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A Cross-Multi-Domain Trust Assessment Authority Delegation Method Based on Automotive Industry Chain

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Computers, Materials & Continua 2025年第1期82卷 407-426页

作者： Binyong Li Liangming deng Jie Zhang Xianhui deng School of Cybersecurity(Xin Gu Industrial College) Chengdu University of Information TechnologyChengdu610225China Advanced Cryptography and System Security Key Laboratory of Sichuan Province Chengdu610225China SUGON Industrial Control and Security Center Chengdu610225China

To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and *** propose a trust evaluation permission delegation method based on the automotive industry *** proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation *** also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and *** analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.

关键词： Automotive industry chain cross-domain access block chain delegate authority trust assessment

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一种高精度分光光度计系统的设计与应用

传感器与微系统 2013年第1期32卷 102-104,111页

作者：林斌飞龙伟万汉伟邓雅婷南昌大学信息工程学院江西南昌330031

介绍了一种高精度分光光度计系统的设计方法及其临床应用。该系统充分利用全息凹面光栅色散器件的优势,结合复杂可编程逻辑器件(CPLD)可自由编程的步进电机细分电路设计和电机定位闭环控制技术,实现了320～800 nm连续光谱范围内1 nm的... 详细信息

介绍了一种高精度分光光度计系统的设计方法及其临床应用。该系统充分利用全息凹面光栅色散器件的优势,结合复杂可编程逻辑器件(CPLD)可自由编程的步进电机细分电路设计和电机定位闭环控制技术,实现了320～800 nm连续光谱范围内1 nm的高精度分光。由该系统作为核心传感部件的生化分析仪临床应用表明:系统具有连续光谱分布范围广、分光精度高、运行稳定和检测可靠等优点。

关键词：全息凹面光栅复杂可编程逻辑器件 1nm精密分光分光光度计

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

髓细胞白血病因子-1抑制剂的三维定量构效关系研究

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化学研究与应用 2019年第2期31卷 192-202页

作者：李静邓雅庭王俊伟王娟林治华重庆理工大学药学与生物工程学院重庆400054 重庆大学化学化工学院重庆400044

髓细胞白血病因子-1(Mcl-1)在多种细胞的生存与死亡中发挥着重要的作用,参与多种肿瘤的发生,已经成为新的研究热点。本文针对52个Mcl-1抑制剂2-吲哚酰基磺酰胺类化合物进行三维定量关系(3D-QSAR)研究,研究其结构与活性的关系。为此,基... 详细信息

髓细胞白血病因子-1(Mcl-1)在多种细胞的生存与死亡中发挥着重要的作用,参与多种肿瘤的发生,已经成为新的研究热点。本文针对52个Mcl-1抑制剂2-吲哚酰基磺酰胺类化合物进行三维定量关系(3D-QSAR)研究,研究其结构与活性的关系。为此,基于分子的共同骨架叠合运用比较分子立场分析(CoMFA)和比较分子相似性指数分析(CoMSIA)两种经典的方法进行了三维定量构效关系的研究,建立相应模型,进行分子结构和抗肿瘤活性的分析。CoMFA模型的交叉验证系数q^2为0.714,相关系数r^2为0.992,预测相关系数r^2pred为0.654,立体场和静电场对活性的贡献为62%和38%。CoMSIA模型的交叉验证系数q^2为0.785,相关系数r^2为0.984,预测相关系数r^2pred为0.763。立体场、静电场、疏水场对活性的贡献为25.1%、41.0%和33.9%。数据证明上述模型都显示出了较好的预测性,为设计新型高活性的小分子抑制剂提供了有效信息。

关键词： Mcl-1抑制 3D-QSAR CoMFA CoMSIA

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo deng Ji Xiong Kai Guo ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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吴茱萸中吲哚喹唑啉类生物碱和吴茱萸内酯的质谱裂解分析

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中药材 2008年第5期31卷 673-676页

作者：廖琼峰谢智勇张蕾邓雅婷李纯魏存芳姚媛广州中医药大学中药学院中药分析教研室广东广州510006 中山大学药学院药物分析与质量评价实验室广东广州510080

目的:应用ESI-MS-MS技术分析吴茱萸中吲哚喹唑啉类生物碱和吴茱萸内酯的质谱断裂。方法:在正离子模式下,以电喷雾离子源分析吴茱萸中生物碱的一级和二级质谱图。结果:解析了吲哚喹唑啉类生物碱和吴茱萸内酯的二级质谱碎片。结论:获得了... 详细信息

目的:应用ESI-MS-MS技术分析吴茱萸中吲哚喹唑啉类生物碱和吴茱萸内酯的质谱断裂。方法:在正离子模式下,以电喷雾离子源分析吴茱萸中生物碱的一级和二级质谱图。结果:解析了吲哚喹唑啉类生物碱和吴茱萸内酯的二级质谱碎片。结论:获得了吴茱萸中主要活性成分生物碱的质谱断裂特点,为吴茱萸质量标准及其生物碱类化学成分研究提供依据。

