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Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun Wei Qiong-Yao Xu Zhao-Wen Pan Yi-Wei Tu Wei Yu Lan huang Wen-Liang Zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the david ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

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High-performance size exclusion chromatography with a multi-wavelength absorbance detector study on dissolved organic matter characterisation along a water distribution system

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Journal of Environmental Sciences 2016年第6期28卷 235-243页

作者： Huiping huang Emma Sawade david Cook Christopher W.K.Chow Mary Drikas Bo Jin School of Chemical Engineering The University of Adelaide Australian Water Quality Centre SA Water Corporation250 Victoria Square School of Earth and Environmental Sciences The University of Adelaide

This study examined the associations between dissolved organic matter（DOM） characteristics and potential nitrification occurrence in the presence of chloramine along a drinking water distribution system. High-performance size exclusion chromatography（HPSEC） coupled with a multiple wavelength detector（200–280 nm） was employed to characterise DOM by molecular weight distribution, bacterial activity was analysed using flow cytometry, and a package of simple analytical tools, such as dissolved organic carbon, absorbance at 254 nm, nitrate,nitrite, ammonia and total disinfectant residual were also applied and their applicability to indicate water quality changes in distribution systems were also evaluated. Results showed that multi-wavelength HPSEC analysis was useful to provide information about DOM character while changes in molecule weight profiles at wavelengths less than 230 nm were also able to be related to other water quality parameters. Correct selection of the UV wavelengths can be an important factor for providing appropriate indicators associated with different DOM compositions. DOM molecular weight in the range of 0.2–0.5 kDa measured at210 nm correlated positively with oxidised nitrogen concentration（r = 0.99）, and the concentrations of active bacterial cells in the distribution system（r = 0.85）. Our study also showed that the changes of DOM character and bacterial cells were significant in those sampling points that had decreases in total disinfectant residual. HPSEC-UV measured at210 nm and flow cytometry can detect the changes of low molecular weight of DOM and bacterial levels, respectively, when nitrification occurred within the chloraminated distribution system.

关键词： HPSEC-UV Distribution system DOM Sum of nitrate and nitrite concentration

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Shifts in community leaf functional traits are related to litter decomposition along a secondary forest succession series in subtropical China

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Journal of Plant Ecology 2015年第4期8卷 401-410页

作者： david Eichenberg Stefan Trogisch Yuanyuan huang Jin-Sheng Heand Helge Bruelheide Department for Geobotany Institute of Biology/Geobotany and Botanical GardenMartin-Luther-University Halle-WittenbergAm Kirchtor 1Halle(Saale)D-06108Germany German Centre for Integrative Biodiversity Research(iDiv) Halle-Jena-LeipzigDeutscher Platz 5eLeipzig D-04103Germany Department of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University5 Yiheyuan RoadBeijing 100871China

Aims We investigated shifts in community-weighted mean traits(CWm)of 14 leaf functional traits along a secondary successional series in an evergreen broadleaf forest in subtropical southeast *** of the investigated traits have been reported to affect litter decomposition in previous *** asked whether changes in CWms along secondary succession followed similar patterns for all investigated traits and whether the shifts in CWm indicated a change in resource use strategy along the successional *** community decomposition rates(k-rates)estimated from annual lit-ter production and standing litter biomass,we asked whether the dynamics of litter decomposition were related to changes in leaf functional traits along the successional *** twenty-seven plots were examined for shifts in leaf CWm traits as well as in k-rates along a series of secondary forest succession cov-ered in the framework of the bEF-China *** investigated whether the changes in CWms followed similar patterns for all traits with ongoing *** alternative linear models were used to reveal the general patterns of shifts in CWm trait ***,multiple regression analysis was applied to investigate whether there were causal relationships between the changes in leaf functional traits and the dynamics of litter decomposition along secondary *** furthermore assessed which traits had the highest impact on community litter *** Findingsshifts in CWm values generally followed logarithmic patterns for all investigated traits,whereas community k-rates remained stable along the successional *** summary,the shifts in CWm values indicate a change in community resource use strategy from high nutrient acquisition to nutrient retention with ongoing *** with higher CWm values of traits related to nutrient acquisition had also higher CWm values of traits related to chemical resistance,whereas stands with higher CWm v

