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Intravitreal fluorogold tracing as a method to label retinal neurons and the retinal pigment epithelium

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Neural Regeneration Research 2021年第10期16卷 2000-2001页

作者： Francisco Javier Valiente-Soriano Fernando Lucas-Ruiz Juan A.Miralles de Imperial-Ollero Manuel vidal-Sanz Marta Agudo-Barriuso Departamento de Oftalmología Facultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIB-Arrixaca)MurciaSpain

Techniques to label the neuroretina and the retinal pigment epithelium(RPE)have been the topic of many studies for *** reliability and reproducibility of these techniques are essential to investigate retinal alterations of ocular pathologies and possible *** particular,the study of the integrity of the RPE is of great importance in pathologies such as retinitis pigmentosa or age-related macular degeneration(Gu et al.,2012;Fisher and Ferrington,2018;Zhang et al.,2019).The most common approaches use antibodies to identify different cell ***,we have described a novel technique to study the integrity of the neuroretina and the RPE,as well as the functionality of the RPE in rats(Valiente-Soriano et al.,2020).

关键词： epithelium al. alterations

High pressure responsive luminescence of flexible Eu^(3+) doped PVDF fibrous mats

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Journal of Materials Science & Technology 2021年第7期66卷 103-111页

作者： Carlos Hernandez San tosh K.Gupta Jose P.Zuniga Jorge vidal Rene Galvan Hector Guzman Lilian Chavez Karen Lozano Yuanbing Mao Department Department of Chemistry University of Texas Rio Grande Valley1201 West University DriveEdinburgTX 78539USA Radiochemistry Division Bhabha Atomic Research CentreTrombayMumbai400085USA Department of Electrical Engineering University of Texas Rio Grande ValleyEdinburgTX 78539USA Department of Chemistry Illinois Institute of Technology3105 South Dearborn StreetChicagoIL 60616USA

Exploring lanthanide doped materials and their high-pressure optical properties is important from the perspective of designing pressure sensors, piezoelectric materials, scintillators, and optoelectronic devices, just to mention a few. Understanding the high-pressure optical properties of polymeric fibrous mats provides significant advantages in terms of flexibility, tunability, facile processability, and malleability. In this work, we have developed flexible polyvinylidene difluoride(PVDF) fibrous mats doped with an Eu^(3+) source of Eu(NO_(3))_(3)·5H_(2)O(EN-PF) or Eu_(2)(SO_(4))_(3)(ES-PF) by a Forcespinning■ method. Microstructural analysis of these two systems indicates that Eu(NO_(3))_(3)·5H_(2)O and Eu_(2)(SO_(4))_(3) are homogeneously distributed and dispersed into the PVDF matrix. Fiber formation promotes a β-phase PVDF. Eu^(3+) doping increases the β-phase. Its fraction is larger for the ES-PF mats. To understand their high-pressure optical properties, their photoluminescence spectra have been taken at various pressures up to 58 GPa in a diamond anvil cell. High-pressure luminescence illustrates a clear change in asymmetry ratio, peak intensity, peak breadth, color coordinate, and color temperature of Eu^(3+) ions from both EN-PF and ES-PF with a different extent of changes. Specifically, Eu^(3+) ions in the ES-PF mats switch from asymmetric to symmetric environment as pressure increases. Those in the EN-PF mats present symmetric environment for all tested pressures. Both of the Eu^(3+) doped PVDF systems present irreversible changes. Therefore,the EN-PF fibrous mats present an opportunity to make pressure induced red-orange-yellow tunable phosphors for multifunctional applications.

关键词： Polyvinylidene difluoride Europium Fiber High pressure Luminescence

ISCHEMIA trial:How to apply the results to clinical practice

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World Journal of Cardiology 2021年第8期13卷 237-242页

作者： Rafael vidal-Perez Alberto Bouzas-Mosquera Jesus Peteiro Jose Manuel Vazquez-Rodriguez Servicio de Cardiologia Unidad de Imagen y Funcion CardiacaComplexo Hospitalario Universitario A Coruna(CHUAC)Centro de Investigacion Biomedica en Red(CIBERCV)-Instituto de Salud Carlos IIIA Coruna 15006Spain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006Spain

