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Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells

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World Journal of Gastroenterology 2005年第40期11卷 6312-6321页

作者： Carine Strup-Perrot Marie-Catherine Vozenin-Brotons Marie Vandamme Christine Linard denis mathé Laboratoire d'étude des pathologies Radio-induites Laboratoire UPRES EA 27-10 'Radiosensibilité des tumeurs et tissus sains'

AIM： To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS： Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, such as zymography, immunohistochemistry and real time reverse transcriptase-polymerase chain reaction, were used to localize and quantify MMPs and the molecules involved in MMP activating and inhibitory pathways （plasmin/ plasminogen, TIMPs）, CD^8＋, as well as inflammatory （interleukin （IL）-1β, IL-8, tumor necrosis factor-s, TNF-α） and fibrogenic mediators （transforming growth factor- β1-3） within ileal tissue at 1, 3, and 7 d after irradiation. RESULTS： A marked increase in MMP-2 and -14 mRNA and protein levels associated with an increased activity of MMP-2 was observed in irradiated ileal tissue. MMP-2 and -14 expression was mainly observed in inflammatory, epithelial, and mesenchymal cells, whereas a slight increase in MMP-3 expression was detected in the few infiltrating macrophages at d i after irradiation. Conversely, MMP-1, -7, and -9 mRNA levels were not found to be affected by abdominal irradiation. Irradiation was found to induce disappearance of CD^8＋ cells. Furthermore, we have observed that TNF-α and IL-1β protein levels increased 6 h after irradiation, whereas those of IL-8 only increased after 3 d and was concomitant with neutrophil infiltration. In addition, the expressions of molecules involved in MMP activating and inhibitory pathways （urokinase-type plasminogen activator andtissue-type plasminogen activator; TIMP-1, TIMP-2, and plasminogen activator-inhibitor-i） were found to be increased after abdominal irradiation. CONCLUSION： This study showed that abdominal irradiation induces an acute remodeling of the ileum associated with an increased expression of MMPs and TIMPs that do not involve CD^8＋ T cells but involve mesenchymal and epi

关键词： Matrix metalloproteinases Irradiation Ileum T cells Cytokines

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One-Dimensional Symmetry and Liouville Type Results for the Fourth Order Allen-Cahn Equation in R^N

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Chinese Annals of mathematics,Series B 2017年第1期38卷 149-172页

作者： denis BONHEURE Franois HAMEL Département de mathématique Université libre de Bruxelles INRIA-Team MEPHYSTO Aix Marseille Univ CNRSCentrale Marseille

In this paper, the authors prove an analogue of Gibbons' conjecture for the extended fourth order Allen-Cahn equation in R^N, as well as Liouville type results for some solutions converging to the same value at infinity in a given direction. The authors also prove a priori bounds and further one-dimensional symmetry and rigidity results for semilinear fourth order elliptic equations with more general nonlinearities.

关键词： Fourth order elliptic equation Allen-Cahn equation Extended Fisher-Kolmogorov equation One-dimensional symmetry Liouville type results

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Quasi-hydrostatic Primitive Equations for Ocean Global Circulation Models

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Chinese Annals of mathematics,Series B 2010年第6期31卷 939-952页

作者： Carine LUCAS Madalina PETCU Antoine ROUSSEAU Laboratoire MAPMO (UMR 6628) Fédération Denis Poisson (FDP-FR2964) Université d'OrléansBtiment de Mathématiques-Route de Chartres B. P. 6759 45067 Orléans Cedex 2 France Laboratoire de mathématiques et Applications Téléport 2-B. P. 30179 Boulevard Marie et Pierre Curie 86962 Futuroscope Chasseneuil Cedex France INRIA Laboratoire Jean Kuntzmann 51 rue des Mathématiques B. P. 53 38041 Grenoble Cedex 9France

Global existence of weak and strong solutions to the quasi-hydrostatic primitive equations is studied in this paper. This model, that derives from the full non-hydrostatic model for geophysical fluid dynamics in the zero-limit of the aspect ratio, is more realistic than the classical hydrostatic model, since the traditional approximation that consists in neglecting a part of the Coriolis force is relaxed. After justifying the derivation of the model, the authors provide a rigorous proof of global existence of weak solutions, and well-posedness for strong solutions in dimension three.

关键词： Hydrostatic approximation Coriolis force Ocean global circulation models Primitive equations Traditional approximation

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