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Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats

Biomedical and Environmental Sciences 2014年第2期27卷 85-96页

作者： daniela-saveta p.p. pompei BOLFA Bela KISS Laurian VLASE Ramona pLTINEAN Anca p.p.Cornel CTOI Gianina CRISAN Felicia LOGHIN Department of Toxicology Faculty of Pharmacy Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Department of pathology Faculty of Veterinary MedicineUniversity of Agricultural Sciences and Veterinary Medicine Department of Biomedical Sciences Ross University School of Veterinary Medicine Department of pharmaceutical Technology and Biopharmacy Faculty of Pharmacy ‘Iuliu Hatieganu'University of Medicine and Pharmacy Cluj-Napoca Department of pharmaceutical Botany Faculty of Pharmacy ‘Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca

Objective To evaluate the influence of an extract of Genista tinctoria L. herba （GT） or methylparaben （Mp） on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A （BpA）. Methods Adult female Wistar rats were orally exposed for 90 d to BpA （50 mg/kg）, BpA＋GT （35 mg isoflavones/kg） or BpA＋Mp （250 mg/kg）. plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BpA or BpA＋Mp treatment. A minimal thyroid receptor antagonist effect was only observed after BpA＋Mp treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both Mp and GT revealed antioxidant properties reducing lipid peroxidation and BpA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BpA and is proved to have antioxidant potential and antitoxic effect. Mp has antioxidant properties, but has either no effect or exacerbates the BpA-induced histopathological changes.

关键词： Food contaminant phytoestrogen Morphological effect Lipid peroxidation Hydroxylradical

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Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes

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Biomedical and Environmental Sciences 2015年第11期28卷 834-838页

作者： GHELDIU Ana-Maria p.p. daniela-saveta LOGHIN Felicia VLASE Laurian Department of pharmaceutical Technology and Biopharmacy Faculty of Pharmacy‘Iuliu Hatieganu’University of Medicine and Pharmacy Cluj-Napoca Department of Toxicology Faculty of Pharmacy‘Iuliu Hatieganu’University of Medicine and Pharmacy Cluj-Napoca

Genistein, the main isoflavone from soy, and bisphenol A （BpA）, a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BpA on estrone （El） metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16a-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16a-OH-E1 ratio,

关键词： BpA Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes

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