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International journal of Automation and computing 2011年第4期8卷 472-483页

作者： david j day Zheng-Xu Zhao School of Computing and Mathematics University of Derby Derby UK Faculty of Information Science and Technology Shijiazhuang Tiedao University Shijiazhuang PRC

Writable XOR executable （W⊕X） and address space layout randomisation （ASLR） have elevated the understanding necessary to perpetrate buffer overflow exploits [1] . However, they have not proved to be a panacea [1 3] , and so other mechanisms, such as stack guards and prelinking, have been introduced. In this paper, we show that host-based protection still does not offer a complete solution. To demonstrate the protection inadequacies, we perform an over the network brute force return-to-libc attack against a preforking concurrent server to gain remote access to a shell. The attack defeats host protection including W⊕X and ASLR. We then demonstrate that deploying a network intrusion detection systems （NIDS） with appropriate signatures can detect this attack efficiently.

关键词： Buffer overflow stack overflow intrusion detection systems (IDS) signature rules return-to-libc attack pre-forking.

Robotics in Industry-Their Role in Intelligent Manufacturing

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Engineering 2018年第4期4卷 440-445页

作者： Chia-Peng day Foxconn Technology Group Shenzhen 518110 China

1. A view of intelligent manufacturing 1.1. Intelligent manufacturing： The coupling of technology and industrialization A perspective on intelligent manufacturing can be gained by examining the development stages of modern industrial manufacturing . The use of steam engines as prime movers around 1784 marked an essential step of the First Industrial Revolution （Fig.1 ）, although an early crude form of the steam engine was invented 50 years earlier by Thomas Newcomen.

关键词：智能制造现代工业发展现状技术创新

Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?

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World journal of Gastroenterology 2015年第40期21卷 11469-11480页

作者： Gudula jAM Boon Andrew S day Chris j Mulder Richard B Gearry Departments of Paediatrics University of Otago Department of Gastroente-rology and Hepatology VU University Medical CenterUniversity of Amsterdam Departments of Medicine University of Otago

AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: "inflammatory bowel disease","Crohn′s disease","ulcerative colitis","faecal markers","calprotectin","lactoferrin","S100A12","endoscop*","mucosal healing","remission". In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric pati

关键词： Crohn’s disease Ulcerative colitis Mucosal healing

A Model System of Development Regulated by the Long-distance Transport of mRNA

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journal of Integrative Plant Biology 2010年第1期52卷 40-52页

作者： david j. Hannapel Plant Biology Major 253 Horticulture Hall Iowa State University

BELl-like transcription factors are ubiquitous in plants and interact with KNOTTEDI-types to regulate numerous developmental processes. In potato, the RNA of several BELl-like transcription factors has been identified in phloem cells. One of these, StBEL5, and its Knox protein partner regulate tuber formation by targeting genes that control growth. RNA detection methods and grafting experiments demonstrated that StBEL5 transcripts move across a graft union to localize in stolon tips, the site of tuber induction. This movement of RNA originates in source leaf veins and petioles and is induced by a short-day photoperiod, regulated by the untranslated regions, and correlated with enhanced tuber production. Addition of the StBEL5 untranslated regions to another *** mRNA resulted in its preferential transport to stolon tips leading to increased tuber production. Upon fusion of the untranslated regions of StBEL5 to a β-glucuronidase marker, translation in tobacco protoplasts was repressed by those constructs containing the 3＇ untranslated sequence. The untranslated regions of the StBEL5 mRNA are involved in mediating its long-distance transport and in controlling translation. The 3＇ untranslated sequence contains an abundance of conserved motifs that may serve as binding motifs for RNA-binding proteins. Because of their presence in the phloem sieve tube system, their unique untranslated region sequences and their diverse RNA accumulation patterns, the family of BEL1-like RNAs from potato represents a valuable model for studying the long-distance transport of full-length mRNAs and their role in development.

