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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas david reyes-corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla david reyes-corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Effective use of FibroTest to generate decision trees in hepatitis C

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World Journal of Gastroenterology 2009年第21期15卷 2617-2622页

作者： Dana Lau-corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz david Kershenobich Department of Experimental Medicine School of MedicineUniversidad Nacional Autonoma de MexicoGeneral Hospital of Mexico Department of Computer Sciences Institute for Applied Mathematics and SystemsUniversidad Nacional Autonoma de Mexico Department of Gastroenterology Lomas Altas Clinic

AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis ***:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver *** FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the *** testing,a 10-fold cross validation was ***:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on *** algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 *** rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were ***:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression.

关键词：丙型肝炎决策树分类算法慢性肝炎结合珠蛋白载脂蛋白交叉验证纤维化

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A Reward Functional to Solve the Replacement Problem

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Intelligent Control and Automation 2012年第4期3卷 413-418页

作者： Eva Selene Hernández Gress Oscar Montano Arango Jose Ramon corona Armenta Antonio Oswaldo Ortega reyes Academic Area of Engineering Autonomous University of HidalgoPachucaMéxico

The replacement problem can be modeled as a finite, irreducible, homogeneous Markov Chain. In our proposal the problem was modeled using a Markov decision process and then, the instance was optimized using dynamic programming. We proposed a new functional that includes a reward functional, that can be more helpful in processing industries because it considerate instances like incomes, maintenance costs, fixed costs to replace equipment, purchase price and salvage values;and this functional can be solved with dynamic programming and used to make effective decisions. Two theorems are proved related with this new functional. A numerical example is presented in order to demonstrate the utility of this proposal.

关键词： Markov Chains Dynamic Programming Replacement Problem

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无法手术切除的肝细胞癌在动脉介入治疗后的MR成像第一部分:疗效判定的函数量化标准的探寻和验证

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国际医学放射学杂志 2013年第5期 480-481页

作者： S.Bonekamp Z.Li J.F.H.Geschwind V.G.Halappa C.P.corona-Villalobos D.reyes 杨君 Russell H.Morgan Department of Radiology and Radiological Science The Johns Hopkins Hospital

摘要目的探寻和验证容积功能磁共振成像的疗效量化标准的最佳阈值,预测无法手术切除的肝细胞癌(HCC)病人经动脉介入治疗(IAT)后的总体生存情况。方法该研究经伦理委员会批准,免除病人的知情同意。共纳入HCC143例,均在IAT前及第Ⅰ期IAT后... 详细信息

摘要目的探寻和验证容积功能磁共振成像的疗效量化标准的最佳阈值,预测无法手术切除的肝细胞癌(HCC)病人经动脉介入治疗(IAT)后的总体生存情况。方法该研究经伦理委员会批准,免除病人的知情同意。共纳入HCC143例,均在IAT前及第Ⅰ期IAT后3～4周内行MRI检查。初次治疗后,运用专业软件分析肝细胞癌的特征性MR征象。病人随机分为实验组[n=114(79.7%)]和对照组[n=29(20.3%)]。运用单因素和多因素Cox模型确定不同组之间容积功能改变的最佳界值,以及生存率的差异。结果实验组中判断疗效改

关键词：肝细胞癌病人手术切除动脉介入 MR

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Thermal Comparison of an Organic Rankine Cycle Activated by a Low-Temperature Geothermal Heat Source

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Journal of Mechanics Engineering and Automation 2018年第7期8卷 309-315页

作者： Vera-Romero Iván corona-Ruíz Silvia L. Martínez reyes J. Moreno Nava I. Ordaz Murillo O. Méndez á brego Víctor M Department of Energy Engineering University of the Ciénega of Michoacán State Sahuayo 59103 Mexico Department of Multicultural Studies University of the Ciénega of Michoacán State Sahuayo 59103 Mexico

This study compares the results from the thermodynamic analysis at an Organic Rankine Cycle power plant,for first and second law efficiency,operating with 14 different working *** plant—located in the town of Los Negritos,in the municipality of Villamar,in the State of Michoacán,Mexico—uses heat from a low-temperature geothermal source with the purpose of identifying the working fluids that are best suited for the operating conditions at *** v.8.0 software was used to collect the thermodynamic *** all the thermodynamic parameters that were analyzed,the fluid that performed the best had an overall energy efficiency of 5.87%,an overall exergy efficiency of 43.07%,and a net output power of 13.04 kWe.

