检索结果-南通市图书馆

Rheumatologic manifestations of hepatic diseases

Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 32-37页

作者： Zhao-Chun Chi Su-Zhen Ma the Division of Gastroenterologr, department of Medicine, People’s hospital, qingdao 266001, china the department of Infectious Diseases, qingdao university college of Medicine, qingdao 266012, china Division of Gastroenterology Department of Medicine People's Hospital Qingdao 266001 China.

A possible link is suggested between hepatic diseases and rheumatic disease. Polyarthralgia and polyarthritis may be seen during the prodromal period of acute viral hepatitis, especially in hepatitis B virus (HBV). The symptoms of arthritis, mild, localized or generalized, mostly involve the small joints of hands. Joint symptoms frequently precede the onset of jaundice, no residual joint deformities. Circulating immune complexes are believed to play a causative role in the development of vasculitis and arthritis. Hemochromatosis is an antosomal recessive disorder of iron. About 43%-81% of patients with hemochromatosis have arthritis. The common extrahepatic manifestations of autoimmune hepatitis are arthralgia and skin rash. The reported prevalence of symptomatic inflammatory arthropathy in patients with primary biliary cirrhosis ranges from 4% to 50%. Skeletal involvement with Wilson's disease is common. Such patients may complain of pain and stiffness, mainly in the knee, wrist, or other large joints. Shwachman's syndrome is a disorder of pancreatic exocrine. Symmetric bone lesions have been reported in 10% to 15% of patients. They are involved predominantly at the femoral neck. Rheumatic symptoms are seen in one third of adult patients with cystic fibrosis and arthritis in 2.5% to 12% of patients. The arthritis caused by pancreatic panniculitis is usually symmetrical and involves the small joints of the hand, wrist, and feet, but may involve such larger joints as the elbow, ankle, and knee.

关键词： hepatic diseases rheumatologic manifestation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An analysis of 680 cases of cholangiocarcinoma from 8 hospitals

引用

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 585-588页

作者： Xiao-Fang Liu, Xian-Ting Zhou and Sheng-Quan Zou department of Hepatobiliary Surgery, affiliated Yantai Yuhuangding hospital, qingdao university medical college, Yantai 264000, china and department of General Surgery, Tongji medical hospital, Wuhan 430000, china department of Hepatobiliary Surgery Yantai Yuhuangding Hospital Yantai 264000 China. liu634@***

BACKGROUND: The outcome of patients with cholangio-carcinoma is poor. To evaluate the experience in the diagnosis and surgical treatment of cholangiocarcinoma, we investigated the status quo of diagnosis and treatment of cholangiocarcinoma in china. METHOD: The clinical data of 680 patients with cholangiocarcinoma treated at 8 hospitals from 1995 to 2001 were retrospectively analyzed with SPSS software package. RESULTS: The incidence of the tumor was the highest in the age group of 60-65 years. Meanwhile,the incidence was higher in aged men than in aged women, with a male to female ratio of 1.39:1. Proximal cholangiocarcinoma was the commonest ( 41.6% ) and distant cholangiocarcinoma the second(28.7% ) in the 680 patients. B-mode ultrasonogra-phy for cholangiocarcinoma was performed in 80.3% of the patients. Non-traumatic examinations such as computed tomography (CT), magnetic resonance image (MRI) and magnetic resonance cholangiopancreatography ( MRCP ) were more widely used than that of traumatic examinations such as percutaneous transhepatic cholangiography (PTC) and endoscopic retrograde cholangiopancreatography ( ER-CP). The low- and middle-differentiation cancer of the proximal bile duct accounted for about 50%. Most of the patients suffered from late-stage cholangiocarcinoma. The resection rate of the tumor was low, and the rate of radical operation was only 21.6% (147/680). CONCLUSIONS: Cholangiocarcinoma is common in the aged men. Its diagnosis and treatment have been improved, but little. Most patients are diagnosed as having late-stage cholangiocarcinoma at the time of outpatient clinic, and the rate of radical operation is low. Thereforce, it is necessary to reinforce the early diagnosis and treatment of cholangiocarcinoma to improve the outcome after operation.

