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Fully 3D-printed organic electrochemical transistors

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npj Flexible Electronics 2023年第1期7卷 453-463页

作者： Matteo Massetti Silan Zhang Padinhare Cholakkal Harikesh Bernhard Burtscher Chiara Diacci daniel t.simon Xianjie Liu Mats Fahlman Deyu tu Magnus Berggren simone Fabiano Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversityNorrköpingSweden.2Wallenberg Wood Science CenterLinköping UniversityNorrköpingSweden

Organic electrochemical transistors(OECts)are being researched for various applications,ranging from sensors to logic gates and neuromorphic *** meet the requirements of these diverse applications,the device fabrication process must be compatible with flexible and scalable digital ***,we report a direct-write additive process to fabricate fully 3D-printed OECts,using 3D printable conducting,semiconducting,insulating,and electrolyte *** 3D-printed OECts,which operate in the depletion mode,can be fabricated on flexible substrates,resulting in high mechanical and environmental *** 3D-printed OECts have good dopamine biosensing capabilities(limit of detection down to 6μM without metal gate electrodes)and show long-term(~1 h)synapse response,indicating their potential for various applications such as sensors and neuromorphic *** manufacturing strategy is suitable for applications that require rapid design changes and digitally enabled direct-write techniques.

关键词： electrochemical hardware printed

LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders？

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Neural Regeneration Research 2017年第8期12卷 1247-1251页

作者： simon Foale Martin Berry Ann Logan daniel Fulton Zubair Ahmed Neuroscience and Ophthalmology Institute of Inflammation and Ageing University of Birmingham Birmingham UK

Leucine rich repeat proteins have gained considerable interest as therapeutic targets due to their expression and biological activity within the central nervous system. LINGO-1 has received particular attention since it inhibits axonal regeneration after spinal cord injury in a Rho A dependent manner while inhibiting leucine rich repeat and immunoglobulin-like domain-containing protein 1（LINGO-1） disinhibits neuron outgrowth. Furthermore, LINGO-1 suppresses oligodendrocyte precursor cell maturation and myelin production. Inhibiting the action of LINGO-1 encourages remyelination both in vitro and in vivo. Accordingly, LINGO-1 antagonists show promise as therapies for demyelinating diseases. An analogous protein to LINGO-1, amphoterin-induced gene and open reading frame-3（AMIGO3）, exerts the same inhibitory effect on the axonal outgrowth of central nervous system neurons, as well as interacting with the same receptors as LINGO-1. However, AMIGO3 is upregulated more rapidly after spinal cord injury than LINGO-1. We speculate that AMIGO3 has a similar inhibitory effect on oligodendrocyte precursor cell maturation and myelin production as with axogenesis. therefore, inhibiting AMIGO3 will likely encourage central nervous system axonal regeneration as well as the production of myelin from local oligodendrocyte precursor cell, thus providing a promising therapeutic target and an area for future investigation.

关键词： multiple sclerosis demyelination oligodendrocyte AMIGO3 LINGO1 oligodendrocyte precursor cell

A Virtual Prototyping Approach for Development of PMSM on Real‑time Platforms: A Case Study on temperature Sensitivity

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Automotive Innovation 2022年第3期5卷 285-298页

作者： René Scheer Yannick Bergheim simon Aleff daniel Heintges Niclas Rahner Rafael Gries Jakob Andert teaching and Research Area Mechatronics in Mobile Propulsion RWTH Aachen UniversityForckenbeckstr.4Aachen 52074Germany DENSO Automotive Deutschland GmbH Friedrich‑List‑Allee 42Wegberg 41844Germany

this paper presents a comprehensive evaluation of system interactions in a battery electric vehicle caused by temperature sensitivity of permanent magnet synchronous machines(PMSM).An analytical model of a PMSM considering iron losses and thermal impact is implemented on a field programmable gate array suitable for hardware-in-the-loop *** the presented virtual prototyping approach,different machine characteristics defined by the design are used to parameterize the analytical *** investigated temperature effect is understood as an interacting influence between machine character-istics and control,which are investigated in terms of torque generation,voltage utilization and efficiency under closed-loop condition in a vehicle *** particular,using a surface permanent magnet rotor and an interior permanent magnet rotor,the performance of both machine designs is analyzed by varying temperature-adjusted feedforward control strategies on the basis of a driving cycle from a *** comparison shows that the machine design with surface-mounted mag-nets is associated with higher temperature *** this case,the temperature consideration in the feedforward control provides a14%loss reduction in closed-loop vehicle test *** can be summarized that the electromagnetic torque is less sensitive to a temperature variation with increasing *** presented development approach demonstrates the impact of interactions in electric powertrains without the need of real prototypes.

