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The Functional Roles of Lipid Rafts in T Cell Activation,Immune Diseases and HIV Infection and Prevention

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Cellular & Molecular Immunology 2008年第1期5卷 1-7页

作者： Cheng Luo Kou Wang dequan liu Yan Li Qinshi Zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Science Kunming 650204 China Department of Breast Cancer Yunnan Tumor Hospital Kunming 650118 China Institute of Biomedicine University of Turku Turku 20520 Finland

The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane events. During the interaction of T cell and antigen presenting cell, a highly organized structure is formed at the interface of the two cells, where cholesterol and sphingolipids are enriched, and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review, we will discuss cholesterolsphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, such as protein-protein interactions by concentrating certain proteins in these microdomains, while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging, and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation, particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts. Cellular ＆ Molecular Immunology.

关键词： lipid raft liquid ordered phase liquid crystal phase cholesterol virus assembly

An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol

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Journal of Traditional Chinese Medicine 2022年第2期42卷 289-295页

作者： Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun liu dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui Jean-Pierre Armand ZHU Miansheng JU Liya Institute Gustave Roussy ParisFrance Research Center of Epidemiology and public health ParisFrance Institute Curie of Paris ParisFrance Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical UniversityKunmingChina PreciMed Platform Europe ParisFrance MD Anderson Cancer Hospital MadridSpain ARIATAS Association pour la Recherche et l’Information de l’Acupuncture Time-Acupoints-Space ParisFrance Yunnan Zhu's expert workstation National famous traditional Chinese medicine expert of Mian-Sheng ZHUKunmingChina

OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and ***:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data *** with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant *** will be delivered once a week during chemotherapy with VAS-F *** order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this ***:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer *** induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life ***,we do not have effective pharmacological interventions *** clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been ***:The findings of the trial will allow us to determine the effects of acupuncture treatment *** will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.

关键词： breast neoplasms chemotherapy adjuvant fatigue immunity clinical protocols time-acupoints-space acupuncture

Status and Plan of the HL-2A Project

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中国核科技报告 2002年 865-873页

作者： YAN Jiancheng ZHOU Caipin liu Yong liu dequan the HL-2A Team

HL-2A is a new divertor tokamak under construction at Southwestern Institute of Physics (SWIP), Chengdu, China, based on the experience from HL-1[1] and HL-1M[2, 3]. HL is the short term of a Chinese word that means "Toroidal Current Device". The main objectives of HL-2A are to produce more adaptable divertor configurations to study energy exhaust and impurity control (the first divertor

关键词： HL-2A Project Installation

Divertor Modification and Stress Analysis of HL-2A Tokamak

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2005年第1期 47-48页

作者： JIANG Jing liu dequan CHENG Fayin RAN Hong

With the development of the fusion technology, the functions of the divertor have extended from single impurity control to multi-task. Many main tokamak devices in the world such as JET, JT-60U, ASDEX-U, DⅢ-D have modified their divertor systems in recent years and many experiments have been performed on them. They have the opened divertor systems which have relatively simplified the divertor structure. The plasma configuration with large minor radius, proper elongation and triangularity is easy to shape. So the opened divertor system is also adopted in the HL-2A modification.

关键词： Divertor Modification Stress analysis

Pellet Injection Experiments in the HL-2A Tokamak

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2005年第1期 45-46页

作者： ZHU Genliang XIAO Zhenggui WANG Mingjian XU Hongbing liu dequan

The advantages of pellet injection as a competitive means of fuelling a tokamak are well known. They include：（ 1 ） deep deposition of fuel, （ 2 ） better fuelling efficiency, （ 3 ） purer plasma, and so on. Meanwhile, improving plasma performance by pellet injection has been proven in many tokamak experiments. The deposition of pellet particles following pellet injection causes a temporal change of the local plasma temperature and density gradients which affects the transport properties of the plasma, so pellet injection can be used as a method of studying the transport process as well.