关键词： secondary forest succession bEF-China nutrient cycling plant polyphenols multiple regression analysis

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A synthetic biological secondary metabolite,Lycogen^TM,produced and extracted from Rhodobacter sphaeroides WL-APD911 in an optimizatioal scale-up strategy

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Food Science and Human Wellness 2017年第4期6卷 195-201页

作者： Cheng-Chin Wang Shi-Ying huang Shu-Hung huang Zhi-Hong Wen Jyun-Ying huang Wen-Sheng Liu Hui-Min david Wang Research and Development Department Chia-Yi SteelTainan 717TaiwanChina College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhou 362000China Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae Quanzhou 362000China Division of Plastic Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807TaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 807TaiwanChina Center for Stem Cell Research Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung 807TaiwanChina Orthopaedic Research Center Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University and Academia SinicaKaohsiung 804TaiwanChina Marine Biomedical Laboratory and Center for Translational Biopharmaceuticals Department of Marine Biotechnology and ResourcesNational Sun Yat-sen UniversityKaohsiung 804TaiwanChina Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 402TaiwanChina Department and Graduate Institute of Aquaculture National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Asia-Pacific Biotech Developing Inc.Kaohsiung 803TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 404TaiwanChina

The optimization of fermentation medium is important for synthetic biological secondary metabolite *** effect of rotation speed,inoculum amount,and medium supplements on the cell growth and Lycogen^TM secretion of photobacterium Rhodobacter sphaeroides WL-APD911 was *** results reveal that a higher rotational speed exhibit a higher cell density,and the increasing in the amount of inoculum amount show a slight augment on the growth of *** *** the case of nitrogen sources adding,Lycogen^TM production was achieved with a 0.5 mM l-lysine ***,the attention of Tween 80 presented a tremendous increase in the secondary *** surface methodology(RSM)exhibited the optimization of medium supplements for Lycogen^TM invention is accomplished at molasses concentration of 10 g/L,yeast extract concentration of 40 g/L,0.3%Tween 80 and NaCl concentration of 5 g/L,***,the batch fermentation is carried out in both 5 L and 20 L fermentors to study the scale-up process factors to be *** a 20 L fermentor,Lycogen^TM yields under the optimal culture condition are over 2 times than in the shake *** present results provide the Lycogen^TM optimal culture mediums,scale-up procedures and efficient extractions from *** WL-APD911.

关键词： Rhodobacter sphaeroides WL-APD911 Lycogen^TM Response surface methodology(RSM) Ferementation

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Enhanced stabilization of inorganic cesium lead triiodide （CsPbl3） perovskite quantum dots with tri-octylphosphine

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Nano Research 2018年第2期11卷 762-768页

作者： Lu, Chang Li, Hui Kolodziejski, Kathy Dun, Chaochao huang, Wenxiao Carroll, david Geyer, Scott M. Department of Chemistry Wake Forest University Winston-Salem USA Center for Nanotechnology and Molecular Materials Department of Physics Wake Forest University Winston-Salem USA

In recent years, significant attention has been paid to perovskite materials. In particular, lead triiodide-based perovskites have exhibited superb optoelectronic properties. Enhancing the stability of these materials is an essential step towards large-scale applications. In this stud） by simply adding trioctylphosphine （TOP） as part of the post-synthesis treatment, we significantly enhance the stability of CsPbI3 quantum dots （QDs） in the solution phase, which otherwise decay rapidly in hours. For CsPbI3 QDs treated with TOP, the absorption and photoluminescence emission properties are unchanged over the course of weeks, and the quantum yield remains almost constant at 30% even after 1 month. The morphologies of both treated and untreated QDs are initially cubic; however, the treated QDs largely maintain their initial size and shape, while the untreated ones lose size uniformity, which is a sign of degradation. Infrared spectroscopy and X-ray photoelectron spectroscopy confirm the presence of P in the TOP-treated QDs. We hope that the technique of utilizing a ligand post-treatment will lead to new insights that help to resolve the intrinsic instability issue of triiodide perovskite materials and devices.