关键词： Organic Rankine cycle geothermal energy Los Negritos thermodynamic analysis exergy

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肝内胆管上皮癌的局部治疗:定量容积ADC图对肿瘤疗效的评估

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国际医学放射学杂志 2012年第5期 481-481页

作者： V.G.Halappa S.Bonekamp C.P.corona-Villalobos M.Mensa D.reyes 韩宗宏 Morgan Department of Radiology and Radiological Sciences Johns Hopkins University School of Medicine 600N Wolfe StRoom 143BaltimoreMD 21287

摘要目的探讨通过分析容积表观扩散系数(ADC)的变化和MR肝动脉期、门静脉期增强成像对比剂强化区域容积变化的方法评价经导管动脉化疗栓塞术(TACE)对胆管细胞癌早期疗效的可行性。材料与方法共29例不能手术切除的胆管细胞癌病人入组,包... 详细信息

摘要目的探讨通过分析容积表观扩散系数(ADC)的变化和MR肝动脉期、门静脉期增强成像对比剂强化区域容积变化的方法评价经导管动脉化疗栓塞术(TACE)对胆管细胞癌早期疗效的可行性。材料与方法共29例不能手术切除的胆管细胞癌病人入组,包括11例男性[平均年龄(60±16.8)岁]和18例女性[平均年龄(63±11.5)岁],本研究为回顾性研究,得到伦理委员会同意并符合HIPAA标准,不需要病人签署知情同意书。在研究期间共进行69次TACE手术(1～5次TACE手术)。所有病人均没有接受TACE以外的其他治疗。

关键词： TACE 容积肝动脉期胆管细胞癌门静脉期 ADC

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利用功能MRI对阿霉素洗脱支架联合索拉菲尼治疗肝细胞肝癌的肿瘤反应进行容积评估

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国际医学放射学杂志 2015年第2期 198-198页

作者： C.P.corona-Villalobos V.G.Halappa J.F.H.Geschwind S.Bonekamp D.reyes D.Cosgrove 庞国栋 The Russell H. Morgan Department of Radiology and Radiological Sciences School of Medicine Johns Hopkins University600 N. Wolfe St. MRI 143 Baltimore MD 21287 USA

摘要目的利用功能MRI体积测量前瞻性地评价阿霉素洗脱支架经动脉化学栓塞(DEB TACE)联合索拉菲尼治疗肝细胞肝癌的肿瘤反应。方法本单中心研究纳入了41例接

关键词：肝细胞肝癌索拉菲尼洗脱支架容积阿霉素 14-羟正定霉素反应 MRI 功能

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动脉内介入疗法治疗神经内分泌性肝转移瘤:早期肿瘤反应和存活的容积功能成像的生物学标记物

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国际医学放射学杂志 2013年第2期 172-172页

作者： V. G. Halappa C.P. corona-Villalobos S. Bonekamp Z. Li D. reyes D. Cosgrove 孙珊珊 Russell H. Morgan Department of Radiology and Radio-logical Sciences Johns Hopkins Hospital 600 N Wolfe St Room 143 Baltimore MD 21287

目的确定扩散加权和对比剂增强MR成像上容积改变是否有助于评估神经内分泌性肝转移瘤(NELM)对动脉内介入疗法(IAT)的早期肿瘤反应。材料与方法这一回顾性单中心影像分析符合HIPAA规定,经机构伦理委员会通过,免除病人的知情同意。回顾性... 详细信息

目的确定扩散加权和对比剂增强MR成像上容积改变是否有助于评估神经内分泌性肝转移瘤(NELM)对动脉内介入疗法(IAT)的早期肿瘤反应。材料与方法这一回顾性单中心影像分析符合HIPAA规定,经机构伦理委员会通过,免除病人的知情同意。回顾性分析71例(39例男性,平均年龄62.3岁)患NELM行IAT治疗的病人。在治疗前和治疗后3～4周行MRI检查。对入围病灶进行分段以提供针对表观扩散系数(ADC)和肝动脉期(HAP)及门静脉期(PVP)增强MR成像的容积功能分析。肿瘤反应定义为容积ADC增加≥15%,同时容积增强在HAP期降低≥25%或PVP期降低≥50%。病人总生存期按治疗开始后的初始结点算起。单变量分析包括Kaplan-Meier生存曲线。Cox比例风险回归模型用于检测容积ADC和对比增强MR成像间的交互作用并计算风险比。结果全部病人平均容积ADC显著增加(27%,P<0.0001),平均容积增强在HAP期间(-25.3%,P<0.0001)和PVP期间(-22.4%,P<0.0001)显著减少。容积ADC增加≥15%的病人(n=49)较容积ADC增加<15%者的治疗后预后(n=22)要好(对数秩检验;;P<0.002)。容积动脉期增强减少≥25%的病人(n=40)或静脉期增强减少≥50%的病人(n=18)预后较动脉期增强减少<25%(n=31)和静脉期减少<50%者(n=53)为好(对数秩检验;;P<0.02)。结论容积功能MR成像准则可作为早期反应的生物标志物;;提示这些准则可能对将来复杂的NELM临床实验很重要。

关键词：肝转移瘤 MR ADC 容积早期肿瘤介入疗法内分泌性动脉内神经反应

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