检索结果-南通市图书馆

Complex Molecular Knots and Links

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complex Molecular Knots and Links

A Longer Siesta?DN1s in Control!

全国第十六届大环化学暨第八届超分子化学学术讨论会

作者： Jean-Francois Ayme Jonathon E.Beves david a.leigh Kari Rissanen Roy M.McBumey david Schultz Key State Laboratory for Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing University Department of Chemistry Nanoscience CenterUniversity of Jyvskyl

＜正＞The presence of knots and links in biological systems（proteins and other biopolymers） has been shown to be crucial to their stability and ***,in synthetic systems the entanglements of polymers significantly alters their properties both through mechanical cross linking,and also though strand weakening by the presence of knotted ***,the molecular level challenge to form precise topologies remains unconquered by chemists! Supramolecular strategies lie at the forefront of methods towards this goal,by allowing the templating of crossing points and the means to control the formation of

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第1期33卷 113-114页

作者： Wesley a.leigh Yong Zhang Department of Biology University of NevadaReno1664 NVirginia StRenoNV 89557USA

Sleep is an essential behavior that is conserved in most animal species. Two molecular mechanisms regulate sleep： circadian clocks for the timing of sleep, and a homeostatic process for the amount of sleep [1]. The fruit fly, Drosophila melanogaster, exhibits robust sleep behavior and serves as an excellent model in which to study the neuronal and molecular mechanisms of sleep.

关键词： In A Longer Siesta?DN1s in Control DN

Design of advanced aerogel structures for oxygen reduction reaction electrocatalysis

在线全文

学校读者我要写书评

暂无评论

SusMat 2023年第1期3卷 44-57页

作者： leigh Peles-Strahl Yeela Persky Lior Elbaz Department of Chemistry Bar-Ilan UniversityRamat-GanIsrael Soreq NRC YavneIsrael

Oxygen reduction reaction(ORR)is considered the bottleneck reaction in fuel *** sluggish kinetics requires the use of scarce and expensive platinum group metal(PGM)*** efforts have been invested in trying to find a PGM-free catalyst to replace Pt for this reaction or reduce its *** interesting family of materials that has shown great promise in doing so is aerogels,which are based on covalent *** aerogels’high surface area and porosity enable good mass transport and high catalyst utilization that is expected to lower PGM loadings or replacing them *** review summarizes recent research in this field,introducing methods of using aerogels as cathodes for ORR,from carbon to metal *** catalytic sites vary from nanoparticles to atomically dispersed metal ions embedded in carbon aerogels that form all-in-one platform which can serve as both the support and the catalyst.

关键词： aerogels catalyst supports electrocatalysis fuel cells oxygen reduction reaction

High-throughput calculations of charged point defect properties with semi-local density functional theory— performance benchmarks for materials screening applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 1628-1639页

作者： Danny Broberg Kyle Bystrom Shivani Srivastava Diana Dahliah Benjamin A.D.Williamson leigh Weston david O.Scanlon Gian-Marco Rignanese Shyam Dwaraknath Joel Varley Kristin A.Persson Mark Asta Geoffroy Hautier Materials Sciences Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Physics An-Najah National UniversityNablusPalestine Institute of Condensed Matter and Nanosciences UniversitéCatholique de LouvainChemin desÉtoiles 8B-1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering NTNU Norwegian University of Science and TechnologyTrondheimNorway Energy Technologies Area Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUK Thomas Young Centre University College LondonGower StreetLondon WC1E 6BTUK Diamond Light Source Ltd. Diamond HouseHarwell Science and Innovation CampusDidcotOxfordshire OX110DEUK Lawrence Livermore National Laboratory LivermoreCA 94550USA Molecular Foundry Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Thayer School of Engineering Dartmouth CollegeHanoverNH 03755USA

Calculations of point defect energetics with Density Functional Theory(DFT)can provide valuable insight into several optoelectronic,thermodynamic,and kinetic *** calculations commonly use methods ranging from semi-local functionals with a-posteriori corrections to more computationally intensive hybrid functional *** applications of DFT-based high-throughput computation for data-driven materials discovery,point defect properties are of interest,yet are currently excluded from available materials *** work presents a benchmark analysis of automated,semi-local point defect calculations with a-posteriori corrections,compared to 245“gold standard”hybrid calculations previously *** consider three different a-posteriori correction sets implemented in an automated workflow,and evaluate the qualitative and quantitative differences among four different categories of defect information:thermodynamic transition levels,formation energies,Fermi levels,and dopability *** highlight qualitative information that can be extracted from high-throughput calculations based on semi-local DFT methods,while also demonstrating the limits of quantitative accuracy.

关键词： properties defect correction

Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2023年第4期11卷 772-783页

作者： Zhousheng Xiao Li Cao Micholas Dean Smith Hanxuan Li Wei Li Jeremy C.Smith leigh Darryl Quarles Department of Medicine University of Tennessee Health Science CenterMemphisTN 38163USA UT/ORNL Center for Molecular Biophysics Oak Ridge National LaboratoryOak RidgeTN 37830USA Department of Biochemistry and Cellular and Molecular Biology The University of Tennessee-KnoxvilleKnoxvilleTN 37996-1939USA Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTN 38163USA

Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly ***,we used mouse genetics,mechanical loading,and pharmacological approaches to test the possibility that polycystin-1 and Wwtr1 have interdependent mechanosensing functions in *** created and compared the skeletal phenotypes of control Pkd1^(flox/)+;Wwtr1^(flox/)+,Pkd1^(Oc-cKO),Wwtr1^(Oc-cKO),and Pkd1/Wwtr1^(Oc-cKO)mice to investigate genetic *** with an interaction between polycystins and Wwtr1 in bone in vivo,Pkd1/Wwtr1^(Oc-cKO)mice exhibited greater reductions of BMD and periosteal MAR than either Wwtr1Oc-cKOor Pkd1^(Oc-cKO)***-CT 3D image analysis indicated that the reduction in bone mass was due to greater loss in both trabecular bone volume and cortical bone thickness in Pkd1/Wwtr1Oc-cKO mice compared to either Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***1/Wwtr1^(Oc-cKO)mice also displayed additive reductions in mechanosensing and osteogenic gene expression profiles in bone compared to Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***,we found that Pkd1/Wwtr1^(Oc-cKO)mice exhibited impaired responses to tibia mechanical loading in vivo and attenuation of loadinduced mechanosensing gene expression compared to control ***,control mice treated with a small molecule mechanomimetic,MS2 that activates the polycystin complex resulted in marked increases in femoral BMD and periosteal MAR compared to vehicle *** contrast,Pkd1/Wwtr1^(Oc-cKO)mice were resistant to the anabolic effects of *** findings suggest that PC1 and Wwtr1 form an anabolic mechanotransduction signaling complex that mediates mechanical loading responses and serves as a potential novel therapeutic target for treating osteoporosis.

关键词： mec impaired additive

Perspectives on the role of Pannexin 1 in neural precursor cell biology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第10期11卷 1540-1544页

作者： Juan C.Sanchez-Arias leigh E.Wicki-Stordeur leigh Anne Swayne Division of Medical Sciences University of Victoria Island Medical Program and Department of Cellular and Physiological Sciences University of British Columbia

We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.

关键词： neural precursor ventricular zone pannexin ATP cytoskeleton proliferation phagoptosis

Reproductive biology of an old endemic murid rodent of Australia, the Spinifex hopping mouse, Notomys alexis:adaptations for life in the arid zone

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2011年第4期6卷 321-333页

作者： William G.BREED Chris M.leigh Discipline of Anatomy and Pathology University of AdelaideAdelaideAustralia

The Spinifex hopping mouse(Notomys alexis Thomas,1922)is an arid adapted Australo–Papuan old endemic rodent that undergoes boom and bust population *** this communication,we review our findings on the timing of reproduction and the potential reproductive rate of this *** investigate the first question,the reproductive condition of adult females,and occurrence of immatures,in a population on a cattle station in central Australia was determined and,for the second,data from a laboratory colony compared to those previously published on closely related species in other *** findings show that,at least in the population at the times that monitoring was performed,reproductive activity was only taking place in spring and early summer,whereas the laboratory study indicates that females have a similar gestation length and litter size to those of most close relatives occurring in other *** have extremely small testes and store relatively few *** findings suggest that Notomys alexis might show some seasonality of reproduction at least in this region of central Australia and that this species does not have a higher reproductive rate than that of related species in other,more predictable,environments.

