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Microscopic colitis: A review of etiology, treatment and refractory disease

World Journal of Gastroenterology 2015年第29期21卷 8804-8810页

作者： Tina park david Cave Christopher Marshall Department of Medicine Division of Gastroenterology University of Massachusetts Worcester

Microscopic colitis is a common cause of chronic,nonbloody diarrhea. Microscopic colitis is more common in women than men and usually affects patients in their sixth and seventh decade. This article reviews the etiology and medical management of microscopic colitis. The etiology of microscopic colitis is unknown, but it is associated with autoimmune disorders, such as celiac disease, polyarthritis, and thyroid disorders. Smoking has been identified as a risk factor of mi-croscopic colitis. Exposure to medications, such as non-steroidal anti-inflammatory drugs, proton pump inhibitors, and selective serotonin reuptake inhibitors, is suspected to play a role in microscopic colitis, although their direct causal relationship has not been proven. Multiple medications, including corticosteroids, anti-diarrheals, cholestyramine, bismuth, 5-aminosalicylates, and immunomodulators, have been used to treat microscopic colitis with variable response rates. Budesonide is effective in inducing and maintaining clinical remission but relapse rate is as high as 82% when budesonide is discontinued. There is limited data on management of steroid-dependent microscopic colitis or refractory microscopic colitis. Immunomodulators seem to have low response rate 0%-56% for patients with refractory microscopic colitis. response rate 66%-100% was observed for use of anti-tumor necrosis factor(TNF) therapy for refractory microscopic colitis. Anti-TNF and diverting ileostomy may be an option in severe or refractory microscopic colitis.

关键词： Chronic diarrhea Etiology of microscopiccolitis Collagenous colitis refractory microscopiccolitis Microscopic colitis Lymphocytic colitis Steroiddependentmicroscopic colitis

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Breaking out from the neuroprotective logjam:combined treatment with remote ischemic conditioning and minocycline in the prehospital setting

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Neural regeneration research 2015年第4期10卷 537-539页

作者： Jung Mi park david C.Hess Departments of Neurology Georgia Regent’s University

The only two treatments effective for acute ischemic stroke are reperfusion therapies. Despite testing of hundreds of neuroprotective agents and treatments, tissue plasminogen activator （tPA）, approved by the Food and Drug Administration （FDA） in 1996, remains the only FDA-approved drug for the treatment of ischemic stroke. recently,

关键词： Breaking out from the neuroprotective logjam rIC

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A Lookahead read Cache： Improving read Performance for Deduplication Backup Storage

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Journal of Computer Science & Technology 2017年第1期32卷 26-40页

作者： Dongchul park Ziqi Fan Young Jin Nam david H. C. Du Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis MN 55455 U.S.A.

Data deduplication （dedupe for short） is a special data compression technique. It has been widely adopted to save backup time as well as storage space, particularly in backup storage systems. Therefore, most dedupe research has primarily focused on improving dedupe write performance. However, backup storage dedupe read performance is also a crucial problem for storage recovery. This paper designs a new dedupe storage read cache for backup applications that improves read performance by exploiting a special characteristic： the read sequence is the same as the write sequence. Consequently, for better cache utilization, by looking ahead for future references within a moving window, it evicts victims from the cache having the smallest future access. Moreover~ to further improve read cache performance. it maintains a small log buffer to judiciously cache future access data chunks. Extensive experiments with real-world backup workloads demonstrate that the proposed read cache scheme improves read performance by up to 64.3%

关键词： deduplication dedupe read cache backup

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A microscale optical implant for continuous in vivo monitoring of intraocular pressure

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Microsystems & Nanoengineering 2017年第1期3卷 11-19页

作者： Jeong Oen Lee Haeri park Juan Du Ashwin Balakrishna Oliver Chen david Sretavan Hyuck Choo Department of Medical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Electrical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Ophthalmology University of California San FranciscoSan FranciscoCA 94143USA Department of Physiology University of California San FranciscoSan FranciscoCA 94143USA

Intraocular pressure(IOP)is a key clinical parameter in glaucoma ***,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a *** we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home *** excited by broadband near-infrared(NIr)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to *** light is minimally absorbed by tissue and is not perceived *** sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm *** were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white *** sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

关键词： glaucoma intraocular pressure(IOP) microscale sensor implant in vivo continuous monitoring remote optical readout near-infrared(NIr)broadband light minimally invasive

