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BIOCELL 2022年第9期46卷 2053-2058页

作者： danila bobkov ANASTASIA POLYANSKAYA ANASTASIA MUSORINA GALINA POLJANSKAYA Collection of Vertebrate Cell Cultures Institute of CytologyRussian Academy of SciencesSt.Petersburg194064Russia Laboratory of Intracellular Signaling and Transport Smorodintsev Research Institute of InfluenzaSt.Petersburg197376Russia Research Laboratory of Translational Oncology Almazov National Research CentreSt.Petersburg197341Russia

All non-immortalized mesenchymal stem cells have a limited proliferative potential,that is,replicative senescence(RS)is an integral characteristic of the life of all mesenchymal stem cells(MSCs).It is known that one of the important signs of RS is a decrease of cell motility,and that violations of migration processes contribute to the deterioration of tissue ***,the characterization of the properties of the cell line associated with RS is a prerequisite for the effective use of MSCs in restorative *** of the key proteins regulating cell motility is the small GTPase *** main purpose of this work was to study the nuclear-cytoplasmic redistribution of the RhoA protein during RS in MSC lines recently obtained and characterized in our *** study found that a comparative analysis of the intracellular localization of RhoA in three cell lines(MSCWJ-1,FetMSC,DF2)showed a decrease in the nuclear localization of RhoA during RS.

关键词： Mesenchymal stem cells RhoA Actin cytoskeleton Replicative senescence

Phase transitions and degradation/oxidation mechanisms in lead-free CsSnI_(3)halide perovskites

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Clean Energy 2024年第3期8卷 109-115页

作者： Alexandra Ivanova Margarita Golikova Lev Luchnikov Pavel Gostishchev Igor Shetinin Victor Voronov danila Saranin Vladimir Khovaylo National University of Science and Technology MISIS(NUST MISIS) Leninsky av.4Moscow119049Russia Belgorod State University Pobedy st.85Belgorod308015Russia

Halide perovskites possess ultra-low thermal conductivity and show high potential for thermoelectric *** chemical properties and molecular structure of halide perovskite materials are not completely stable under ambient conditions,which hinders their use in thermoelectric *** in the properties of bulk halide perovskite thermoelectrics are accompanied by partial phase transitions and surface oxidation *** this paper,we conducted a comprehensive study of the transport and structural properties of CsSnI_(3),which were pristine by vacuum melting followed by spark plasma *** research results on the electrical transport of these materials revealed that exposure to an inert atmosphere does not deteriorate stability and the properties of the materials remain ***,prolonged exposure to air leads to a significant degradation of the electrical transport *** to thin-film samples,the shift to the double perovskite structure from the perovskite one is limited to a specific surface *** change significantly influences the electrical transport of the material while maintaining the essential properties of both perovskite types.

关键词： halide perovskites degradation oxidation transport properties surface

Histone deacetylase inhibitors for treatment of hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第9期26卷 1025-1033页

作者： danila CORADINI Annalisa SPERANZA UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy

Hepatocellular carcinoma(HCC)is one of the most common cancers in the *** resection has been considered the optimal treatment approach,but onlya small proportion of patients are suitable candidates for surgery,and the relapserate is *** to prevent recurrence,including chemoemboliza-tionbefore and adjuvant therapy after surgery,have proven to have a limited benefit;liver transplantation is successful in treating limited-stage HCC because only aminority of patients qualify for ***,new therapeutic strat-egies are urgently *** in addition to the classical genetic mecha-nisms of deletion or inactivating point mutations,epigenetic alterations,such ashyperacetylation of the chromatin-associated histones(responsible for genesilencing),are believed to be involved in the development and progression ofHCC,novel compounds endowed with a histone deacetylase(HDAC)inhibitoryactivity are an attractive therapeutic *** particular,pre-clinical resultsobtained using HA-But,an HDAC inhibitor in which butyric acid residues areesterified to a hyaluronic acid backbone and characterized by a high affinity forthe membrane receptor CD44,indicated that this class of compounds may repre-sent a promising approach for hepatocellular carcinoma treatment.

