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中国建立男性包皮环切手术标准化和培训的重要性

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中华男科学杂志 2009年第5期15卷 390-394页

作者：李石华吕年青程跃彭弋峰田龙刘毅东贲昆龙徐建春 Richard LEE Howard KIM david c.sokal center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA 江苏省计划生育科学技术研究所江苏南京210036 宁波大学医学院附属宁波市第一医院泌尿科浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 首都医科大学附属北京朝阳医院泌尿科北京100034 上海交通大学医学院附属仁济医院泌尿科上海200127 昆明康涛生物技术有限公司云南昆明650106 昆明医学院第一附属医院男性科云南昆明650106 Family Health International Research Triangle ParkNC 27709USA

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(H... 详细信息

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(HPV)、单纯疱疹病毒2型(HSV-2)和其他性传播疾病(STD)的感染率。虽然男性包皮环切技术有许多,但是没有标准化的手术方案和培训计划。研究表明,男性包皮环切技术的标准化与培训计划的实施可以大大降低并发症发生率。并发症发生率高是实施男性包皮环切服务的一个主要障碍。我们建议,在推广男性包皮环切之前应建立手术标准和培训计划。

关键词：包皮环切术 HIV感染性传播疾病

应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告

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中华男科学杂志 2009年第7期15卷 584-592页

作者：程跃彭弋峰刘毅东田龙吕年青苏新军严泽军胡嘉盛 Richard LEE Howard KIM david c. sokal 李石华宁波大学医学院附属宁波市第一医院泌尿中心浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 上海交通大学医学院附属仁济医院泌尿科上海200127 首都医科大学附属北京朝阳医院泌尿科北京100034 江苏省计划生育科学技术研究所江苏南京210036 center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA Family Health International Research Triangle ParkNC 27709USA

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环... 详细信息

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称"商环,ShangRing")包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18～58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。

关键词：包皮环切术中国商环标准化方案并发症男性成年人

Vasectomy techniques-need for better occlusion methods

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Asian Journal of Andrology 2010年第3期12卷 442-443页

作者： david c. sokal Behavioral and Biomedical Research Family Health International Research Triangle Park NC 27709 USA

I was disappointed to read about a device that was not successful in producing reliable vas occlusion in Amory et al. ＇s report in this issue of the journal [1]. For those who are unfamiliar with vasectomy terminology, it is important to understand that a vasectomy procedure has three major aspects：（1） anesthesia; （2） accessing or approaching the vas （that is, the method used to isolate a loop of the vas）; and （3） occluding the vas.

关键词： Vasectomy occlusion methods

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Hepato-biliary profile of potential candidate liver progenitor cells from healthy rat liver

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World Journal of Gastroenterology 2012年第27期18卷 3511-3519页

作者： cédric Maerckx Isabelle Scheers Tatiana Tondreau david campard Omar Nyabi Mustapha Najimi Etienne sokal Laboratory of Pediatric Hepatology and cell Therapy Université Catholique de Louvain1200 BrusselsBelgium

AIM： To evaluate the presence of progenitor cells in healthy adult rat liver displaying the equivalent ad- vanced hepatogenic profile as that obtained in humans. METHODS： Rat fibroblastic-like liver derived cells （rFLDc） were obtained from collagenase-isolated liver cell suspensions and characterized and their phenotype profile determined using flow cytometry, immunocyto- chemistry, reverse transcription polymerase chain reac- tion and functional assays. RESULTS： rFLDc exhibit fibroblastoid morphology, ex- press mesenchymal （cD73, cD90, vimentin, m-smooth muscle actin）, hepatocyte （UGTIA1, cK8） and biliary （cK19） markers. Moreover, these cells are able to store glycogen, and have glucose 6 phosphatase activity, but not UGTIA1 activity. Under the hepatogenic differentia- tion protocol, rFLDc display an up-regulation of hepatocyte markers expression （albumin, tryptophan 2,3-di- oxygenase, G6Pase） correlated to a down-regulation of the expression of the biliary marker cK19. cONcLUSION： Advanced hepatic features observed in human liver progenitor cells could not be demonstrated in rFLDc. However, we demonstrated the presence of an original rodent hepato-biliary cell type.

关键词： Hepato biliary profile Hepatogenic differentiation Liver Progenitor cell Rat

Stem cells for liver tissue repair:current knowledge and perspectives

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World Journal of Gastroenterology 2008年第6期14卷 864-875页

作者： Philippe A Lysy david campard Fran oise Smets Mustapha Najimi Etienne M sokal Université catholique de Louvain & cliniques Universitaires Saint Luc HPED Department Unit PEDI Laboratory of Pediatric Hepatology and Cell Therapy Brussels 1200 Belgium

Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated.

关键词： Stem cells Hepatocyte differentiation Liver regeneration cell therapy

coronavirus disease-2019: A tocsin to our aging, unfit, corpulent, and immunodeficient society

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Journal of Sport and Health Science 2020年第4期9卷 293-301页

作者： david c.Nieman Department of Biology College of Arts and SciencesAppalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

Acute and chronic respiratory illnesses cause widespread morbidity and mortality,and this class of illness now includes the novel coronavirus severe acute respiratory syndrome that is causing coronavirus disease-2019(cOVID-19).The world is experiencing a major demographic shift toward an older,obese,and physically inactive *** factor assessments based on pandemic data indicate that those at higher risk for severe illness from cOVID-19 include older males,and people of all ages with obesity and related comorbidities such as hypertension and type 2 *** in and of itself leads to negative changes in innate and adaptive immunity,a process termed *** causes systemic inflammation and adversely impacts immune function and host defense in a way that patterns *** primary prevention strategies to reduce the risk for cOVID-19 at both the community and individual levels include mitigation activities and the adoption of lifestyle practices consistent with good immune *** and human studies support the idea that,in contrast to high exercise workloads,regular moderate-intensity physical activity improves immunosurveillance against pathogens and reduces morbidity and mortality from viral infection and respiratory illnesses including the common cold,pneumonia,and *** odds are high that infectious disease pandemics spawned by novel pathogens will continue to inflict morbidity and mortality as the world’s population becomes older and more ***-19 is indeed a wake-up call,a tocsin,to the world that primary prevention countermeasures focused on health behaviors and hygiene demand our full attention and support.

关键词： cOVID-19 Exercise Immunology Infection Obesity

ANALYSIS OF LIQUID SLUG MOTION IN A VOIDED LINE

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Journal of Hydrodynamics 1993年第3期5卷 75-88页

作者： Yang, Jiandong Wigget, david c Wuhan Univ of Hydraulic and Electric Engineering Wuhan China

A quasi two-dimensional two-phase flow cylinder model of slug motion in a voided line developed in this paper can predict reasonably the change of flow pattern of the slug, air entrainment, holdup and the distribution of axial velocity. However, if using the theory of transfer momentum to estimate the pressure-time history of slug at the elbow, the result of calculation is not good in agreement with that of experiment. Analysis of the experiment results and the estimations of using the theory of transient two-phase flow indicate that an evident water hammer response occurs in the slug, when the high-speed slug impacts on the elbow, and the peaks and waveform of pressure-time history are dependent mainly on the propagation of transient two-phase flow in the slug.

关键词： Pipe flow Water hammer

Exercise immunology:Novel insights

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Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： david c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune *** were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby