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Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang jinan Guo Di Gu Jing Liu Piao Luo Yunmeng Bai Jiayun Chen Xinzhou Zhang Sheng Nie Chunbo Chen Yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

A polynomial algorithm for finding (g,f)-colorings orthogonal to stars in bipartite graphs

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Science china Mathematics 2005年第3期48卷 322-332页

作者： LIU Guizhen & DENG Xiaotie department of Mathematics, Shandong university, jinan 250100, china department of Computer Science, The city university of Hong Kong, Hong Kong, china 1. department of Mathematics Shandong University 250100 Jinan China 2. department of Computer Science The City University of Hong Kong Hong Kong China

Let G be a bipartite graph with vertex set V(G) and edge set E(G), and let g and f be two nonnegative integer-valued functions defined on V(G) such that g(x) ≤f(x)for every vertex x of V(G). A(g,f)-coloring of G is a generalized edge-coloring in which each color appears at each vertex x at least g(x) and at most f(x) times. In this paper a polynomial algorithm to find a(g, f)-coloring of a bipartite graph with some constraints using the minimum number of colors is given. Furthermore, we show that the results in this paper are best possible.

关键词： bipartite graph, (g, f)-coloring, (g, f)-factor, orthogonal coloring.

Mapping forest fire risk zones with spatial data and principal component analysis

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Science china(Technological Sciences) 2006年第z1期49卷 140-149页

作者： XU Dong, Guofan Shao, DAI Limin, HAO Zhanqing, TANG Lei & WANG Hui Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, china Graduate university of Chinese Academy of Sciences, Beijing 100039, china department of Forestry and Natural Resources, Purdue university, West Lafayette, IN 47907, USA department of Management, Shenyang Institute of Aeronautical Engineering, Shenyang 110034, china department of city development, jinan university, jinan 2.0002. china 1. Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China2. Graduate University of Chinese Academy of Sciences Beijing 100039 China3. Department of Forestry and Natural Resources Purdue University West Lafayette IN 47907 USA4. Department of Management Shenyang Institute of Aeronautical Engineering Shenyang 110034 China5. Department of City Development Jinan University Jinan 250002 China

By integrating forest inventory data with remotely sensed data, new data layers for factors that affect forest fire potentials were generated for Baihe Forestry Bureau in Jilin Province of china. The principle component analysis was used to sort out the relationships between forest fire potentials and environmental factors. The classifications of these factors were performed with GIS, generating three maps: a fuel-based fire risk map, a topography-based fire risk map, and an anthropogenic-factor fire risk map. These three maps were then synthesized to generate the final fire risk map. The linear regression method was used to analyze the relationship between an area-weighted value of forest fire risks and the frequency of historical forest fires at each forest farm. The results showed that the most important factor contributing to forest fire ignition was topography, followed by anthropogenic factors.

关键词： wildfire risk, regression analysis, geographic information system, remote sensing, Baihe Forestry Bureau.

GIS-based analysis of forest degradations in Baihe Forestry Bureau,northeast china

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Science china(Technological Sciences) 2006年第z1期49卷 167-176页

作者： ZHOU Li, DAI Limin , Guofan Shao, XU Dong, WANG Hui & BAI Jianwei Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, china Graduate university of Chinese Academy of Sciences, Beijing 100101, china department of Forestry and Natural Resources, Purdue university, West Lafayette, IN 47907, USA department of city development, jinan university, jinan 2.0002. china Academy of Forest Inventory and Planning, State Forestry Administration, Beijing 100714, china 1. Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China 2. Graduate university of Chinese Academy of Sciences Beijing 100101 China 3. department of Forestry and Natural Resources Purdue University West Lafayette IN 47907 USA 4. department of city development Jinan University Jinan 250002 China 5. Academy of Forest Inventory and Planning State Forestry Administration Beijing 100714 China

Forests in the Changbai Mountains are important timber sources for economic development of the society and provide ecological services in northeast china. In order to strengthen forest resource management, this paper analyzed management-induced changes in forest structure, tree species composition and forest landscape pattern from 1987 to 2000 for Baihe Forestry Bureau in Jilin Province based on digitized forest parcel maps and forest survey data. The results suggested that the area of Mature, High-Stocking, and Close-Canopy Forests decreased by 31.4%, 55.9% and 10.7% respectively; volume of Mixed Forest, the native forest vegetation type, decreased by 17.8%;the number of patches increased tremendously but the mean patch density decreased sharply for Mature, High-Stocking, Close-Canopy, and Mixed Forests. All the changes in forest structure, species composition, and landscape pattern indicated severe degradations going on with the forests in Baihe Forestry Bureau. Because of the effect of degradation to forest services, restoring forest resources and protecting biodiversity has become urgently important. The strategies of sustainable forest management need to be worked out and implemented.

关键词： geographic information system, forest management, Changbai Mountains, forest change, forest decline.

Partitioning series-parallel multigraphs into υ*-excluding edge covers

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Science china Mathematics 2006年第8期49卷 1082-1093页

作者： LIU Guizhen, DENG Xiaotie & XU Changqing School of Mathematics and System Science, Shandong university, jinan 250100, china department of Computer Science, city university of Hong Kong, Kowloon, Hong Kong, china department of Applied Mathematics, Hebei university of Technology, Tianjin 300130, china School of Mathematics and System Science Shandong University Jinan 250100 China department of Computer Science City University of Hong Kong Kowloon Hong Kong Hong Kong department of Applied Mathematics Hebei University of Technology Tianjin 300130 China

We prove that, for any given vertexν* in a series-parallel graph G, its edge set can be partitioned into k= min{k′(G) + 1,δ(G)} subsets such that each subset covers all the vertices of G possibly except forν*, whereδ(G) is the minimum degree of G and k′(G) is the edge-connectivity of G. In addition, we show that the results in this paper are best possible and a polynomial time algorithm can be obtained for actually finding such a partition by our proof.

