检索结果-南通市图书馆

Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第2期19卷 260-275页

作者： Elena Hernández-García Francisco J.Cueto Emma C.L.Cook Ana Redondo-Urzainqui Sara Charro-Zanca Iñaki Robles-Vera Ruth Conde-Garrosa Ivana Nikolić Guadalupe Sabio david sancho Salvador Iborra Department of Immunology Ophthalmology and ENTSchool of MedicineUniversidad Complutense de MadridMadrid 28040Spain Centro Nacional de Investigaciones Cardiovasculares(CNIC) Madrid 28029Spain

Conventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic *** cDCs are critical in maintaining immune balance,their role in preserving energy homeostasis is ***,we showed that Batf3-deficient mice lacking conventional type 1 DCs(cDC1s)had increased body weight and adiposity during *** led to impaired energy expenditure and glucose tolerance,insulin resistance,dyslipidemia,and liver ***1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+invariant NKT(iNKT)***,among antigen-presenting cells,cDC1s exhibited notable induction of IFN-γproduction by iNKT cells,which plays a metabolically protective role in lean adipose ***3L treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent *** effect was partially mediated by NK1.1+*** results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis.

关键词： Dendritic Cells NKT Obesity ageing FLT3L

Metabolic profiling of four synthetic stimulants,including the novel indanyl-cathinone 5-PPDi,after human hepatocyte incubation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2020年第2期10卷 147-156页

作者： david Fabregat-Safont Marie Mardal Juan V.sancho Félix Hernández Kristian Linnet María Ibánez Research Institute for Pesticides and Water University Jaume IAvda.Sos Baynat s/n12071CastellónSpain Department of Forensic Medicine Section of Forensic ChemistryFaculty of Health and Medicinal SciencesUniversity of CopenhagenFrederik V's vej 112100KФbenhavnФDenmark Department of Occupational and Environmental Medicine University Hospital of Northern NorwaySykehusvegenTromsoeNorway

Synthetic cathinones are new psychoactive substances that represent a health risk *** most of the 130 reported compounds,information about toxicology and/or metabolism is not available,which hampers their detection(and subsequent medical treatment)in intoxication *** principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stab-lishing the most appropriate biomarkers for these *** metabolic fate of synthetic cathinones can be assessed by the analysis of urine and blood obtained from authentic consumers;however,this type of samples is limited and difficult to *** this work,the metabolic behaviour of three synthetic cathinones(4-CEC,4-CPrC and 5-PPDi)and one amphetamine(3-FEA)has been evalu-ated by incubation with pooled human hepatocytes and metabolite identification has been performed by high-resolution mass *** in vitro approach has previously shown its feasibility for obtaining excretory human metabolites.4-CEC and 3-FEA were not metabolised,and for 4-CPrC only two minor metabolites were *** the contrary,for the recently reported 5-PPDi,twelve phase I metabolites were *** to our knowledge,this is the first metabolic study of an *** reported in this paper will allow the detection of these synthetic stimulants in intoxi-cation cases,and will facilitate future research on the metabolic behaviour of other indanyl-based cathinones.

关键词： Synthetic cathinones 5-PPDi Metabolite identification In vitro metabolism Hepatocyte incubation High resolution mass spectrometry

Integrated Multi-Head Self-Attention Transformer model for electricity demand prediction incorporating local climate variables

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy and AI 2023年第4期14卷 620-644页

作者： Sujan Ghimire Thong Nguyen-Huy Mohanad S.AL-Musaylh Ravinesh C.Deo david Casillas-Perez sancho Salcedo-Sanz School of Mathematics Physics and ComputingUniversity of Southern QueenslandSpringfieldQLD4300Australia Centre for Applied Climate Sciences University of Southern QueenslandToowoomba4350QLDAustralia Department of Information Technologies Management Technical CollegeSouthern Technical UniversityBasrah 61001Iraq Department of Signal Processing and Communications Universidad Rey Juan CarlosFuenlabrada28942MadridSpain Department of Signal Processing and Communications Universidad de AlcaláAlcaláde Henares28805MadridSpain

This paper develops a trustworthy deep learning model that considers electricity demand(G)and local climate *** model utilises Multi-Head Self-Attention Transformer(TNET)to capture critical information from𝐻,to attain reliable predictions with local climate(rainfall,radiation,humidity,evaporation,and maximum and minimum temperatures)data from Energex substations in Queensland,*** TNET model is then evaluated with deep learning models(Long-Short Term Memory LSTM,Bidirectional LSTM BILSTM,Gated Recurrent Unit GRU,Convolutional Neural Networks CNN,and Deep Neural Network DNN)based on robust model assessment *** Kernel Density Estimation method is used to generate the prediction interval(PI)of electricity demand forecasts and derive probability metrics and results to show the developed TNET model is accurate for all the *** study concludes that the proposed TNET model is a reliable electricity demand predictive tool that has high accuracy and low predictive errors and could be employed as a stratagem by demand modellers and energy policy-makers who wish to incorporate climatic factors into electricity demand patterns and develop national energy market insights and analysis systems.

