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Towards Targeted Photodynamic Therapy

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Towards Targeted Photodynamic Therapy

Is perinatal neuroendocrine programming involved in the developmental origins of metabolic disorders?

中国化学会第27届学术年会

作者： david phillips President-elect Royal Society of ChemistryDepartment of ChemistryImperial CollegeLondonExhibition Road London SW7 2AZ

＜正＞Photodynamic therapy. PDT, is a minimally invasive procedure used in treating a range of cancerous diseases, infections, and in ophthalmology to treat the wet form of

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World Journal of Diabetes 2011年第12期2卷 211-216页

作者： david IW phillips Stephen G Matthews MRC Lifecourse Epidemiology Unit South-ampton General Hospital Department of Physiology Faculty of Medicine University of Toronto Medical Sciences Building 1 King's College Circle

The discovery that small size at birth and during infancy are associated with a higher risk of diabetes and related metabolic disease in later life has pointed to the importance of developmental factors in these conditions. The birth size associations are thought to refl ect exposure to adverse environmental factors during early development but the mechanisms involved are still not fully understood. Animal and human work has pointed to the importance of changes in the setpoint of a number of key hormonal systems controlling growth and development. These include the IGF-1/GH axis, gonadal hormones and, in particular, the systems mediating the classical stress response. Several studies show that small size at birth is linked with increased activity of the hypothalamic-pituitary-adrenal axis and sympathoadrenal system in adult life. More recent human studies have shown associations between specif ic adverse experiences during pregnancy, such as famine or the consumption of adverse diets, and enhanced stress responses many decades later. The mediators of these neuroendocrine responses are biologically potent and are likely to have a direct infl uence on the risk of metabolic disease. These neuroendocrine changes may also have an evolutionary basis being part of broader process, termed phenotypic plasticity, by which adverse environmental cues experienced during development modify the structure and physiology of the adult towards a phenotype adapted for adversity. The changes are clearly advantageous if they lead to a phenotype which is well-adapted for the adult environment, but may lead to disease if there is subsequent overnutrition or other unexpected environmental conditions.

关键词： Neuroendocrine fetal programming Metabolic disease Diabetes Hypothalamic-pituitary-adrenal axis Stress responses Birth weight

The Effect of Brief Mindfulness Meditation on Cold-Pressor Induced Pain Responses in Healthy Adults

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Pain Studies and Treatment 2017年第2期5卷 11-19页

作者： david Burnett Gillian phillips Osama A. Tashani School of Clinical and Applied Sciences Leeds Beckett University Leeds United Kingdom

We hypothesised a 10 minute mindfulness based intervention performed by a novice therapist would have a beneficial effect on pain responses in naive participants. Twenty-four participants were randomly assigned to the control group or mindfulness meditation group. The control group sat quietly for 10 minutes in between two cold pressor tasks. The mindfulness meditation intervention group practiced 10 minutes of mindfulness meditation in between cold-pressor tasks following standardised mindfulness of breathing meditation technique instructions provided by a male investigator. A significant interaction effect was found between anxiety towards pain ratings (pre-intervention vs. post-intervention) and intervention (F = 6.29, p = 0.02). There was a significant decrease (t = 4.07, p = 0.002) in anxiety towards pain ratings in the mindfulness meditation group following intervention. A significant interaction effect was found between pain threshold times (pre-intervention vs. post-intervention) and intervention (F = 18.45, p 0.001) in pain threshold times in the mindfulness meditation group following intervention. A significant interaction effect was found between pain tolerance times (pre-intervention vs. post-intervention) and intervention (F = 18.34, p < 0.001). A significant increase (t = -4.20, p = 0.001) in pain tolerance times in the mindfulness meditation group following intervention was also found. The results suggest a single 10 minute mindfulness meditation intervention administered by a novice therapist can improve pain tolerance, pain threshold and decrease anxiety towards pain in na?ve healthy university aged individuals.

关键词： Mindfulness Pain Cold-Pressor Task Brief Session Pain Relief

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单极四杆GC/MS分析VOCs的最新进展

环境化学 2012年第9期31卷 1462-1463页

作者： Jessie Butler david Steiniger Eric phillips Trisa Robarge Thermo Fisher Scientific Austin Texas USA

根据美国环境保护署（EPA）方法,采用赛默飞世尔公司ISQ单四极杆气质联用仪建立了挥发性有机物（VOCs）的分析检测方法.整个方法所需的仪器包括进样器、气相色谱、质谱、数据处理软件等.为了满足法规中日益严格的检出限要求及新型污染... 详细信息

根据美国环境保护署（EPA）方法,采用赛默飞世尔公司ISQ单四极杆气质联用仪建立了挥发性有机物（VOCs）的分析检测方法.整个方法所需的仪器包括进样器、气相色谱、质谱、数据处理软件等.为了满足法规中日益严格的检出限要求及新型污染物的加入,我们对实验方案进行了改进,以提高检测灵敏度及提高样品通量.