关键词： cholangiocarcinoma diagnosis treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

全反式维甲酸对球囊损伤大鼠胸主动脉内皮后内膜增生及PDGF-BB表达的影响

引用

复旦学报（医学版） 2004年第6期31卷 637-639页

作者：张先明董果雄张社华褚现明张斌李宁青岛大学医学附属医院心内科青岛266003 青岛大学医学附属医院中心实验室青岛266021

目的　研究全反式维甲酸 (all transretinoicacid ,ATRA)对球囊损伤大鼠胸主动脉内皮后内膜增生及血小板衍生生长因子B(BDGF BB)表达的影响。方法　球囊剥脱大鼠胸主动脉内皮 ,并随机将大鼠分为手术组、ATRA治疗组及对照组 ,各组大鼠均... 详细信息

目的　研究全反式维甲酸 (all transretinoicacid ,ATRA)对球囊损伤大鼠胸主动脉内皮后内膜增生及血小板衍生生长因子B(BDGF BB)表达的影响。方法　球囊剥脱大鼠胸主动脉内皮 ,并随机将大鼠分为手术组、ATRA治疗组及对照组 ,各组大鼠均于术前 4d灌胃 ,分别在术后 2、7、14和 18d处死大鼠并摘除胸主动脉。通过组织学检查和免疫组化技术检测内膜增生情况、PDGF BB的表达及ATRA[30mg/ (kg·d) ]灌胃对它们的影响。结果　 (1)对照组及内皮损伤后 2d均无血管内膜增厚 ,7d内膜开始增生 ,2 8d血管平滑肌细胞 (VSMCs)的增殖减弱 ,但细胞外基质增加 ,内膜继续增生 ;(2 )PDGF BB的表达于术后 2d开始升高 ,至 14d达高峰 ;(3)使用ATRA后内膜增生程度及PDGF BB的表达明显降低。结论　ATRA可有效地抑制血管损伤后内膜增生 ,其机制可能是通过抑制PDGF BB表达。

关键词： PDGF-BB 内膜增生大鼠胸主动脉表达 ATRA 内皮灌胃增殖全反式维甲酸

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical Features and Topographic Characteristics of Internal Watershed Infarction in Occlusive Diseases of Carotid Artery System

Clinical Features and Topographic Characteristics of Interna...

引用

第4届国际脑血管病高峰论坛

作者： H Li,X Zhang,Y Zhang,X Pan,H Zhao,H Li department of neurology,affiliated hospital of medical college,qingdao university,qingdao 266003,china

Background and Purpose:To describe the clinical features and topographic characteristics of internal watershed infarction(IWI) and to analyze the relationship between IWI and occlusive diseases of carotid artery ***:We identified IWI patients with diffusion-weighted magnetic resonance imaging by commonly used templates within ten days after the onset of *** with

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Relationship of cerebral arterial stenosis to cognitive and memory disorders

引用

Neural Regeneration Research 2006年第8期1卷 760-762页

作者： Jifeng Li1,2, Zhou Wang3, Shenggang Sun1, Gaomei Cai2, Kejin Gu2, Yaoqun Li4 1department of neurology, affiliated Union hospital, Tongji medical college, Huazhong university of Science and Technology, Wuhan 430030, Hubei Province, china 2Second department of neurology, affiliated hospital of Jining medical college, Jining 242013, Shandong Province, china 3department of Pathology, Jining medical college, Jining 242013, Shandong Province, china 4TCD Room, affiliated hospital of Jining medical college, Jining 242013, Shandong Province, china department of neurology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Second department of neurology Hospital of Jining Medical College Jining 242013 Shandong Province China hospital of Jining medical college Jining 242013 Shandong Province China department of Pathology Jining Medical College Jining 242013 China

