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Multimodality management for chronic subdural hematoma in China: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study

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中华神经外科杂志(英文) 2024年第2期10卷 1-10页

作者： Liu Tao Zhao Zhihao Huang Jinhao Zhu Xide Chen Weiliang Lin Kun Yu Yunhu Li Zhanying Fan Yibing Liu Mingqi Nie Meng Liu Xuanhui Gao Chuang quan Wei Qian Yu wu Chenrui Yuan Jiangyuan wu Di Lv Chuanxiang Dong Shiying Mi Liang Tian Yu Tian Ye Zhang Jianning Jiang Rongcai department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Ministry of Education Tianjin Neurological Institute Key Laboratory of Post Neuro-injury Neuro-repair and Regeneration in Central Nervous System Tianjin Medical University General Hospital Tianjin China department of Neurosurgery Linyi People’s Hospital Shandong China department of Neurosurgery Haining People’s Hospital Zhejiang China department of Neurosurgery Fujian Provincial Hospital Fujian China department of Clinical Research Center for Neurological Disease the People’s Hospital of HongHuaGang District of ZunYi Guizhou China department of Neurosurgery Kailuan General Hospital Hebei China department of Neurosurgery Tianjin First Central Hospital Tianjin China department of Neurosurgery The First Hospital of Jilin University Changchun China

Background despite its prevalence, there is ongoing debate regarding the optimal management strategy for chronic subdural hematoma (CSDH), reflecting the variability in clinical presentation and treatment outcomes. This ambidirectional, nationwide, multicenter registry study aims to assess the efficacy and safety of multimodality treatment approaches for CSDH in the Chinese ***/design A multicenter cohort of CSDH patients from 59 participating hospitals in mainland China was enrolled in this study. The treatment modalities encompassed a range of options and baseline demographics, clinical characteristics, radiographic findings, and surgical techniques were documented. Clinical outcomes, including hematoma resolution, recurrence rates, neurological status, and complications, were assessed at regular intervals during treatment, 3 months, 6 months, 1 year, and 2 years *** Between March 2022 and August 2023, a comprehensive cohort comprising 2173 individuals who met the criterion was assembled across 59 participating clinical sites. Of those patients, 81.1% were male, exhibiting an average age of 70.12 ± 14.53 years. A historical record of trauma was documented in 48.0% of cases, while headache constituted the predominant clinical presentation in 58.1% of patients. The foremost surgical modality employed was the burr hole (61.3%), with conservative management accounting for 25.6% of cases. Notably, a favorable clinical prognosis was observed in 88.9% of CSDH patients at 3 months, and the recurrence rate was found to be 2.4%.Conclusion This registry study provides critical insights into the multimodality treatment of CSDH in China, offering a foundation for advancing clinical practices, optimizing patient management, and ultimately, improving the quality of life for individuals suffering from this challenging neurosurgical *** registration ChiCTR2200057179

关键词： Chronic subdural hematoma Multimodality therapy Outcome Recurrence

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婴儿肉毒中毒14例临床表现及早期识别

中华实用儿科临床杂志 2024年第7期39卷 533-536页

作者：范祎慕武洁霍枫张哲哲刘霜君王硕王荃国家儿童医学中心首都医科大学附属北京儿童医院急诊内科北京国家儿童医学中心首都医科大学附属北京儿童医院重症医学科北京

目的探讨婴儿肉毒中毒的临床表现及早期识别特点。方法回顾性病例分析。对首都医科大学附属北京儿童医院2019年1月至2023年6月急诊内科收治的14例婴儿肉毒中毒患儿的临床资料进行回顾性分析。结果发病年龄4.2(1.9～8.6)月龄, 6月龄以下... 详细信息

目的探讨婴儿肉毒中毒的临床表现及早期识别特点。方法回顾性病例分析。对首都医科大学附属北京儿童医院2019年1月至2023年6月急诊内科收治的14例婴儿肉毒中毒患儿的临床资料进行回顾性分析。结果发病年龄4.2(1.9～8.6)月龄, 6月龄以下者10例(71.4%), 9例存在中毒诱因。首次就诊时间1(0～8) d, 13例(92.9%)主诉为纳差/拒奶, 其中12例(85.7%)瞳孔对光反射迟钝/消失, 11例(78.6%)存在便秘, 10例(71.4%)伴反应弱和/或嗜睡, 10例(71.4%)肠鸣音减弱或消失, 9例(64.3%)四肢无力和/或四肢活动减少。患儿均出现四肢对称性肌张力和肌力减低。首诊仅2例疑诊婴儿肉毒中毒。14例患儿粪便小鼠生物实验均阳性, 确诊时间3(1～10) d。11例(84.6%)存在不同程度肠淤张, 1例小肠生理积气减少。10例行新斯的明试验, 1例阳性, 1例可疑阳性。10例(71.4%)需机械通气者, 7例(50.0%)为有创呼吸支持。住院时间26(11～61) d, 所有患儿出院时基本痊愈。结论对于既往体健、意识清楚, 以主诉为纳差、反应弱、四肢无力急性起病的婴儿, 查体发现存在颅神经麻痹、急性弛缓性麻痹体征、腹胀及肠鸣音减弱者, 应考虑到婴儿肉毒中毒的可能, 尽早送检粪便标本进行肉毒毒素测定确诊。