关键词： BEL A Model System of Development Regulated by the Long-distance Transport of mRNA Long

Emulsion cold mix asphalt in the UK: A decade of site and laboratory experience

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journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 359-365页

作者： Dennis day Ian Michael Lancaster Dougie McKay Nynas UK AB Ellesmere Port CH651AJUK Tayside Contracts Dundee DD38SSUK

Cold mix asphalt manufactured using bitumen emulsion, by its very nature, has struggled to gain market penetration in the UK due to lack of design guidance and specifications and the need to comply with prevailing hot mix asphalt specification requirements. Despite this, a number of contractors have successfully utilized emulsion cold mix asphalt materials containing recycled asphalt planings on various categories of road. Whilst the majority of schemes in the UK have been on lower category traffic roads, in this paper we discuss the use of one material which has been used on a strategic highway(trunk road) in2008 which saved 43 t of CO2 during construction and is still performing well in situ to this day. Site construction details along with an analysis of traffic loading are presented. Laboratory simulations of in-situ curing of material supplied to site demonstrated an indirect tensile stiffness modulus at 10℃ of 5 GPa was achieved within 6 months. Binder recovered from site cores was found to be in line with comparable hot mix materials, whilst wheel tracking of site cores demonstrated excellent deformation resistance which has been borne out by site performance over the last decade. The continued development of standards enabling engineers to design and specify cold mix asphalt in the UK is also reviewed.

关键词： Cold mix Bitumen emulsion Specifications Carbon savings

CALLISTO facilities in Peru:spectrometer commissioning and observations of typeⅢsolar radio bursts

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Research in Astronomy and Astrophysics 2021年第6期21卷 329-336页

作者： javier Alonso Rengifo Veronica Loaiza-Tacuri jose Bazo Walter Robert Guevara day Seccion FIsica Departamento de CienciasPontificia Universidad Catolica del PeruAv.Universitaria 1801Lima 32Peru Direction de Astroflsica Comision National de Investigacion y Desarrollo AeroespacialCONIDALuis Felipe Villaran 1069LimaPeru Observatorio National Rua General Jose Cristino7720921-400 Sao CristovaoRio de JaneiroRJBrazil Facultad de Ciencias Ffsicas Universidad Nacional Mayor de San MarcosP.O.Box 14-149Lima 14Peru

The Astrophysics Directorate of CONIDA has installed two radio spectrometer stations belonging to the e-CALLISTO network in Lima,*** their strategic location near the Equator,it is possible to observe the Sun evenly throughout the whole *** receiver located at Pucusana,nearby the capital city of Lima,took data from October 2014 until August 2016 in the metric and decimetric bands looking for radio *** this period,this e-CALLISTO detector was unique in its time-zone *** asses the suitability of the sites and the performance of the antennas,we analyzed the radio ambient background and measured their radiation pattern and *** demonstrate the capabilities of the facilities for studying solar dynamics in these radio frequencies,we have selected and analyzed typeⅢSolar Radio *** study of this kind of burst helps to understand the electron beams traversing the solar corona and the solar atmospheric *** have characterized the most common radio bursts with the following mean values:a negative drift rate of-25.8±3.7 MHz s^(-1),a duration of 2.6±0.3 s and 35 MHz bandwidth in the frequency range of 114 to 174 *** addition,for some events,it was possible to calculate a global frequency drift which on average was 0.4±0.1 MHz s^(-1).

关键词： instrumentation:spectrographs Sun:radio radiation

New 0D/1D Physical Approach for Modelling the Gas Dynamics Behavior Inside the Intake System of an Engine

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journal of Thermal Science 2018年第4期27卷 394-403页

作者： david CHALET Mohamad YASSINE jérome MIGAUD Ecole Centrale de Nantes LHEEA lab. (ECN/CNRS) Nantes France MANN+HUMMEL France Laval France

The competition among carmakers to introduce the most innovative solutions is growing day by day. Since few years, simulation is being used widely in automotive industries. Instead of building costly prototypes and expending fuel for doing tests on a real engine, simulation became a good solution before taking new decisions. Concerning the study of gas dynamics and pressure wave's propagation in the intake system of an internal combustion engine, a precise modelling is needed in order to obtain good results. Unfortunately, the computational time for these simulations is considered as high compared to the real time. The main objective of the new approach presented in this paper, is to reduce simulation time of models in the internal combustion engine simulation code, allowing them to accomplish many engine simulations faster than one-dimensional non-linear approach. A transfer function is defined to link directly the relative pressure and the air mass flow rate. In a second time, the model is included into an internal combustion engine simulation code. The results obtained with this code are compared to experimental ones which are measured on a one-cylinder engine test bench. A good agreement is obtained between the experimental results and the numerical one. The model was improved by adding a transfer function for temperature evolution. The convergence time is then reduced as well as the global simulation time of the model.