BACKGROUND: Cerebral arterial stenosis can cause cerebral hypoperfusion, and than result in the decline of cognitive function, whereas the cognitive dysfunction induced by different cerebral arterial stenosis have different manifestations and types. OBJECTIVE: To observe the differences of cognitive and memory dysfunctions in patients with cerebral arterial stenosis of different types. DESIGN: A comparative observation. SETTING: affiliated hospital of Jining medical college. PARTICIPANTS: Forty-two outpatients or inpatients with cerebral arterial stenosis were selected from the department of neurology, affiliated hospital of Jining medical college from February 2005 to January 2006, including 25 males and 17 females. There were 18 cases of internal carotid arterial stenosis, 14 cases of vertebrobasilar arterial stenosis and 10 cases of whole cerebral arterial stenosis. The diagnostic standards for cerebral arterial stenosis were identified according to North American Symptomatic Carotid Endarterectomy Trial (NASCET). Meanwhile, 18 healthy physical examinees were enrolled as the control group, including 10 males and 8 females, aged 58-80 years old. All the enrolled subjects were informed and agreed with the detection and evaluation. METHODS: ① The memory function was evaluated using revised Wechsler memory scale for adults, including long-term memory (experience, orientation and counting), short-term memory (visual recognition, picture memory, visual regeneration, association and thigmesthesia) and sensory memory (forward and backward recitation of numbers). The scale scores were turned to memory quotients. The higher the scores, the better the memory function. ② The cognitive function was evaluated using revised Wechsler adult intelligence scale: It consisted of eleven subtests, including six language scales (information, digit span, vocabulary, arithmetics, apprehension, similarity) and five operation scales (picture completion, picture arrangement, block design, g

关键词： than Relationship of cerebral arterial stenosis to cognitive and memory disorders

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

X连锁凋亡抑制蛋白反义寡核苷酸逆转K562细胞及难治性癫痫大鼠对卡马西平和苯妥英钠耐药性

引用

生物化学与生物物理进展 2010年第6期37卷 635-640页

作者：陈英辉王乃东祖衡兵洪震复旦大学附属金山医院神经内科上海200540 青岛大学医学院附属医院青岛266003 复旦大学附属华山医院神经科上海200040

凋亡在癫痫发生机制中起重要作用,但其在难治性癫痫耐药机制中的作用尚不清楚.为研究X连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)反义寡核苷酸对K562/Dox(阿霉素诱导)耐药细胞及难治性癫痫大鼠耐药性的影响,首先... 详细信息

凋亡在癫痫发生机制中起重要作用,但其在难治性癫痫耐药机制中的作用尚不清楚.为研究X连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)反义寡核苷酸对K562/Dox(阿霉素诱导)耐药细胞及难治性癫痫大鼠耐药性的影响,首先建立耐药的K562/Dox细胞株,比较XIAP在耐药细胞株和正常K562细胞株的表达情况,观察转染XIAP反义寡核苷酸后,线粒体膜电位变化以及对卡马西平和苯妥英钠耐药性的影响.另外,建立慢性杏仁核点燃癫痫模型,筛选出耐药组和药物敏感组,通过侧脑室注射XIAP反义寡核苷酸,对照组注射生理盐水.观察其对各组大鼠后放电阈值(after dischargethreshold,ADT)、后放电时程(after discharge duration,ADD)等电生理指标的影响.结果发现,XIAP在K562/Dox耐药细胞上的表达明显高于正常K562细胞,XIAP反义寡核苷酸转染K562/Dox耐药细胞后,XIAP的表达明显下降.导致了K562/Dox细胞线粒体跨膜电位的下降,而且对苯妥英钠和卡马西平的耐药性明显下降,IC50分别由(1978.2±90.3)mg/L和(1875.6±83.2)mg/L,降低到(1123.5±54.2)mg/L和(1084.5±60.6)mg/L,逆转倍数分别为1.76和1.73.同时动物实验发现,耐药组大鼠在给予XIAP反义寡核苷酸后,ADT明显高于对照组(P<0.05),ADD时程也明显缩短.上述结果证明,XIAP在耐药的K562/Dox细胞株存在高表达,下调XIAP在K562/Dox细胞株表达可以改善K562/Dox对卡马西平和苯妥英钠的耐药性.而且下调XIAP表达可以协助AEDs改善耐药大鼠的电生理活动,提示XIAP参与了难治性癫痫的耐药.