关键词： perovskite quantum dots ligand chemistry phase stabilization

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A Novel Design Framework for Smart Operating Robot in Power System

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IEEE/CAA Journal of Automatica Sinica 2018年第2期5卷 531-538页

作者： Qiang Wang Xiaojing Yang Zhigang huang Shiqian Ma Qiao Li david Wenzhong Gao Fei-Yue Wang State Grid Tianjin Electric Power Company Tianjin 300010 China State Grid Tianjin Electric Power Research Institute Tianjin 300384 China University of Denver Denver Colorado 80210 USA Institute of Automation Chinese Academy of Sciences Beijing 100190 China IEEE

This paper proposes the concept and framework of smart operating system based on the artificial intelligence(AI)techniques. The demands and the potential applications of AI technologies in power system control centers is discussed in the beginning of the paper. The discussion is based on the results of a field study in the Tianjin Power System Control Center in China. According to the study, one problem in power systems is that the power system analysis system in the control center is not fast and powerful enough to help the operators in time to deal with the incidents in the power system. Another issue in current power system control center is that the operation tickets are compiled manually by the operators, so that it is less efficient and human errors cannot be avoided. Based on these problems, a framework of the smart operating robot is proposed in this paper, which includes an intelligent power system analysis system and a smart operation ticket compiling system to solve the two problems in power system control centers. The proposed framework is mainly based on the AI techniques, especially the neural network with deep learning, since it is faster and more capable of dealing with the highly nonlinear and complex power system.

关键词： Index Terms-Artificial intelligence deep learning human-in-the-loop power system control center power system operatingrobot machine learning.

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Nucleotide coordination with 14 lanthanides studied by isothermal titration calorimetry

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Chinese Chemical Letters 2018年第1期29卷 151-156页

作者： zijie zhang kiyoshi morishital wei ting david lin po-jung jimmy huang juewen liu department of chemistry waterloo institute for nanotechnology university of waterlooWaterloo N213G1 Canada

With their hydrolytic, optical and magnetic properties, nucleic acids, In addition, nucleotide-coordinated LnTM anthanide ions （Ln3＋） are versatile probes for ons form useful oanoparticles. However, the thermodynamic basis of their interaction is still lacking. In this work, isothermal titration calorimetry （ITC） is used to study the binding between nuc]eotides and 14 different Ln3＋ ions. Ln3＋ interacts mainly with the phosphate of cytidine and thymidine monophosphate （CMP and TMP）, while the nucleobases in adenosine and guanosine monophosphate （AMP and GMP） are also involved. Phosphate binding is fully entropy driven since the reactions absorb heat. Nucleosides alone do not bind Ln3＋ and the purines need the phosphate for chelation. With increasing atomic number of Ln3＋, tile binding reaction with GMP goes from exothermic to endothermic. The entropy contribution starts to increase from Gd3＋, explaining the ＇gadolinium break＇ observed in many Ln3＋-mediated RNA cleavage reactions. This study provides fundamental insights into the Ln3＋/nucleotide interactions, and it is useful for understanding related biosensors, nanomaterials, catalysts, and for lanthanide separation.

关键词： DNANucleic acidsMetal ionsLanthanidesEntropy

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Fatigue crack propagation behavior of Ni-based superalloys after overloading at elevated temperatures

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Progress in Natural Science:Materials International 2016年第2期26卷 197-203页

作者： Xinyue huang Liang Wang Yunming Hu Guangping Guo david Salmon Ying Li Wenxia Zhao National Key Laboratory of Science and Technology on Advanced High Temperature Structural Materials Beijing Institute of Aeronautical Materials MTS Systems Corporation Eden Prairie 3. Beijing Key Laboratory of Aeronautical Materials Testing and Evaluation Beijing Institute of Aeronautical Materials

The fatigue crack propagation behavior of three superalloys subjected to a single overloading at elevated temperatures was investigated. The fatigue crack propagation rate FCPR versus stress intensity factor range data da/dN—ΔK were calculated using the two-point secant method. It was found that the crack growth rates of the investigated materials were retarded after overloading with an overload ratio R OL=1.6. The size of the plastic zone in the front of the crack tip and its relation to loading level were discussed. The overload retardation effects are attributed to crack closure. The fatigue damage in the plastic zone can also be a factor to explain the overload retardation.

