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Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-yun Wang Wen-Jing Xu Bo-nan Li Tian-Song Sun Wen Sheng department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

ON THE ESTIMATIONS OF BOUNDS FOR DETERMInanT OF HADAMARD PRODUCT OF H-MATICES

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Journal of Computational Mathematics 2001年第4期19卷 365-370页

作者： Yao-tang Li (department of Mathemotics, Yuunan university, kunming 650091, china) Ji-cheng Li (department of Mathematics, Xian Jiaotong university, Xian 71049, china) 云南大学云南昆明 650091 西安交通大学陕西西安 710049

In this paper, some estimations of bounds for determinant of Hadamard product of H-matrices are given. The main result is the following: if A= (aij) and B=(bij) are nonsingular H-matrices of order n and ∏in=1, aiibii> 0, and Ak and Bk, k = 1, 2,…,n, are the k× k leading principal submatrices of A and B, respectively, then where M(Ak) denotes the comparison mains of Ak.

关键词： H-matrix Determinant Hadamard product.

Desulfurization of Nickel Pyrrhotite by Steam in the Microwave Field

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Journal of Materials science & Technology 2001年第5期17卷 561-564页

作者： Jinhui PENG and Chunpeng LIU department of Metallurgy, kunming university of science and Technology, kunming 650093, china kunming Univ Sci & Technol Dept Met Kunming 650093 Peoples R China

Desulfurization of Ni pyrrhotite by steam in the microwave field was studied. According to the experimental data, the desulfurization rate by microwave heating is faster than that by conventional one. The desulfurization reaction is in a non-isothermal state and in a diffusion control because of the effect of chemical reaction heat, phase formation and intrinsic properties of materials of microwave absorbability. When the flow rate of steam was in the range of 180 similar to 220 mL/min, the temperature and desulfurization rate approached to a maximum and the activation energy to a minimum.

关键词： Ni Desulfurization of Nickel Pyrrhotite by Steam in the Microwave Field

Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 40-52页

作者： Tao Pang nan Weng Yong Chen Cui-yun Huang Mei Sun Feng Zhang Wan-Sheng Chen department of Pharmacy Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina department of Pharmacognosy Shenyang Pharmaceutical university ShenyangLiaoning ProvinceChina Traditional Chinese Medicine Resource and Technology Center Shanghai University of Traditional Chinese MedicineShanghaiChina

Introduction:The Shengxian decoction(SXT),a Chinese herbal medication used to treat heart failure,is composed of Astragali Radix,Anemarrhenae Rhizoma,Bupleuri Radix,Cimicifuage Rhizoma,and Platycodonis *** of the excretion of the active compounds in this herbal medication is vital for investigating the underlying mechanisms behind its ***,this remains ***:Liquid chromatography coupled with mass spectrometry was performed in both positive and negative modes to assay 18 constituents of SXT from rat urinary,fecal,and biliary ***:The methodology was validated and showed good linearity(r≥0.9),precision,stability,repeatability,and *** relative standard deviations and relative errors for the precision and accuracy did not exceed 15%.The recoveries of all the compounds ranged from 77.37%to 114.82%,and the matrix effect was between 82.53%and 105.71%.The results suggested that,when combined with Platycodonis Radix,the levels of 14 constituents from the four herbs were reduced in the urine,while the levels of six constituents were reduced in the ***:The comparative excretion results indicated that Platycodonis Radix reduced the excretion of compounds in SXT,demonstrating the compatibility mechanism and holistic properties of these compounds,favoring the pharmacological effects of SXT.

关键词： Compatibility excretion liquid chromatography coupled with mass spectrometry Platycodonis Radix Shengxian decoction

Abundant Semigroups with a Multiplicative Adequate Transversal

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Acta Mathematica Sinica,English Series 2002年第2期18卷 229-244页

作者： GUO Xiao Jiang department of Mathematics.yunnan university.kunming 650091,P.R.china department of Mathematics Yunnan University Kunming P. R. China

The aim of this paper is to investigate abundant semigroups with a multiplicative adequate *** properties and characterizations for such semigroups are *** particular. we establish the structure of this class of abundant semigroups in terms of left normal bands,right normal braids and adequate semigroups with some simple Compatibility *** apply this structure to some special cases.

关键词： Abundant semigroup Adequate semigroup Left(Right)normal band

Dielectric polymer grafted electrodes enhanced aqueous supercapacitors

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nano Research 2024年第3期17卷 1525-1534页

作者： Shian Dong kunming Shi Jie Chen Yingke Zhu Hongfei Li Weihang Gao Zhenli Xu Qinglei Liu Xingyi Huang Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Department of Polymer Science and EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China School of Mathematical sciences Institute of Natural Sciences and MOE−LSCShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China

Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long *** SCs are promising for large-scale engineering applications because of their low cost and ***,the low operating voltage and low energy density of aqueous SCs severely limit their practical *** this study,a nanoscale dielectric layer is grafted onto a graphene electrode to achieve both a high operating voltage and enhanced *** with an SC without dielectric grafting,a dielectric-enhanced SC(DESC)shows a higher capacitance by 2200%.The mechanism of the capacitance enhancement can be attributed to three factors:the dielectric polarization,the ions desolvation by the dielectric,and the enhanced quantum capacitance from charge transfer and ion adsorption in the polymer *** addition,a 2.5 V pouch DESC with a 1 M KCl electrolyte is confirmed to cycle up to 50,000 times with a capacitance retention of 87.5%.The DESC presents the optimal electrochemical properties after it is grafted with a 5 nm dielectric *** study provides new insights into the design of high-voltage and high-energy-density aqueous SCs.

