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cytokines from the pig conceptus:roles in conceptus development in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney D Geisert Matthew c Lucy Jeffrey J Whyte Jason W Ross daniel J Mathew Animal Sciences Research center University of Missouri Department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

In vivo radiometric analysis of glucose uptake and distribution in mouse bone

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Bone Research 2016年第1期4卷 31-38页

作者： Meredith L Zoch Diane S Abou Thomas L clemens daniel LJ Thorek Ryan c Riddle Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Baltimore USA Division of Nuclear Medicine an Molecular Imaging Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore USA Baltimore Veterans Administration Medical center Baltimore USA Department of Oncology Cancer Molecular and Functional Imaging Program Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore USA

Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts, particularly during periods of rapid bone growth. Despite increasing evidence linking bone cell activity to global energy homeostasis, little is known about the relative energy requirements or substrate utilization of bone cells. In these studies, we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting 18F-fluorodeoxyglucose （[lSF]-FDG） and non-invasive, high-resolution positron emission tomography/computed tomography （PE~/cT） imaging and ex vivo autoradiography. Assessment of [~SF]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog..Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development. PET/cT imaging revealed that [lSF]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones, which accords with the increased osteoblast numbers and activity at this skeletal site. Insulin administration significantly increased skeletal accumulation of [lSF]-FDG, while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet. Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism.

关键词： bone FDG

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Happiness for humans

Happiness for humans

Three-dimensional light structure of an upland Quercus stand post-tornado disturbance

作者： daniel c. Russell.

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Journal of Forestry Research 2020年第1期31卷 141-153页

作者： Kevin G.Willson Lauren E.cox Justin L.Hart daniel c.Dey Department of Geography University of AlabamaTuscaloosaAL 35487USA Department of Environmental Science Policyand ManagementUniversity of CaliforniaBerkeleyCA 94720USA Northern Research Station USDA Forest ServiceColumbiaMO 65211USA

Light is the most common limiting factor in forest plant communities,influencing species composition,stand structure,and stand productivity in closed canopy *** vertical light structure is relatively simple under a closed canopy because most light is captured by overstory ***,wind disturbance events create canopy openings from local to landscape scales that increase understory light intensity and vertical light structural *** studied the effects of an EF-1 tornado on horizontal and vertical(***-dimensional)light structure within a Quercus stand to determine how light structure changed with increasing disturbance *** used a two-tiered method to collect photosynthetic photon flux density at 4.67 m and 1.37 m above the forest floor to construct three-dimensional light structure across a canopy disturbance severity gradient to see if light intensity varied with increasing tornado *** indicate that increased canopy disturbance closer to the tornado track increased light penetration and light structure heterogeneity at lower forest *** light intensity correlated with increased sapling density that was more randomly distributed across the plot and had shifted light capture higher in the stand *** penetration through the overstory was most strongly correlated with decreased stem density in the two most important tree species(based on relative dominance and relative density)in the stand,Quercus alba L.(r=-0.31)and Ostrya virginiana(Mill.)***(r=-0.27,pcated that understory light penetration was most affected by these two *** managers are increasingly interested in patterning silvicultural entries on natural disturbances,they must understand residual stand and light structures that occur after natural disturbance *** providing spatial light data that quantifies light structure post-disturbance,managers can use these results to improve planning required for long-term man

关键词： Photosynthetic photon flux density Midstory Blowdown Heterogeneity

Disturbance history,species diversity,and structural complexity of a temperate deciduous forest

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Journal of Forestry Research 2020年第2期31卷 397-414页

作者： Jonathan D.Goode carson R.Barefoot Justin L.Hart daniel c.Dey Department of Geography University of AlabamaTuscaloosaAL 35487USA Northern Research Station USDA Forest ServiceColumbiaMO 65211USA

Stand structural complexity enhancement is an increasingly popular management objective,especially on public *** stand structures are hypothesized to support a relatively high degree of native forest diversity and be more resistant and resilient to *** structures are characterized by the presence of deadwood and heterogeneity of tree-size classes and tree *** little is known about how discrete disturbance events affect structural complexity and compositional diversity in Quercus-dominated stands at fine spatial scales(***).We established 200.05 ha fixed-radius plots on the Sipsey Wilderness of William *** National Forest in northern Alabama to quantify woody plant species composition and *** were mapped on each plot to quantify overstory structural complexity and compositional *** extracted two cores from all canopy Quercus spp.c 5 cm diameter at breast height to quantify age,recruitment pulses,and reconstruct canopy disturbance *** species diversity in the sampled area was 1.75 for trees,2.08 for saplings,and 1.69 for *** alba had the greatest basal area,and Ostrya virginiana had the highest *** stand exhibited a reverse J-shaped distribution with a q-factor of *** oldest Quercus dated to 1795,and the largest recruitment pulse occurred in the *** mean return interval for intermediateseverity disturbance was 38 *** we documented no relationships between disturbance frequency and compositional diversity at the neighborhood scale(0.05 ha),less frequent disturbance was associated with higher structural complexity(r^2=0.258,p=0.026)at the neighborhood *** suggest that localized disturbance increases species diversity and structural complexity,but these processes are manifest at the stand level and not at the neighborhood *** conclude that the spatial variability(***,shape,orientation,microsite conditions)is likel

关键词： canopy gap Quercus(oak) Stand development Succession

Do forest health threats affect upland oak regeneration and recruitment?Advance reproduction is a key co-morbidity

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Forest Ecosystems 2023年第6期10卷 743-751页