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Highly stable integration of graphene Hall sensors on a microfluidic platform for magnetic sensing in whole blood

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Microsystems & Nanoengineering 2023年第3期9卷 115-127页

作者： Nishal Shah Vasant Iyer Zhiping Zhang Zhaoli Gao Juhwan park Venkata Yelleswarapu Firooz Aflatouni A.T.Charlie Johnson david Issadore Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Biomedical Engineering Chinese University of Hong KongShatinHong Kong Department of Physics and Astronomy University of PennsylvaniaPhiladelphiaPA 19104USA Department of Chemical and Biomolecular University of PennsylvaniaPhiladelphiaPA 19104USA

The detection and analysis of rare cells in complex media such as blood is increasingly important in biomedical research and clinical ***-Hall detectors(μHD)for magnetic detection in blood have previously demonstrated ultrahigh sensitivity to rare *** sensitivity originates from the minimal magnetic background in blood,obviating cumbersome and detrimental sample ***,the translation of this technology to clinical applications has been limited by inherently low throughput(rcial CMOS foundry *** help overcome these challenges,we have developed CMOS-compatible graphene Hall sensors for integration with PDMS microfluidics for magnetic sensing in *** demonstrate that these grapheneμHDs can match the performance of the best publishedμHDs,can be passivated for robust use with whole blood,and can be integrated with microfluidics and sensing electronics for in-flow detection of magnetic *** show a proof-of-concept validation of our system on a silicon substrate and detect magnetic agarose beads,as a model for cells,demonstrating promise for future integration in clinical applications with a custom CMOS chip.

关键词： integration magnetic fluid

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Ultrasonic Approach of rayleigh Pitch-Catch Contact Ultrasound Waves on CFrP Laminated Composites

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Journal of Materials Science & Technology 2008年第3期24卷 407-409页

作者： In-Young Yang Kwang-Hee Im Uk Heo david K Hsu Je-Woong park Hak-Joon Kim Sung-Jin Song School of Mechanical Eng. Chosun Univ Department of Automotive Eng. Woosuk Univers-ity Center for Nondestructive Evaluation Iowa State University Dept.of Naval Arch.and Ocean Eng. Chosun Univ School of Mechanical Eng. Sungkyunkwan University

CFrP （carbon fiber reinforced plastics） composite materials have wide applicability because of their inherent design flexibility and improved material properties. However, impacted composite structures have 50%-75% less strength than undamaged structures. In this work, a CFrP composite material was nondestructively characterized in order to ensure product quality and structural integrity of CFrP and one-sided pitch-catch technique was developed to measure impacted-damaged area by using an automated-data acquisition system in an immersion tank. A pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave under defect conditions in the composite.

关键词： Impact damages C-scanner Carbon fiber reinforced plastics (CFrP) Pitchcatch mode

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How Fast Can You Improve Your English？

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疯狂英语（口语版） 2009年第4期 52-52,55页

作者： david park

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ULTrASONIC INFLUENCE OF POrOSITY LEVEL ON CFrP COMPOSITE LAMINATES USING rAYLEIGH PrOBE WAVES

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Acta Mechanica Solida Sinica 2008年第4期21卷 298-307页

作者： Je-Woong park Do-Jung Kim Kwang-Hee Im Sang-Kyu park david K.Hsu Adam H.Kite Sun-Kyu Kim Kil-Sung Lee In-Young Yang Dept.of Naval Architecture and Ocean Eng. Chosun UniversityKwangju 501-759Korea Dept.of Automotive Eng. Woosuk UniversitySamrae-upWanju-kunChonbuk565-701Korea Center for Nondestructive Evaluation Iowa State UniversityAmesIowa 50011USA Division of Precision Mec.Eng. Chonbuk National UniversityJeonju 561-756Korea School of Mechanical Engineering Chosun UniversityKwangju 501-759Korea

It was found that a pitch-catch signal was more sensitive than normal incidence backwall echo of longitudinal wave to subtle flaw conditions in the composites （damages, fiber orientation, low level porosity, ply waviness, and cracks）. Both the strength and stiffness depend on the fiber orientation and porosity volume in the composites. The porosity content of a composite structure is critical to the strength and performance of the structure in general. The depth of the sampling volume where the pitch-catch signal came from was relatively shallow with the head- to-head miniature rayleigh probes, but the depth can be increased by increasing the separation distance of the transmitting and receiving probes. Also, a method was utilized to determine the porosity content of a composite lay-up by processing micrograph images of the laminate. A free software package was utilized to process micrograph images of the test sample. The results from the image processing method were compared with existing data. Beam profile was characterized in unidirectional CFrP（carbon fiber reinforced plastics） using pitch-catch rayleigh probes and the one-sided pitch-catch technique was utilized to produce C-scan images with the aid of the automatic scanner.