关键词： GC/MS分析 VOCs 美国环境保护署检测灵敏度单极挥发性有机物数据处理软件气质联用仪

Uranium sequestration in sediment at an iron-rich contaminated site at Oak Ridge, Tennessee *** followed by reoxidation

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Journal of Environmental Sciences 2019年第11期31卷 156-167页

作者： Peng-Song Li Wei-Min Wu Debra H.phillips david B.Watson Shelly Kelly Bing Li Tonia Mehlhorn Kenneth Lowe Jennifer Earles Hu-Chun Tao Tong Zhang Craig S.Criddle Department of Civil and Environmental Engineering William & Cloy Codiga Resource Recovery Center Center for Sustainable Development & Global Competitiveness Stanford University Stanford CA 94305-4020 USA Key Laboratory for Heavy Metal Pollution Control and Reutilization School of Environment and Energy Peking University Shenzhen Graduate School Shenzhen 518055 China Institute of New Energy Technology Tsinghua University Beijing 100084 China School of Natural and Built Environment Queen's University Belfast Belfast BT9 5AG Northern Ireland UK Environmental Sciences Division Oak Ridge National Laboratory Oak Ridge P.O.Box 2008 TN 37831 USA EXAFS Analysis Bolingbrook IL 60440 USA Department of Civil Engineering The University of Hong Kong Hong Kong China

This study evaluated uranium sequestration performance in iron-rich (30 g/kg) sediment via bioreduction followed by *** tests (1383 days) at Oak Ridge,Tennessee demonstrated that uranium contents in sediments increased after bioreduced sediments were re-exposed to nitrate and oxygen in contaminated *** of contaminated sediments (1200 mg/kg U) with ethanol in microcosm reduced aqueous U from 0.37 to 0.023 mg/*** of the bioreduced sediment were reoxidized with O2,H2O2,and NaNO3,respectively,over 285 days,resulting in aqueous U of 0.024,1.58 and 14.4 mg/L at pH 6.30,6.63 and 7.62,*** source-and the three reoxidized sediments showed different desorption and adsorption behaviors of U,but all fit a Freundlich *** adsorption capacities increased sharply at pH 4.5 to 5.5,plateaued at pH 5.5 to 7.0,then decreased sharply as pH increased from 7.0 to *** O2-reoxidized sediment retained a lower desorption efficiency at pH over *** NO3--reoxidized sediment exhibited higher adsorption capacity at pH 5.5 to *** pH-dependent adsorption onto Fe(Ⅲ) oxides and formation of U coated particles and precipitates resulted in U sequestration,and bioreduction followed by reoxidation can enhance the U sequestration in sediment.

关键词： Sediments Uranium Sequestration Bioreduction Reoxidation

Value within otolaryngology:Assessment of the cost-utility analysis literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第1期2卷 -页

作者： Krupa R. Patel david J. phillips Jason M. Leibowitz Theresa Scognamiglio Victoria E. Banuchi William I. Kuhel david I. Kutler Marc A. Cohen Weill Cornell Medical College New York NY 10065 USA Department of 0tolaryngology-Head and Neck Surgery New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA Department of 0tolaryngology-Head and Neck Surgery University of Miami Miami FL 33136 USA Department of Pathology&Laboratory Medicine New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA

UNASSIGNED:To assess the characteristics and quality of cost utility analyses (CUA) related to otolaryngology within the CEA registry and to summarize their collective results.;UNASSIGNED:All cost-utility analyses published between 1976 and 2011 contained in the Cost-Effectiveness Analysis Registry (CEA Registry) were evaluated. Topics that fall within the care of an otolaryngologist were included in the review regardless of the presence of an otolaryngologist author. Potential associations between various study characteristics and CEA registry quality scores were evaluated using the Pearson product moment correlation coefficient.;UNASSIGNED:Sixty-one of 2913 (2.1%) total CUA publications screened were related to otolaryngology. Eighteen of 61 (29.5%) publications included an otolaryngologist as an author. Fourteen studies agreed on the cost effectiveness of at least unilateral cochlear implantation and six of seven (85.7%) studies demonstrated the cost effectiveness of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA). Forty-six percent (28 of 61) of all manuscripts were published between 2008 and 2011. A more recent publication year was associated with a higher CEA registry quality score while the presence of an otolaryngologist author and journal impact factor had no significant correlation with the quality of the CUA.;UNASSIGNED:Based on current evidence in the CEA registry, unilateral cochlear implantation for hearing loss and CPAP for OSA are both cost-effective therapeutic interventions. Although CUAs in otolaryngology have increased in quantity and improved in quality in more recent years, there is a relative lack of CUAs in otolaryngology in comparison to other subspecialties.