During the last years two questions have been continuously asked in chronic coronary syndromes:(1)Do revascularization procedures(coronary artery bypass grafting or percutaneous coronary intervention)really improve symptoms of angina?and(2)Do these techniques improve outcomes,*** they prevent new myocardial infarction events and cardiovascular death?Therefore,there was a need for a large definitive *** study was the ISCHEMIA trial,a large,multicentric trial sponsored by the National Heart,Lung,and Blood *** main trial compared coronary revascularization and optimal medical treatment(OMT)vs OMT alone in 5179 patients enrolled after a stress *** a median 3.2-year follow-up,318 primary outcome events occurred;the adjusted hazard ratio for the invasive strategy as compared with the conservative strategy was 0.93(95%confidence interval 0.80-1.08,P=0.34).The ISCHEMIA trial deeply disrupted many of our prior attitudes regarding management strategies for patients with stable coronary artery *** findings underscore the benefits of disease-modifying OMT for stable coronary artery disease *** main purposes of ischemia assessment before this trial were:Diagnostic purposes,assessment of outcome,and adding to decision-making ***,this changed after the trial *** results of ISCHEMIA might challenge the current diagnostic approach for stable angina patients recommended in the last European Society of Cardiology guidelines on chronic coronary disease that were based on studies published before the ISCHEMIA *** this editorial we propose our approach based on the ISCHEMIA study and the pretest probability for a positive test in patients with chronic coronary syndromes.

关键词： Stable angina Chronic coronary syndrome ISCHEMIA Stress testing Therapy Diagnosis

Wind effects on the migration routes of trans-Saharan soaring raptors： geographical, seasonal, and interspecific variation

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Current Zoology 2016年第2期62卷 89-97页

作者： Javier vidal-MATEO Ugo MELLONE Pascual LOPEZ-LOPEZ Javier De LA PUENTE clara GARCIA-RIPOLLES Ana BERMEJO Vicente URIOS Vertebrates Zoology Research Group Departamento de Ciencias Ambientales y Recursos Naturales Universityof Alicante Apdo. 99 E-03080 Alicante Spain SEO/BirdLife Area de Estudio y Seguimiento de AyesC/Melquiades Biencinto 34 E-28053 Madridl Spain

Wind is among the most important environmental factors shaping birds' migration patterns. Birds must deal with the displacement caused by crosswinds and their behavior can vary according to different factors such as flight mode, migratory season, experience, and distance to goal areas. Here we analyze the relationship between wind and migratory movements of three raptor species which migrate by soaring-gliding flight: Egyptian vulture , booted eagle , and short-toed snake eagle . We analyzed daily migratory segments (i.e., the path joining consecutive roosting locations) using data recorded by GPS satellite telemetry. Daily movements of Egyptian vultures and booted eagles were significantly affected by tailwinds during both autumn and spring migrations. In contrast, daily movements of short-toed eagles were only significantly affected by tailwinds during autumn migration. The effect of crosswinds was significant in all cases. Interestingly, Egyptian vultures and booted eagles showed latitudinal differences in their behavior: both species compensated more frequently at the onset of autumn migration and, at the end of the season when reaching their wintering areas, the proportion of drift segments was higher. In contrast, there was a higher drift at the onset of spring migration and a higher compensation at the end. Our results highlight the effect of wind patterns on the migratory routes of soaring raptors, with different outcomes in relation to species, season, and latitude, ultimately shaping the loop migration patterns that current tracking techniques are showing to be widespread in many long distance migrants.

关键词：迁徙路线季节种间变异撒哈拉地理迁移模式鸟类迁徙环境因子

International NeuroAIDS: prospects of HIV-1 associated neurological com-plications

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Cell Research 2005年第Z1期15卷 962-969页

作者： J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E vidal Joseph BRYANT Robert C GALLO Institute of Human Virology University of Maryland Biotechnology Institute 725 W Lombard Street Baltimore MD 21201 USA Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil Clinical Research Unit in Human Retrovirology University of CampinasSao Paulo 01246 Brazil. Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil

Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain.

关键词： NeuroAIDS HIV-1 neurotropism AIDS dementia complex.

Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype

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World Journal of Gastroenterology 2007年第41期13卷 5446-5453页

作者： Elisabet Cantó Elena Ricart david Busquets david Monfort Esther García-Planella Dolors González Joaquim Balanzó José L Rodríguez-Sánchez Sílvia vidal Department of Immunology Sant Pau Hospital & Research Inst.Sant Pau HospitalBarcelona 08025Spain Department of Gastroenterology CIBER-EHD.Clinic HospitalBarcelona-08025Spain Department of Digestive Pathology Sant Pau HospitalBarcelona 08025Spain

