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Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy

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World Journal of Hepatology 2015年第5期7卷 761-768页

作者： dede sit Bennur Esen Ahmet Engin Atay Hasan Kayabasi Department of Internal Medicine and Nephrology Bagcilar Education and Research Hospital

Impaired renal function is associated with a high risk of chronicity of hepatitis B virus(HBV) *** on hemodialysis(HD) or peritoneal dialysis are at an increased risk of viral transmission due to frequent necessity of blood product transfer as well as use of contaminated dialysate or dialysis ***,health professionals may cause viral spread via contaminated hands and carelessness against hygiene *** frequency of chronic HBV infection may be as high as 80% in patients on renal replacement *** is because HBV vaccination is essential to eliminate chronic HBV ***,response rates of HD patients to HBV vaccination vary between 10%-50%.Dialysis adequacy and early vaccination before the onset of dialysis therapy seem to be major determinants of high seroconversion *** age,male gender,duration of dialysis therapy and nutritional status are other well-known factors associated with seroconversion *** are controversial reports regarding the role of the presence of diabetes mellitus,HCV positivity,erythropoietin resistance,hyperparathyroidism,and vitamin D *** role of genetic alteration in the functions or production of cytokines still needs to be elucidated.

关键词： Hepatitis B virus Vaccine Hemodialysis Response End stage renal disease

The Predictive Role of New Markers in Early Diagnosis of Acute Kidney Injury in Patients with Acute Pancreatitis

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Open Journal of Nephrology 2020年第3期10卷 254-263页

作者： Ferdi Karagöz dede sit Aysegül Kirankaya Yasemin Aker Karagöz Arif Savas Yildiz Ipek Bennur Esen Atay Ahmet Engin Atay Clinic of Internal Medicine Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Nephrology Umraniye Training and Research Hospital Istanbul Turkey Clinic of Biochemistry Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Family Medicine Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Nephrology Bagcilar Training and Research Hospital Istanbul Turkey

Objective: Acute Kidney Injury (AKI) is a serious early complication that significantly increases the mortality rate in patients with acute pancreatitis (AP). AKI can improve with an early diagnosis and appropriate treatment protocols. We aimed to evaluate the role of IL-6, IL-18, NGAL, IL-1β, TNF-α, Cys-C and KIM-1 in serum and IL-18 in urine in the early detection of AKI in patients with AP. Materials and Methods: Fifty-six patients, who were diagnosed with AP and underwent standard treatment, between July 2011 and December 2013, were included in the study. Patients were sampled for markers at admission and discharge, or when the patients died. Patients were grouped by presence or absence of AKI. Results: The mean age of the cases was 56.41 ± 20.23 (17 - 91), of which 21 (37.5%) of the cases were male and 35 (62.5%) were female. AKI was detected in 13 (23.2%) patients. The Cys-C level was significantly higher in AKI patients (at hospitalization p sitive correlation between serum KIM-1 and creatinine, but a negative correation between GFR and spot urine amylase/creatinine ratio during AKI patients’ admission (respectively;p Conclusion: In this study, Cys-C and KIM-1 proved to be statistically significant to predict AKI in patients with AP. However further studies are required to support these conclusions.

关键词： Acute Pancreatitis AKI Cystatin-C KIM-1

以专业使命为本的行业——专访中国香港会计师公会会长梁思杰

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新理财（公司理财） 2024年第4期 73-75页

作者： Jemelyn Yadao Calvin sit(图) 不详

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察... 详细信息

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察觉到会计师为社会作出的贡献。

关键词：香港会计师公会会计师会长影响力

FORGING ASIA′S GLOBAL TRANSPARK IN THE PEARL RIVER DELTA AT ZHUHAI

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Chinese Geographical Science 2003年第4期13卷 300-309页

作者： Victor F S sit .

The main purpose of the paper is to introduce the concept of the Global TransPark (GTP). It is a critical time to develop air logistics infrastructure in the New Economy. The paper also presents a brief review of the air cargo industry in the Asian-Pacific region and China,in particular China’s development in the industry as its economy has grown rapidly and globalized in the past two decades. The paper argues that China needs to develop a GTP to support its future growth,and explains why the Pearl River Delta-Hong Kong-Macao city-region or Extended Metropolitan Region (EMR) is the best location. Finally,it proposes that Zhuhai Airport,one of the five airports in the EMR,is the best site for the GTP. New policies from Chinese government as well as close cooperation between local governments of Guangdong and the two Special Administrative Regions of Hong Kong and Macao will be needed to make the establishment of the GTP possible.

