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Bleeding Dieulafoy's-like lesions of the gut identified by capsule endoscopy

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World Journal of Gastroenterology 2013年第29期19卷 4823-4826页

作者： Lidia Ciobanu Oliviu Pascu Brindusa diaconu daniela Matei Cristina Pojoga Marcel Tantu Regional Institute of Gastroenterology and Hepatology University of Medicine and Pharmacy 400162 Cluj Romania

Dieulafoy's-like lesions (DLs-like) represent a cause of obscure gastrointestinal bleeding, enteroscopy being the main diagnostic and therapeutic procedure. Frequently, more than one enteroscopy is needed to identify the bleeding vessel. In our practice, video capsule endoscopy (VCE) identified and guided therapy in four cases of DLs-like; three of them were localized on the small bowel. We report, for the first time, a diagnosis of colonic DL-like performed by colon capsule endoscopy. Two patients presented with severe cardiovascular disorders, being hemodynamically unstable during VCE examination. Based on the VCE findings, only one invasive therapeutic procedure per patient was necessary to achieve hemostasis. VCE and enteroscopy may be regarded as complementary procedures in patients with gut DLs-like.

关键词： Obscure gastrointestinal bleeding Dieulafoy’ s-like lesion Video capsule endoscopy Enteroscopy Small bowel

Density and thermal expansion coefficients of liquid and austenite phase in lamellar cast iron

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China Foundry 2020年第2期17卷 127-136页

作者： Kristina Hellstrm Vasile-Lucian diaconu Attila Diószegi School of Engineering J.nk.ping UniversitySweden

Volume change related defects formation mechanisms are an important detracting phenomenon in production of complex shaped cast *** different technical alloys,cast iron behaves in a complex manner due to the combined volume change of the formed *** liquid and the austenitic phase are contracting while the graphite phase is expanding during the *** complex volume change in combination with complex casting shapes causes a considerable deviation from isotropy in the solidification *** mentioned difficulties are considered the main reason why an extensive research work is condensed in the literature within this *** multitude of reported experimental set up and the various efforts to interpret the volume change phenomena in terms of density and thermal expansion coefficients makes the results difficult to compare from different *** these difficulties in mind,the present paper presents a broad experimental series and measures unidirectional linear deformation of an industrially spread lamellar cast iron alloy system(Fe-C-2Si)using the push-rod based dilatometer *** measurements are divided into two major groups with respect to the liquid iron deformation over the liquidus temperature line,and the austenite deformation below the solidus temperature *** obtained results are interpreted as thermal expansion coefficients,density variation slopes,and density data at the liquids and solidus *** obtained results are compared with literature data and with calculated values by the Thermo Calc software.

关键词： density thermal expansion coefficient dilatometer castiron Fe-C-2Si CALPHAD

Testosterone,cardiomyopathies,and heart failure:a narrative review

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Asian Journal of Andrology 2021年第4期23卷 348-356页

作者： Rodica diaconu Ionuţ Donoiu Oana Mirea Tudor Adrian Bălşeanu Department of Cardiology University of Medicine and PharmacyCraiova 200349Romania Department of Physiology University of Medicine and PharmacyCraiova 200349Romania

Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.

关键词： androgens cardiomyocytes heart disease myocardial prognosis

International accounting system and its major challenges in time

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Journal of Modern Accounting and Auditing 2009年第1期5卷 14-19页

作者： diaconu PAUL Faculty of Accounting and Information Systems Academy of Economic Studies Bucharest Bucharest 010374 Romania

The process of globalization is one of the biggest social processes which the humanity has faced ever. That＇s why its impact on the global economy is huge and due to this the accounting sector is very important. That＇s why one of the main international accounting processes on the actual period is the harmonization of the national accounting systems. The harmonization process is influenced by several factors like culture, politics, economy and sociological behaviors. The paper is trying to present the evolution of harmonization process during the time advantages and weakness generated by its solutions. The paper is trying to present also the efforts of the process to main accounting systems： US GAAP and IAS/IFRS, in order to achieve in the next period the convergence, in order to be able to propose to the financial world a unique accounting model.

关键词： globalization harmonization convergence international accounting standards

New therapeutic options opened by the molecular classification of gastric cancer

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World Journal of Gastroenterology 2018年第18期24卷 1942-1961页

作者： Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C diaconu Department of Cellular and Molecular Pathology Stefan S. Nicolau Institute of Virology Nicolae Cajal Institute Titu Maiorescu University

Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC.

关键词： Gastric cancer Molecular classification Immunotherapy Targeted therapy Clinical trials

The Analysis of Human Behaviour and Evacuation in a Fire Situation in a Building for Higher Education

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Journal of Civil Engineering and Architecture 2024年第2期18卷 86-91页

作者： Dan diaconu-Şotropa Technical University“Gh.Asachi” Iassy 700050Romania

The paper presents the analysis of a human evacuation from a higher education building located in Iassy,Romania,by means of engineering techniques to approach fire *** in Romania(as in other European countries)fire safety design of buildings is prescriptive and not performance-based,a fire safety engineering approach arouse great interest in many countries such as the U.S.A.,Australia,New Zealand,England,Sweden,Finland,*** paper is based on the assumption of starting a fire in the space of a hall for festivities,located on the ground floor of the building,near two human evacuation routes;We consider two building evacuation scenarios:two exits and,respectively,just one exit(assuming that the second would be accidentally blocked).