关键词： arid environment hopping mouse reproduction

Cue hierarchy in the foraging behaviour of the brackish cladoceran Daphniopsis australis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2018年第6期36卷 2050-2060页

作者： MCCLOUD Clayton leigh ISMAIL Hasnun Nita SEURONT Laurent Australian Fisheries Management Authority CanberraAustralia School of Biology Universiti Teknologi MARASelangorMalaysia CNRS Univ.LilleUniv.Littoral Coe d'OpaleUMR 8187LOGLaboratoire d'Océnologie et de GésciencesF 62930 WimereuxFrance

Zooplankton communities are an essential component of marine and freshwater food webs. However, there is still a relative lack of information on how these organisms behaviourally respond to a range of abiotic and biotic stressors. Specifically, the behaviour of the cladoceran D aphniopsis australis, a species endemic to South-eastern Australian saline lakes and ponds, is still unknown despite its potential role in the structure and function of inland water ecosystems. The swimming behaviour of males, parthenogenetic females and epiphial females was investigated under various conditions and combinations of food and conspecific cues. In the absence of cues, males displayed the most extensive swimming behaviour, exploring all areas of the container, and swimming in a series of relatively straight trajectories. In contrast, females typically exhibited a hop-and-sink motion characterised by the alternation between short bursts of swimming and sinking phases. Both females spent long periods near the bottom of the container, but epiphial females appeared to be more active than parthenogenetic ones that rarely made an excursion in the water column. In the presence of cues, males and females showed abilities to detect infochemicals from food and conspecifics, but exhibited specific behavioural strategies. Males essentially increased their swimming speed in the presence of food and/or conspecific infochemicals, and this increase was independent on the source of the cues, i.e. food, conspecific or a mixture of food and conspecifics. In contrast, females exhibited cue hierarchies that were related to their sexual status. Parthenogenetic females swam faster in the presence of food and a mixture of food and conspecific infochemicals than in the presence of cue from the opposite sex, which did not significantly differ from control observations conducted in the absence of cues. Epiphial females decreased their swimming speed in the presence of cues, with the most significant behavi

关键词： zooplankton chemical cues sex-specific behaviour

The role of Ca,Al and Zn on room temperature ductility and grain boundary cohesion of magnesium

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2021年第5期9卷 1536-1551页

作者： Supriya Nandy Shao-Pu Tsai leigh Stephenson Dierk Raabe Stefan Zaefferer Max-Planck Institut für Eisenforschung Düsseldorf 40237Germany

It is know from literature that small additions(<1 wt%)of Ca,Al and Zn significantly improve the intrinsic ductility of *** exact role of each element,both qualitatively and quantitatively,and their combined effects,however,are poorly *** we achieved a much clearer view on the quantitative role of each element with respect to ductility improvement and on the collaborative effect,particularly of Ca and Zn in *** of our findings and conclusions are in disagreement with data and interpretation found in *** different alloys,namely,Mg-0.1 Ca,Mg-0.1 Ca-1 Al,Mg-0.05 Ca-1 Al,Mg-0.1 Ca-2 Al-1 Zn(all are in wt%)were selected for this *** alloys were treated such that *** grain sizes and textures were *** largely excludes the effect of extrinsic factors on ***-guided slip trace analyses reveal that the addition of Ca eases activation of prismatic and pyramidal II slip *** in-situ deformation experiments in SEM and atom probe tomography observations of grain boundaries direct evidence is given for the individual and synergetic effects of Ca and Zn on grain boundary cohesion as an important contribution to improve the ductility of these *** conclude that Ca reduces the slip anisotropy and ameliorates ductility,however,the weak grain boundary cohesion in the Mg-0.1 wt%Ca alloy limits the material’s tensile *** addition of Zn alters the Ca segregation at the grain boundaries and helps to retain their cohesive strength,an effect which thus enables higher ductility and *** further addition of Al primarily improves the *** results show that the balanced influence of reduced slip anisotropy on the one hand and increased grain boundary cohesion on the other hand allow to design a high strength high ductility rare-earth free Mg alloy.

关键词： Magnesium–Calcium–Zinc alloys Ductility Slip system determination grain boundary cohesion