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Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yun ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei liu de-zhong liu Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG deng-liang KANG de-zhi department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 120 patients were enrolled and randomly assigned between March 30, 2018 and April 15, 2020. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), P0.05). Furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

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Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 842-859页

作者： Bo-Tao Duan Xue-Kai Zhao Yang-Yang Cui de-Zheng liu Lin Wang Lei Zhou Xing-Yuan Zhang department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina department of Ophthalmology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

关键词： Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis

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籼型三系杂交水稻新组合九优粤禾丝苗高产稳产制种技术

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杂交水稻 2024年第2期39卷 86-88页

作者：刘德安徽荃银超大种业有限公司安徽合肥230088

九优粤禾丝苗是安徽荃银超大种业有限公司利用恢复系粤禾丝苗与不育系荃9311A配组育成的三系杂交水稻新组合,2019年通过国家农作物品种审定委员会审定。结合该组合在江西南城的高产制种实践,阐述其亲本特征特性,总结其高产稳产制种技术。

关键词：杂交水稻九优粤禾丝苗制种技术

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融合深度特征与多核学习的LSTWSVM及其工业应用

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控制与决策 2024年第8期39卷 2622-2630页

作者：刘颖刘德彦吕政赵珺王伟大连理工大学控制科学与工程学院辽宁大连116024

为了提高多核学习(MKL)的表示能力同时降低其计算成本,提出一种融合深度特征与多核学习的最小二乘孪生支持向量机(LSTWSVM)算法.针对支持向量机等核分类器在多核学习中高计算复杂度的问题,提出一种基于边缘错误最小化原则的多核LSTWSVM... 详细信息

为了提高多核学习(MKL)的表示能力同时降低其计算成本,提出一种融合深度特征与多核学习的最小二乘孪生支持向量机(LSTWSVM)算法.针对支持向量机等核分类器在多核学习中高计算复杂度的问题,提出一种基于边缘错误最小化原则的多核LSTWSVM框架,利用分类器优势提高多核学习的性能.针对高斯多核浅层结构的问题,采用MKL法设计一种基于深度神经网络多层信息的高鲁棒性深度映射核,将此深度核与多尺度高斯基核以核矩阵哈达玛积方式相融合,构造一组新的具有高度表达能力的改进核.最后,将基于LSTWSVM的多核训练算法与改进的多核结构进行高度集成,通过大量基准数据集与工业数据实验表明,其能有效结合深度学习与多核学习的优势,且以较低的计算成本提高分类精度与泛化能力.

关键词：多核学习深度学习最小二乘孪生支持向量机复杂工业数据建模

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分散固相萃取/荧光检测法选择性富集和定量人体血浆中的α-细辛醚

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分析测试学报 2024年第3期43卷 432-439页

作者：唐芃刘铁刘德龙河北师范大学化学与材料科学学院河北石家庄050024 西北师范大学化学化工学院甘肃兰州730070

该研究采用基于共价有机框架TpBD-Me_(2)(COF-TpBD-Me_(2))的分散固相萃取/荧光检测法对人体血浆中的α-细辛醚进行选择性富集和定量检测。优化了COF-TpBD-Me_(2)对α-细辛醚的最佳吸附条件,包括吸附剂质量浓度、吸附时间、pH值、解吸... 详细信息

该研究采用基于共价有机框架TpBD-Me_(2)(COF-TpBD-Me_(2))的分散固相萃取/荧光检测法对人体血浆中的α-细辛醚进行选择性富集和定量检测。优化了COF-TpBD-Me_(2)对α-细辛醚的最佳吸附条件,包括吸附剂质量浓度、吸附时间、pH值、解吸试剂和解吸时间。此外,还通过吸附等温线和吸附动力学实验阐明了吸附行为和机理。α-细辛醚在0.1~10µg/mL范围内呈良好的线性关系,相关系数(r^(2))大于0.999,检出限(LOD)为0.0025µg/mL。该方法对人体血浆中α-细辛醚的加标回收率为92.2%~98.0%,相对标准偏差为1.9%~3.8%。实验结果证明所建方法可选择性富集人体血浆中的α-细辛醚并实现准确定量。该方法为选择性富集和快速定量复杂生物基质中的药物活性成分提供了参考。

关键词：共价有机框架分散固相萃取吸附 α-细辛醚荧光检测

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Bidirectional relationship between diabetes mellitus and depression:Mechanisms and epidemiology

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World Journal of Psychiatry 2024年第10期14卷 1429-1436页

作者： Yun liu Shi-Yan Huang de-Le liu Xin-Xing Zeng Xiao-Rui Pan Jie Peng department of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNumber 43Shangfang RoadNanchang 330029China The Second Clinical Medical College Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina department of Psychosomatic Medicine Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina

Diabetes mellitus and depression exhibit a complex bidirectional relationship that profoundly impacts patient health and quality of *** review explores the physiological mechanisms,including inflammation,oxidative stress,and neu-roendocrine dysregulation,that link these *** factors such as social support and lifestyle choices also contribute *** insights reveal a higher prevalence of depression among diabetics and an in-creased risk of diabetes in depressed individuals,influenced by demographic *** management strategies combining mental health asse-ssments and personalized treatments are *** research should focus on longitudinal and multi-omics studies to deepen understanding and improve therapeutic outcomes.

