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Neutrino Mass constraints from Reconstructing the Large-scale Structure:Systematic Uncertainty

Research in Astronomy and Astrophysics 2023年第6期23卷 65-73页

作者： chok Lap chung derek Inman Xin Wang Erhao Shang Zi Zhuang Fucheng Yuan Ue-Li Pen School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 5109082China Kavli IPMU(WPI) UTIASThe University of TokyoKashiwaChiba 277-8583Japan cSST Science center for the guangdong-Hong Kong-Macao greater Bay Area SYSUChina Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PlHiloHI 96720USA canadian Institute for Theoretical Astrophysics 60 St.George StreetTorontoON M5S 3H8Canada canadian Institute for Advanced Research 180 Dundas St WestTorontoON M5G 1Z8Canada Dunlap Institute for Astronomy and Astrophysics University of Toronto50 St George StreetTorontoON M5S 3H4Canada Perimeter Institute of Theoretical Physics 31 Caroline Street NorthWaterlooON N2L 2Y5Canada

We examine the possibility of applying the baryonic acoustic oscillation reconstruction method to improve the neutrino massΣm_ν*** to the gaussianization of the process,we demonstrate that the reconstruction algorithm could improve the measurement accuracy by roughly a factor of *** the other hand,the reconstruction process itself becomes a source of systematic *** the algorithm is supposed to produce the displacement field from a density distribution,various approximations cause the reconstructed output to deviate on intermediate ***,it is still possible to benefit from this gaussianized field,given that we can carefully calibrate the“transfer function”between the reconstruction output and theoretical displacement divergence from *** limitation of this approach is then set by the numerical stability of this transfer *** an ensemble of simulations,we show that such systematic error could become comparable to statistical uncertainties for a DESI-like survey and be safely neglected for other less ambitious surveys.

关键词： (cosmology:)large-scale structure of universe cosmology:observations neutrinos

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各种二茂铁基席夫碱的合成、表征和对革兰氏阳性和革兰氏阴性细菌的抗菌筛选

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无机化学学报 2022年第4期38卷 705-715页

作者： Oladeji S.Olatunde Ikhile I.Monisola Mamo Messai Ndungu g.Patrick Ndinteh T.derek Department of chemical Sciences Faculty of ScienceUniversity of JohannesburgJohannesburgSouth Africa

合成了10种二茂铁基席夫碱1~10,并采用UV⁃Vis光谱、FT⁃IR、元素分析、1 H和13c NMR谱对其进行了表征。评价了所合成的化合物对11种细菌菌株(枯草芽孢杆菌ATcc19659、产气克雷伯氏菌肠杆菌ATcc13882、粪肠球菌ATcc13047、耻垢分枝杆菌Mc2... 详细信息

合成了10种二茂铁基席夫碱1~10,并采用UV⁃Vis光谱、FT⁃IR、元素分析、1 H和13c NMR谱对其进行了表征。评价了所合成的化合物对11种细菌菌株(枯草芽孢杆菌ATcc19659、产气克雷伯氏菌肠杆菌ATcc13882、粪肠球菌ATcc13047、耻垢分枝杆菌Mc2155、表皮葡萄球菌ATcc14990、金黄色葡萄球菌ATcc25923、大肠杆菌ATcc25922、阴沟肠杆菌ATcc13047、产酸克雷伯氏菌ATcc8724、奇异变形杆菌ATcc7002、普通变形杆菌ATcc6380)的抗菌活性。抗菌试验结果表明,与标准物萘啶酸和硫酸链霉素对比,合成的席夫碱1~10可抑制产气克雷伯氏菌和粪肠球菌的潜在生长,最低抑菌浓度(MIc)分别为15.6~31.25和31.25~125μg·mL^(-1)。

关键词：抗菌席夫碱萘啶合成抑制

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Performance of the Enhanced Liver Fibrosis Score,comparison with Vibration-controlled Transient Elastography Data,and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a community-based Liver Service:A Retrospective Evaluation

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Journal of clinical and Translational Hepatology 2023年第4期11卷 800-808页

