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疯狂英语（口语版） 2009年第4期 52-52,55页

作者： david park

Case Study of Middle East Respiratory Syndrome (MERS-CoV) Outbreak in South Korea and Future Implications

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Advances in Infectious Diseases 2020年第2期10卷 76-89页

作者： Woo Hyung Lee david Ahn Kunmin Kim Peter S. park Seog In Moon Hark Joon Lee david park Hyun Seung Shin Eunice Kang Daniel Choo david S. Chung Biotechnology School of Science Hong Kong University of Science of Technology Hong Kong China Department of Economics William & Mary Williamsburg VA USA Department of Chemistry and Biochemistry University of California San Diego CA USA Department of Biology College of Art and Science Biology Cornell University Ithaca NY USA Department of Biology Amherst College Amherst MA USA Department of Biology Washington University St. Louis MO USA College of Art and Science Biology Emory University Atlanta GA USA Division of Biomedical Informatics University of Virginia Charlottesville VA USA Youth with Talents Fairfax VA USA School of Medicine University of Virginia Charlottesville VA USA

The Middle East Respiratory Syndrome (MERS-CoV) is a potentially fatal respiratory viral infection that has had outbreaks in the Middle East and Asia region starting in 2012. As recent as 2015, MERS had outbreaks in South Korea, resulting in 36 deaths among 186 infected patients. The purpose of this thesis is to gain an in-depth understanding of how this viral infection behaves in outbreaks and how it is spread around the globe. To gain insight, real time analysis was performed under a case study methodology based on pooled data from the Ministry of Health & Welfare of South Korea. We calculated a striated mortality rate based on gender, age, and the presence of pre-existing health conditions ranging from heart, lung, and kidney diseases. We found that MERS outbreak follows the pattern of a point source outbreak, largely spurred by the patient-referral system under the universal healthcare system in South Korea. The purpose of this case is to discuss the benefits and challenges of such patient referral system, and to offer a possible solution in improving transparency between healthcare providers and the government under a universal healthcare system to prevent future outbreaks.

关键词： Infectious Diseases Respiratory Viral Infections Public Health Disease Prevention

Human Rights and Social Stigma Review for Leprosy Patients in Korea

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Advances in Infectious Diseases 2021年第1期11卷 73-83页

作者： Seungshin Lee david Ahn Justin Kim Cathy park Kunmin Kim Alice Kim Chae Eun Kim Jisu Shin Timothy Cho Jonathan Jo david park Tae Youn Kim Paul S. Chung School of Medicine University of California Irvine CA USA Youth with Talents Fairfax VA USA Fuzbien Technology Institute Rockville MD USA

Leprosy is a chronic disease caused by a low multiplying bacillus, Mycobacterium leprae, which primarily affects the skin and the extremities. Multidrug therapy (MDT) and Bacillus Calmette-Guérin (BCG) vaccinations are effective at treatment of the disease, but social misconceptions about the disease inhibit efficient health care for affected individuals. In South Korea, leprosy patients face social, economic, and political discrimination. Korean leprosy patients are isolated into Sorokdo island and face challenges such as difficulty receiving education and limited job opportunities. Leprosy cognitively, emotionally, and socially impacts patients’ lives, and represents a serious social inequality issue. To raise awareness, dispel myths about the disease, and to end patient discrimination that destroys families, we conducted case studies based on scientific journals. The paper specifically focuses on difficulties faced by Korean leprosy patients, and subsequent initiatives by the government to aid patients. To reach the WHO’s target of health and wellbeing for all by 2030, we need to educate the masses about leprosy and address relevant social inequality issues.

关键词： Leprosy Sorokdo

Microscopic colitis: A review of etiology, treatment and refractory disease

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World Journal of Gastroenterology 2015年第29期21卷 8804-8810页

作者： Tina park david Cave Christopher Marshall Department of Medicine Division of Gastroenterology University of Massachusetts Worcester

