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Using multilayer network analysis to explore the temporal dynamics of collective behavior

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Current Zoology 2021年第1期67卷 71-80页

作者： david n.fisher noa PInTER-WOLLMAn Department of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonON L8S 4K1Canada School of Biological Sciences University of AberdeenAberdeenAB243FXUK Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCAUSA

Social organisms often show collective behaviors such as group foraging or *** behaviors can emerge from interactions between group members and may depend on the behavior of key *** social interactions change over time,collective behaviors may change because these behaviors emerge from interactions among *** the importance of,and growing interest in,the temporal dynamics of social interactions,it is not clear how to quantify changes in interactions over time or measure their ***,the temporal scale at which we should observe changes in social networks to detect biologically meaningful changes is not always *** we use multilayer network analysis to quantify temporal dynamics of social networks of the social spider Stegodyphus dumicola and determine how these dynamics relate to individual and group *** found that social interactions changed over time at a constant *** in both network structure and the identity of a keystone individual was not related to the mean or variance of the collective prey attack *** that maintained a large and stable number of connections,despite changes in network structure,were the boldest individuals in the ***,social interactions and boldness are linked across time,but group collective behavior is not influenced by the stability of the social *** work demonstrates that dynamic social networks can be modeled in a multilayer *** approach may reveal biologically important temporal changes to social structure in other systems.

关键词： collective behavior dynamic network multilayer network multiplex social stability Stegodyphus

Multilayer network analysis:new opportunities and challenges for studying animal social systems

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Current Zoology 2021年第1期67卷 45-48页

作者： Matthew J.HASEnJAGER Matthew SILk david n.fisher Department of Biological Sciences Royal HollowayUniversity of LondonEghamUK Centre for Ecology and Conservation University of ExeterExeterUK School of Biological Sciences University of AberdeenAberdeenUK

Introduction Many behavioral,ecological,and evolutionary processes are closely intertwined with patterns of social interactions,such as the evolution of cooperation(Croft et al.2006),information and disease transmission(VanderWaal et al.2014;Aplin et al.2015),predator-prey dynamics(Ioannou et al.2012),and dispersal decisions(Blumstein et al.2009).Even in species where individuals are traditionally viewed as leading a relatively solitary existence,interac-tions occur across diverse contexts,including territorial defense,resource competition,and courtship.

关键词： solitary predator network

Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison n.DeVore Marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Are claudin-5 tight-junction proteins in the blood-brain barrier porous?

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neural Regeneration Research 2020年第10期15卷 1838-1839页

作者： david fisher Shireen Mentor Department of Medical Biosciences University of the Western CapeBellvilleCape TownSouth Africa School of Health Professions University of MissouriColumbiaMOUSA

The capillaries of the brain are particularly special,as they are not simply conduits for blood,but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic *** endothelial cells(BECs)express a plethora of ion channels on its luminal and abluminal surfaces,namely:potassium(K^+)channels(i.e.,Kir2 and Kv1),chloride(Cl^)/bicarbonate(HCO3^–)channels,as well as a number of ion-solute exchangers(Redzic et al.,2011).

关键词： porous potassium solute

Multi-Material ALE with AMR for Modeling Hot Plasmas and Cold Fragmenting Materials

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Plasma Science and Technology 2015年第2期17卷 117-128页

作者： Alice KOnIGES nathan MASTERS Aaron.fisher david EDER Wangyi LIU Robert AnDERSOn david BEnSOn Andrea BERTOZZI Lawrence Berkeley national Laboratory Lawrence Livermore national Laboratory Jacobs School of Engineering 9500 Gilman Dr.UCSDLa JollaCA 92093USA Department of Mathematics 520 Portola PlazaUCLALos AngelesCA 90095USA