关键词：婴儿肉毒中毒肉毒杆菌早期识别

CPTPP与dePA框架下数字产品非歧视待遇规则及中国应因

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中国流通经济 2024年第8期38卷 115-126页

作者：徐泉吴若惜西南政法大学国际法学院重庆市401120

数字产品非歧视待遇在CPTPP与dePA中均有规定,是我国加入CPTPP与dePA必须面对的规则。适用该规则要注意数字产品原产地、同类数字产品以及歧视性待遇的认定问题。鉴于目前国际社会尚未对数字产品的性质达成共识,可暂时参考WTO中货物或... 详细信息

数字产品非歧视待遇在CPTPP与dePA中均有规定,是我国加入CPTPP与dePA必须面对的规则。适用该规则要注意数字产品原产地、同类数字产品以及歧视性待遇的认定问题。鉴于目前国际社会尚未对数字产品的性质达成共识,可暂时参考WTO中货物或者服务关于以上问题的认定标准。在其适用问题上,有关国家的实践如征收数字服务税、限制网络接入与使用、限制国外数字产品购买可能会与该规则的规定相悖。数字产品非歧视待遇在自由贸易协定、数字贸易协定以及WTO电子商务谈判中均有涉及,以美国、日本等为首的发达国家对该规则持积极肯定态度,不仅在其签署的自贸协定中纳入该规则,同时也积极倡导将该规则纳入WTO电子商务中。与此同时不少发展中国家如智利、秘鲁等在其签订的自贸协定或者数字贸易协定中也纳入了该规则。但是在我国目前签订的自贸协定中均没有涉及该规则,而且我国在WTO电子商务的提案中对该规则也持谨慎态度,主要原因在于我国数字产品与美国、日本、韩国等发达国家的数字产品相比竞争力较弱,接受该规则可能会进一步削弱我国数字产品的竞争力。我国积极申请加入CPTPP与dePA,必须接受该规则对我国带来的机遇与挑战。该规则对我国的挑战主要表现为美式数字产品定义冲击我国数字贸易、负面清单模式扩大数字产品非歧视待遇适用范围、我国现行数字产品监管规定与其相冲突。为保护我国数字产品的发展,可通过援引政府补贴例外发展数字产品、利用负面清单限缩数字产品非歧视待遇适用范围、修改数字文化产品监管规定予以应对。

关键词：数字产品非歧视待遇例外规定负面清单

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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng quan Zhang Xiaogang Xia Peng Li Lingwei Gu Ting wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

南京主城区共享单车的骑行环境评估及其优化策略

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现代城市研究 2024年第5期39卷 71-79页

作者：全雨霏吴晓东南大学建筑学院

共享单车的大规模使用,为居民出行带来便利的同时,也引发了城市空间资源分配的一系列问题,对城市空间尤其是骑行环境提出了新要求。在此背景下,文章从南京市主城区遴选典型样本路段,评估共享单车的骑行环境,以探索亟待优化提升的影响因... 详细信息

共享单车的大规模使用,为居民出行带来便利的同时,也引发了城市空间资源分配的一系列问题,对城市空间尤其是骑行环境提出了新要求。在此背景下,文章从南京市主城区遴选典型样本路段,评估共享单车的骑行环境,以探索亟待优化提升的影响因素,再据此提出综合优化策略,提供学术借鉴和实践参照。研究发现:交通设施与环境以及道路设施的相关指标对骑行环境的影响相对较大;用户年龄和单车使用方式是导致人群评价分异的主要个体属性;骑行环境的优化提升可从宏观层面的自行车道规划、换乘停放提升以及微观层面的道路断面优化、隔离设施完善等方面入手。

关键词：共享单车骑行环境评估优化策略南京主城区

非缠结苯乙烯-对叔丁基苯乙烯共聚物的非线性拉伸流变行为

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应用化学 2024年第8期41卷 1098-1106页

作者：洪宗昊吴世龙陈全中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026

聚焦于苯乙烯和对叔丁基苯乙烯的非缠结聚合物以及其共聚物样品的线性和非线性拉伸流变学性质。所有样品均具有相似的链均库恩链段数(约为30个),表现出相似且符合Rouse模型预测的线性黏弹行为。在单轴拉伸实验中,样品在快速拉伸过程,即... 详细信息