作者： Lance A.Vickers Benjamin O.Knapp daniel c.Dey Lauren S.Pile Knapp School of Natural Resources University of Missouri203 Anheuser-Busch Natural Resources BuildingColumbiaMO65211USA USDA Forest Service Northern Research Station 202 Anheuser-Busch Natural Resources BuildingColumbiaMO65211USA

We analyzed national forest inventory data collected from circa 2000–2018 across 37 states in the eastern United States to better understand the influence of forest health related canopy disturbances on the regeneration and recruitment dynamics of upland oaks(Quercus).We found low levels of oak recruitment across all disturbance types examined but limited evidence of any direct effects from the type of disturbance on the population of regenerating *** general lack of differences in oak regeneration response between forest health disturbances and disturbances caused by harvested or non-disturbed plots does not indicate that the effects of forest health disturbances were benign,***,low level of oak recruitment across all disturbance types highlights the pervasiveness of the trend of shifting composition in once oak-dominated forests where oak is absent or sparse in the regeneration *** results show that oak recruitment was higher when oak was present as advance reproduction prior to disturbance from any cause ***,these results lead us to conclude that the widespread inadequacy of oak advance reproduction in mature oak-dominated forests is the prevailing threat to oak forest health and *** suggest the status of advance reproduction be treated as a co-morbidity when weighing the risk and potential outcomes from other threats to upland oak forests in the eastern United States.

关键词： Temperate deciduous forest Regeneration ecology Forest inventory and analysis Oak/hickory Forest pests Insect Disease Harvesting

The importance of public engagement in clinical xenotransplantation

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Health Care Science

Health care Science 2024年第2期3卷 124-130页

作者： daniel J.Hurst David K.c.cooper Department of Family Medicine Rowan-Virtua School of Osteopathic MedicineStratfordNew JerseyUSA center for Transplantation Sciences Massachusetts General Hospital/Harvard Medical SchoolBostonMassachusettsUSA

Over the past several decades,significant scientific progress in xenotransplantation has brought the field to the threshold of clinical *** the past 3 years in the United States,experimental pig kidney and heart xenotransplantation have been performed on human subjects recently declared dead by neurological criteria(decedents).In addition,two pig heart transplants have been carried out in living patients under the United States Food and Drug Administration's expanded access ***,though there has been a flurry of activity there remain unanswered questions regarding how the public views xenotransplantation,what concerns may exist,and how to address these concerns in a meaningful *** paper aims to underscore the importance of public engagement in xenotransplantation,emphasizing the ongoing need for studies to assess public *** current evidence on public engagement studies is reviewed and gaps in our understanding are *** propose practical steps to advance this *** studies to determine the extent of racial/ethnic differences in attitudes to xenotransplantation should be *** and descriptive analysis of certain religious viewpoints—especially minority faiths—would be *** public engagement is an important aspect of public acceptance of novel research that is accompanied by risk,we suggest that xenotransplantation biotechnology companies might consider leading the way in funding this research.

关键词： clinical trials ethics public engagement viewpoints xenotransplantation

Modelling policy combinations of vaccination and transmission suppression of SARS-coV-2 in Rio de Janeiro,Brazil

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Infectious Disease Modelling 2022年第1期7卷 231-242页

作者： Naiara c.M.Valiati daniel A.M.Villela Universidade Federal Rural do Rio de Janeiro SeropedicaRJBrazil Programa de computaçao científica Fundaçao Oswaldo CruzRio de JaneiroRJBrazil

cOVID-19 vaccination in Brazil required a phased program,with priorities for age groups,health workers,and vulnerable *** distancing and isolation interventions have been essential to mitigate the advance of the pandemic in several *** developed a mathematical model capable of capturing the dynamics of the SARS-coV-2 dissemination aligned with social distancing,isolation measures,and *** data from the city of Rio de Janeiro provided a case study to analyze possible scenarios,including non-pharmaceutical interventions and vaccination in the epidemic *** results demonstrate that the combination of vaccination and policies of transmission suppression potentially lowered the number of hospitalized cases by 380þand 66þthousand cases,respectively,compared to an absence of such *** top of transmission suppressiononly policies,vaccination impacted more than 230þthousand averted hospitalized cases and 43þthousand averted ***,health surveillance activities should be maintained along with vaccination planning in scheduled groups until a large vaccinated coverage is ***,this analytical framework enables evaluation of such scenarios.

关键词： SARS-coV-2 Vaccination cOVID-19

Intermediate conductance, ca^2＋-activated K^＋ channels： a novel target for chronic renal diseases

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Frontiers in Biology 2015年第1期10卷 52-60页

作者： claudia A. BERTUccIO daniel c. DEVOR Department of cell Biology School of Medicine University of Pittsburgh Pittsburgh PA 15261 USA

Renal failure is a medical condition in which the kidneys are not working properly. There are two types of kidney failure： 1） acute kidney failure, which is sudden and often reversible with adequate treatment; and 2） chronic renal failure, which develops slowly and often is not reversible. The last stage of chronic renal failure is fatal without dialysis or kidney transplant. The treatment for chronic renal failure is focusing on slowing the progression of kidney damage. Several reports have described a promising approach to slow the loss of renal function through inhibition of the basolateral membrane, ca^2＋-activated K^＋（Kca3.1） channel with a selective and nontoxic blocker TRAM-34. This review summarizes pathophysiological studies that describe the role of Kca3.1 in kidney diseases.

关键词： ca^2+-activated K^+ channels Kca3.1 renal fibrosis polycystic kidney disease diabetes nephropathy transplant,cell proliferation c1 secretion renal failure