作者： Tina Reinson Janisha Patel Mead Mathews derek Fountain Ryan M.Buchanan christopher DByrne Nutrition and Metabolism Faculty of MedicineUniversity of SouthamptonSouthamptonUK National Institute for Health and care Research Southampton Biomedical Research CenterUniversity Hospital SouthamptonSouthamptonUK Hepatology Department University Hospital SouthamptonSouthamptonUK St Mary’s Surgery SouthamptonUK core Minutes Ltd RingwoodUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthamptonUK

Background and Aims:Liver fibrosis is a key risk factor for cirrhosis,hepatocellular carcinoma and end stage liver *** National Institute for Health and care Excellence guidelines for assessment for advanced(≥F3)liver fibrosis in people with nonalcoholic fatty liver disease recommend the use of enhanced liver fibrosis(ELF)test,followed by vibration-controlled transient elastography(VcTE).Performance of ELF at predicting significant(≥F2)fibrosis in real-world practice is *** assess the accuracy of ELF using VcTE;investigate the optimum ELF cutoff value to identify≥F2and≥F3;and develop a simple algorithm,with and without ELF score,for detecting≥***:Retrospective evaluation of patients referred to a community Liver Service for VcTE,Jan-Dec *** included:body mass index(BMI),diabetes status,alanine aminotransferase(ALT)levels,ELF score and biopsy-validated fibrosis stages according to ***:Data from 273 patients were available.n=110 patients had *** showed fair performance for≥F2 and≥F3,area under the curve(AUc)=0.70,95%confidence interval(cI)0.64-0.76 and AUc=0.72,95%cI:0.65-0.79 ***≥F2 Youden's index for ELF=9.85 and for≥F3,ELF=*** ALT,BMI,and HbA1c(ALBA algorithm)to predict≥F2 showed good performance(AUc=0.80,95%cI:0.69-0.92),adding ALBA to ELF improved performance(AUc=0.82,95%cI:0.77-0.88).Results were independently ***:Optimal ELF cutoff for≥F2 is 9.85 and 9.95 for≥***,BMI,and HbA1c(ALBA algorithm)can stratify patients at risk of≥*** is improved by adding ALBA.

关键词： Primary health care Retrospective evaluation Liver disease Diabetes Nonalcoholic fatty liver disease

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Lemierre’s Syndrome Associated With campylobacter rectus Bacteremia

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Infectious Microbes & Diseases 2019年第1期1卷 27-29页

作者： derek L.L.Hung Jade L.L.Teng Susanna K.P.Lau Patrick c.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina carol Yu centre for Infection The University of Hong KongHong KongChina collaborative Innovation center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction campylobacter rectus is a gram-negative,anaerobic rod,first described in 1981 as Wolinella recta,subsequently re-classified to campylobacter based on phylogenetic analysis in 1991.1 It is found in the oral cavity and gastrointestinal tract,and is mainly implicated in oral and periodontal *** far,there are only a handful of case reports in the literature describing extra-oral invasive *** infections.2–6 Recently,we described a case of fatal *** infection,due to subdural empyema and ruptured mycotic intracranial aneurysm.2 In this article,we report a case of Lemierre’s syndrome associated with *** bacteremia.

关键词： Lemierre’s syndrome campylobacter rectus bacteremia

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Soluble Triggering Receptor Expressed on Myeloid cells-1 and Inflammatory Markers in colorectal cancer Surgery： A Prospective cohort Study

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chinese Medical Journal 2017年第22期130卷 2691-2696页

作者： Lovorka derek Drazen Servis Adriana Unic Department of clinical chemistry Sestre Milosrdnice University Hospital Center Zagreb 10000 Croatia Department of general and Abdominal Surgery St. Anna Hospital Sulzbach-Rosenberg 92237 Germany