We have developed a new 3D multi-physics multi-material code, ALE-AMR, which combines Arbitrary Lagrangian Eulerian （ALE） hydrodynamics with Adaptive Mesh Refinement （AMR） to connect the continuum to the microstructural regimes. The code is unique in its ability to model hot radiating plasmas and cold fragmenting solids. new numerical techniques were developed for many of the physics packages to work efficiently on a dynamically moving and adapting mesh. We use interface reconstruction based on volume fractions of the material components within mixed zones and reconstruct interfaces as needed. This interface reconstruction model is also used for void coalescence and fragmentation. A flexible strength/failure framework allows for pluggable material models, which may require material history arrays to determine the level of accumulated damage or the evolving yield stress in J2 plasticity models. For some applications laser rays are propagating through a virtual composite mesh consisting of the finest resolution representation of the modeled space. A new 2nd order accurate diffusion solver has been implemented for the thermal conduction and radiation transport packages. One application area is the modeling of laser/target effects including debris/shrapnel generation. Other application areas include warm dense matter, EUV lithography, and material wall interactions for fusion devices.

关键词： multi-physics simulations arbitrary lagrangian eulerian hydrodynamics,adaptive mesh refinement fragmentation laser ray tracing nIF

A methodological framework for improving air quality monitoring network *** to environment management

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Journal of Environmental Sciences 2021年第4期33卷 138-147页

作者： david Galán-Madruga Department of Atmospheric Pollution National Center for Environment HealthHealth Institute Carlos IIICtra.Majadahonda a Pozuelo km 2228220 MadridSpain

This work aims to provide a methodology framework which allows to improve the performance and efficiency of an air quality monitoring network(AQMn).It requires to be constituted by a minimum and reliable number of measurement ***,the AQMn efficiency should be assessed over time,as a consequence of the possible emergence of new emission sources of air pollutants,which could lead to variations on their spatial distribution within the target ***_(10)particles data monitored by the Community of Madrid's(Spain)AQMn between 2008 and 2017 were used to develop a methodology to optimize the AQMn *** annual spatial distribution of average PM_(10)levels over the studied period monitored by all current stations vs those more representative was provided by a geographic information system(GIS),and the percentage of similarity between both postulates was quantified using simple linear regression(>95%).As one innovative tool of this study,the practical application of the proposed methodology was validated using PM_(10)particles data measured by AQMn during 2007 and 2018,reaching a similitude degree higher than 95%.The influence of temporal variation on the proposed methodological framework was around 20%.The proposed methodology sets criteria for identifying non-redundant stations within AQMn,it is also able to appropriately assess the representativeness of fixed monitoring sites within an AQMn and it complements the guidelines set by European legislation on air pollutants monitoring at fixed stations,which could help to tackle efforts to improve the air quality management.

关键词： Air quality Ambient air monitoring network PM_(10)particles Redundant stations Optimization Environment management

Manipulation of the intestinal microbiome-a slow journey to primetime

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World Journal of Clinical Cases 2023年第21期11卷 4975-4988页

作者： Ofra Kriger-Sharabi Stephen D H Malnick david fisher Institute of Gastroenterology Assuta Medical CenterAshdod 7747629Israel Department of Internal Medicine Kaplan Medical CenterRehovot 76100Israel Department of Endocrinology Soroka Medical CenterBeer Sheva POB 151Israel

The gut microbiota has important functions in the regulation of normal body *** of the microbiota are being increasingly linked to various disease *** microbiome has been manipulated via the administration of stool from animals or humans,for more than 1000 ***,fecal microbiota transplantation can be performed via endoscopic administration of fecal matter to the duodenum or colon or via capsules of lyophilized *** recently fecal microbial transplantation has been shown to be very effective for recurrent Clostridoides difficile infection(CDI).In addition there is some evidence of efficacy in the metabolic syndrome and its hepatic manifestation,metabolic associated fatty liver disease(MAFLD),irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).We review the current literature regarding the microbiome and the pathogenesis and treatment of CDI,MAFLD,IBS and IBD.

关键词： Gut microbiota Fecal microbiota transplantation Clostridoides difficile Metabolic associated fatty liver disease Irritable bowel syndrome Inflammatory bowel disease