关键词： FPGA PMSM Iron loss FEM Spatial harmonics Rt-MIL Virtual prototyping Frontloading Closed-

Pneumothorax in a thiel cadaver model of cardiopulmonary resuscitation

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World Journal of Emergency Medicine 2023年第2期14卷 143-147页

作者： daniel Auinger simon Orlob Johannes Wittig Gabriel Honnef Stefan Heschl Georg Feigl Gerhard Prause Division of Anaesthesiology and Intensive Care Medicine 1 Department of Anaesthesiology and Intensive Care MedicineMedical University of GrazGraz 8036Austria Division of Anaesthesiology and Intensive Care Medicine 2 Department of Anaesthesiology and Intensive Care MedicineMedical University of GrazGraz 8036Austria Medical University of Graz Graz 8036Austria Research Center for Emergency Medicine Aarhus University HospitalAarhus 8200Denmark Department of Medicine Randers Regional HospitalRanders 8930Denmark Chair of Macroscopic and Clinical Anatomy Gottfried Schatz Research CenterMedical University of GrazGraz 8036Austria Institute of Morphology and Clinical Anatomy Faculty of Health/School of MedicineWitten/Herdecke UniversityWitten 58448Germany

INtRODUCtION there has been some previous research in the field of cardiopulmonary resuscitation (CPR) using cadaver models.[1]the thiel method was developed by Professor Walter thiel (Graz, Austria) and described in 1992 and 2002. It consists of both an intravascular injection of the embalming solution and submersion of the bodies in a tank with the same solution for a determined period.[2,3]

关键词： Walter cardiopulmonary bal

towards maximized utilization of iridium for the acidic oxygen evolution reaction

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Nano Research 2019年第9期12卷 2275-2280页

作者： Marc Ledendecker simon Geiger Katharina Hengge Joohyun Lim Serhiy Cherevko Andrea M. Mingers daniel Gohl Guilherme V. Fortunato daniel Jalalpoor Ferdi Schuth Christina Scheu Karl J. J. Mayrhofer Department of Interface Chemistry and Surface Engineering Nanoanalytics and Interfaces Max-Planck-Institut fur Eisenforschung GmbH40237 DusseldorfGermany Department of Heterogeneous Catalysis Max-Planck-Institut fur KohlenforschungKaiser- Wilhelm-Platz 145470 Mulheim an der RuhrGermany Helmholtz-Institute Erlangen-Nurnbergfar Renewable Energy (IEK-11) Forschungszentrum Jillich91058 ErlangenGermany Department of Chemical and Biological Engineering Friedrich-Alexander- Universitat Erlangen -Nurnberg91058 ErlangenGermany Institute of Chemistry Universidade Federal de Mato Grosso do SulAv. Senador Filin to Muller1555Campo GrandeMS 79074-460Brazil

the reduction in noble metal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale commercialisation of polymer electrolyte membrane *** catalytic stability and activity are inversely related,long service lifetime still demands large amounts of low-abundant and expensive *** this manuscript we elaborate on the concept of maximizing the utilisation of iridium for the oxygen evolution *** combining different tin oxide based support materials with liquid atomic layer deposition of iridium oxide,new possibilities are opened up to grow thin layers of iridium oxide with tuneable noble metal ***-situ,time-and potential-resolved dissolution experiments reveal how the stability of the substrate and the catalyst layer thickness directly affect the activity and stability of deposited iridium *** on our results,we elaborate on strategies how to obtain stable and active catalysts with maximized iridium utilisation for the oxygen evolution reaction and demonstrate how the activity and durability can be tailored *** results highlight the potential of utilizing thin noble metal films with earth abundant *** for future catalytic applications in the energy sector.