关键词： Pellet injection Plasma performance

On a Game Model of Forestry Investment between the Central Government and the Local Government in China

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On a Game Model of Forestry Investment between the Central G...

Vacuum System for HL-2A Tokamak

2009中国控制与决策会议

作者： Wang Wei,liu dequan Harbin University of Commerce,Harbin 150028,China

＜正＞Through founding a game model of forestry investment between the central government and the local government,the paper deeply analyzes two kinds of interest subjects in a certain *** the results,the problem of local finance quota is discussed,which is always difficult to fulfill in investment *** reason can be found that the central government and the local government have presented the kinds of games in producing the strategy of forestry *** paper also puts forward some advices that may affect and break the plight balancing investment of forestry,strengthening the regulations of forestry investment system of government,reforming the concept of performance among the local government and staff,further improving the mechanism of investing information, promoting the transfer payment system of the central government in order to establish a new Nash equilibrium based on the concept of sustainable development.

关键词： Game Model Forestry Investment the Central Government the Local Government

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2004年第1期 51-54页

作者： CAO Zeng CUI Chenghe FU Weidong liu dequan CAI Xiao GAO Xiaoyan

The vacuum system of today＇s tokamak devices is designed to meet the operational requirements of the experiments. The operation can be divided into five modes, （1） pumping down and leak detecting of the vacuum vessel, （2） baking, （3） plasma-facing component （PFC） conditioning, （4）evacuating and controlling of the particles at plasma edge, （5） plasma discharge experiments.

关键词： Pumping system Pumping divertor GDC system

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智能交通信号机系统电路设计与仿真

实验技术与管理 2014年第10期31卷 107-111页

作者：刘德全宁夏师范学院物理与信息技术学院宁夏固原756000

提出一种基于Proteus虚拟技术对智能交通信号系统的实验电路进行设计与仿真的方法,该系统的电路主要包括交通信号灯控制机电路、人行横道信号灯控制电路和车道信号灯控制电路3大模块,交通信号灯控制电路以AT89S52为嵌入式控制器,构成嵌... 详细信息

提出一种基于Proteus虚拟技术对智能交通信号系统的实验电路进行设计与仿真的方法,该系统的电路主要包括交通信号灯控制机电路、人行横道信号灯控制电路和车道信号灯控制电路3大模块,交通信号灯控制电路以AT89S52为嵌入式控制器,构成嵌入式微控制器电路;信号灯电路以低功耗、高亮度的7段数码和发光二极管作为信号灯,降低了整个系统的功耗。利用Proteus对电路进行设计和仿真,实现了预期目标。该方法缩短了系统开发的周期,提高了系统设计的可靠性。

关键词：交通信号系统电路设计 Proteus AT89S52

石墨粒度对电刷材料用Cu-石墨复合材料组织及性能的影响

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热加工工艺 2018年第10期47卷 110-112,118页

作者：刘德泉广西水利电力职业技术学院

通过材料性能测试手段研究石墨粒度对电刷材料用Cu-Sn粉末压坯组织及性能的影响,分析了该材料磨损后的形貌和氧化行为。研究结果表明：对于没有粘结剂的样品,随石墨粒度增大,硬度与烧结密度升高,开孔率下降;有粘结剂的样品烧结密度提高... 详细信息

通过材料性能测试手段研究石墨粒度对电刷材料用Cu-Sn粉末压坯组织及性能的影响,分析了该材料磨损后的形貌和氧化行为。研究结果表明：对于没有粘结剂的样品,随石墨粒度增大,硬度与烧结密度升高,开孔率下降;有粘结剂的样品烧结密度提高,开孔率下降。较大石墨粒度样品形成了具有集中孔洞的区域。石墨粒度越低磨损现象越显著,其样品摩擦表面形成的犁沟数量也不断减少,铜基体形貌也变得更加光滑。在摩擦过程中,Cu区域被Cu2O区域包围,特别是处于孔洞或者石墨和铜的界面处,材料内部也发生了氧化反应。

关键词：石墨粒度 Cu-Sn粉末磨损氧化