关键词： series-parallel graph, edge-connectivity, edge cover coloring, min-max theorem.

STUDY ON SPATIAL LANDSCAPE PATTERN OF YANTAI city BASED ON RS AND GIS

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Chinese Geographical Science 2003年第3期13卷 254-258页

作者： WU Quan-yuan (department of Geography, Shandong Normal university, jinan 250014, P. R. china) department of Geography Shandong Normal University Jinan P. R. China

Influenced by artificial factors, landscape pattern of Yantai city, Shandong Province changes continuously. Revealing its landscape pattern and its changing process has a practical significance for the urban development and layout. Zhifu District, development Zone, Laishan District and Fushan District in Yantai city were selected to study the landscape pattern. Remote sensing technology was used to obtain landscape information of different periods. Under the support of Geographic Information System (GIS), the spatial landscape pattern of Yantai city was analyzed and simulated by using various special quantitative analysis models. The analysis shows that built-up area lies in the center of Yantai city, the outside is vegetable land, irrigated land, dry land, garden land and woodland.

关键词： landscape remote sensing geographic information system yantai city

The Effect of Anti-Human CD134 Monoclonal Antibody on Phytohemagglutinin-Induced mRNA Expression of Perforin in Peripheral Blood Mononuclear Cells

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Cellular & Molecular Immunology 2005年第6期2卷 467-471页

作者： Ming Li~1 Yuanchao Zhang~(1,2) ~1department of Rheumatology and Immunology,Shandong Provincial Hospital,Shandong university,jinan 250021,china ~2department of Rheumatology and Immunology,Shandong Provincial Hospital,Shandong university,jinan 250021,Shandong,china. department of Rheumatology and Immunology Shandong Provincial Hospital Shandong University Jinan 250021 China.

CD134, a member of the tumor necrosis factor receptor superfamily, plays a crucial role in T cell survival. In this study, peripheral blood mononuclear cells （PBMCs） stimulated with phytohemagglutinin （PHA, 50 μg/ml） were treated by CD134 mAb （1μg/ml, 5 μg/ml, 10 μg/ml） for 6 h, 12 h, 24 h and 48 h. The level of perforin mRNA was measured by reverse transcription-polymerase chain reaction （RT-PCR） technique. Our data showed that the expression of perforin mRNA in PBMCs was down-regulated by CD134 mAb in a dose-dependent manner in range of 1 μg/ml to 5 μg/ml and dropped down to its minimum on 24 h （p 〈 0.05）. The level of perforin mRNA reached a plateau when the concentration of CD134 mAb exceeded 5 μg/ml. In conclusion, CD134 mAb can inhibit perforin expression, which may enhance the ability of T cells for survival. Cellular ＆ Molecular Immunology. 2005;2（6）： 467-471.

关键词： CD134 perforin phytohemagglutinin

A study on neogene volcanic landforms of the middle Tanlu fault belt

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Journal of Geographical Sciences 2000年第4期10卷 121-128页

作者： HAN Mei (Geography department, Shandong Normal university, jinan 250014,china) 山东师范大学山东济南

The west block of the middle belt of TanLu fault belt is one of the areas where volcanic landforms are mainly distributed. This paper divides the volcanic landforms into four grades according to formation, morphology, and ingredient of matter. Lava cones are divided into two types based on the force of top-support and the fluid form of magma: the arc-projecting type and spring-spilling type. Furthermore, the courses of development of volcanic landforms are divided into three stages according to the form and strength of volcanic activities.

关键词： volcanic landforms Neogene TanLu fault belt

Correlation of zeros of automorphic L-functions

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Science china Mathematics 2008年第7期51卷 1147-1166页

作者： LIU JianYa1 & YE YangBo1,2 1 School of Mathematics,Shandong university,jinan 250100, china 2department of Mathematics,The university of Iowa,Iowa city,IA 52242-1419,USA 1. School of Mathematics Shandong University Jinan 250100 China 2. department of Mathematics The University of Iowa Iowa City IA 52242-1419 USA

We compute the n-level correlation of normalized nontrivial zeros of a product of Lfunctions: L(s, π1) … L(s, π k ), where πj, j = 1, …, k, are automorphic cuspidal representations of GL mj (?A). Here the sizes of the groups GL mj (?A) are not necessarily the same. When these L(s, π j ) are distinct, we prove that their nontrivial zeros are uncorrelated, as predicted by random matrix theory and verified numerically. When L(s, π j ) are not necessarily distinct, our results will lead to a proof that the n-level correlation of normalized nontrivial zeros of the product L-function follows the superposition of Gaussian Unitary Ensemble (GUE) models of individual L-functions and products of lower rank GUEs. The results are unconditional when m 1, …, m k ? 4, but are under Hypothesis H in other cases.

关键词： automorphic L-function zero correlation Selberg’s orthogonality conjecture 11F70 11M26 11M41