关键词： oxygen evolution reaction liquid atomic layer depositi on catalysis iridium core-shell nano particles

Weave geometry generation avoiding interferences for mesoscale RVEs

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Journal of Materials Science & technology 2019年第12期35卷 2869-2882页

作者： daniel Höwer Shengkai Yu trenton M.Ricks Brett A.Bednarcyk Evan J.Pineda Bertram Stier Stefanie Reese Jaan-Willem simon Institute of Applied Mechanics RWTH Aachen University52074 AachenGermany NASA Glenn Research Center ClevelandOH 44135USA Collier Research and Development Corporation Newport NewsVA 23606USA

An algorithm which allows the generation of representative volume elements(RVEs) for complex woven and warp-interlaced fiber-reinforced composite topologies while avoiding unphysical tow intersections is presented. this is achieved by extending an existing RVE generation strategy in two significant ways:(1) the local cross section shape of the tow is adjusted depending on the local tow curvature in a way that preserves the cross sectional area of the tow, and(2) the elementary crimp interval is separated into a planar and a transition region. the modifications facilitate the generation of a wide range of elaborate textile topologies without tow intersections, which are present without the proposed modifications unless complex tow to tow contact models are introduced. the mechanical properties of plain weaves were predicted based on the topology generated with the proposed algorithm as well as based on RVEs which were constructed based on actual micrographs, i.e. a "digital twin" of the actual microstructure. A comparison of the predicted mechanical properties based on finite element and Multiscale Generalized Method of Cells techniques shows close agreement. However, some differences exist with respect to experimentally determined material parameters due to the finite dimensions of the specimens. Lastly,mechanical properties of multilayered weaves are predicted with the finite element method. the considered material systems are carbon fiber in epoxy matrix as well as C/C-SiC. However, the procedure is applicable to a wide range of material systems.

关键词： RVE generation Multiscale analysis Composites

Non-optical polyp-based resect and discard strategy:A prospective clinical study

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World Journal of Gastroenterology 2022年第19期28卷 2137-2147页

作者： Mahsa taghiakbari Celia Hammar Mira Frenn Roupen Djinbachian Heiko Pohl Erik Deslandres simon Bouchard Mickael Bouin daniel von Renteln Department of Gastroenterology Montreal University Hospital Research Center(CRCHUM)Montréal H2X 0A9QuebecCanada Department of Gastroenterology University of MontrealFaculty of MedicineMontreal H2X 0A9QuebceCanada Department of Internal Medicine University of Montreal Hospital Center(CHUM)Montreal H2X 0A9QuebecCanada Department of Medicine Veterans Affairs Medical CenterWhite River JunctionVT 05009United States Department of Gastroenterology Dartmouth Geisel School of Medicine and The Dartmouth InstituteHanoverNH 03755United States

BACKGROUND Post-polypectomy surveillance intervals are currently determined based on pathology *** to evaluate a polyp-based resect and discard model that assigns surveillance intervals based solely on polyp number and *** Patients undergoing elective colonoscopies at the Montreal University Medical Center were enrolled *** polyp-based strategy was used to assign the next surveillance interval using polyp size and *** intervals were also assigned using optical diagnosis for small polyps(the primary outcome was surveillance interval agreement between the polyp-based model,optical diagnosis,and the pathology-based reference standard using the 2020 United States Multi-Society task Force *** outcomes included the proportion of reduction in required histopathology evaluations and proportion of immediate post-colonoscopy recommendations provided to *** Of 944 patients(mean age 62.6 years,49.3%male,933 polyps)were *** surveillance interval agreement for the polyp-based strategy was 98.0%[95%confidence interval(CI):0.97-0.99]compared with pathology-based *** diagnosis-based intervals achieved 95.8%(95%CI:0.94-0.97)agreement with *** using the polyp-based strategy and optical diagnosis,the need for pathology assessment was reduced by 87.8%and 70.6%,*** polyp-based strategy provided 93.7%of patients with immediate surveillance interval recommendations vs 76.1%for optical *** the polyp-based strategy achieved almost perfect surveillance interval agreement compared with pathology-based assignments,significantly reduced the number of required pathology evaluations,and provided most patients with immediate surveillance interval recommendations.

关键词： Colonoscopy Colorectal pathology Colorectal adenomas Endoscopy Surveillance Optical diagnosis

temporal trends in concentrations of legacy and novel brominated flame retardants in house dust from Birmingham in the United Kingdom

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Emerging Contaminants 2020年第1期6卷 323-329页

作者： daniel simon Drage Sonthinee Waiyarat Stuart Harrad Mohamed Abou-Elwafa Abdallah Suwanna Kitpati Boontanon School of Geography Earth&Environmental SciencesUniversity of BirminghamBirminghamB152TTUK Department of Civil and Environmental Engineering Faculty of EngineeringMahidol UniversityNakhon PathomThailand

