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Nanostructured biohybrid material with wide-ranging antiviral action

Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-Garcia Angela Vazquez-Calvo david Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami Jose m.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBeRehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACe)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229e(HCoV-e229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

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Self-assembled formation of long, thin, and uncoalesced GaN nanowires on crystalline TiN films

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Nano Research 2018年第1期11卷 565-576页

作者： david van Treeck Gabriele Calabrese Jelle J. W. Goertz Vladimir m. Kaganer Oliver Brandt Sergio Fernandez-Garrido, Lutz Geelhaar PauI-Drude-lnstitut f~r Festk6rperelektronik Leibniz-lnstitut im Forschungsverbund Berlin e.V. Hausvogteiplatz 5-7 I 0117 Berlin Germany

We investigate in detail the self-assembled nucleation and growth of vertically oriented GaN nanowires by molecular beam epitaxy on crystalline TiN films. We demonstrate that this type of substrate allows for the growth of long and thin GaN nanowires that do not suffer from coalescence, a problem common to the growth on Si and other substrates. Only beyond a certain nanowire length that depends on the nanowire density and exceeds here 1.5 bun, coalescence takes place by bundling, i.e. the same process as on Si. By analyzing the nearest neighbor distance distribution, we identify the diffusion-induced repulsion of neighboring nanowires as the main mechanism limiting nanowire density during nucleation on TiN. Since on Si the final density is determined by shadowing of the impinging molecular beams by existing nanowires, it is the difference in adatom surface diffusion that enables the formation of nanowire ensembles with reduced density on TiN. These nanowire ensembles combine properties that make them a promising basis for the growth of core-shell heterostructures.

关键词： nanocolumn gallium nitride nucleation metal substrate coalescence core-shell

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electrically pumped quantum-dot lasersgrownon 300 mm patterned Si photonic wafers

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Light(Science & Applications) 2022年第11期11卷 2698-2705页

作者： Chen Shang Kaiyin Feng eamonn THughes Andrew Clark mukul Debnath Rosalyn Koscica Gerald Leake Joshua Herman david Harame Peter Ludewig Yating Wan John e.Bowers materials Department University of California Santa BarbaraSanta BarbaraCA 93106USA Department of electrical and Computer engineering University of California Santa BarbaraSanta BarbaraCA 93106USA OQe IncGreensboroNC 27409USA RF SUNY Polytechnic Institute AlbanyNY 12203USA NAsPIII/NV GmbH MarburgGermany

monolithic integration of quantum dot(QD)gain materials onto Si photonic platforms via direct epitaxial growth is a promising solution for on-chip light *** developments have demonstrated superior device reliability in blanket hetero-epitaxy ofⅡ-Ⅴdevices on Si at elevated ***,thick,defect management epi designs prevent vertical light coupling from the gain region to the Si-on-lnsulator ***,we demonstrate the frst electrically pumped QD lasers grown by molecular beam epitaxy on a 300 mm patterned(001)Si wafer with a buttcoupled *** growth and fabrication challenges imposed by the template architecture have been resolved,contributing to continuous wave lasing to 60℃and a maximum double-side output power of 126.6 mW at 20℃with a double-side wall-plug efficiency of 8.6%.The potential for robust on-chip laser operation and effcient lowloss light coupling to Si photonic circuits makes this heteroepitaxial integration platform on Si promising for scalable and low-cost mass production.

关键词： pumped quantum coupling

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A cluster-randomized trial comparing two SWITCH implementation support strategies for school wellness intervention effectiveness

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Journal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz Philip m.Dixon david A.Dzewaltowski Gabriella m.mcLoughlin Joey A.Lee Senlin Chen Spyridoula Vazou Lorraine m.Lanningham-Foster Doug A.Gentile Gregory J.Welk Department of Food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Department of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Department of Health Promotion University of NebraskaOmahaNE 68198-4365USA Implementation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Department of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Department of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Department of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Department of Food Science&Human Nutrition Iowa State UniversityAmesIA 50011USA Department of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has demonstrated feasibility as an implementation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen time(SST),and dietary intake(DI).This study evaluated the comparative effectiveness of enhanced(individualized)implementation and standard(group-based)***:Twenty-two Iowa elementary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were matched within region and randomized to receive either individualized or group implementation *** PA,SST,and DI outcomes of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** mixed models evaluated differential change in outcomes by condition,for comparative effectiveness,and by ***:Both implementation conditions led to significant improvements in PA and SST over time(pmprove commensurately(p value range:0.02‒0.05).There were no differential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).effect sizes for both conditions equated to approximately 6 min more PA per day and approximately 3 min less sedentary ***:The observed lack of difference in outcomes suggests that group implementation of SWITCH is equally effective as individualized implementation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence implementation(and outcomes)of SWITCH.

