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Engineered Nano−Bio Interfaces for Stem Cell Therapy

Precision Chemistry 2023年第6期1卷 341-356页

作者： Arsalan Umer Muhammad daniyal Ghouri Theoneste Muyizere Raja Muhammad Aqib Abdul Muhaymin Rong Cai Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience and Technology of China Chinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China GBA National Institute for Nanotechnology Innovation Guangdong 5110700China

Engineered nanomaterials(ENMs)with different topographies provide effective nano−bio interfaces for controlling the differentiation of stem *** interaction of stem cells with nanoscale topographies and chemical cues in their microenvironment at the nano−bio interface can guide their *** use of nanotopographical cues,in particular nanorods,nanopillars,nanogrooves,nanofibers,and nanopits,as well as biochemical forces mediated factors,including growth factors,cytokines,and extracellular matrix proteins,can significantly impact stem cell *** factors were seen as very effective in determining the proliferation and spreading of stem *** specific outgrowth of stem cells can be decided with size variation of topographic nanomaterial along with variation in matrix stiffness and surface structure like a special *** precision chemistry enabled controlled design,synthesis,and chemical composition of ENMs can regulate stem cell *** parameters of size such as aspect ratio,diameter,and pore size of nanotopographic structures are the main factors for specific termination of stem *** corona nanoparticles(NPs)have shown a powerful facet in stem cell therapy,where combining specific proteins could facilitate a certain stem cell differentiation and cellular ***−bio reactions implicate the interaction between biological entities and nanoparticles,which can be used to tailor the stem cells’*** ion release can also be a parameter to enhance cellular proliferation and to commit the early differentiation of stem *** research is needed to fully understand the mechanisms underlying the interactions between engineered nano−bio interfaces and stem cells and to develop optimized regenerative medicine and tissue engineering designs.

关键词： nano−bio interface protein corona stem cell therapy extracellular matrix biochemical forces

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近十年哈中石油合作：评估与展望

近十年哈中石油合作：评估与展望

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作者： NURSEITOV daniyal 华东师范大学

学位级别：硕士

石油和天然气是世界经济快速发展的重要基础,国家间的石油合作是涉及政治、经济和国家安全的综合性问题。随着中国经济实力的不断增强和经济发展速度的不断提高,石油和天然气对于中国而言,是非常重要的。为了保证能源安全和促进经济的... 详细信息

石油和天然气是世界经济快速发展的重要基础,国家间的石油合作是涉及政治、经济和国家安全的综合性问题。随着中国经济实力的不断增强和经济发展速度的不断提高,石油和天然气对于中国而言,是非常重要的。为了保证能源安全和促进经济的健康发展,中国对石油等能源的对外依赖逐渐增强,哈萨克斯坦是中国的友好邻邦,两国的经济贸易关系发展良好,哈萨克斯坦蕴藏着丰富的石油资源,石油的出口已经成为了哈国经济增长的重要动力。哈萨克斯坦与中国保持了良好的战略合作伙伴关系,同时双方国家政府非常重视发展两国的经济关系,哈中两国经济合作的前提就在于两国有着很强的互补性,同时发展前景光明,加快和深化两国的能源领域合作,有利于加快哈萨克斯坦和中国石油管道建设,在石油合作领域,不断取得新的发展成就。推动哈国经济实现又好又快的发展,使得哈萨克斯坦可以更好的参与经济全球化和区域经济一体化的进程,并取得与中国贸易的持续性发展。2013年,一带一路战略的提出和发展,为哈中两国的石油合作带来了新的发展机遇。通过对2008年到2018年的相关数据进行分析,阐述哈中石油合作的历史进程和发展现状,进而分析哈中石油合作面临的机遇和挑战。从机遇方面来看,哈中两国的石油合作在上海合作组织的框架下,在一带一路不断建设发展的背景下,具有能源供需互补、地缘优势、战略基础。但是两国的石油合作同样面临着挑战,哈国能源政策多变、中国油气企业竞争力较弱、“三股势力”对哈中石油合作的威胁和“中国威胁论”的喧嚣,俄罗斯对于哈萨克斯坦石油资源的争夺等等,这些都对哈萨克斯坦和中国的石油合作产生了不利的影响。针对上述分析,本文对哈中石油合作提出了用上海合作组织作用为石油合作提供机制保障、中国应充分实施能源节约战略,建立能源战略储备机制、发挥新疆的地缘优势,建设中国陆上能源安全通道、积极履行义务,展现负责任大国形象的针对性建议并对哈中石油合作的未来前景进行了展望。

关键词：哈中石油合作 2008-2018 前景

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Lanostane Tetracyclic Triterpenoids as Important Sources for Anti-Inflammatory Drug Discovery