关键词： Electricity demand forecasting Sustainable energy Artificial Intelligence Deep learning Transformer Networks Kernel Density Estimation

An Approach to Outpatient Screening, Treatment, and Community Health Outreach during the Coronavirus Epidemic in New York City

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2020年第3期10卷 1-5页

作者： Janet Kim david H. Kim Ines sancho-Torres John Nwangwu Nwanyieze N. Jiakponnah Beacon Christian Community Health Center New York USA World Health Organization Geneva Switzerland Department of Public Health Southern Connecticut State University New Haven USA

The emergence of the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) pneumonia, also referred to as COVID-19 in New York City in March 2020, has put an overwhelming strain on the healthcare system in the city. Many local hospitals have reported a surge of cases, with most cases presenting with severe respiratory complications. We aim to present a comprehensive surge filter protocol for outpatient programs to mitigate the surge of cases admitted in the emergency rooms and intensive care units (ICUs) of local hospitals in our community. Our surge filter protocol was developed based on a detailed review of how South Korea and Spain mounted their outpatient surge responses. Our preliminary findings revealed that our Four-Ts approach (i.e., Test, Treat, Track, and Teach) has resulted in none of our patients reaching a clinical requirement for inpatient care.

关键词： Coronavirus Epidemic Filter Protocol Surge Quarantine

Assessing radiation dose for postoperative radiotherapy in prostate cancer: Real world data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2022年第7期13卷 652-662页

作者： Asunción Hervás-Morón Jose Domínguez-Rullán Victor Duque Santana Mireia Valero Carmen Vallejo Sonsoles sancho Juan david García Fuentes Miguel Cámara Gallego Fernando López-Campos Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Medical Physics Hospital Universitario Ramón Y CajalMadrid 28034Spain

BACKGROUND Approximately 30%of patients with localized prostate cancer(PCa)who undergo radical prostatectomy will develop biochemical *** these patients,the only potentially curative treatment is postoperative radiotherapy(PORT)with or without hormone ***,the optimal radiotherapy dose is unknown due to the limited data *** To determine whether the postoperative radiotherapy dose influences biochemical failure-free survival(BFFS)in patients with *** Retrospective analysis of patients who underwent radical prostatectomy for PCa followed by PORT-either adjuvant radiotherapy(ART)or salvage radiotherapy(SRT)-between April 2002 and July *** 2002 to 2010,the prescribed radiation dose to the surgical bed was 66-70 Gy in fractions of 2 Gy;from 2010 until July 2015,the prescribed dose was 70-72 *** were grouped into three categories according to the total dose administered:66-68 Gy,70 Gy,and 72 *** primary endpoint was BFFS,defined as the post-radiotherapy prostatespecific antigen(PSA)nadir+0.2 ng/*** endpoints were overall survival(OS),cancer-specific survival(CSS),and metastasis-free survival(MFS;based on conventional imaging tests).Treatment-related genitourinary(GU)and gastrointestinal(GI)toxicity was evaluated according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer ***,we aimed to identify potential prognostic ***,OS,CSS,and MFS were calculated with the Kaplan-Meier method and the log-rank *** and multivariate Cox regression models were performed to explore between-group differences in survival outcome *** A total of 301 consecutive patients were *** these,93(33.6%)received ART and 186(66.4%)SRT;22 patients were excluded due to residual macroscopic disease or local recurrence in the surgical *** this subgroup(n=93),43 patients(46.2%)were Gleason score(GS)≤6,44(47.3%)GS 7,and 6(6.5%)GS≥8;clinical stage

关键词： Prostate cancer Postoperative radiotherapy Dose intensified Radiation dose Biochemical relapse free survival

An Approach to Outpatient Screening, Treatment, and Community Health Outreach during the Coronavirus Epidemic in New York City

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论