Background： Major abdominal surgery, including colorectal cancer （cRc） surgery, leads to systemic inflammatory response syndrome that can be detected and monitored with inflammatory markers testing. The aims of the study were to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-l （sTREM-1 ）, interleukin-6 （IL-6）, procalcitonin （PcT）, and c-reactive protein （cRP） in following the inflammatory response in cRc surgery and postoperative period, as well as to determine if duration of the surgery and the time that the colon has been opened during the surgery （open colon time [OcT]） refect a larger surgical stress through inflammatory markers rise. Methods： The study included 20 patients who underwent cRc surgery and 19 healthy volunteers from June 2011 to September 2012. We determined inflammatory markers 1 day before surgery （T0）, 24 h （T1）, 48 h （T2）, and 7 days after the surgery （T3）. All statistical analyses were calculated using Medcalc Statistical Software version 14.8.1 （Medcalc Software bvba, Ostend, Belgium）. Results： concentrations ofcRP, PcT, and I L-6 in all measurement times were statistically different and sTREM- 1 did not yield statistical significance. A weak positive correlation was/bund between l L-6 in T 1 and T2 with the duration of the surgery （T 1 ： r= 0.4060, P 〈 0.0001 ; T2：r =0.3430, P〈0.0001）andOcT（T1：r= 0.3640, P〈0.0001,T2：r=0.3430, P〈0.0001）.AweakpositivecorrelationbetweencRP in T2 and OcT （r = 0.4210, P 〈 0.0001 ） was also found. The interconnectivity of tested parameters showed a weak positive correlation between cRP and IL-6 in T1 （r= 0.3680; P 〈 0.0001 ）, moderate positive correlation in T2 （r = 0.6770; P 〈 0.0001）, and a strong positive correlation in T3 （r = 0.8651; P 〈 0.0001）. conclusions： cRP, IL-6, and PcT were shown to be reliable for postoperative monitoring. Simultaneous determination of cRP and IL-6 might not be useful as they follow similar kinetics, sTREM- 1 might not be useful in cRc postoperat

关键词： Acute-phase Proteins colorectal cancer Surgery Soluble Triggering Receptor Expressed on Myeloid cells-1

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Realization of flexible in-memory computing in a van der Waals ferroelectric heterostructure tri-gate transistor

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Nano Research 2024年第3期17卷 1886-1892页

作者： Xinzhu gao Quan chen Qinggang Qin Liang Li Meizhuang Liu derek Hao Junjie Li Jingbo Li Zhongchang Wang Zuxin chen School of Semiconductor Science and Technology South China Normal UniversityFoshan 528225China guangdong Provincial Key Laboratory of chip and Integration Technology Guangzhou 510631China Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230601China School of Science STEM CollegeRMIT UniversityMelbourne 3000Australia cAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi 830011China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China college of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/nBraga 4715-330Portugal

combining logical function and memory characteristics of transistors is an ideal strategy for enhancing computational efficiency of transistor ***,we rationally design a tri-gate two-dimensional(2D)ferroelectric van der Waals heterostructures device based on copper indium thiophosphate(cuInP_(2)S_(6))and few layers tungsten disulfide(WS_(2)),and demonstrate its multi-functional applications in multi-valued state of data,non-volatile storage,and logic *** co-regulating the input signals across the tri-gate,we show that the device can switch functions flexibly at a low supply voltage of 6 V,giving rise to an ultra-high current switching ratio of 107 and a low subthreshold swing of 53.9 mV/*** findings offer perspectives in designing smart 2D devices with excellent functions based on ferroelectric van der Waals heterostructures.

关键词： two-dimensional(2D)ferroelectric heterostructure tri-gate polymorphic regulation in-memory computing

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Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

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Journal of chinese Pharmaceutical Sciences 2017年第12期26卷 858-871页

作者： Monisola Itohan Ikhile Marthe carine Djuidje Fotsing charmaine Ardeme Jane catherine Ngila derek Tantoh Ndinteh Department of Applied chemistry University of JohannesburgDoornfontein CampusPO 17011Johannesburg 2028South Africa Department of chemistry University of JohannesburgP O Box 524Auckland ParkJohannesburg 2006South Africa

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2_1/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

关键词： Schiff bases Biological activity Synthesis X-ray diffraction characterization

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Next-generation Sequencing-Based Diagnosis of Bacteremic Listeria monocytogenes Meningitis in a Patient with Anti-Interferon gamma Autoantibodies:A case Report

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Infectious Microbes & Diseases 2022年第1期4卷 44-46页