关键词： Cost-utility analysis

Comparison of Low Stress Mechanical Properties of Light Weight Wool and Wool Blend Fabrics using the KES-F and FAST Instruments

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Journal of China Textile University(English Edition) 2000年第4期17卷 99-102页

作者：王革辉张渭源 Postle Ron phillips david

This study compares the test results of the FAST (Fabric Assurance by Simple Testing) with those of the KES - F (Kawabata Evaluation Systems for Fabrics) for a range of nineteen light weight wool and wool blend fabrics in terms of the low - stress mechanical properties of bending, shear, and tensile deformation. It is found that there are very significant correlations between the corresponding parameters for extensibility and shear rigidity obtained from the test results of the two systems. The correlation between the values of bending rigidity obtained from the two systems is only moderate. Furthermore, for the fabrics tested in this study, the values of bending rigidity, shear rigidity, and extensibility measured using the KES - F instruments are higher than those of the corresponding parameters measured using the FAST instruments. The linear regression equation is given for each pair of corresponding parameter.

关键词： low stress mechanical properties the KES - F system the FAST system light weight wool fabrics

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印度工程机械市场综观

今日工程机械 2012年第3期 74-80页

作者： david phillips 英国工程机械咨询有限公司

中国工程机械行业的从业者目前正享受着高成长、发展迅速的市场环境,但是面临的挑战同样巨大。中国工程机械行业正在或者已经出现一定程度的产能过剩,预计到2015年中国将会有40%;0%过剩的产能无法得到利用。如何应对这一情况已经成为很... 详细信息

中国工程机械行业的从业者目前正享受着高成长、发展迅速的市场环境,但是面临的挑战同样巨大。中国工程机械行业正在或者已经出现一定程度的产能过剩,预计到2015年中国将会有40%;0%过剩的产能无法得到利用。如何应对这一情况已经成为很多中国制造商关心的问题,市场、渠道的整合是一方面,同时海外市场的拓

关键词：印度压实设备南亚挖掘装载机起重机工程机械市场履带式挖掘机销量

Negotiating a new chair package:context and considerations

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Family Medicine and Community Health 2023年第1期11卷 26-32页

作者： Amanda Weidner Samantha Elwood Richelle Koopman Julie phillips david Schmitz Li Li A Peter Catinella Jehni Robinson Nahid Rianon C J Peek Irfan Asif Family Medicine University of WashingtonSeattleWashingtonUSA Association of Departments of Family Medicine LeawoodKansasUSA Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Family and Community Medicine University of Missouri School of MedicineColumbiaMissouriUSA Family Medicine Michigan State UniversityEast LansingMichiganUSA Family and Community Medicine University of North Dakota School of Medicine and Health SciencesGrand ForksNorth DakotaUSA Family Medicine University of Virginia School of MedicineCharlottesvilleVirginiaUSA Family Medicine Texas Tech University TransmountainEl PasoTexasUSA Family&Community Medicine Texas Tech University Health Sciences Center El PasoPaul L.Foster School of MedicineEl PasoTexasUSA Family Medicine University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA Family and Community Medicine The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical SchoolHoustonTexasUSA Family Medicine and Community Health University of Minnesota Medical SchoolMinneapolisMinnesotaUSA Family and Community Medicine The University of Alabama at Birmingham Heersink School of MedicineBirminghamAlabamaUSA

Negotiating a resource package as a potential new department chair is common practice in academic *** foundations for this negotiation include the historical presence of the department in relation to the broader institution,projections for future growth,accounting for mission/vision,resource needs(space,personnel,finances,etc),faculty and staff development,and external partnerships within and outside the *** similarities in this process across departments,many nuances influence the development of a specific new chair package,such as,department size;desires,perspectives and talents of the incoming chair,the department faculty,the medical school and dean;prevailing agendas and mission imperatives;and the overall priorities of the *** strategy and forethought,a new chair package can promote a successful chair tenure and departmental *** through the Association of Departments of Family Medicine with input from several dozen department chairs and senior leaders,this is intended to serve as a practical guide to new chair packages for chair candidates.

关键词： finance prevailing outside