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Propulsion and Power Research 2022年第3期11卷 353-375页

作者： debanjan das P.Padmanabhan Systems Reliability Group ISRO Propulsion ComplexIndian Space Research OrganisationTirunelveli(Mahendragiri)Tamil Nadu627133India

In this paper, transient phenomenon during start up process of a pump fed liquidrocket engine is investigated through numerical simulation. The engine studied in this workis designed such that engine systems are not wetted with propellant until the engine is com-manded to start. This is achieved by positioning the valves for propellant admission at the inter-face of test stand/flight stage and the engine. To evaluate engine performance during starttransient for such systems, unsteady flow simulation was conducted using Method of Charac-teristics and equations for priming. The same has been reported in this work. The results indi-cated a brief period of abrupt pressure rise at pump upstream after opening of the propellantadmission valves, during the process of priming of engine systems at valve *** peak pressure obtained was significantly higher than the propellant tank pressure as wellas the steady state pump suction pressure. The transitory pressure rise was found to occurdue to flow resistance at impeller inlet caused by formation of a forced vortex for orientingthe flow through impeller blades during off design transient regime. The maximum pressureat pump upstream, as computed from start transient simulation, was used as a design inputfor pump inlet feed lines. The engine was realized and subsequently qualified in a ground test facility. Hot test data obtained for pressure and flow rate during transient regime were found tobe in good agreement with the simulation results.

关键词： Method of Characteristics Priming analysis Liquid rocket engines Start transient Off design pump losses

In silico comparative structural and compositional analysis of glycoproteins of RSV to study the nature of stability and transmissibility of RSV A

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Systems Microbiology and Biomanufacturing 2023年第2期3卷 312-327页

作者： debanjan Mitra Pradeep K.das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current scenario of COVID-19 makes us to think about the devastating diseases that kill so many people every *** of viral proteins contributes many things that are utterly useful in the evolution of therapeutic drugs and *** this study,sequence and structure of fusion glycoproteins and major surface glycoproteins of respiratory syncytial virus(RSV)were analysed to reveal the stability and transmission *** A has the highest abundance of aromatic *** Kyte–Doolittle scale indicates the hydrophilic nature of RSV A protein which leads to the higher transmission rate of this ***-protein interactions such as carbonyl interactions,cation-pi,and salt bridges were shown to be greater in RSV A compared to RSV B,which might lead to improved *** study discovered the presence of a network aromatic–sulphur interaction in viral *** of ligand binding pocket of RSV proteins indicated that drugs are performing better on RSV B than RSV *** was also shown that increasing the number of tunnels in RSV A proteins boosts catalytic *** study will be helpful in drug discovery and vaccine development.

关键词： Respiratory syncytial virus Stability Intra-protein interactions Tunnels Drug discovery

Cold adaptation strategy of psychrophilic bacteria:an in-silico analysis of isocitrate dehydrogenase

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Systems Microbiology and Biomanufacturing 2021年第4期1卷 483-493页

作者： debanjan Mitra Pradeep Kr.das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

Non-specific electrostatics is crucial for structure and stability;recently,it has been argued that psychrophilic proteins may also utilize specific electrostatic *** psychrophilic proteins increase the number of salt bridges for cold adaptation?Are there any changes that occur in their sequence,which helps them to adapt in an extreme environment?Do intra-protein interactions affect their stability?Is there any special type of intra-protein interaction present in psychrophilic protein structure?This study will give all those ***(n~100)and structures of psychrophilic isocitrate dehydrogenase and mesophilic isocitrate dehydrogenase extracted from *** had been analyzed in BLOCK and non-BLOCK *** sequences of psychrophiles and mesophiles create two separate *** number of charged and uncharged polar residues is very much high in psychrophilic *** formation of long network aromatic-aromatic interactions and network aromatic-sulfur interactions are very crucial for psychrophilic protein *** of these types of interactions is also a novelty of this *** mutation of charged residues with high-energy contributions affects the protein *** study will help in protein engineering.

关键词： Cold adaptation Aromatic-aromatic interactions Aromatic-sulfur interactions Non-covalent interactions Mutation

Intra-protein interactions of SARS-CoV-2 and SARS:a bioinformatic analysis for plausible explanation regarding stability,divergency,and severity

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 653-664页

作者： debanjan Mitra Aditya K.Pal Pradeep Kr.das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current nightmare for the whole world is *** occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China,was first reported on December 30,***-CoV first disclosed in 2002 but had not outspread *** 18 years,in 2020,it reemerged and outspread worldwide as SARS-CoV-2(COVID-19),as the most dangerous virus-creating disease in the *** it possible to create a favorable evolution within the short time(18 years)?If possible,then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated?What are the fundamental differences between SARS-CoV-2 and SARS?The study is one of the initiatives to find out all those ***,four types of protein sequences from SARS-CoV-2 and SARS were retrieved from the database to study their physicochemical and structural *** showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution and contribute to the helix *** formation of the cyclic salt bridge and other intra-protein interactions specially network aromatic-aromatic interaction also play the crucial role in *** comparative study will help to understand the evolution from SARS to SARS-CoV-2 and helpful in protein engineering.

关键词： COVID-19 Evolution Cyclic salt bridge Intra-protein interactions Protein engineering