关键词： ply-layup orientation unidirectional CFrP beam profile pitch-catch contact mode,porosity level

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Coronary Artery Chronic Total Occlusion

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Cardiovascular Innovations and Applications 2016年第B5期1卷 325-335页

作者： Calvin Choi Nayan Agarwal Ki park.r.david Anderson Division of Cardiovascular Medicine University of Florida1600 SW Archer RoadGainesvilleFL 32610-0277USA

Coronary artery chronic total occlusion(CTO)is defi ned as an occluded coronary artery segment without anterograde fl ow for at least three *** can be classified as a“true”or“functional”CTO based on flow ***“true”CTO,there is no anterograde ***“functional”CTO,there is minimal anterograde flow through the occluded segment of the coronary *** is a common fi nding during coronary angiography and its prevalence may vary depending on the reported *** patients without previous coronary artery bypass grafting(CABG),CTO is found in about 20–30% of the *** may develop insidiously over a period of time and involve a complex interplay between intracellular and extracellular factors,smooth muscle and foam cells,calcifi cation,and *** is a growing body of evidence to support that CTO revascularization may improve clinical outcome when compared to medical *** the European and American cardiovascular societies support CTO revascularization with a class 2a recommendation(level of evidence B).Historically,due to low procedural success rate,apparent ineffi cient resource utilization,potential increase in complication rates and uncertain clinical benefi ts,only about 10–20%of patients with CTO are treated with percutaneous coronary intervention(PCI).recent advances using novel and innovative techniques with dedicated equipment have signifi cantly improved the procedural success rate for CTO PCI to about 90%in the hands of experienced *** increasing interest in CTO PCI coupled with increased educational effort,CTO PCI likely will become more accessible to patients in need of CTO *** advancement in innovative techniques and equipment will continue to improve procedural success rates and reduce procedural complication rate for CTO ***,there are a number of prospective clinical trials on the horizon which should help defi ne the clinical benefi ts and limitat

关键词： coronary artery disease chronic total occlusion percutaneous coronary intervention

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Is quantum capacitance in graphene a potential hurdle for device scaling？

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Nano research 2014年第4期7卷 453-461页

作者： Jaeho Lee Hyun-Jong Chung david H. Seo Jaehong Lee Hyungcheol Shin Sunae Seo Seongjun park Sungwoo Hwang Kinam Kim Samsung Advanced Institute of Technology Samsung Electronics Yongin-Si Gyeonggi-Do 446-712 Korea Inter-University Semiconductor research Center (ISrC) School of Electrical Engineering and Computer Science Seoul National University Seoul 151-742 Korea Division of Quantum Phases and Devices Department of Physics Konkuk University Seou1143-701 Korea Semiconductor r&D Center Somsung Electronics Hwasung-City Gyeonggi-Do 446-711 Korea Department of Physics Sejong University Seou1143-74 7 Korea Memory Division Samsung Electronics Hwasung-City Gyeonggi-Do 446-711 Korea

Transistor size is constantly being reduced to improve performance as well as power consumption. For the channel length to be reduced, the corresponding gate dielectric thickness should also be reduced. Unfortunately, graphene devices are more complicated due to an extra capacitance called quantum capacitance （CQ） which limits the effective gate dielectric reduction. In this work, we analyzed the effect of CQ on device-scaling issues by extracting it from scaling of the channel length of devices. In contrast to previous reports for metal-insulator- metal structures, a practical device structure was used in conjunction with direct radio-frequency field-effect transistor measurements to describe the graphene channels. In order to precisely extract device parameters, we reassessed the equivalent circuit, and concluded that the on-state model should in fact be used. By careful consideration of the underlap region, our device modeling was shown to be in good agreement with the experimental data. CQ contributions to equivalent oxide thickness were analyzed in detail for varying impurity concentrations in graphene. Finally, we were able to demonstrate that despite contributions from CQ, graphene＇s high mobility and low-voltage operation allows for ~raphene channels suitable for next generation transistors.

关键词： graphene equivalent circuit quantum capacitance intrinsic delay

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