关键词： X连锁凋亡抑制蛋白耐药凋亡反义寡核苷酸难治性癫痫

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inosine inhibits apoptosis and cytochrome C mRNA expression in rat neurons after cerebral ischemia/reperfusion

引用

Neural Regeneration Research 2006年第7期1卷 589-592页

作者： Jinrong Wang1, Mingjun Bi1, Qin Li2 1department of neurology, Rongcheng Second People’s hospital, Rongcheng 264309, Shandong Province, china 2department of neurology, affiliated Union hospital, Tongji medical college, Huazhong university of Science and Technology, Wuhan 430030, Hubei Province, china department of neurology Rongcheng Second People's Hospital Rongcheng 264309 Shandong Province China department of neurology Union Hospital Huazhong University of Science ad Technology Wuhan 430030 Hubei Province China

BACKGROUND: It has been demonstrated that adenosine can induce glial cell to release cytochrome C, enhance expression of apoptotic gene bax, inhibit anti-apoptotic gene bcl-2, and activate caspase-3 to apoptosis; Whereas inosine can inhibit neuronal apoptosis which is similar to bcl-2. OBJECTIVE: To observe the effects of inosine on neuronal apoptosis and expression of cytochrome C mRNA in rats after focal cerebral ischemia/reperfusion, and analyze the pathway of its neuroprotective effect. DESIGN: A randomised controlled animal trial. SETTINGS: department of neurology, Rongcheng Second People's hospital; department of neurology, affiliated Union hospital, Tongji medical college, Huazhong university of Science and Technology. MATERIALS: Sixty-eight rats, weighing 230-280 g and clean grade, were used. TdT-mediated dUTP-biotin nick end labeling (TUNEL) and cytochrome C mRNA in situ hybridization kits and DAB staining kit were purchased from Wuhan Boster Biological Co., Ltd.; Inosine injection [200 mg (2 mL) each] from qingdao First Pharmaceutical Factory. METHODS: The experiment was accomplished in the animal experimental center in Tongji medical college of Huazhong university of Science and Technology from December 2003 to June 2005. ① Sixty-four rats were made into focal ischemia by middle cerebral artery occlusion (MCAO) with a nylon monofilament suture. The successfully induced rats were assigned to inosine group (n =32) and model group (n =32) at random. Rats in the inosine group were intraperitoneally administrated with inosine in dose of 100 mg/kg preoperatively, twice a day, 7 days in all. The rats in the control group were injected with the same dose of saline solution by the similar way preoperatively. Each group was randomized into ischemia /reperfusion 2, 6, 12, 24 hours, 2, 3, 7 and 14 days subgroups consisted of 4 rats. The other 4 rats were taken as the sham-operated group, the rats were given the same treatment except for not introduced the filament in

关键词： mRNA Inosine inhibits apoptosis and cytochrome C mRNA expression in rat neurons after cerebral ischemia/reperfusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polypeptide from Chlamys farreri attenuates murine thymocytes damage induced by ultraviolet B

引用

Acta Pharmacologica Sinica 2007年第10期28卷 1665-1670页

作者： Hai-ying CHEN~(2,3),Xiao CHU~4,Chun-ling YAN~5,Xue-hong CHEN~5,Mi SUN~6,Yue-jun WANG~6,Chun-bo WANG~(3,7),Wen-gong YU~(2,7)~2 department of Pharmacochemistry,Ocean university of china,qingdao 266003,china ~3 department of Pharmacology,medical college,qingdaouniversity,qingdao 266021,china ~4 qingdao Municipal hospital,qingdao 266010,china ~5 department of Pathophysiology,medicalcollege,qingdao university,qingdao 266021,china ~6 Yellow Sea Fishery Research Institute,qingdao 266071,china ment of Pharmacochemistry Ocean University of China Qingdao 266003 China. cbwang666@***.

Aim:Polypeptide from Chlamys farreri (PCF,molecular mass is 879) is a newmarine polypeptide compound isolated from Chlamys *** study investi-gates the possible protective roles and the mechanism of PCF against ultravioletB (UVB)-induced apoptosis in murine ***:The rate of apoptosisand caspase-3 activation was measured by flow *** expression ofstress-response genes c-fos and c-jun was observed by *** blotanalysis was performed to determine the release of cytochrome ***:It wasfound that UVB induced murine thymocyte *** cells treated with UVBshowed an increase in cytochrome c release,caspase-3 activity,as well as in theexpression of c-fos and *** addition,all were involved in UVB-induced ***:Our present observations pointed to the ability of PCF toavert UVB-induced apoptosis in thymocytes by modulating c-fos and c-junexpression,cytochrome c release,and the consequent activation of caspase-3,which were essential components of the UV-induced cell apoptotic *** suggested that PCF is a promising protective substance against UVradiation.