关键词： hepatocellular carcinoma histone deace-tylase inhibitors cancer therapy

The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation

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Chinese Journal of Cancer 2014年第2期33卷 51-67页

作者： danila Coradini Saro Oriana Department of Clinical and Community Health Sciences Medical Statistics Biometry and BioinformaticsUniversity of Milan20133 Italy Senology Center Casa di Cura Ambrosiana Istituto Sacra FamigliaCesano BosconeMilan Italy

During normal postnatal mammary gland development and adult remodeling related to the menstrual cycle, pregnancy, and lactation, ovarian hormones and peptide growth factors contribute to the delineation of a definite epithelial cell identity. This identity is maintained during cell replication in a heritable but DNAindependent manner. The preservation of cell identity is fundamental, especially when cells must undergo changes in response to intrinsic and extrinsic signals. The maintenance proteins, which are required for cell identity preservation, act epigenetically by regulating gene expression through DNA methylation, histone modification, and chromatin remodeling. Among the maintenance proteins, the Trithorax(TrxG) and Polycomb(PcG) group proteins are the best characterized. In this review, we summarize the structures and activities of the TrxG and PcG complexes and describe their pivotal roles in nuclear estrogen receptor activity. In addition, we provide evidence that perturbations in these epigenetic regulators are involved in disrupting epithelial cell identity, mammary gland remodeling, and breast cancer initiation.

关键词：上皮细胞乳腺癌蛋白质保存表观遗传学组蛋白修饰雌激素受体引发

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Anemia in inflammatory bowel disease: A neglected issue with relevant effects

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World Journal of Gastroenterology 2014年第13期20卷 3542-3551页

作者： danila Guagnozzi Alfredo J Lucendo Department of Gastroenterology Hospital General de Tomelloso 13700 TomellosoCiudad RealSpain

Anemia, a common complication associated with inflammatory bowel disease (IBD), is frequently overlooked in the management of IBD patients. Unfortunately, it represents one of the major causes of both decreased quality of life and increased hospital admissions among this population. Anemia in IBD is pathogenically complex, with several factors contributing to its development. While iron deficiency is the most common cause, vitamin B12 and folic acid deficiencies, along with the effects of pro-inflammatory cytokines, hemolysis, drug therapies, and myelosuppression, have also been identified as the underlying etiology in a number of patients. Each of these etiological factors thus needs to be identified and corrected in order to effectively manage anemia in IBD. Because the diagnosis of anemia in IBD often presents a challenge, combinations of several hematimetric and biochemical parameters should be used. Recent studies underscore the importance of determining the ferritin index and hepcidin levels in order to distinguish between iron deficiency anemia, anemia due to chronic disease, or mixed anemia in IBD patients. With regard to treatment, the newly introduced intravenous iron formulations have several advantages over orally-administered iron compounds in treating iron deficiency in IBD. In special situations, erythropoietin supplementation and biological therapies should be considered. In conclusion, the management of anemia is a complex aspect of treating IBD patients, one that significantly influences the prognosis of the disease. As a consequence, its correction should be considered a specific, first-line therapeutic goal in the management of these patients.

关键词： Anemia Inflammatory bowel disease Iron deficiency Anemia of chronic disease Erythropoietin

Towards a new paradigm of microscopic colitis: Incomplete and variant forms

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World Journal of Gastroenterology 2016年第38期22卷 8459-8471页

作者： danila Guagnozzi Stefania Landolfi Maria Vicario Department of Gastroenterology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Department of Pathology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Translational Mucosal Immunology Lab Digestive Diseases Research UnitVall d’Hebron Institut de RecercaDepartment of Gastroenterology.Hospital Universitario Vall d’HebronUniversitat Autónoma de Barcelona08035 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) 08035 BarcelonaSpain

Microscopic colitis(MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis(LC) and collagenous colitis(CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC(MCi) is nowadays universally accepted. However, it is still unresolved whether CC, LC and MCi should be considered as one clinical entity or if they represent three related conditions. In contrast to classical MC, the real epidemiological impact of MCi remains unknown, because only few epidemiological studies and case reports have been described. MCi presents clinical characteristics indistinguishable from complete MC with a good response to budesonide and cholestiramine. Although a number of medical treatments have been assayed in MC patients, currently, there is no causal treatment approach for MC and MCi, and only empirical strategies have been performed. Further studies are needed in order to identify their etiopathogenic mechanisms, and to better classify and treat MC.