关键词： Global TransPark airport air cargo transport Hong Kong Extended Metropolitan Region the Pearl River Delta New Economy

Identifying disaster-related tweets and their semantic,spatial and temporal context using deep learning,natural language processing and spatial analysis:a case study of Hurricane Irma

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International Journal of Digital Earth 2019年第11期12卷 1205-1229页

作者： Muhammed Ali sit Caglar Koylu Ibrahim Demir Department of Computer Science University of IowaIowa CityIAUSA Department of Geographical and Sustainability Sciences University of IowaIowa CityIAUSA Department of Civil and Environmental Engineering University of IowaIowa CityIAUSA

We introduce an analytical framework for analyzing tweets to(1)identify and categorize fine-grained details about a disaster such as affected individuals,damaged infrastructure and disrupted services;(2)distinguish impact areas and time periods,and relative prominence of each category of disaster-related information across space and *** first identify disaster-related tweets by generating a human-labeled training dataset and experimenting a series of deep learning and machine learning methods for a binary classification of *** employ LSTM(Long Short-Term Memory)networks for the classification task because LSTM networks outperform other methods by considering the whole text structure using long-term semantic word and feature ***,we employ an unsupervised multi-label classification of tweets using Latent Dirichlet Allocation(LDA),and identify latent categories of tweets such as affected individuals and disrupted ***,we employ spatiallyadaptive kernel smoothing and density-based spatial clustering to identify the relative prominence and impact areas for each information category,*** Hurricane Irma as a case study,we analyze over 500 million keyword-based and geo-located collection of tweets before,during and after the *** results highlight potential areas with high density of affected individuals and infrastructure damage throughout the temporal progression of the disaster.

关键词： Social sensing Twitter deep learning natural language processing spatial analysis hurricane

Symptom clusters and quality of life among patients with advanced heart failure

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Journal of Geriatric Cardiology 2016年第5期13卷 408-414页

作者： Doris SF Yu Helen YL Chan Doris YP Leung Elsie Hui Janet WH sit The Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China Department of Medicine and Geriatrics Shatin Hospital Hong Kong China

Objectives To identify symptom clusters among patients with advanced heart failure （HF） and the independent relationships with their quality of life （QoL）. Methods This is the secondary data analysis of a cross-sectional study which interviewed 119 patients with advanced HF in the geriatric unit of a regional hospital in Hong Kong. The symptom profile and QoL were assessed by using the Edmonton Symptom Assessment Scale （ESAS） and the McGill QoL Questionnaire. Exploratory factor analysis was used to identify the symptom clusters. Hier- archical regression analysis was used to examine the independent relationships with their QoL, after adjusting the effects of age, gender, and comorbidities. Results The patients were at an advanced age （82.9± 6.5 years）. Three distinct symptom clusters were identified： they were the distress cluster （including shortness of breath, anxiety, and depression）, the decondition cluster （fatigue, drowsiness, nausea, and reduced appetite）, and the discomfort cluster （pain, and sense of generalized discomfort）. These three symptom clusters accounted for 63.25% of variance of the patients＇ symptom experience. The small to moderate correlations between these symptom clusters indicated that they were rather independent of one another. After adjusting the age, gender and comorbidities, the distress （β = -0.635, P 〈 0.001）, the decondition （β = -0.148, P = 0.01）, and the discomfort （β = -0.258, P 〈 0.001） symptom clusters independently predicted their QoL. Conclusions This study identified the distinctive symptom clusters among patients with advanced HF. The results shed light on the need to develop palliative care interventions for optimizing the symptom control for this life-limiting disease.

关键词： Advanced heart failure Palliative care model Quality of life Symptom clusters

IoMT-Based Healthcare Framework for Ambient Assisted Living Using a Convolutional Neural Network

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Computers, Materials & Continua 2023年第3期74卷 6867-6878页

作者： Waleed T.Al-sit Nidal A.Al-Dmour Taher M.Ghazal Ghassan F.Issa Department of Computer Engineering Mutah UniversityAl-KarakJordanHigher Colleges of TechnologyDubaiUAE Department of Computer Engineering College of EngineeringMutah UniversityJordan School of Information Technology Skyline University CollegeUniversity City SharjahSharjahUAE Center for Cyber Security Faculty of Information Science and TechnologyUKM43600BangiSelangorMalaysia

