Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy
作者机构：Department of Endocrinology and MetabolismShanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Department of EndocrinologyAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu 210029China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第5期
页 面：6-8页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the Shanghai Municipal Health Commission health Industry clinical research special project(No.20214Y0353) Excellent young cultivation plan of Shanghai Pudong New Area Health System(No.PWRq2021-27) Top-100 Talent Cultivation Plan of Shanghai University of Medicine and Health Sciences(No.A3-0200-22-311007) The second round of medical discipline construction project of Pudong New Area-clinical characteristic discipline(No.PWYts2021-09)
主 题：urinary metabolism diagnosis
摘 要：Diabetic nephropathy(DN)is one of the major microvascular complications of diabetes mellitus and a major cause of end-stage renal disease(ESRD).The pathogenesis of DN is unknown,but it is closely related to disorders of glucolipid metabolism,abnormal hemodynamics,chronic inflammatory response,oxidative stress,and *** DN develops into ESRD,it is often more difficult to treat than ESRD caused by other kidney ***,a deeper knowledge of the pathophysiological mechanisms of DN and the discovery of candidate markers for early diagnosis are *** secreted by renal cells can regulate a series of pathophysiological processes such as translation and transcription by releasing miRNAs or proteins,thereby regulating the biological functions and phenotype of recipient kidney *** has been found that miRNA secreted by urinary exosomes in patients with DN is involved in the occurrence and development of DN and may become biological markers.1 However,studies on exosome proteins are relatively few and lack validation in *** the present study,we identified an altered pathway in urinary exosomes from DN patients for the first ***,the altered ferroptosis-related proteins may represent novel candidate markers for early progression of disease and/or early treatment effects.
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