胞凋亡的影响,探讨糖尿病视网膜神经损伤的潜在机制。方法采用不同浓度的葡萄糖刺激视网膜Müller细胞构建糖尿病视网膜神经损... 详细信息

目的检测微小RNA-26a-5p(microRNA-26a-5p,miR-26a-5p)对PTEN/PI3K/Akt信号通路及高糖刺激的视网膜Müller细胞凋亡的影响,探讨糖尿病视网膜神经损伤的潜在机制。方法采用不同浓度的葡萄糖刺激视网膜Müller细胞构建糖尿病视网膜神经损伤模型,采用CCK-8及流式细胞仪观察细胞增殖及凋亡情况,细胞转染过表达miR-26a-5p模拟物,Real-time PCR检测miR-26a-5p、PTEN、PI3K、Akt的表达情况,ElISA测定细胞上清液中Il-1β及Il-6的水平,采用Graphpad 8.0软件处理数据。结果高糖刺激视网膜Müller细胞生长活跃,与对照组相比,50 mmol/l高糖刺激Müller细胞活力在12 h、24 h时逐渐增加,48 h时活力减弱,细胞凋亡增加,组间差异有统计学意义(Pller细胞中miR-26a-5p水平下降,PTEN的表达显著升高,PI3K及Akt水平下降,Il-1β及Il-6的水平明显升高,过表达miR-26a-5p后,PTEN水平降低,PI3K/Akt及炎性因子降低,细胞凋亡减少(Pller细胞凋亡。

关键词：视网膜Müller细胞微小RNA-26a-5p(miR-26a-5p) PTEN/PI3K/Akt 炎症糖尿病视网膜病变

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A-PRF促进兔膝关节骨软骨损伤愈合的观察

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上海交通大学学报（医学版） 2024年第1期44卷 13-22页

作者：朱泽宇吕成奇刘旭凌陈昱璐邹德荣陆家瑜上海交通大学医学院附属第六人民医院口腔科上海200233

目的·探讨改良型富血小板纤维蛋白(advanced platelet-rich fibrin,A-PRF)在骨软骨再生中的作用。方法·获取新西兰兔骨髓间充质干细胞(bone-marrow mesenchymal stem cells,BMSCs)和膝关节软骨细胞;通过低速离心兔心脏血液获得A-PRF... 详细信息

目的·探讨改良型富血小板纤维蛋白(advanced platelet-rich fibrin,A-PRF)在骨软骨再生中的作用。方法·获取新西兰兔骨髓间充质干细胞(bone-marrow mesenchymal stem cells,BMSCs)和膝关节软骨细胞;通过低速离心兔心脏血液获得A-PRF。采用光学显微镜观察A-PRF的组织学结构;ElISA法检测A-PRF中生长因子,包括血小板衍生生长因子、转化生长因子-β、胰岛素样生长因子、血管内皮生长因子、表皮生长因子和成纤维细胞生长因子的释放;采用活/死细胞双染法及MTT法检测A-PRF对兔BMSCs细胞毒性及增殖情况的影响;采用实时荧光定量聚合酶链反应(qRT-PCR)检测A-PRF对兔BMSCsⅡ型胶原蛋白、聚集蛋白聚糖、碱性磷酸酶(AlP)和骨钙素(OCN)基因表达的影响;使用transwell小室测定A-PRF对于兔BMSCs以及软骨细胞迁移能力的影响。建立兔膝关节骨软骨缺损模型,将18只兔随机分为3组:A-PRF组(n=6)在缺损处植入A-PRF;A-PRF+BMSCs组(n=6)植入接种兔BMSCs的A-PRF;对照组(n=6)不进行植入操作。术后12周处死兔,采用苏木精-伊红(H-E)、甲苯胺蓝和番红O-固绿染色进行膝关节标本的组织学观察,并根据膝关节的表面形态学与组织学情况,采用国际软骨修复协会(International Cartilage Repair Society,ICRS)评分系统进行宏观与组织学评分。结果·A-PRF具有松散的网络结构,可以缓慢释放生长因子。加入A-PRF后,未观察到其对兔BMSCs具有细胞毒性;在加入A-PRF后24、48和72 h,BMSCs的增殖能力均明显升高(均PlP和OCN均显著上调(均P<0.05)。加入A-PRF后,兔BMSCs与软骨细胞的迁移能力均显著增强(均P<0.05),且兔BMSCs的迁移能力显著高于软骨细胞(P=0.025)。在兔膝关节缺损模型中,观察关节表面形态,可见A-PRF组和A-PRF+BMSCs组缺损均基本恢复,而对照组仅有软组织覆盖。在ICRS宏观评分方面,A-PRF组与A-PRF+BMSCs组的差异无统计学意义,但2组评分均显著高于对照组(均P<0.05)。组织学观察显示,A-PRF组和A-PRF+BMSCs组均产生骨软骨修复,但A-PRF组软骨更加成熟,对照组则形成纤维修复。在ICRS组织学评分方面,A-PRF组与A-PRF+BMSCs组的差异无统计学意义,但2组评分均显著高于对照组(均P<0.05)。结论·自体A-PRF具有良好的生物相容性和促进BMSCs增殖的能力,在体外和体内均可促进软骨和软骨下骨的修复。

关键词：骨软骨损伤改良型富血小板纤维蛋白生长因子硬组织再生

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Femtosecond pulse laser scanning using Acousto-Optic Deflector

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Science China(Physics,Mechanics & Astronomy) 2009年第5期52卷 685-692页

作者： ZENG ShaoQun luO QingMing lI derong lü XiaoHua Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

Acousto-optic modulation of the femtosecond laser beam has wide potential in various fields such as microscopic imaging, micromachining and optical storage because of its rapidity, high accuracy and good repeatability. This paper reviews the latest research on acousto-optic modulation of femtosecond laser, describes the effects of spatial and temporal dispersion of such lasers after acousto-optic modulation, introduces the theoretical outcomes on pulse width evolution of the Gaussian laser pulses after acousto-optic modulation, discusses the characteristics of contemporary dispersion-compensating techniques for the acousto-optic modulation of femtosecond laser, and finally refers to the challenges of this technique.

关键词： femtosecond laser acousto-optic modulation dispersion microscopic imaging laser machining optical storage

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