关键词： supercapacitors dielectric polymer high voltage capacitance enhancement

Abrupt climate change and collapse of ancient civilizations at 2200BC-2000BC

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Progress in Natural science:Materials International 2005年第10期15卷 46-52页

作者： WANG Shaowu (department of atmospheric science, School of Physics, Peking university, Beijing 100871, china) department of atmospheric science School of Physics Peking University Beijing 100871 China

Plentiful evidence of historical, archaeological and palaeoclimatic studies proved that an abrupt change from wetter to drier climate occurred over the Nile Valley,the Mesopotamia, the Indus Valley and Huanghe River Valley at 2200BC-2000BC. The abrupt change was developed based on the general lowering of temperature in the middle latitudes, and was a strong cold event since the beginning of the Megathermal (8.5-3.0 kaBP). Collapse of Nile civilization appeared at the First Intermediate Period (2181BC-2040BC). Civilization of Mesopotamia began collapse following the disintegration of Akkadian Empire. This process lasted to the foundation of Babylon Kingdom from 2200BC to 1900BC. Indus civilization abruptly fell off at 1800BC. A widespread alternation of archaeological cultures happened in china at ca. 2000BC except only in its central part. Longsheng culture was replaced by the Erlitou culture, which is now acknowledged in china as Xia Culture. Foundation of Xia Dynasty at 2070BC opened a new chapter in the development of Chinese civilization. Studies indicated that abrupt climate change may be caused by the weakening of the Thermohaline Circulation (THC).

关键词： 2200BC-2000BC abrupt climate change collapse of ancient civilization.

Carbendazim residue in plant-based foods in china:Consecutive surveys from 2011 to 2020

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Environmental science and Ecotechnology 2024年第1期17卷 109-118页

作者： Dou Wang Guiling Yang Xiao yun Ting Luo Hao Guo Liying Pan Wei Du Yanhua Wang Qiang Wang Pu Wang Qinghua Zhang yun Li nan Lin State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Laboratory(Hangzhou)for Risk Assessment of Agricultural Products of Ministry of AgricultureInstitute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou310021ZhejiangChina College of Urban and Environmental sciences Peking UniversityBeijing100871China yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control Faculty of Environmental Science&EngineeringKunming University of Science&TechnologyKunming650500China Hubei Key Laboratory of Industrial Fume and Dust Pollution Control School of Environment and HealthJianghan UniversityWuhan430056China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Key Laboratory of Agro-Product Quality and Safety of Ministry of Agriculture Institute of Quality Standards and Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijing100081China department of Environmental Health School of Public HealthShanghai Jiao Tong UniversityShanghai200025China

Carbendazim,a widely used fungicide in china,has been found to have reproductive toxicity and mutagenic ***,information on the spatial-temporal variations of carbendazim residues in food in china is ***,we investigated the presence of carbendazim in china's plant-based foods from 2011 to 2020,evaluated the spatial-temporal characteristics,and assessed the associated exposure risks in the Chinese *** results revealed a high detection frequency of carbendazim in fruits(26.4%)and high concentrations in vegetables(~110 mg kg^(-1)),indicating widespread misuse of the *** acute risks of consuming certain vegetables and cereals exceeded the recommended limits by up to 12 and 5 times,*** there has been a decline in carbendazim residue levels in food since the implementation of the Chinese government's action plan for zero growth of pesticide use in 2015,some provinces still exhibited high levels of carbendazim in multiple food categories,which were positively correlated with annual pesticide *** highlight that carbendazim contamination reflects the broader issue of pesticide use in *** emphasizes the need for committed and targeted national policies to reduce carbendazim residues in food and suggests that such measures could also regulate the use of other pesticides,given that pesticide abuse in china is not limited to specific *** call for the re-evaluation of maximum residue limits of carbendazim,particularly in highly consumed foods such as cereals.

关键词： Carbendazim Plant-based foods china Spatial-temporal variations Exposure and risk assessment

Interannual variability of Antarctic Oscillation and its influence on East Asian climate during boreal winter and spring

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science china Earth sciences 2006年第5期49卷 554-560页

作者： FAN Ke1,2,3 & WANG Huijun2 1. nansen-Zhu International Research Center, Institute of atmospheric Physics, Chinese Academy of sciences, Beijing 100029, china 2. department of atmospheric science, yunnan university, kunming 650091, china 3. Graduate university of the Chinese Academy of sciences, Beijing 100049, china 1. nansen-Zhu International Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China 2. department of atmospheric science Yunnan University Kunming 650091 China 3. Graduate university of the Chinese Academy of sciences Beijing 100049 China

The interannual variability of Antarctic Oscillation (AAO) and its influence on East Asian climate during both boreal winter and spring are addressed. The results show that the positive AAO anomaly decreases the cold activity over East Asia during both boreal winter and spring. AAO-related barotropic meridional teleconnection from Antarctic to Arctic is found through analysis of mean me- ridional circulations. This meridional teleconnection is remarkable over Eurasia during boreal winter and over the Pacific Ocean during boreal spring. The results also show that zonal mean zonal wind at high latitudes in Southern Hemisphere has well positive correlation with that of Eurasia during boreal winter and has negative correlation with Pacific North American teleconnection (PNA) during boreal spring, which again display the meridional teleconnection. Thus, local meridional teleconnection is a possible linkage for interaction of circulations at mid-high latitudes between both hemispheres.

关键词： Antarctic Oscillation, Eurasian west wind, meridional teleconnection, mean meridional circulation.