关键词： CFD(computational fluid dynamics) FDS(fire dynamics simulator) fire safety engineering smoke human behaviour fire simulation educational building

Therapies targeting cancer stem cells: Current trends and future challenges

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World Journal of Stem Cells 2015年第9期7卷 1185-1201页

作者： Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C diaconu Mihaela Chivu-Economescu Cellular and Molecular Department Stefan S. Nicolau Institute of Virology Nicolae Cajal Institute Titu Maiorescu University Biochemistry-Proteomics Department Victor Babes National Institute of Pathology

Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers.

关键词： Cancer stem cells Targeted therapy Anticancer drug

The Conformity of University Accounting Education Curriculum to the Needs of the Labor Market in Romania

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Journal of Modern Accounting and Auditing 2011年第5期7卷 431-442页

作者： diaconu Paul Sandru Codrina Academy of Economic Studies Romania Sandru Codrina University of Transilvania RomaniaComan Nicoleta Gorgan Catalina Vasile GorganAcademy of Economic Studies Romania

This study represents empirical research that aims to investigate how the labor market for the financial-accounting segment in Romania requires professional and personal skills developed within the accounting education curriculum in the Romanian universities of this profile, or these produce young practitioners inappropriate from the curricular point of view to the employers＇ demands. The study develops a statistical analysis of frequencies, aiming to find an importance stratification of the professional and personal characteristics in the employers＇ demands. The study groups the job advertisements into three categories： for financial accounting, managerial accounting and audit, and seeks to identify specific curriculum descriptors for these categories of professional development. At the same time, the study does a frequency analysis of curriculum descriptors and job execution, comparatively to the management jobs, attempting to do a hierarchy of professional and personal skills, depending on the wording of notices by employers. The conclusions of the report attempts to be a synthesis of the study assumptions results that lead to the idea that the curricular programs of the universities of this profile, though responding in terms of theoretical knowledge, should be extended in practice, but particularly in the personal skills development, which are defining in a competitive selection process.

关键词： accounting education curriculum personal skills professional skills ethics IES's (International Education Standards)

Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters

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World Journal of Diabetes 2020年第5期11卷 193-201页

作者： Mihnea-Alexandru Găman Mirela Elena Epîngeac Camelia Cristina diaconu Amelia Maria Găman "Carol Davila"University of Medicine and Pharmacy Bucharest 050474Romania Department of Hematology Center of Hematology and Bone Marrow TransplantationFundeni Clinical InstituteBucharest 022328Romania Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 014461Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania

BACKGROUND Obesity and diabetes are associated with high levels of oxidative *** Romanian patients with obesity and(or)diabetes,this association has not been sufficiently *** To evaluate oxidative stress in obese and(or)diabetic subjects and to investigate the possible correlations between oxidative stress and anthropometric/biochemical *** Oxidative stress was evaluated from a single drop of capillary *** oxygen species(ROS)were evaluated using the free oxygen radical test(FORT).The free oxygen radical defence(FORD)assay was used to measure antioxidant *** FORT levels were higher in obese subjects(3.04±0.36 mmol/L H2O2)vs controls(2.03±0.14 mmol/L H2O2)(P<0.0001).FORD levels were lower in obese subjects(1.27±0.13 mmol/L Trolox)vs controls(1.87±1.20 mmol/L Trolox)(P=0.0072).Obese diabetic subjects had higher FORT values(3.16±0.39 mmol/L H2O2)vs non-diabetic counterparts(2.99±0.33 mmol/L H2O2)(P=0.0233).In obese subjects,FORT values correlated positively with body mass index(BMI)(r=0.48,P=0.0000),waist circumference(WC)(r=0.31,P=0.0018),fasting plasma glucose(FPG)(r=0.31,P=0.0017),total cholesterol(TC)(r=0.27,P=0.0068)and uric acid(r=0.36,P=0.0001).FORD values correlated negatively with BMI(r=-0.43,P=0.00001),WC(r=-0.28,P=0.0049),FPG(r=-0.25,P=0.0130),TC(r=-0.23,P=0.0198)and uric acid(r=-0.35,P=0.0002).In obese diabetic subjects,FORT values correlated positively with BMI(r=0.49,P=0.0034)and TC(r=0.54,P=0.0217).FORD values were negatively associated with BMI(r=-0.54,P=0.0217)and TC(r=-0.58,P=0.0121).CONCLUSION Oxidative stress levels,as measured by the FORT and FORD assays,were higher in obese subjects vs *** levels were elevated in diabetic obese patients vs obese non-diabetic patients and controls.

关键词： Oxidative stress Obesity Diabetes Reactive oxygen species Antioxidants Dyslipidaemia