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Endoplasmic reticulum-mitochondrial crosstalk:a novel role for the mitochondrial peptide humanin

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Neural regeneration research 2017年第1期12卷 35-38页

作者： Parameswaran G.Sreekumar david.r.hinton ram Kannan Arnold and Mabel Beckman Macular research Center Doheny Eye InstituteLos AngelesCAUSA Department of Pathology and Ophthalmology USC Roski InstituteKeck School of Medicine of the University of Southern CaliforniaLos AngelesCAUSA

In this review,the interactive mechanisms of mitochondria with the endoplasmic reticulum（Er） are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin（HN） in Er *** Er and mitochondria are dynamic organelles capable of modifying their structure and function in response to changing environmental *** Er and mitochondria join together at multiple sites and form mitochondria-Er associated membranes that participate in signal transduction pathways that are under active *** laboratory previously showed that HN protects cells from oxidative stress induced cell death and more recently,described the beneficial role of HN on Er stress-induced apoptosis in retinal pigment epithelium cells and the involvement of Er-mitochondrial cross-talk in cellular *** protection was achieved,in part,by the restoration of mitochondrial glutathione that was depleted by Er ***,HN may be a promising candidate for therapy for diseases that involve both oxidative and Er *** novel approaches for retinal delivery of HN,its analogues as well as small molecular weight Er stress inhibitors would prove to be a valuable approach in the treatment of age-related macular degeneration.

关键词： endoplasmic reticulum mitochondria mitochondrial-derived peptide antioxidants retinal pigment epithelium age-related macular degeneration

Transgenic technologies for the study of epididymal function

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Asian Journal of Andrology 2000年第1期2卷 33-38页

作者： r.JohnLye BarryT.hinton Department of Cell Biology University of Virginia Health System School of Medicine Charlotesville VA 22908 USADepartment of Cell Biology University of Virginia Health System School of Medicine Charlotesville VA 22908 USA

Sperm mature and acquire the capacity for fertilization during their transit through the epididymis, however little isknown of the molecular events that comprise sperm maturation. recent advances in transgenic mouse technology holdpromise for illumination of this process. Most of the existing infertile, transgenic mouse lines seem to have defects inepithelial structure or sperm transport rather than direct defects in the maturation of sperm. Temporally and spatially re-stricted targeted disruptions of epididymal specific genes should provide great insight into the epididymal contribution tosperm maturation. (Asian J Androl 2000; 2: 33 - 38 )

关键词： epididymis sperm maturation transgenic organisms fertility

Thrombospondin-1 Expression in rPE and Choroidal Neovascular Membranes

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眼科学报 2006年第4期22卷 265-274页

作者： Shikun He Francesca Incardona Manlin Ji Stephen J. ryan david r. hinton Departments of Patholog Keck School of Medicine of the University of Southern Cdifornia Ophthalmology Keck School of Medicine of the University of Southern Cdifornia Doheny Eye Institute Los A ngeles CA

Purpose: To investigate the expression of thrombospondin 1 (TSP-1) in retinal pigment epithelium (rPE) and choroidal neovascular membranes (CNVMs) from patients with age-related macular degeneration (AMD). Methods: Tissue sections from normal human fetal and adult eyes and surgically removed CNVMs were immunostained for TSP-1 localization. Polymerase chain reaction and Western blotting were used to analyze TSP-1 mrNA and protein from human rPE cells, respectively. TSP-1 in the supernatant of cultured rPE cells and eye explants were measured using enzyme-linked immunosorbent assay. MTT assay was used to evaluate the rPE survival after TSP-1 treatment. results: The strongest immunostaining for TSP-1 was observed in the rPE monolayer around drusen in early AMD. The intensity of TSP-1 staining in normal eye sections was much weaker than that of early AMD and CNVM. TSP-1 mrNA was positive in cultured fetal and adult rPE cells. There was increasing secretion of TSP-1 into the supernatant of cultured rPE and eye explants. The specific band of TSP-1 was identified by Western blot. No significant inhibition of rPE survival was found with the exposure to TSP-1. Conclusions: TSP-1 expression in drusen and CNVM was upregulated and associated with rPE monolayer. TSP-1 may be a natural negative regulator for choroidal neovascularization.

关键词： thrombospondin 1 retinal pigment epithelium choroidal neovascular membrane

杰弗里·辛顿接受尤利西斯奖章时发表的获奖感言

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当代语言学 2024年第4期26卷 489-495页

作者：陈国华(译) 杰弗里·埃佛勒斯·辛顿北京外国语大学外国语言研究所英国皇家学会

非常感谢学院赞誉有加的颁奖辞.我想特别指出一点,那就是,我的成功在很大程度上归功于能够招到真正优秀的研究生。因此我们永远不要忘记,在这一领域,工作是研究生做的。只要有机会给他人讲课,我就无法拒绝。很多人实际上并不知道人工智... 详细信息

非常感谢学院赞誉有加的颁奖辞.我想特别指出一点,那就是,我的成功在很大程度上归功于能够招到真正优秀的研究生。因此我们永远不要忘记,在这一领域,工作是研究生做的。只要有机会给他人讲课,我就无法拒绝。很多人实际上并不知道人工智能是怎么回事。因此,我将用大约20分钟做一个非常基础的、关于人工智能如何工作的演讲,让那些不喜欢方程式、不知道这些大型聊天机器人究竟在做什么或如何做事的人们,知道是怎么回事,还请计算机科学专业的学生和已经知道人工智能是怎么回事的各位海涵。

关键词：计算机科学专业人工智能聊天机器人尤利西斯研究生获奖感言杰弗里方程式

Improved Unlike-Particle Collision Operator for delta-f Drift-Kinetic Particle Simulations