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World Journal of Traditional Chinese Medicine 2020年第3期6卷 229-238页

作者： Yu-Pei Yang Shumaila Tasneem Muhammad daniyal Liu Zhang Yan-Zhe Jia Yu-Qing Jian Bin Li Wei Wang School of Pharmacy TCM and Ethnomedicine Innovation and Development International LaboratoryInnovative Drug Research InstituteHunan University of Chinese MedicineChangshaChina Department of Pharmacology Faculty of Pharmaceutical SciencesDow College of PharmacyDow University of Health Sciences.Gulzar‑e‑HijriKarachiPakistan

Inflammation is a defensive reaction of the human body to numerous detrimental stimuli,including physical trauma,noxious chemicals,as well as microbial *** inflammation is the pathological basis of multiple diseases,such as rheumatoid arthritis(RA),neurodegenerative diseases,liver disease,and lung *** triterpenoids are natural tetracyclic triterpenoids with significant anti-inflammatory *** extensive review of the published literature regarding the phytochemistry and anti-inflammatory pharmacology of lanostane triterpenoids has been performed and analyzed using several search engines,such as SciFinder,Web of Science,Scopus,PubMed,Google Scholar,and *** review is devoted to naturally occurring lanostane-type triterpenes with anti-inflammatory activity,including their sources,biosynthesis,and mechanism of *** review also discusses the inflammation-related diseases and the clinical significance of traditional Chinese medicine as multi-target therapeutic agents for the prevention and treatment of inflammatory *** the past 30 years,more than 100 new lanostane-type triterpenes have been reported from the families Schisandraceae,Ganodermataceae,and *** compounds,fomitopinic acid A,fomitosides E and F,obtusifoliol,4α,l4α-dimethyl-5α-ergosta-7,9(11),24(28)-trien-3β-ol,and gramisterol exhibited the most potent anti-inflammatory activity against cyclooxygenase-1(COX-1)and COX-2,with IC50 values ranging from 0.087 to 1.15μ*** of these compounds exhibited significant activity by mediating the inhibition of the pro-inflammatory cytokines,inducible nitric oxide synthase,and COX-2 *** review provides a basis for identifying anti-inflammatory drugs with high selectivity,high potency,and few adverse effects from lanostane-type triterpenes.

关键词： Inflammation inflammatory diseases lanostane triterpenoids rheumatoid arthritis

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Semantic Web Services for Ocean Knowledge Management

Semantic Web Services for Ocean Knowledge Management

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International Conference on Intelligent Computational Systems

作者： Syed SR.Abidi Ali daniyal Ashraf Abusharek Samina R.Abidi the Faculty of Computer Science Dalhousie University

We present a web-services based e-research platform to support scientific research about oceans and marine life. The featured Platform for Ocean Knowledge Management（POKM） employs a services-oriented approach to offer a suite of web services to support the handling, filtering and visualization of large-scale marine-life and ocean data sets. Taking a knowledge management approach, we have employed semantic web technologies to model both the domain knowledge and the service descriptions. This allows a seamless interoperability between the different data-sets and services. The web-services are supported by Canada’s CANARIE high bandwidth network that enables the transfer of large volumes of data from multiple sites and the execution of the various web services. In this paper, we present an overview of the architecture and functionality of POKM.

关键词： Knowledge Management Services-Oriented Architectures Web Services

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土家族药物扣子七中三萜皂苷成分及抗肿瘤活性研究

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中草药 2020年第7期51卷 1831-1838页

作者：王晓娟谢谦刘杨陆世银 Muhammad daniyal 李斌段淑莉龚力民梁娜毛羽于勇王炜湖南食品药品职业学院湖南长沙410208 湖南中医药大学药学院创新药物研究所中药民族药物创新发展实验室中国-巴基斯坦中医药民族医药研究国际合作基地(湖南)湖南长沙410208 广西壮族自治区柳州市中医医院药学部广西柳州545026

目的研究土家族药物扣子七Panax japonicus var. major中三萜皂苷类成分,对其抑制肿瘤细胞增殖活性进行筛选,并初步探讨化合物结构与活性的关系。方法应用多种色谱方法对土家族药物扣子七正丁醇部位进行分离,所分离化合物运用核磁共振... 详细信息