关键词： High temperature fatigue Fatigue crack propagation rate Overloading Crack closure Superalloys

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东北亚地缘安全环境新变化与中国的应对

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吉林大学社会科学学报 2024年第4期64卷 99-113,237页

作者：黄凤志刘勃然吉林外国语大学国际关系学院长春130000 蒙古国科学院国际研究所乌兰巴托13330

当前,中国东北亚政治环境复杂严峻,美日韩与朝鲜间的地缘政治博弈依旧,又叠加了美国对华全面战略竞争,其主要特点是持续对华进行极限施压阻遏中国发展,东北亚地区成为美国塑造中国和平发展的地缘政治环境的前沿。美国对华全面战略竞争... 详细信息

当前,中国东北亚政治环境复杂严峻,美日韩与朝鲜间的地缘政治博弈依旧,又叠加了美国对华全面战略竞争,其主要特点是持续对华进行极限施压阻遏中国发展,东北亚地区成为美国塑造中国和平发展的地缘政治环境的前沿。美国对华全面战略竞争是一套组合拳,需要借力盟国,建构针对中国的地缘政治“地震带”,而日韩采取了随从立场,美日韩战略合作的新动向是《戴维营精神》《戴维营原则》和《协商约定》三份文件的问世,其推动了东北亚地缘政治局势阵营化的趋向,东北亚存在着是建构亚洲版北约,还是发展中日韩合作的悖论。美国对华战略竞争正在建构针对中国的东北亚地缘安全困境,具有剑指中国和平发展的意蕴,严重威胁中国的东北亚地缘安全。东北亚的安全困境有悖于中国追求东北亚地区和平、稳定、繁荣的战略利益诉求,但有利于美国推动美日、美韩同盟关系强化,建构亚洲版北约和阻遏中国崛起的图谋。中国能否破解东北亚安全困境最终取决于国际体系变迁和中国和平发展的前景。鉴于此,我们应把握好中美关系元首外交增信释疑、管控分歧、拓展合作的作用,团结一切爱好和平、主张合作共赢的力量,结成东北亚地区和平发展国际统一战线,适时推动中日韩三国合作。同时,我们要努力增强中国护持和平发展战略的国家实力,奉行以实力求和平的东北亚安全战略,稳定东北亚地缘安全环境,坚定维护中国在东北亚的国家安全利益。

关键词：东北亚地缘政治安全环境中国美国战略竞争

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Reinvigorating the Wiener-Hopf technique in the pursuit of understanding processes and materials

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National Science Review 2021年第2期8卷 11-13页

作者： david Abrahams Xun huang Anastasia Kisil Gennady Mishuris Michael Nieves Sergei Rogosin Ilya Spitkovsky IsaacNewtonInstituteforMathematicalSciences CollegeofEngineering PekingUniversity DepartmentofMathematics UniversityofManchester DepartmentofMathematics AberystwythUniversity SchoolofComputingandMathematics KeeleUniversity FacultyofEconomics BelarusianStateUniversity ScienceandMathematics NewYorkUniversityAbuDhabi

The Wiener-Hopf(WH) method was created in 1931, by Norbert Wiener and Eberhard Hopf, to deliver exact solutions to integral equations with convolutiontype kernels on a half-line. It appears that this problem is closely related to that posed by Riemann in 1857 on the problem concerning the construction of a Fuchsian system of differential equations with given singular points and a prescribed monodromy group. This later became known as the 21 st Hilbert problem. The WH method is a powerful and long-standing tool that served as a catalyst in broadening the applicability of Fourier analysis, owing to the essential characteristics of analytic functions. Employing the Fourier transform(FT) to the integral equation leads to a RiemannHilbert(RH) problem on the real axis:

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