关键词： Microscopic colitis Incomplete microscopic colitis Collagenous colitis Lymphocytic colitis

Pronormality and Submaximal X-Subgroups on Finite Groups Dedicated to celebrate the Sixtieth anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 289-317页

作者： Wenbin Guo danila O.Revin School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026People’s Republic of China Sobolev Institute of Mathematics SB RAS NovosibirskRussia Novosibirsk State University NovosibirskRussia 630090

According to Hall,a subgroup H of a group G is said to be pronormal if H and H^(g) are conjugate infor every g∈*** this survey,we discuss the role of pronormality for some subgroups of finite groups:Hall subgroups,su... 详细信息

关键词： Pronormal subgroup Hallπ-subgroup Submaximal X-subgroup Subgroup of odd index

Vulnerability to Earthquake Hazard:Bucharest Case Study,Romania

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International Journal of Disaster Risk Science 2017年第2期8卷 182-195页

作者： Iuliana Armas Dragos Toma-danila Radu Ionescu Alexandru Gavris Department of Geomorphology-Pedology-Geomatics Faculty of GeographyUniversity of Bucharest National Institute for Earth Physics Department of Tourism and Geography Bucharest University of Economic Studies

Recent seismic events show that urban areas are increasingly vulnerable to seismic damage,which leads to unprecedented levels of *** are complex systems and as such their analysis requires a good understanding of the interactions between space and the socioeconomic variables characteristic of the inhabitants of urban *** is a clear need to develop and test detailed models that describe the behavior of these interactions under seismic *** article develops an overall vulnerability index to seismic hazard based on a spatial approach applied to Bucharest,Romania,the most earthquake-prone capital in the European *** methodology relies on:(1) spatial post-processed socioeconomic data from the2011 Romanian census through multicriteria analysis;and(2) analytical methods(the Improved Displacement Coefficient Method and custom-defined vulnerability functions)for estimating damage patterns,incorporated in a GIS *** computed vulnerability indices for the128 census tracts of the *** sensitivity assessment tested the robustness of spatially identified patterns of building vulnerability in the face of uncertainty in model *** results show that useful seismic vulnerability indices can be obtained through interdisciplinaryapproaches that enhance less detailed datasets,which leads lead to better targeted mitigation efforts.

关键词： Bucharest Romania Seismic loss estimation Seismic risk Spatial multicriteria analysis Vulnerability index

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Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： Massimiliano Bernabei NicolòFabbri danila Romeo Elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report

Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation

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Chinese Journal of Cancer 2014年第10期33卷 501-510页

作者： danila Coradini Patrizia Boracchi Saro Oriana Elia Biganzoli Federico Ambrogi Department of Clinical Sciences and Community Health Medical StatisticsBiometry and BioinformaticsUniversity of MilanVia Vanzetti 5Milan 20133Italy Senology Center Ambrosiana ClinicCesano BosconeMilan 20090Italy

The establishment and maintenance of mammary epithelial cell identity depends on the activity of a group of proteins, collectively called maintenance proteins, that act as epigenetic regulators of gene transcription through DNA methylation, histone modification, and chromatin remodeling. Increasing evidence indicates that dysregulation of these crucial proteins may disrupt epithelial cell integrity and trigger breast tumor initiation. Therefore, we explored in silico the expression pattern of a panel of 369 genes known to be involved in the establishment and maintenance of epithelial cell identity and mammary gland remodeling in cell subpopulations isolated from normal human mammary tissue and selectively enriched in their content of bipotent progenitors, committed luminal progenitors, and differentiated myoepithelial or differentiated luminal cells. The results indicated that, compared to bipotent cells, differentiated myoepithelial and luminal subpopulations were both characterized by the differential expression of 4 genes involved in cell identity maintenance: CBX6 and PCGF2, encoding proteins belonging to the Polycomb group, and SMARCD3 and SMARCE1, encoding proteins belonging to the Trithorax group. In addition to these common genes, the myoepithelial phenotype was associated with the differential expression of HDAC1, which encodes histone deacetylase 1, whereas the luminal phenotype was associated with the differential expression of SMARCA4 and HAT1, which encode a Trithorax protein and histone acetylase 1, respectively. The luminal compartment was further characterized by the overexpression of ALDH1A3 and GATA3, and the down-regulation of NOTCH4 and CCNB1, with the latter suggesting a block in cell cycle progression at the G2 phase. In contrast, myoepithelial differentiation was associated with the overexpression of MYC and the down-regulation of CCNE1, with the latter suggesting a block in cell cycle progression at the G1 phase.

关键词：基因表达差异乳腺细胞分化遗传调控乳腺上皮细胞组蛋白修饰人类表观

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