关键词： Diabetes depression Mechanisms Epidemiology Bidirectional relationship

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《春秋》决狱与复仇讨贼——明季“红丸案”引发的经学论争

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东南大学学报（哲学社会科学版） 2024年第5期26卷 139-147,150页

作者：刘德州江苏师范大学历史文化与旅游学院江苏徐州221116

明季政事日坏,光宗继位后颇有革新气象,但服用“红丸”后暴崩。此事对士大夫群体的刺激很大,言官、礼臣纷纷上疏,请求从严查处,光宗时之首辅方从哲亦多受牵连,甚至被认为是主使进药之罪魁。尤其是孙慎行、魏大中等,援引《春秋》经义,追... 详细信息

明季政事日坏,光宗继位后颇有革新气象,但服用“红丸”后暴崩。此事对士大夫群体的刺激很大,言官、礼臣纷纷上疏,请求从严查处,光宗时之首辅方从哲亦多受牵连,甚至被认为是主使进药之罪魁。尤其是孙慎行、魏大中等,援引《春秋》经义,追究方从哲弑君之罪。反对者则认为光宗“令德考终”,并非崔、李之药所害,其间亦有引经义为佐证者。由于熹宗不问政事,朝局为党争所裹挟,围绕“红丸案”的争论亦被牵涉其中。尤其是东林与阉党之争,无疑助推了针对此案的争论之风。至于在此过程中所涉及的经义纠葛,既是有关“红丸案”争论的内容,也是引发讨论热潮的原因之一。

关键词：红丸案《春秋》决狱经学论争明季党争

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基于欧洲规范的非饱和土沉降计算研究

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公路 2024年第2期69卷 112-115页

作者：刘德功刘锋中交第一公路勘察设计研究院有限公司西安市710068

近年来,越来越多的中国工程企业在海外从事“一带一路”建设工作,在公路建设过程中经常遇到非饱和土的沉降计算问题。中国规范和指南对非饱和土的沉降计算少有涉及,中国工程师面临非饱和土沉降计算时往往由于缺乏必要的理论支撑而无从... 详细信息

近年来,越来越多的中国工程企业在海外从事“一带一路”建设工作,在公路建设过程中经常遇到非饱和土的沉降计算问题。中国规范和指南对非饱和土的沉降计算少有涉及,中国工程师面临非饱和土沉降计算时往往由于缺乏必要的理论支撑而无从下手。结合基于欧洲规范进行设计的相关公路的建设经验,研究了非饱和土沉降计算的若干问题,研究了基于欧洲规范的非饱和土的沉降计算公式,其结论可供同类地区公路建设参考。

关键词：路基工程欧洲规范非饱和土沉降计算

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Switchable K-O bonds unveiling anomalous ferroelastic transitions in a polar hybrid crystal

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Science China Materials 2024年第10期67卷 3408-3414页

作者： Yao-Bin Li Wei-Jian Xu Xiao-Xian Chen de-Xuan liu Zhi-Shuo Wang Wei-Xiong Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistryIGCMESun Yat-sen UniversityGuangzhou 510275China department of Chemistry&CICECO-Aveiro Institute of Materials University of AveiroAveiro 3810-193Portugal

Hybrid ferroelastic crystals have garnered considerable interest due to their promising potential as mechanical switches and *** anomalous ferroelastic phase transitions,in which ferroelasticity occurs in the hightemperature phase rather than the low-temperature phase,are of particular interest,but they are sporadically-documented and none of them is involved in breaking of the chemical ***,a hydroxyl-containing cation,i.e.,Me_(3)NOH^(+),is employed to construct a three-dimensional hybrid crystal(Me_(3)NOH)_(2)KBiCl_(6)(1).This crystal undergoes distinct twostep structural phase transitions with space-group changes of Pna21–P112_(1)–P63mc,belonging to an anomalous temperaturereversed mm2F2 ferroelastic transition and a normal 6mmF2 ferroelastic transition,*** anomalous ferroelastic transition is entirely driven by switchable K–O coordination bonds involving breaking and ***,the dynamic behavior of Me_(3)NOH^(+)cations along with the distortion of inorganic framework enables the manifestation of unusual“high-low-medium”second-harmonic generation-switching *** study presents the enormous benefits of switchable coordination bonds for inducing anomalous ferroelastic phase transitions,offering valuable insight for the exploration of new multifunctional ferroelastic materials.

关键词： bond-switching transition ferroelastic phase transition hybrid crystal

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数字人才与中小企业开放式创新绩效:一个中介调节效应模型

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经济问题 2024年第4期 114-121页

作者：张守凤刘德胜刘昊蓉泰山学院山东泰安271000 齐鲁工业大学(山东省科学院)经济与管理学部山东济南250353 济南大学管理科学与工程学院山东济南250024

随着数字经济的深入发展,人才在数字化转型过程中的作用得到了学术界和企业界的大量关注。在数字化转型背景下,数字人才如何影响开放式创新缺乏深入探讨。立足数字化赋能的视角,基于“数字人才—知识搜索—开放式创新”的基本逻辑,构建... 详细信息

随着数字经济的深入发展,人才在数字化转型过程中的作用得到了学术界和企业界的大量关注。在数字化转型背景下,数字人才如何影响开放式创新缺乏深入探讨。立足数字化赋能的视角,基于“数字人才—知识搜索—开放式创新”的基本逻辑,构建了一个有中介的调节效应模型。在此基础上,利用1930家中小企业的调研数据,对提出的理论模型进行实证检验。研究发现:数字人才有助于改善中小企业开放式创新绩效;数字人才通过知识搜索广度和知识搜索深度正向影响中小企业开放式创新绩效,知识搜索广度和知识搜索深度对中小企业开放式创新绩效也有正向影响。同时,IT能力正向调节了数字人才通过知识搜索广度和知识搜索深度对中小企业开放式创新绩效关系。研究结论对中小企业如何提升开放式创新绩效以及如何应对数字化转型都具有重要指导意义。

关键词：数字人才知识搜索广度知识搜索深度开放式创新中小企业

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