关键词： polypeptide from Chlamys farreri (PCF) ultraviolet B apoptosis cytochrome c caspase-3

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Pathogenesis of cholangiocarcinoma in the porta hepatis and infection of hepatitis virus

引用

Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 601-605页

作者： Xiao-Fang Liu Sheng-Quan Zou Fa-Zu Qiu the department of Hepatobiliary Surgery of affiliated Yantai Yuhuangding hospital, qingdao university medical college, Yantai 264000, china department of General Surgery of Tongji medical hospital, Wuhan 430030, china department of Hepatobiliary Surgery of affiliated Yantai Yuhuangding hospital Qingdao University Medical College Yantai 264000 China. liu634@***

OBJECTIVE: To study the correlation between human cholangiocarcinoma in the porta hepatis and the infection of hepatitis virus. METHODS: Immunohistochemistry was used to detect HBxAg and HCV-C protein in formalin-fixed and paraffin-embedded samples taken from 68 patients with cholangiocarcinoma in the porta hepatis. The findings were reviewed against the clinical records of the patients. RESULTS: Six patients (8.8%) were positive for HBxAg and 24 (35%) for HCV-C protein, respectively. One patient was positive for both HBxAg and HCV-C protein. There were statistically differences in the extent of differentiation, invasion, lymph-node metastasis, and treatment between the patients with cholangiocarcinomas in the porta hepatis with HB(C) V infection and those without infection. CONCLUSIONS: HB(C) V infection is correlated to the development of cholangiocarcinoma in the porta hepatis. The tumor with HB(C) V infection may have a higher malignancy biologically and poorer prognosis. HBxAg and HCV-C protein may play an important role in the pathogenesis of cholangiocarcinoma in the porta hepatis.

关键词： cholangiocarcinoma porta hepatis hepatitis B virus hepatitis C-like virus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

右美托咪定2种剂量对靶控输注丙泊酚效应室浓度的影响

引用

中国新药与临床杂志 2010年第10期29卷 778-782页

作者：邹鑫王世端冯伟青岛大学医学院附属医院麻醉科山东青岛266003

目的以脑电双频指数(BIS)为麻醉镇静深度指标,探讨2种剂量右美托咪定静脉泵注对靶控输注丙泊酚效应室浓度的影响。方法妇科腹腔镜手术患者60例,ASAⅠ或Ⅱ级,随机分为3组,每组20例。右美托咪定Ⅰ组(D1组)及Ⅱ组(D2组)予右美托咪定0.3及0.... 详细信息

目的以脑电双频指数(BIS)为麻醉镇静深度指标,探讨2种剂量右美托咪定静脉泵注对靶控输注丙泊酚效应室浓度的影响。方法妇科腹腔镜手术患者60例,ASAⅠ或Ⅱ级,随机分为3组,每组20例。右美托咪定Ⅰ组(D1组)及Ⅱ组(D2组)予右美托咪定0.3及0.6μ***-1,对照组(C组)予等容量氯化钠注射液,均以微量泵于麻醉诱导前在10 min内泵注完毕。3组麻醉诱导方法相同,术中根据BIS值调节丙泊酚血浆靶浓度维持麻醉。记录用药前、诱导前、插管前和后、切皮前、切皮后30 min、术毕及拔管后时间点的丙泊酚效应室浓度及血流动力学参数。并记录苏醒时间及不良反应的发生情况。结果 3组间麻醉时间、苏醒时间无显著差异(P>0.05),而丙泊酚用量差异非常显著(P<0.01),C组、D1组和D2组分别为(8.4±s 1.5)、(6.0±1.0)和(4.8±1.1)***-1.h-1。麻醉诱导及维持期间D1和D2组丙泊酚效应室浓度低于C组(P<0.01),且D2组低于D1组(P<0.05)。与C组相比,D1和D2组患者平均动脉压及心率波动较小。D2组术中发生心率减慢4例,予阿托品后好转,3组均未见严重不良反应发生。结论右美托咪定单次泵注可以降低靶控输注丙泊酚效应室浓度、减少丙泊酚用量,但剂量增大,术中心率减慢的发生率也相应增加。

关键词：右美托咪定丙泊酚麻醉,静脉靶控输注

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：