聚焦于苯乙烯和对叔丁基苯乙烯的非缠结聚合物以及其共聚物样品的线性和非线性拉伸流变学性质。所有样品均具有相似的链均库恩链段数(约为30个),表现出相似且符合Rouse模型预测的线性黏弹行为。在单轴拉伸实验中,样品在快速拉伸过程,即韦森堡数大于1的过程中拉伸黏度呈现出随拉伸速率增加先“增稠”后“变稀”的行为,在样品具有相似的最大拉伸比λ_(max)=√n_(K)(≈6)前提下,二者转变的特征韦森堡数随着叔丁基苯乙烯含量的增加而增加。该结果表明,链沿拉伸方向的共同取向导致的链段摩擦系数减少效应随着侧基数量的增加而弱化,侧基具有一定的“溶剂化”作用。

关键词：聚苯乙烯聚对叔丁基苯乙烯非线性拉伸流变学

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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马来酸噻吗洛尔中有关物质的识别和测定

药物分析杂志 2024年第3期44卷 450-461页

作者：田珩吴纯敏严全鸿广东省药品检验所国家药品监督管理局药用辅料质量控制与评价重点实验室广州510525

目的:采用超高效液相色谱-四极杆/静电场轨道阱质谱(UPLC-Q/Orbitrap HRMS)鉴定马来酸噻吗洛尔中的有关物质。方法:采用ACE Excel3 C18-AR(150 mm×4.6 mm,3μm)色谱柱,以含0.01 mol·L^(-1)乙酸铵的0.2%甲酸水-甲醇为流动相梯度洗脱,流... 详细信息

目的:采用超高效液相色谱-四极杆/静电场轨道阱质谱(UPLC-Q/Orbitrap HRMS)鉴定马来酸噻吗洛尔中的有关物质。方法:采用ACE Excel3 C18-AR(150 mm×4.6 mm,3μm)色谱柱,以含0.01 mol·L^(-1)乙酸铵的0.2%甲酸水-甲醇为流动相梯度洗脱,流速0.6 mL·min^(-1),紫外检测器检测波长295 nm,质谱检测器采用HESI离子源,正负离子检测模式,碎片和裂解分析借助Mass Frontier 8.0和Compound Discover 3.3软件,通过对主成分进行破坏可以获得系统适用性溶液对样品中的杂质采用UPLC-Q/Orbitrap进行鉴定和分析。结果:主成分在特定条件下可产生出噻吗洛尔杂质B{(±)-1-(叔丁氨基)-2-[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-1-丙醇}、噻吗洛尔杂质D(4-吗啉基-1,2,5-噻二唑)、噻吗洛尔杂质E((S,Z)-4{(-)-1-(叔丁氨基)-2[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-4-氧代丁烯二酸})和噻吗洛尔杂质C{(±)-N-(叔丁氨基)-2,3-二[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-2-丙烷胺},噻吗洛尔峰和各杂质峰分离良好,采用紫外检测器测定,定量限为0.05μg·mL^(-1),检测限为0.015μg·mL^(-1)。结合UPLC-Q/Orbitrap HRMS结果和文献报道,推测了另外6个主要杂质的结构。4家企业生产的8批样品测定结果单个杂质含量在0.0004%~0.09%,总杂质含量在0.02%~0.12%。结论:通过主成分破坏可获得系统适用性溶液,并用于马来酸噻吗洛尔中杂质的检测与鉴定,结果可为马来酸噻吗洛尔的质量控制提供参考依据。

关键词：马来酸噻吗洛尔 β-受体阻断剂有关物质杂质鉴定超高效液相色谱-四极杆/静电场轨道阱质谱

考虑大规模新能源接入的电网性能评价指标体系

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电力系统保护与控制 2024年第15期52卷 178-187页

作者：李响武海潮王文雪安全郑州航空工业管理学院河南郑州450015 河南聚研电力科技有限公司河南郑州450000

为了解决传统电网评价体系在评价大规模新能源和电网相互作用复杂机理时存在的不足,建立一套考虑大规模新能源接入的电网性能指标评价体系。首先,从新型电力系统的核心特征出发,贯穿“源网荷储”各个环节,构建包含接入水平、协调水平、... 详细信息

为了解决传统电网评价体系在评价大规模新能源和电网相互作用复杂机理时存在的不足,建立一套考虑大规模新能源接入的电网性能指标评价体系。首先,从新型电力系统的核心特征出发,贯穿“源网荷储”各个环节,构建包含接入水平、协调水平、适应水平以及承载水平4个维度的电网性能评价指标,显性表达各个指标的统计或计算方式。其次,采用AHP-CRITIC法进行主客观组合赋权,依据电网发展数据自身的客观属性,考虑数据离散程度以及皮尔逊相关系数,挖掘指标间的冲突性和变异性,以增强权重设置的科学性。最后,利用某城市新能源和电网数据对指标体系进行测算,通过对比分析说明所提指标体系与评价方法的有效性,并依据指标灵敏度大小对电网薄弱环节提出发展建议。

关键词：新能源新型电力系统指标体系皮尔逊相关系数权重