目的研究土家族药物扣子七Panax japonicus var. major中三萜皂苷类成分,对其抑制肿瘤细胞增殖活性进行筛选,并初步探讨化合物结构与活性的关系。方法应用多种色谱方法对土家族药物扣子七正丁醇部位进行分离,所分离化合物运用核磁共振方法进行结构鉴定,应用MTT法测定分离化合物对体外培养人肿瘤细胞增殖的影响。结果从扣子七根茎正丁醇部位分离得到14个三萜皂苷,分别鉴定为竹节参皂苷IVa甲酯(1)、竹节参皂苷Ⅳa丁酯(2)、竹节参皂苷Ⅳ(3)、竹节参皂苷Ⅳa(4)、28-去糖竹节参皂苷Ⅳa(5)、齐墩果酸-3-O-β-D-(6′-甲酯)-吡喃葡萄糖醛酸苷(6)、(24R)-珠子参苷R1(7)、(24R)-拟人参皂苷F11(8)、(20S)-三七皂苷R2(9)、(20S)-人参皂苷Rg2(10)、人参皂苷Rg1(11)、人参皂苷Re(12)、人参皂苷Rd(13)、竹节参皂苷V甲酯(14)。活性研究结果显示,化合物5和6对胃癌BGC-823细胞、结肠癌HCT-116细胞、宫颈癌HeLa细胞及肝癌Hep G2细胞均显示了较强的活性,呈良好的剂量依赖关系,其中化合物5对BGC-823、HCT-116细胞的IC50分别为9.94、14.17μmol/L,化合物6对肝癌HepG2细胞的抑制作用最强(IC50=12.70μmol/L)。结论首次从扣子七中分离得到化合物6并报道了其光谱数据;其部分化学成分显示出抗肿瘤活性,其抗肿瘤活性与齐墩果烷型皂苷密切相关,且活性强弱可能与C-28取代基有关联,相关抗肿瘤机制值得进一步研究。

关键词：土家族药物扣子七三萜皂苷抗肿瘤活性 28-去糖竹节参皂苷Ⅳa 齐墩果酸-3-O-β-D-(6′-甲酯)-吡喃葡萄糖醛酸苷

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别人的房间，别样的景观

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作者： (巴基)达尼亚尔·穆伊努丁(daniyal Mueenuddin)

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BIoMT:A Blockchain-Enabled Healthcare Architecture for Information Security in the Internet of Medical Things

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Computer Systems Science & Engineering 2023年第9期46卷 3667-3684页

作者： Sahar Badri Sana Ullah Jan daniyal Alghazzawi Sahar Aldhaheri d Nikolaos Pitropakis Information Systems Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah80200Saudi Arabia School of Computing Edinburgh Napier UniversityEdinburghEH105DYUK

Rapid technological advancement has enabled modern healthcare systems to provide more sophisticated and real-time services on the Internet of Medical Things(IoMT).The existing cloud-based,centralized IoMT architectures are vulnerable to multiple security and privacy *** blockchain-enabled IoMT is an emerging paradigm that can ensure the security and trustworthiness of medical data sharing in the IoMT *** article presents a private and easily expandable blockchain-based framework for the *** proposed framework contains several participants,including private blockchain,hospitalmanagement systems,cloud service providers,doctors,and *** security is ensured by incorporating an attributebased encryption ***,an IoT-friendly consensus algorithm is deployed to ensure fast block validation and high scalability in the IoMT *** proposed framework can perform multiple healthcare-related services in a secure and trustworthy *** performance of blockchain read/write operations is evaluated in terms of transaction throughput and *** outcomes indicate that the proposed scheme achieved an average throughput of 857 TPS and 151 TPS for read and write *** average latency is 61 ms and 16 ms for read and write operations,respectively.

关键词： Blockchain cybersecurity IoT IoMT smart healthcare

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Network Learning-Enabled Sensor Association for Massive Internet of Things

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Computer Systems Science & Engineering 2023年第10期47卷 843-853页

作者： Alaa Omran Almagrabi Rashid Ali daniyal Alghazzawi Bander A.Alzahrani Fahad M.Alotaibi Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information and Communication Technologies Universitat Pompeu FabraBarcelona08018Spain

The massive Internet of Things(IoT)comprises different gateways(GW)covering a given region of a massive number of connected devices with *** IoT networks,transmission interference is observed when different sensor devices(SD)try to send information to a single *** is mitigated by allotting various channels to adjoining ***,SDs are permitted to associate with anyGWin a network,naturally choosing the one with a higher received signal strength indicator(RSSI),regardless of whether it is the ideal choice for network *** an appropriate GW to optimize the performance of IoT systems is a difficult task given the complicated conditions among GWs and ***,in remote IoT networks,the utilization of machine learning(ML)strategies has arisen as a viable answer to determine the effect of various models in the system,and reinforcement learning(RL)is one of these ML ***,this paper proposes the use of an RL algorithm for GW determination and association in IoT *** this purpose,this study allows GWs and SDs with intelligence,through executing the multi-armed bandit(MAB)calculation,to investigate and determine the optimal GW with which to *** this paper,rigorous mathematical calculations are performed for this purpose and evaluate our proposed mechanism over randomly generated situations,which include different IoT network *** evaluation results indicate that our intelligentMAB-based mechanism enhances the association as compared to state-of-the-art(RSSI-based)and related research approaches.