关键词：吴茱萸吴茱萸碱质谱断裂 ESI-MS-MS

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不同显色剂对续断皂苷含量测定的影响

时珍国医国药 2011年第11期22卷 2586-2587页

作者：邓雅婷刘莉刘美佑李新方杨欣梅其炳中国人民解放军第四军医大学陕西西安710032

目的考察不同显色剂对紫外-可见分光光度法测定续断总皂苷含量的影响,确定最优显色方法。方法采用紫外-可见分光光度法测定续断总皂苷含量,分别用3种显色法显色,方法A显色剂为浓硫酸:甲醇(4∶1);方法B显色剂为5%香草醛-冰乙酸∶高氯酸... 详细信息

目的考察不同显色剂对紫外-可见分光光度法测定续断总皂苷含量的影响,确定最优显色方法。方法采用紫外-可见分光光度法测定续断总皂苷含量,分别用3种显色法显色,方法A显色剂为浓硫酸:甲醇(4∶1);方法B显色剂为5%香草醛-冰乙酸∶高氯酸∶醋酸乙酯(2∶8∶10);方法C显色剂为高氯酸。结果方法B专属性较差,方法A和C均适合不同提取物中续断皂苷的测定,方法A加样回收率优于方法C。结论方法A为最佳显色方法。

关键词：续断皂苷类显色剂紫外-可光分光光度法

黄连-吴茱萸药对化学成分的HPLC-DAD-MS分析

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药学学报 2008年第3期43卷 299-302页

作者：邓雅婷廖琼峰毕开顺姚美村姜晓飞谢智勇沈阳药科大学药学院辽宁沈阳110016 广州中医药大学中药学院广东广州510006 中山大学药学院广东广州510080

建立黄连-吴茱萸药对半仿生提取液化学成分的HPLC-DAD-MS分析方法,研究黄连-吴茱萸配伍机制的物质基础。以Hypersil BDS C18为色谱柱,梯度洗脱后,综合分析不同样品的色谱峰保留时间、紫外光谱,一级和二级全扫描质谱图,归属了黄连-吴茱... 详细信息

建立黄连-吴茱萸药对半仿生提取液化学成分的HPLC-DAD-MS分析方法,研究黄连-吴茱萸配伍机制的物质基础。以Hypersil BDS C18为色谱柱,梯度洗脱后,综合分析不同样品的色谱峰保留时间、紫外光谱,一级和二级全扫描质谱图,归属了黄连-吴茱萸(6∶1)半仿生提取液中的17个色谱峰,8个来自吴茱萸,其他9个均来自黄连,确认了4个色谱峰分别为药根碱、羟基吴茱萸碱、巴马汀和小檗碱;推断了3个色谱峰分别为表小檗碱、非洲防己碱和黄连碱,同时测定了小檗碱和巴马汀的含量。黄连配伍吴茱萸后半仿生提取无新物质生成,但小檗碱和巴马汀的溶出量降低。

关键词：黄连-吴茱萸药对 HPLC-DAD-MS 半仿生提取

火炬松SSR-PCR反应体系的建立及引物筛选

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广西林业科学 2016年第3期45卷 253-258页

作者：张蝶郭小丹邓亚婷徐刚标中南林业科技大学林学院湖南长沙410004

以火炬松(Pinus teada)幼嫩针叶为材料,采用单因素试验设计分析各组分对SSR-PCR扩增结果的影响,并进一步应用正交试验设计,从DNA模板、引物、d NTPs、Mg2+和Taq酶5个因素3个水平对SSR扩增效果进行研究,确定火炬松SSR-PCR的最佳反应体系... 详细信息

以火炬松(Pinus teada)幼嫩针叶为材料,采用单因素试验设计分析各组分对SSR-PCR扩增结果的影响,并进一步应用正交试验设计,从DNA模板、引物、d NTPs、Mg2+和Taq酶5个因素3个水平对SSR扩增效果进行研究,确定火炬松SSR-PCR的最佳反应体系。结果表明:各因素不同水平浓度对SSR-PCR反应结果均有影响,火炬松SSR-PCR优化后的反应体系为:DNA模板80 ng、引物0.3μmol/L、dNTPs 0.20 mmol/L、Mg^(2+)2.0 mmol/L、Taq酶1.00 U、1×PCR Buffer,总体积25μL。运用该体系从60对引物中筛选出扩增条带清晰、多态性丰富的SSR引物8对,并用不同火炬松家系进行了检验,证明该体系稳定可靠。

关键词：火炬松 SSR-PCR 单因素试验正交设计引物筛选