AIM: To examine genetic variation of nucleotide oligomerization domain 1 (NOD1 ) and NOD2 ,their respective influences on Crohn's disease phenotype and gene-gene interactions. METHODS: (ND1+326561 ) NOD1 polymorphism and SNP8,SNP12 and SNP13 of NOD2 were analyzed in 97 patients and 50 controls. NOD2 variants were determined by reaction restriction fragment length polymorphism analysis. NOD1 genotyping and NOD2 variant confirmation were performed by specific amplification and sequencing. RESULTS: The distribution of NOD1 polymorphism in patients was different from controls (P = 0.045) and not altered by existence of NOD2 mutations. In this cohort,30.92% patients and 6% controls carried at least one NOD2 variant (P < 0.001) with R702W being the most frequent variant. Presence of at least one NOD2 mutation was inversely associated with colon involvement (9.09% with colon vs 36.4% with ileal or ileocolonic involvement,P = 0.04) and indicative of risk of penetrating disease (52.63% with penetrating vs 25.64% with non-penetrating or stricturing behavior,P = 0.02). L1007finsC and double NOD2 mutation conferred the highest risk for severity of disease (26.3% with penetrating disease vs 3.8% with non-penetrating or stricturing behavior presented L1007finsC,P = 0.01 and 21.0% with penetrating disease vs 2.5% with non-penentrating or stricturing behavior carried double NOD2 mutation,P = 0.007). Exclusion of patients with NOD2 mutations from phenotype/NOD1 -genotype analysis revealed higher prevalence of 11 genotype in groups of younger age at onset and colonic location. CONCLUSION: This study suggests population differences in the inheritance of risk NOD1 polymorphism and NOD2 mutations. Although no interaction between NOD1 -NOD2 was noticed,a relationship between disease location and Nod-like receptor molecules was established.

关键词：克罗恩氏病核苷酸低聚反应等位基因

Ce que voulait de Gaulle en 1966

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法语学习 2013年第3期 60-63页

作者： Dominique vidal 蓝霸

《La France considère que les changements accomplis ou en voie de l’être , depuis 1949 , en Europe , en Asie et ailleurs , ainsi que l’évolution de sa propre situation et de ses propres

关键词：法语学习学习方法阅读知识阅读材料

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

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分子细胞生物学报:英文版 2016年第2期8卷 129-143页

作者： Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert vidal Jennifer Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin *** mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are *** this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse *** of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and *** glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional *** disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

The association between sexual function and prostate cancer risk in US veterans

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Asian Journal of Andrology 2017年第2期19卷 191-195页

作者： Daniel F Zapata Lauren E Howard Jennifer Frank Ross M Simon Cathrine Hoyo Delores J Grant Stephen J Freedland Adriana C vidal Duke University Medical Center Division of Urology Department of Surgery Durham NC 27710 USA Durham Veterans Affairs Medical Center Urology Division Durham NC 27710 USA North Carolina State University Department of Biology Raleigh NC 27695 USA North Carolina Central University Department of Biology Durham NC 27707 USA Department of Surgery Division of Urology Samuel Oschin Comprehensive Cancer institute Cedars-Sinai Medical Center Los Angeles California 90048 USA

Sexual dysfunction and prostate cancer are common among older men. Few studies explored the association between these two illnesses. We examined whether sexual function is associated with prostate cancer risk among older men. Among 448 men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, sexual function was ascertained from the Expanded Prostate Cancer Index Composite sexual assessment. We tested the link between sexual function and prostate cancer risk adjusting for multiple demographic and clinical characteristics using logistic regression. Multinomial logistic regression was used to test the associations with risk of low-grade （Gleason 〈6） and high-grade （Gleason 〉7 or 〉4 ＋ 3） disease versus no cancer. Of 448 men, 209 （47%） had a positive biopsy; these men were less likely to be white （43% vs 55%, P=0.013）, had higher prostate-specific antigen （PSA）（6.0 vs 5.4 ng ml-1, P 〈 0.001）, but with lower mean sexual function score （47 vs 54, P = 0.007）. There was no difference in age, BMI, pack years smoked, history of heart disease and/or diabetes. After adjusting for baseline differences, sexual function was linked with a decreased risk of overall prostate cancer risk （OR. 0.91 per lO-point change in sexual function, P= 0.004） and high-grade disease whether defined as Gleason ≥7 （OR： 0.86, P= 0.001） or 〉4 ＋ 3 （OR： 0.85, P= 0.009）. Sexual function was unrelated to low-grade prostate cancer （OR： 0.94, P = 0.13）. Thus, among men undergoing prostate biopsy, higher sexual function was associated with a decreased risk of overall and high-grade prostate cancer. Confirmatory studies are needed.

关键词： erectile dysfunction prostate prostate cancer risk sexual function