关键词： gas dynamics compressible flow transfer function accuracy simulation time engine

Time-varying and state-dependent recovery rates in epidemiological models

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Infectious Disease Modelling 2017年第4期2卷 419-430页

作者： Scott Greenhalgh Troy day Department of Mathematics Siena CollegeLoudonvilleNY12211USA Department of Mathematics and Statistics Queen's UniversityJeffery HallKingstonONK7L 3N6Canada

Differential equation models of infectious disease have undergone many theoretical extensions that are invaluable for the evaluation of disease *** instance,while one traditionally uses a bilinear term to describe the incidence rate of infection,physically more realistic generalizations exist to account for effects such as the saturation of ***,such theoretical extensions of recovery rates in differential equation models have only started to be *** is despite the fact that a constant rate often does not provide a good description of the dynamics of recovery and that the recovery rate is arguably as important as the incidence rate in governing the dynamics of a *** provide a first-principles derivation of state-dependent and time-varying recovery rates in differential equation models of infectious *** this derivation,we demonstrate how to obtain time-varying and state-dependent recovery rates based on the family of Pearson distributions and a power-law distribution,*** recovery rates based on the family of Pearson distributions,we show that uncertainty in skewness,in comparison to other statistical moments,is at least two times more impactful on the sensitivity of predicting an epidemic's *** addition,using recovery rates based on a power-law distribution,we provide a procedure to obtain state-dependent recovery *** such state-dependent rates,we derive a natural connection between recovery rate parameters with the mean and standard deviation of a power-law distribution,illustrating the impact that standard deviation has on the shape of an epidemic wave.

关键词： Differential equations Integral equations Infectious disease modeling Waiting time distribution Duration of infectiousness SIR epidemic model

Appropriate management of asymptomatic carotid stenosis

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Stroke & Vascular Neurology 2016年第2期1卷 64-71页

作者： j david Spence Hongsong Song Guanliang Cheng Robarts Research Institute Western UniversityLondonOntarioCanada Peking University Third Hospital BeijingThe People’s Republic of China Huai’an First People’s Hospital Nanjing Medical UniversityHuai’anThe People’s Republic of China

With modern intensive medical therapy,the annual risk of ipsilateral stroke in patients with asymptomatic carotid stenosis(ACS)is now down to∼0.5%.Despite this,there is a widespread practice of routine intervention in ACS with carotid endarterectomy(CEA)and stenting(CAS).This is being justified on the basis of much higher risks with medical therapy in trials conducted decades ago,compared with lower risks of intervention in recent trials with no medical *** extrapolations are *** recent trials have shown that after subtracting periprocedural risks the outcomes with CEA and CAS are now comparable to medical therapy,the periprocedural risks still far outweigh the risks with medical *** the asymptomatic carotid trial(ACT)1 trial,the 30-day risk of stroke or death was 2.9%with CAS and 1.7%with *** the CREST trial,the 30-day risk of stroke or death among asymptomatic patients was 2.5%for stenting and 1.4%for ***,intensive medical therapy is much safer than either CAS or *** only patients with ACS who should receive intervention are those who can be identified as being at high *** best validated method is transcranial Doppler embolus *** approaches in development for identifying vulnerable plaques include intraplaque haemorrhage on MRI,ulceration and plaque lucency on ultrasound,and plaque inflammation on positron emission tomography/*** medical therapy for ACS includes smoking cessation,a Mediterranean diet,effective blood pressure control,antiplatelet therapy,intensive lipid-lowering therapy and treatment with B vitamins(with methylcobalamin instead of cyanocobalamin),particularly in patients with metabolic B12 deficiency.A new strategy called‘treating arteries instead of risk factors’,based on measurement of carotid plaque volume,is promising but requires validation in randomised trials.

关键词： carotid asymptomatic stenosis

Magnetic systems for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2172-2196页

作者： Nicole B.day William C.Wixson C.Wyatt Shields IV Department of Chemical&Biological Engineering University of ColoradoBoulderCO 80303USA

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional *** cell modulation through the administration of drugs,proteins,and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive *** systems offer several advantages for improving the performance of immunotherapies,including increased spatiotemporal control over transport,release,and dosing of immunomodulatory drugs within the body,resulting in reduced off-target effects and improved *** to alternative methods for stimulating drug release such as light and pH,magnetic systems enable several distinct methods for programming immune ***,we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug ***,we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target ***,we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated ***,we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor ***,we discuss translational considerations of these systems,such as toxicity,clinical compatibility,and future opportunities for improving cancer treatment.

关键词： Drug delivery Immunotherapy Magnetic hyperthermia Magnetic nanoparticles Microrobotics Biomaterials