Concentrations of polybrominated diphenyl ethers(PBDEs),hexabromocyclododecane(HBCDD),tetrabromobisphenol-A(tBBPA)and two potential replacements decabromodiphenylethane(DBDPE)and 1,2-bis(2,4,6-tribromophenoxy)ethane(BtBPE)were measured in dust samples collected from 14 homes across Birmingham(UK).Concentrations were compared with those from the same city in previous studies to ascertain any temporal changes and to assess the effects of legislative *** average PHBCDDs concentration(46,000 ng/g;median=280 ng/g)included the highest dust concentration recorded globally(570,000 ng/g).this is despite the listing of HBCDD under the Stockholm Convention in 2013,demonstrating that decreases in indoor contamination will likely be slow as existing sources are gradually *** contrast,concentrations of BDE-47(mean=5.7 ng/g;median=0.93 ng/g)and BDE-99(mean=11 ng/g;median=2.9 ng/g)were significantly lower than in all previous(ptudies in the same city since 2006,suggesting restrictions on the Penta-BDE formulation have been *** average BDE-209 concentration(4800 ng/g;median=1600 ng/g)is lower than the peak average concentration,which was observed in 2007(280,000 ng/g),however this is not a significant decline,probably due to the later imposition of Deca-BDE restrictions compared to those on *** in PBDE concentrations have coincided with a significant(ptrations(average=1500 ng/g;median=660 ng/g)since 2014,suggesting its use as a replacement flame retardant for *** no significant change was detected for BtBPE(average 11 ng/g;median=0.84 ng/g in this study);concentrations of tBBPA(average=34 ng/g;median=35 ng/g)were significantly lower(pthan in 2007(average 62 ng/g).the decreases observed in PBDE concentrations,demonstrates that legislation has been effective in reducing the commercial use of PBDEs,however this has coincided with increases of alternative flame retardants such as DBDPE.

关键词： Brominated Flame Retardants(BFRs) Polybrominated diphenyl ethers(PBDEs) Hexabromocyclododecane(HBCDD) Decabromodiphenyl ethane(DBDPE) Stockholm convention tetrabromobisphenol A(tBBPA) BtBPE

Sex differences in injury rates in team-sport athletes:A systematic review and meta-regression analysis

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Journal of Sport and Health Science 2022年第1期11卷 104-114页

作者： Astrid Zech Karsten Hollander Astrid Junge simon Steib Andreas Groll Jonas Heiner Florian Nowak daniel P.feiffer Anna Lina Rahlf Department of Human Movement Science and Exercise Physiology Friedrich Schiller University JenaJena 07749Germany MSH Medical School Hamburg Hamburg 20457Germany Swiss Concussion Center Schulthess KlinikZürich 8008Switzerland Department of Human Movement Training and Active AgingHeidelberg UniversityHeidelberg 69117Germany Department of Statistics Technical University of DortmundDortmund 44227Germany Department of Sports and Exercise Medicine Institute of Human Movement ScienceUniversity of HamburgHamburg 20146Germany

Background:team-sport players have a particularly high injury *** female sex is considered a risk factor,it is still unknown whether female and male team-sport players,in fact,differ in their injury *** aimed to compare injury rates between female and male players by systematically reviewing and meta-analyzing injury surveillance studies of both sexes in order to evaluate sex-specific differences in team-sport ***:Studies that prospectively collected injury data for high-level female and male players(age≥16 years)in basketball,field hockey,football(soccer),handball,rugby(union and sevens),and volleyball were *** reviewers(AZ and ALR)independently assessed study quality and extracted data for overall,match,training,and severe injuries(>28 days’time loss)as well as data regarding injury locations and *** rate ratios(IRRs)were pooled in a meta-analysis,and meta-regression analysis was performed when 10 or more studies were ***:Of 20 studies,9 studies reported injury data from football,3 studies from rugby,3 studies from handball,1 study from basketball,1 study from field hockey,2 studies from volleyball,and 1 study from basketball and field *** overall injuries,the pooled IRR=0.86(95%confidence interval(95%CI):0.76-0.98)indicated significantly more injuries in male than in female *** injury location,the pooled IRR showed higher injury rates in male athletes than in female athletes for upper extremity,hip/groin,thigh,ande foot *** players had a significantly higher rate of anterior cruciate ligament injuries(IRR=2.15,95%CI:1.27-3.62)than male *** significant sex-specific differences in IRR were found for match,training,severe injuries,concussions,or ankle ***:Our meta-analysis provides evidence for sex-specific differences in the injury rates in team *** epidemiological studies including both sexes in sports other than football are needed in order t

关键词： Athletes Female Injuries Male team sports