关键词： Children Implementation science Obesity prevention Physical activity School health

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Left atrial dimension and atrial fibrillation in surgical heart disease patients

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Journal of Geriatric Cardiology 2008年第1期5卷 11-14页

作者： david Shek Division of Cardiology Hospital of University of Pennsylvania

Objective The effect of left atrial (LA) dimension on the occurrence of atrial fibrillation (AF) has been examined in some small *** is known about the relationship of LA dimension,hemodynamic with AF during echocardiographic evaluation,especially,the flow dynamics in LA poorly *** objective of this study was to investigate the relationship between LA dimension and the occurrence of Ae methods Two hundred and forty-five consecutive patients with heart disease scheduled to undergo open heart surgery were prospectively enrolled in the *** were divided into 2 groups according to atrial fibrillation:AF group (n=148,99 men and 49 women,with a mean age 59.3+8.4 years),and no-AF group (n= 97,60 men and 37 womem).echocardiography was performed before *** measurements were performed following the American Society of echocardiography *** There were more patients with congestive heart failure in AF group than in no-AF group (45.9% vs 39.1%,P ＜0.05).The mean LA volume was 49.2±12.2 ml/m2 in AF group and 33.1±10.8 ml/m2 in no-AF *** were also significant differences between two groups in left atrial end systolic dimension (LAeSD) (50±13mm vs 27±14mm),left atrial end diastolic dimension (LAeDD) (79±17mm vs 53±13mm),PA pressure ( 41.3+11.6 mmHg vs 37.5±10.4 mmHg),and ratio of mitral e velocity and septal mitral annulus motion velocity (e/e') .The percentage of abnormal diastolic function grades (DGF) was also higher in AF than in no-AF group (89.9% versus 59.8% );.Conclusion Atrial fibrillation is associated more frequently with an increased LA dimension and more severe atrial hemodynamics disorder.(J Geriatr Cardiol 2008;5:11-4)

关键词： LA dimension hemodynamics atrial fibrillation

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A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

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Bone Research 2020年第3期8卷 356-364页

作者： maria A.Christou Georgios Ntritsos Georgios markozannes Fotis Koskeridis Spyros N.Nikas david Karasik Douglas P.Kiel evangelos evangelou evangelia e.Ntzani Department of Hygiene and epidemiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Department of medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of medicine Bar llan UniversitySafedIsrael Department of epidemiology and Biostatistics Imperial College LondonLondonUK Department of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** pleiotropy occurs when a single genetic element is associated with more than one *** aimed to identify pleiotropic loci associated with bone mineral density(BmD)and nonbone phenotypes in genome-wide association *** the discovery stage,the NHGRI-eBI Catalog was searched for genome-wide significant associations(P valueexcluding bone-related *** was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BmD data from the GeFOS *** variants were claimed at a false discovery ratemD andese genetic markers was performed among more than 400000 UK Biobank participants of european ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BmD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK *** SNPs were associated,in addition to BmD,with 14 different *** pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(m U C 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BmD-related genome-wide significant SNPs showed pleiotropy with nonbone *** associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Replication

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Trans-Gulf of mexico loop migration of tree swallows revealed by solar geolocation

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Current Zoology 2014年第5期60卷 653-659页

作者： david W. BRADLeY Robert G. CLARK Peter O. DUNN Andrew J. LAUGHLIN Caz m. TAYLOR Carol VLeCK Linda A. WHITTINGHAm david W. WINKLeR D. Ryan NORRIS Department of Integrative Biology University of Guelph Guelph Ontario N1G 2W 1 Canada Bird Studies Canada Port Rowan Ontario N0E 1M0 Canada environment Canada. Saskatoon. Saskatchewan S7N 0X4. Canada Behavioral and molecular ecology Group Department of Biological Sciences University of Wisconsin Milwaukee Wisconsin 53201 USA Department of ecology and evolutionary Biology Tulane University New Orleans Louisiana 70118 USA Department of ecology Evolution and Organismal Biology Iowa State University Ames IA 50011-1020 USA Department of ecology and evolutionary Biology Museum of Vertebrates and Lab of Ornithology Comell University Ithaca New York 14853 USA