Microscopic colitis is a common cause of chronic,nonbloody diarrhea. Microscopic colitis is more common in women than men and usually affects patients in their sixth and seventh decade. This article reviews the etiology and medical management of microscopic colitis. The etiology of microscopic colitis is unknown, but it is associated with autoimmune disorders, such as celiac disease, polyarthritis, and thyroid disorders. Smoking has been identified as a risk factor of mi-croscopic colitis. Exposure to medications, such as non-steroidal anti-inflammatory drugs, proton pump inhibitors, and selective serotonin reuptake inhibitors, is suspected to play a role in microscopic colitis, although their direct causal relationship has not been proven. Multiple medications, including corticosteroids, anti-diarrheals, cholestyramine, bismuth, 5-aminosalicylates, and immunomodulators, have been used to treat microscopic colitis with variable response rates. Budesonide is effective in inducing and maintaining clinical remission but relapse rate is as high as 82% when budesonide is discontinued. There is limited data on management of steroid-dependent microscopic colitis or refractory microscopic colitis. Immunomodulators seem to have low response rate 0%-56% for patients with refractory microscopic colitis. Response rate 66%-100% was observed for use of anti-tumor necrosis factor(TNF) therapy for refractory microscopic colitis. Anti-TNF and diverting ileostomy may be an option in severe or refractory microscopic colitis.

关键词： Chronic diarrhea Etiology of microscopiccolitis Collagenous colitis Refractory microscopiccolitis Microscopic colitis Lymphocytic colitis Steroiddependentmicroscopic colitis

Breaking out from the neuroprotective logjam:combined treatment with remote ischemic conditioning and minocycline in the prehospital setting

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Neural Regeneration Research 2015年第4期10卷 537-539页

作者： Jung Mi park david C.Hess Departments of Neurology Georgia Regent’s University

The only two treatments effective for acute ischemic stroke are reperfusion therapies. Despite testing of hundreds of neuroprotective agents and treatments, tissue plasminogen activator （tPA）, approved by the Food and Drug Administration （FDA） in 1996, remains the only FDA-approved drug for the treatment of ischemic stroke. Recently,

关键词： Breaking out from the neuroprotective logjam RIC

A Lookahead Read Cache： Improving Read Performance for Deduplication Backup Storage

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Journal of Computer Science & Technology 2017年第1期32卷 26-40页

作者： Dongchul park Ziqi Fan Young Jin Nam david H. C. Du Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis MN 55455 U.S.A.

Data deduplication （dedupe for short） is a special data compression technique. It has been widely adopted to save backup time as well as storage space, particularly in backup storage systems. Therefore, most dedupe research has primarily focused on improving dedupe write performance. However, backup storage dedupe read performance is also a crucial problem for storage recovery. This paper designs a new dedupe storage read cache for backup applications that improves read performance by exploiting a special characteristic： the read sequence is the same as the write sequence. Consequently, for better cache utilization, by looking ahead for future references within a moving window, it evicts victims from the cache having the smallest future access. Moreover~ to further improve read cache performance. it maintains a small log buffer to judiciously cache future access data chunks. Extensive experiments with real-world backup workloads demonstrate that the proposed read cache scheme improves read performance by up to 64.3%

关键词： deduplication dedupe read cache backup

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

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Microsystems & Nanoengineering 2017年第1期3卷 11-19页

作者： Jeong Oen Lee Haeri park Juan Du Ashwin Balakrishna Oliver Chen david Sretavan Hyuck Choo Department of Medical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Electrical Engineering California Institute of TechnologyPasadenaCA 91106USA Department of Ophthalmology University of California San FranciscoSan FranciscoCA 94143USA Department of Physiology University of California San FranciscoSan FranciscoCA 94143USA

Intraocular pressure(IOP)is a key clinical parameter in glaucoma ***,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a *** we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home *** excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to *** light is minimally absorbed by tissue and is not perceived *** sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm *** were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white *** sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

关键词： glaucoma intraocular pressure(IOP) microscale sensor implant in vivo continuous monitoring remote optical readout near-infrared(NIR)broadband light minimally invasive

Highly stable integration of graphene Hall sensors on a microfluidic platform for magnetic sensing in whole blood

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Microsystems & Nanoengineering 2023年第3期9卷 115-127页

作者： Nishal Shah Vasant Iyer Zhiping Zhang Zhaoli Gao Juhwan park Venkata Yelleswarapu Firooz Aflatouni A.T.Charlie Johnson david Issadore Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Biomedical Engineering Chinese University of Hong KongShatinHong Kong Department of Physics and Astronomy University of PennsylvaniaPhiladelphiaPA 19104USA Department of Chemical and Biomolecular University of PennsylvaniaPhiladelphiaPA 19104USA