作者： Fanfan Xing derek L.L.Hung Simon K.F.Lo Shuang chen Susanna K.P.Lau Patrick c.Y.Woo Department of clinical Microbiology and Infection control The University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of Microbiology The University of Hong KongHong KongChina Department of Pathology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina

Although various opportunistic infections have been described in patients with anti-interferon gamma autoantibodies,so far there is no Listeria monocytogenes infection reported to be associated with this primary ***,we describe the first case of bacteremic *** meningitis in a 59-year-old chinese man with anti-interferon gamma autoantibodies,who presented with acute onset of fever and severe *** culture was positive but culture of the cerebrospinal fluid was negative,although it showed features suggestive of partially treated bacterial *** presence of *** in the cerebrospinal fluid was confirmed by next-generation *** of high-risk food items in these patients is important for the prevention of *** use of antibiotic regimens that cover Listeria is crucial for empirical treatment,particularly if such patients develop acute or subacute ***-generation sequencing is becoming an important diagnostic modality for culture-negative infections.

关键词： Listeria monocytogenes meningitis anti-interferon gamma autoantibody next-generation sequencing

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Ectopic Tcf1 expression instills a stem-like program in exhausted cD8^(+) T cells to enhance viral and tumor immunity

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cellular & Molecular Immunology 2021年第5期18卷 1262-1277页

作者： Qiang Shan Sheng’en Hu Xia chen derek B.Danahy Vladimir P.Badovinac chongzhi Zang Hai-Hui Xue center for Discovery and Innovation Hackensack Meridian HealthNutleyNJ07110USA Department of Microbiology and Immunology Carver College of MedicineUniversity of IowaIowa CityIA52242USA center for Public Health genomics University of Virginia School of MedicineCharlottesvilleVA22908USA Department of Pathology Carver College of MedicineUniversity of IowaIowa CityIA52242USA Interdisciplinary Immunology graduate Program Carver College of MedicineUniversity of IowaIowa CityIA52242USA Iowa city Veterans Affairs Health care System Iowa CityIA52246USA

Exhausted cD8^(+)T(Tex)cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts.A stem cell-like Tex(Tex-stem)subset can self-renew and differentiate into terminally exhausted(Tex-term)***,we show that ectopic Tcf1 expression potently promoted the generation of Tex-stem cells in both a chronic viral infection and preclinical tumor ***1 overexpression diminished coinhibitory receptor expression and enhanced polycytokine-producing capacity while retaining a heightened responses to checkpoint blockade,leading to enhanced viral and tumor ***,ectopically expressed Tcf1 exploited existing and novel chromatin accessible sites as transcriptional enhancers or repressors and modulated the transcriptome by enforcing pre-existing expression patterns in Tex-stem cells,such as enhanced suppression of Blimp1 and Bim and acquisition of new downstream genes,including Mx1,Tox2,and *** findings reveal a pronounced impact of ectopic Tcf1 expression on Tex functional restoration and highlight the therapeutic potential of harnessing Tcf1-enforced transcriptional programs.

关键词： T cell exhaustion Tcf1 Stem cell features

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In Situ Test on Dynamic Response of Single Surface Slope

In Situ Test on Dynamic Response of Single Surface Slope

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Shengwen Qi c.derek Martin Shenglin Qi Yu Zou Key Laboratory of Engineering geomechanics Institute of Geology and GeophysicsChinese Academy of Sciences Department of civil and Environmental Engineering University of Alberta University of chinese Academy of Sciences

An in situ explosion test on dynamic responses of one single surface slope(stepped slope) of open-pit iron mine in Miyun county,Beijing has been carried *** slope consists of gneiss and magnetite quartzite with blocky structure and its surface is strongly disturbed due to excavation and *** explosion recorders have been used as data acquisition instruments in the *** of the recorder has two channels and can record horizontal and vertical component at the same *** recorders have been placed at different elevation of the slope to monitor the dynamic responses of the slope during *** explosion point was located at the foot of the *** results indicate that peak ground velocity(PgV) and peak ground acceleration(PgA) varies with elevation *** can be seen that both PgV and PgA decrease gradually with elevation increasing,and then amplify at the near crest of the slope.

关键词： Single surface slope Peak ground velocity Peak ground acceleration Explosion Dynamic response

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