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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Gene bank scheduling of seed regeneration: Interim report on a long term storage study

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Journal of Integrative Agriculture 2019年第7期18卷 1529-1540页

作者： Robert Redden debra Partington Australian Temperate Field Crops Collection Private Bag 260Agriculture Victoria

A major challenge for the management of gene banks is the maintenance of good seed health in the *** germplasm collections >10 000 accessions often have been acquired from different sources over a range of dates,may differ in germination at time of deposition in the gene bank,and may have genetic differences in seed *** major storage variables affecting seed longevity are temperature and seed moisture *** varieties of each pea(Pisum sativus L.),lentil(Lens culinaris Medikus ***),and chickpea(Cicer arietinum L.),were stored at three temperatures;40,20,and 2°C,each with three seed moisture levels of 10.9–13.8%(high),7.9–10.3%(medium),and 7–7.8%(low),in the Australian Temperate Field Crops Collection gene *** longevity at a given storage period was estimated by the corresponding germination percentage for each *** paper is an interim report on seed viability decline in the first seven years of this seed longevity study,in which viability decline towards zero was almost completed in the three seed moisture treatments at 40°C and the 20°C high seed moisture treatment,but had not declined in the other *** longevity positively responded to a reduction in temperature and then to a reduction in seed *** number of days in storage for seed germination decline to 85%(p85),and to 50%(p50) for mean seed viability,are reported by storage/varietal *** p85 and p50 showed significant inverse linear responses with seed moisture at 40°C for pea and lentil varieties,with intra-specific variation for *** long term trial aims to provide informed timing of seed regeneration for accessions in a gene bank.

关键词： gene bank storage moisture level temperature regeneration pea lentil chickpea

semantic segmentation of Lumbar Vertebrae Using Meijering U-Net(MU-Net)on spine Magnetic Resonance Images

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Computer Modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： Lakshmi s V V shiloah Elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Direct Observation of Arthrobacter 4-Hydroxybenzoyl-Coenzyme A Thioesterase Catalysis complexes using Electrospray Ionization Mass spectrometry

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生物物理学报 2009年第S1期25卷 163-164页

作者： debra Dunaway-Mariano Karen s.Anderson Department of Chemistry University of New Mexico Albuquerque New Mexico 87131 USA Department of Pharmacology Yale University School of Medicine 333 Cedar Street New Haven CT 06520 USA

Investigating enzymatic reaction in multimeric enzymes is utmost interest to improve our understanding of the mechanism of enzymatic reaction and regulation. In this study,

关键词： Arthrobacter thioesterase multinary enzyme-ligand complex mass spectrometry

Limits of drag augmentation at spacecraft end-of-mission and a mitigation strategy

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Astrodynamics 2021年第2期5卷 109-120页

作者： Emma Kerr Malcolm macdonald University of strathclyde GlasgowG11XJUK

An increasing number of objects are being launched into low-Earth ***,to avoid the possibility of future in-orbit collisions space object removal techniques are receiving *** one of the most developed techniques,drag augmentation is increasingly being considered as an option for end-of-mission removal of objects from low-Earth *** paper highlights a common misconception around drag augmentation:although it can be used to reduce de-orbit time,when used inappropriately it can increase the volume swept by an object and,thus,increase the occurrence risk of collision with another space *** ignoring this increased risk of collisions could leave spacecraft operators,and consequently their responsible state party,open to liability *** investigating the volume swept and de-orbit lifetime,a strategy of delayed deployment is proposed as a compromise between reducing volume swept and time to ***,this increases system complexity and,likely,cost.

关键词： drag augmentation volume area-time-product space debris liability Learned Hand formula calculus of negligence

Tau's function and dysfunction in the brain:when small changes have big consequences

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Neural Regeneration Research 2024年第1期19卷 152-153页

作者： Miguel Portillo debra Toiber Department of Life sciences Ben-Gurion University of the NegevBeer ShevaIsraelThe Zlotowski Center for NeuroscienceBen-Gurion University of the NegevBeer ShevaIsrael

With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by *** diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of *** the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.

关键词： diseases consequences function