关键词： Reinforcement learning association internet of things massive IoT sensors network

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Triterpenoid Saponins from Tu Jia Ethnomedicine Bai San Qi and Their Cytotoxicity on Hep G2 and BGC-823 Cell Lines

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Digital Chinese Medicine 2019年第2期2卷 117-124页

作者： LI Wei XIE Qing-Ling LIU Yang XIE Qian LI Bin PENG Cai-Yun WANG Wei TCM and Ethnomedicine Innovation & Development International Laboratory Innovative Materia Medica Research InstituteSchool of PharmacyHunan University of Chinese MedicineChangshaHunan 410208China

Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare medicinal plant to treat weakness, fatigue and rheumatism in Tu Jia ethnomedicine. This paper is to discover more substance evidence for the application of Tu Jia ethnomedicine. Methods Column chromatography and preparative high performance liquid chromatography (HPLC) was applied for isolation and purification;1H-NMR, 13C-NMR, 1H-1H COSY, HSQC and HMBC NMR spectra were applied for structure identification;Methyl thiazolyl tetrazolim (MTT) assays were applied for cytotoxicity evaluation. Results Totally 12 known compounds were isolated by column chromatography and preparative HPLC from rhizomes of Panax japonicus C. A. Mey.(Bai San Qi,白三七). Structures of these compounds were identified by their NMR spectra. All the 12 compounds were triterpenoid saponins. Five of them were oleanolic acid type, and the remaining 7 were dammarane type. Eleven compounds were assayed for their cytotoxic activity against Hep G2 human liver cancer cell lines and BGC-823 human gastric cancer cell lines. Three of the 11 showed relatively dominant cytotoxicity against these cell lines. Conclusions A total of 12 known compounds have been identified from Panax japonicus C. A. Mey.(Bai San Qi,白三七);NMR spectra of compounds with similar skeletons showed regular characteristics;3 compounds showed relatively dominant cytotoxicity against Hep G2 and BGC-823 cancer cell lines, and the result can be valued as weak while setting the taxol as a positive control.

关键词： Triterpenoid Saponin Cytotoxicity Araliaceae Panax japonicus C. A. Mey.(Bai San Qi,白三七) Tu Jia ethnomedicine

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The Global Soil Mycobiome consortium dataset for boosting fungal diversity research

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Fungal Diversity 2021年第6期111卷 573-588页

作者： Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby P.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov Mycology and Microbiology Center University of TartuTartuEstonia Institute of Ecology and Earth Sciences TartuEstonia Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden Department of Botany University of the PunjabQuaid-e-Azam CampusLahorePakistan Centro de Investigaciones en Microbiología y Biotecnología-UR(CIMBIUR) Facultad de Ciencias NaturalesUniversidad del RosarioBogotáColombia Grupo de Microbiología Ambiental y BioMicro Escuela de MicrobiologíaUniversidad de Antioquia UdeAMedellínColombia Department of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly Royal Botanic Gardens SurreyUK Department of Biomedical Sciences University of CagliariCagliariItaly Research Group Mycology Department of BiologyGhent UniversityGhentBelgium Department of Biomedicine Indonesia International Institute for Life SciencesJakartaIndonesia Plant Pathology and Agricultural Zoology Research Unit Department of Plant ProtectionFaculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Department of Ecology and Genetics Uppsala UniversityUppsalaSweden Eukaryotic Microbiology University of Duisburg-EssenEssenGermany Department of Biological Sciences and Biotechnology Botswana International University of Science and TechnologyPalapyeBotswana Natural History Museum of Zimbabwe BulawayoZimbabwe Institute of Botany Czech Academy of SciencesPrůhoniceCzech Republic Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingPeople’s Republic of China Department of Botany Jawaharlal Nehru Rajkeeya MahavidyalayaPondicherry UniversityPort BlairIndia British Antarctic Survey NERCCambridgeUK Natural History Museum of Denmark University of CopenhagenCopenhagenDenmark Department of Environmental Science Saint Mary’s UniversityHalifaxNSCanada Altai State University BarnaulRussia CSIRO Land and Water WembleyWAAustralia Department of N

Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and *** data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and *** dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all *** plots are supplied with geographical and edaphic *** OTUs are taxonomically and functionally assigned to guilds and other functional *** entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential *** dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published *** GSMc dataset is available over the PlutoF repository.

关键词： Soil fungi Global dataset PacBio sequencing Fungal richness

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