The detection and analysis of rare cells in complex media such as blood is increasingly important in biomedical research and clinical ***-Hall detectors(μHD)for magnetic detection in blood have previously demonstrated ultrahigh sensitivity to rare *** sensitivity originates from the minimal magnetic background in blood,obviating cumbersome and detrimental sample ***,the translation of this technology to clinical applications has been limited by inherently low throughput(<1 mL/h),susceptibility to clogging,and incompatibility with commercial CMOS foundry *** help overcome these challenges,we have developed CMOS-compatible graphene Hall sensors for integration with PDMS microfluidics for magnetic sensing in *** demonstrate that these grapheneμHDs can match the performance of the best publishedμHDs,can be passivated for robust use with whole blood,and can be integrated with microfluidics and sensing electronics for in-flow detection of magnetic *** show a proof-of-concept validation of our system on a silicon substrate and detect magnetic agarose beads,as a model for cells,demonstrating promise for future integration in clinical applications with a custom CMOS chip.

关键词： integration magnetic fluid

Ultrasonic Approach of Rayleigh Pitch-Catch Contact Ultrasound Waves on CFRP Laminated Composites

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Journal of Materials Science & Technology 2008年第3期24卷 407-409页

作者： In-Young Yang Kwang-Hee Im Uk Heo david K Hsu Je-Woong park Hak-Joon Kim Sung-Jin Song School of Mechanical Eng. Chosun Univ Department of Automotive Eng. Woosuk Univers-ity Center for Nondestructive Evaluation Iowa State University Dept.of Naval Arch.and Ocean Eng. Chosun Univ School of Mechanical Eng. Sungkyunkwan University

CFRP （carbon fiber reinforced plastics） composite materials have wide applicability because of their inherent design flexibility and improved material properties. However, impacted composite structures have 50%-75% less strength than undamaged structures. In this work, a CFRP composite material was nondestructively characterized in order to ensure product quality and structural integrity of CFRP and one-sided pitch-catch technique was developed to measure impacted-damaged area by using an automated-data acquisition system in an immersion tank. A pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave under defect conditions in the composite.

关键词： Impact damages C-scanner Carbon fiber reinforced plastics (CFRP) Pitchcatch mode

ULTRASONIC INFLUENCE OF POROSITY LEVEL ON CFRP COMPOSITE LAMINATES USING RAYLEIGH PROBE WAVES

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Acta Mechanica Solida Sinica 2008年第4期21卷 298-307页

作者： Je-Woong park Do-Jung Kim Kwang-Hee Im Sang-Kyu park david K.Hsu Adam H.Kite Sun-Kyu Kim Kil-Sung Lee In-Young Yang Dept.of Naval Architecture and Ocean Eng. Chosun UniversityKwangju 501-759Korea Dept.of Automotive Eng. Woosuk UniversitySamrae-upWanju-kunChonbuk565-701Korea Center for Nondestructive Evaluation Iowa State UniversityAmesIowa 50011USA Division of Precision Mec.Eng. Chonbuk National UniversityJeonju 561-756Korea School of Mechanical Engineering Chosun UniversityKwangju 501-759Korea

It was found that a pitch-catch signal was more sensitive than normal incidence backwall echo of longitudinal wave to subtle flaw conditions in the composites （damages, fiber orientation, low level porosity, ply waviness, and cracks）. Both the strength and stiffness depend on the fiber orientation and porosity volume in the composites. The porosity content of a composite structure is critical to the strength and performance of the structure in general. The depth of the sampling volume where the pitch-catch signal came from was relatively shallow with the head- to-head miniature Rayleigh probes, but the depth can be increased by increasing the separation distance of the transmitting and receiving probes. Also, a method was utilized to determine the porosity content of a composite lay-up by processing micrograph images of the laminate. A free software package was utilized to process micrograph images of the test sample. The results from the image processing method were compared with existing data. Beam profile was characterized in unidirectional CFRP（carbon fiber reinforced plastics） using pitch-catch Rayleigh probes and the one-sided pitch-catch technique was utilized to produce C-scan images with the aid of the automatic scanner.

关键词： ply-layup orientation unidirectional CFRP beam profile pitch-catch contact mode,porosity level