In the age of universal computing,human life is becoming smarter owing to the recent developments in the Internet of Medical Things(IoMT),wearable sensors,and telecommunication innovations,which provide more effective and smarter healthcare *** has the potential to shape the future of clinical research in the healthcare *** sensors,patients,healthcare providers,and caregivers can connect through an IoMT network using software,information,and communication *** assisted living(AAL)allows the incorporation of emerging innovations into the routine life events of *** learning(ML)teaches machines to learn from human experiences and to use computer algorithms to“learn”information directly instead of relying on a *** the sample size accessible for learning increases,the performance of the algorithms *** paper proposes a novel IoMT-enabled smart healthcare framework for AAL to monitor the physical actions of patients using a convolutional neural network(CNN)algorithm for fast analysis,improved decision-making,and enhanced treatment *** simulation results showed that the prediction accuracy of the proposed framework is higher than those of previously published approaches.

关键词： Smart healthcare system neural network machine learning

Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong

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Journal of Geriatric Cardiology 2016年第5期13卷 415-419页

作者： Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH sit Eliza ML Wong Siu Wai Tang The Nethersole School of Nursing: Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Cardiac Rehabilitation Centre Tung Wah Eastern Hospital Hong Kong China

Background Heart failure （HF） is a physically and socially debilitating disease that carries the burden of hospital re-admission and mortality. As an aging society, Hong Kong urgently needs to find ways to reduce the hospital readmission of HF patients. This study evaluates the effects of a nurse-led HF clinic on the hospital readmission and mortality rates among older HF patients in Hong Kong. Methods This study is a retrospective data analysis that compares HF patient in a nurse-led HF clinic in Hong Kong compared with HF patients who did not attend the clinic. The nurses of this clinic provide education on lifestyle modification and symptom monitoring, as well as titrate the medications and measure biochemical markers by following established protocols. This analysis used the socio-demographic and clinical data of HF patients who were aged 〉 65 years old and stayed in the clinic over a six-month period. Results The data of a total of 78 HF patients were included in this data analysis. The mean age of the patients was 77.38 ± 6.80 years. Approximately half of the HF patients were male （51.3%）, almost half were smokers （46.2%）, and the majority received 〈 six years of formal education. Most of the HF patients （87.2%） belonged to classes II and III of the New York Heart Association Functional Classification, with a mean ejection fraction of 47.15± 20.31 mL. The HF patients who attended the clinic （n = 38, 75.13 ± 5.89 years） were significantly younger than those who did not attend the clinic （n = 40, 79.53 ± 6.96 years）（P = 0.04）, and had lower recorded blood pressure. No other statistically significant difference existed between the socio-demographic and clinical characteristics of the two groups. The HF patients who did not attend the nurse-led HF clinic demonstrated a significantly higher risk of hospital readmission [odd ratio （OR）： 7.40; P 〈 0.01] than those who attended after adjusting for the effect of age and blood pressure. In addition, HF patients who att

关键词： Heart failure Hospital readmission Mortality Nurse-led clinic

边臂修饰的水杨醛亚胺第四族金属配合物的合成、结构及其乙烯聚合行为研究(英文)

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化学学报 2012年第18期70卷 1909-1916页

作者：王新科 sit Met-Met 孙杰唐勇谢作伟金属有机化学国家重点实验室中国科学院上海有机化学研究所上海200032 沪港化学合成联合实验室中国科学院上海有机化学研究所上海200032 香港中文大学化学系中国香港新界沙田

通过给电子基团取代的(E)-2,4-二-叔丁基-6-(苯基亚胺基甲基)苯酚与等当量的M(CH2Ph)4反应制备了一系列第四族金属的双苄基配合物.反应经历了甲苯消除及分子内苄基从金属至亚胺碳的迁移反应,中间体的分离和结构鉴定证实了该反应历程.通... 详细信息

通过给电子基团取代的(E)-2,4-二-叔丁基-6-(苯基亚胺基甲基)苯酚与等当量的M(CH2Ph)4反应制备了一系列第四族金属的双苄基配合物.反应经历了甲苯消除及分子内苄基从金属至亚胺碳的迁移反应,中间体的分离和结构鉴定证实了该反应历程.通过核磁、元素分析和X-ray单晶衍射表征了配合物的结构.在甲基铝氧烷(MMAO)的活化下,钛配合物可以高活性地催化乙烯的均聚合和乙烯/1-己烯的共聚合,而相应的锆、铪的配合物在同样的条件下则几乎没有活性.

关键词：乙烯聚合乙烯/己烯共聚合第四族金属配合物水杨醛亚胺分子内迁移