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Communications in Computational Physics 2011年第2期9卷 231-239页

作者： r.A.Kolesnikov W.X.Wang F.L.hinton Los Alamos National Laboratory Los AlamosNM 87544USA Plasma Physics Laboratory P.O.Box 451PrincetonNJ 08543USA Center for Astrophysics&Space Science University of CaliforniaSan DiegoLa JollaCA 92093USA

Plasmas in modern tokamak experiments contain a significant fraction of impurity ion species in addition to main deuterium background.A new unlike-particle collision operator forδf particle simulation has been developed to study the nonlocal effects of impurities due to finite ion orbits on neoclassical transport in toroidal plasmas.A new algorithm for simulation of cross-collisions between different ion species includes test-particle and conserving field-particle *** improved field-particle operator is designed to exactly enforce conservation of number,momentum and energy.

关键词： Drift-kinetics magnetized plasmas

rOS-mediated regulation of CXCr4 in cancer

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Frontiers in Biology 2013年第3期8卷 273-278页

作者： CimonaV.hinton Center for Cancer research and Therapeutic Development Clark Atlanta University Atlanta GA 30314 USA

Oxidative stress and the accumulation of reactive oxygen specie （rOS） play a role in cancer cells developing an advanced, phenotypic signature that associates with metastasis and progression. Increased rOS concentrations are involved in promoting cancer development and metastasis by inducing expression of oncogenes, suppressing activity of anti-survival molecules and by activating various cell survival and proliferation signaling pathways. Oxidative stress is higher in the epithelium of cancer patients than patients without the disease, and antioxidant trials are currently being explored as a therapeutic option. However, studies have shown that rOS increases expression of CXCr4 in cancer and immune cells. CXCr4 expression in tumors strongly correlates to metastasis and poor prognosis. Herein, we discuss an emerging relationship between rOS and CXCr4 in cancer cells.

关键词： reactive oxygen species CXCr4 HIFla metastasis PI3K/AKT ErK1/2

Down in the Dump:The Abject in Alice Notley’s Culture of One

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Journal of Foreign Languages and Cultures 2019年第1期3卷 127-137页

作者： Laura hinton The City College of New York

Alice Notley’s Culture of On e(2011)is a“poet’s novel”about a woman who lives in the dump of a *** desert *** female character who“inhabits”the dump-and this poet’s novel-is both metonym for and guide into the lost representation of“the abject,”a concept developed by Julia Kristeva as a psychic state of horror and response to that which lies outside culturally“normalized”subjects and objects,and our“desire for meaning.”Utilizing her dump refuse for its materials,the main character,Marie,creates her own“culture of one,”standing as figure for the artist/writer plunging not“meaning”but meaninglessness and its abject association with death,which is prefigured as the unclean,the improper,rejected body parts,deviant“non-existent”personae-and,ultimately,Marie’s figural status as marginal inhabitant/“culture remaker”/older woman/multi-media“poet”*** traditional conventions of novelistic character development,plot,and visual description,Notley’s“poet’s novel”formally engages in what Viktor Shkolvsky,in his well-known essay“Art as Technique,”terms“defamiliarization”or“strangeness”(“ostranenie,”in russian),including those principles he cites of“deceleration”and“deviation of the norm.”Notley’s work twists the binary logic implied in Shkolvsky’s“deviation”versus“norm”further by revealing abjection’s“strangeness”in the poet’s novel itself as form,”a text that is always becoming its own site of the linguistic abject,never codifying identity,or the interpreted known.

关键词： Alice Notley the poet’s novel prose poem the abject Kristevan theory.

Dysregulated rPE growth factor expression in retinal disease

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Dysregulated RPE growth factor expression in retinal disease

白介素2α受体在人视网膜色素上皮细胞中的表达(英文)

中华医学会第十二届全国眼科学术大会

作者： david.r.hinton Doheny Eye Institute USA

retinal diseases such as age related macular degeneration,proliferative diabetic retinopathy and prolifer- ative vitreoretinopathy are associated with dysregulated growth factor *** retinal pigmented epi- thelium (rPE...

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来源： cnki会议评论

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眼科研究 2006年第5期24卷 452-456页

作者：何世坤 david.r.hinton 美国洛杉矶南加州大学Keck医学院

目的研究白介素2α受体（IL-2rα）在人视网膜色素上皮（rPE）细胞中的表达及白介素2（IL-2）对rPE细胞增生的影响。方法收集培养的2～4代的人胚胎rPE细胞，应用rT-PCr技术，用IL-2α受体特异引物对IL-2α受体进行检测，应用荧光激活... 详细信息

目的研究白介素2α受体（IL-2rα）在人视网膜色素上皮（rPE）细胞中的表达及白介素2（IL-2）对rPE细胞增生的影响。方法收集培养的2～4代的人胚胎rPE细胞，应用rT-PCr技术，用IL-2α受体特异引物对IL-2α受体进行检测，应用荧光激活细胞分类技术检测IL-2的结合。用抗CD25抗体的免疫荧光染色法识别IL-2α受体的表达，通过^3H摄取技术评估重组IL-2对rPE细胞增生的影响。结果 rPE细胞可表达IL-2rα mrNA，免疫荧光染色和IL-2结合试验也可表明IL-2α受体的表达，高浓度的IL-2可诱导rPE细胞的增生（P〈0．05）。结论培养的rPE细胞能够表达IL-2α受体，重组IL-2可促进rPE细胞的增生。

关键词：视网膜色素上皮细胞细胞因子 IL-2受体