One of the greatest feats of avian migration is the non-stop crossing of extensive areas of inhospitable habitat such as deserts and seas. Differences in spring and autumn migration routes have been reported in species that cross such barriers, and are thought to have evolved in response to seasonal variation in prevailing wind direction. We tested the hypothesis that migration routes vary seasonally with respect to the Gulf of mexico in the tree swallow Tachycineta bicolor using solar geolocators attached and retrieved at 4 breeding sites in central North America. We found that 100 % of birds （n = 10） made a trans-Gulf flight of 〉850 km from Louisiana south to their wintering grounds in the Yucatan Peninsula in 12-36 hours, achieving minimum ground speeds as high as 32 m/s. Although most days during autumn migration were characterized by unfavorable headwinds blowing to the northwest, migration over the Gulf mostly occurred on days with strong winds blowing to the south. In contrast, in 8 of 9 （88 %） birds on spring migration returned from the wintering grounds towards Louisiana following a clockwise loop pat- tern flying over land to the west around the Gulf. During this spring period there were few days with prevailing winds from the south to assist northward migration. Results suggest that, despite being up to three times further （ca. 2,700 kin）, a coastal circum-Gulf spring migration represents the less risky route when wind conditions are not favorable. These findings also help to resolve a long-standing dispute in the literature concerning migration patterns between the US Gulf coast and mexico, and provide insight into the factors shaping migration strategies of small songbirds migrating across large bodies of water [Current Zoology 60（5）： 653-559, 2014].

关键词： ecological Barrier Geolocation Gulf of mexico Tachycineta bicolor Tree swallow migration

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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang Li‑Yong Zhang Jian‑Jun He Richard James deBoer michael Wiescher Alexander Heger david Kahl Jun Su Daniel Odell Xin‑Yue Li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi Jiang Luo‑Huan Wang Zi‑ming Li Lu‑Yang Song Liang‑Ting Sun Qi Wu Jia‑Qing Li Bao‑Qun Cui Li‑Hua Chen Rui‑Gang ma er‑Tao Li Gang Lian Yao‑De Sheng Zhi‑Hong Li Bing Guo Wei‑Ping Liu Key Laboratory of Beam Technology of the ministry of education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic energy Beijing 102413China College of Physics and Optoelectronic engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(mOe) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of e_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRe *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

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Variable Configuration Fiber Optic Laser Doppler Vibrometer System

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Photonic Sensors 2016年第2期6卷 97-106页

作者： Julio e. POSADA-ROmAN david A. JACKSON Jose A. GARCIA-SOUTO Department of electronics Technology GOTL University Carlos 111 de Madrid Butarque 15 28911 Legan6s MadridSpain Applied Optics Group School of Physical Sciences University of Canterbury Kent CT2 7NH UK

A multichannel heterodyne fiber optic vibrometer is demonstrated which can be operated at ranges in excess of 50m. The system is designed to measure periodic signals, impacts, rotation, 3D strain, and vibration mapping. The displacement resolution of each channel exceeds 1 nm. The outputs from all channels are simultaneous, and the number of channels can be increased by using optical switches.

关键词： Laser Doppler vibration digital processing nanometer resolution multiplexing optical fiber

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Subtle Variations in Surface Properties of Black Silicon Surfaces Influence the Degree of Bactericidal efficiency

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Nano-micro Letters 2018年第2期10卷 239-246页

作者： Chris m.Bhadra marco Werner Vladimir A.Baulin Vi Khanh Truong mohammad Al Kobaisi Song Ha Nguyen Armandas Balcytis Saulius Juodkazis James Y.Wang david e.mainwaring Russell J.Crawford elena P.Ivanova School of Science Faculty of Science Engineering and Technology Swinburne University of Technology Departament d’enginyeria Química Universitat Rovira i Virgili melbourne Center for Nanofabrication School of Science RMIT University

One of the major challenges faced by the biomedical industry is the development of robust synthetic surfaces that can resist bacterial colonization. much inspiration has been drawn recently from naturally occurring mechano-bactericidal surfaces such as the wings of cicada(Psaltoda claripennis) and dragonfly(Diplacodes bipunctata) species in fabricating their synthetic analogs. However,the bactericidal activity of nanostructured surfaces is observed in a particular range of parameters reflecting the geometry of nanostructures and surface wettability. Here,several of the nanometer-scale characteristics of black silicon(bSi) surfaces including the density and height of the nanopillars that have the potential to influence the bactericidal efficiency of these nanostructured surfaces have been investigated. The results provide important evidence that minor variations in the nanoarchitecture of substrata can substantially alter their performance as bactericidal surfaces.

关键词： Black silicon Nanoarchitecture Bactericidal efficiency Deep reactive ion etching(DRIe) Neural network analysis

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