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Exploring kidney biopsy findings in congenital heart diseases:Insights beyond cyanotic nephropathy

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World Journal of Nephrology 2024年第1期13卷 25-32页

作者： Jose daniel Juarez-Villa Iván Zepeda-Quiroz Sebastián Toledo-Ramírez Victor Hugo Gomez-johnson Francisco pérez-Allende Brian Ricardo Garibay-Vega Francisco E Rodríguez Castellanos Bernardo Moguel-González Edgar Garcia-Cruz Salvador Lopez-Gil Department of Nephrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico Congenital Heart Disease Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BACKGROUND The association between congenital heart disease and chronic kidney disease is well *** mechanisms of kidney damage associated with congenital heart disease have been *** etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical *** To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our *** This is a retrospective observational study conducted at the Nephrology Depart-ment of the National Institute of Cardiology“Ignacio Chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the *** Ten patients with congenital heart disease and kidney biopsy were *** average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 *** most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)*** the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement *** remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific *** Determining the cause of chronic kidney disease can help in delaying the need for kidney replacement *** 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was *** studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.

关键词： Renal biopsy Congenital heart disease Chronic kidney disease Focal segmental glomerulosclerosis

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M. Navarro daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. paurus Kent J. Bloodsworth Kelsey A. Allen Lisa M. Bramer Fernando Montes Kathleen A. Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-johnson Biological Sciences Division Pacific Northwest National Laboratory Environmental and Molecular Sciences Division Pacific Northwest National Laboratory Centers for Disease Control and prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National Security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by Student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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Electrical geophysical evaluation of susceptibility to flooding in University of Nigeria, Nsukka main campus and its environs, Southeastern Nigeria

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Journal of Groundwater Science and Engineering 2023年第4期11卷 422-434页

作者： daniel Nnaemeka Obiora johnson Cletus Ibuot Department of physics and Astronomy University of NigeriaNsukkaEnugu State

Flooding occurs when rainfall exceeds the absorption capacity of soil and causes significant environmental *** this study,electrical resistivity techniques were employed to assess the flood susceptibility of the study area by examining variations in electrical *** to flooding,Vertical Electrical Sounding(VES)and Electrical Resistivity Tomography(ERT)profiles were conducted to determine the variations in resistivity within subsurface lithologies exposed to the injected *** injected current penetrated the subsurface units characterised by resistivity ranging from 190.5Ω·m to 6,775.7Ω·m,42.3Ω·m to 7,297.4Ω·m,and 320.2Ω·m to 24,433.3Ω·m in the first,second and third layers,*** layers were identified as lateritic topsoil,medium-coarse brownish grained sand,and coarse pebbly blackish sand,*** calculated reflection coefficients between layers 1,2,and 3 reveal alternation in layers with values ranging from−0.04 to 0.66 and 0.36 to 0.95 for and,*** transverse resistivity,longitudinal resistivity and anisotropy ranged from 243.59Ω·m to 24,115.42Ω·m,199.61Ω·m to 14,950.76Ω·m,and 1.02 to *** derived from the ERT profiles reveal variations in resistivity,pinpointing areas of low resistivity which correspond to waterlogged and impermeable *** result of this study underscores the importance of integrated resistivity techniques in the study of floods,as it provides valuable insights into flood behaviour,and subsurface dynamics.

关键词： Anisotropy Vertical electrical sounding Electrical resistivity tomography Geoelectric layer permeability

Re-evaluating monazite as a record of metamorphic reactions

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Geoscience Frontiers 2022年第2期13卷 237-254页

作者： Kyle p.Larson Sudip Shrestha John M.Cottle Carl Guilmette T.Alex johnson H.daniel Gibson Félix Gervais Department of Earth Environmental and Geographic SciencesUniversity of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada Fipke Laboratory for Trace Element Research University of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada Department of Earth Science University of CaliforniaSanta BarbaraSanta BarbaraCA 93106-9630USA Géologie et Génie Géologique UniversitéLavalQuébec CityQuebecCanada Department of Earth Sciences Simon Fraser University8888 University DriveBurnabyBC V5A 1S6Canada Départment des Génies Civil Géologique et des MinesPolytechnique MontréalMontréalQC H3T 1J4Canada

This study presents a re-examination of historical specimens(DG136 and DG167)from the Monashee complex in the southeastern Canadian Cordillera that are critical to the current understanding of rare earth element(REE)distribution between garnet and monazite(and other accessory minerals)during ***-hundred and fifty-one new monazite petrochronology spot analyses on 29 different grains across two specimens outline detailed(re)crystallization *** element data collected from the same ablated volume,interpreted in the context of new phase equilibria modelling that includes monazite,xenotime and apatite,link ages to specific portions of the pressure-temperature(p-T)paths followed by the *** linkages are further informed by garnet Lu-Hf geochronology and xenotime *** clockwise p-T paths indicate prograde metamorphism was ongoing by ca.80 Ma in both *** structurally deeper specimen,DG136,records peak p-T conditions of~755-770℃and 8.8-10.4 kbar,interpreted to coincide with(re-)crystallization of low Y monazite at~75-70 ***-rim garnet isopleths from DG167 cross in the observed peak assemblage field at~680℃ and 9.3 *** conditions are interpreted to correspond with low Y monazite(re-)crystallisation at~65 *** specimens record decompression along their retrograde path coincident with high Y 70-55 Ma and 65-55 Ma monazite populations in DG136 and DG167,*** findings broadly agree with those initially reported~20 years ago and confirm early interpretations using trace elements in monazite as generally reliable markers of metamorphic *** phase equilibria modelling and in situ petrochronological analysis,however,provide additional insight into monazite behaviour during anatexis and the effects of potential trace element buffering by REE-bearing phases such as apatite.

关键词： Monazite petrochronology phase equilibria modelling Geochronology p-T-t paths

Soil water content and nitrogen differentially correlate with multidimensional leaf traits of two temperate broadleaf species

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plant Diversity 2023年第6期45卷 694-701页

作者： Ming-Yue Jin daniel J.johnson Guang-Ze Jin Qing-Xi Guo Zhi-Li Liu Center for Ecological Research Key Laboratory of Sustainable ForestEcosystem Management-Ministry of EducationNortheast Asia Biodiversity Research CenterNortheast Forestry UniversityHarbin 150040HeilongjiangChina School of Forest Resources and Conservation University of FloridaGainesvilleFLUSA

The variation and correlation of leaf economics and vein traits are crucial for predicting plant ecological strategies under different environmental ***,correlations between these two suites of traits and abiotic factors such as soil water and nitrogen content remain *** measured leaf economics and vein traits as well as soil water and nitrogen content for two different shade-tolerant species(Betula platyphylla and Acer mono)in four mixed broadleaved-Korean pine(pinus koraiensis)forests along a latitudinal gradient in Northeast *** found that leaf economics traits and vein traits were decoupled in shade-intolerant species,Betula platphylla,but significantly coupled in a shadetolerant species,*** found stronger correlations among leaf traits in the shade tolerant species than in the shade intolerant ***,leaf economic traits were positively correlated with the soil water gradient for both species,whereas vein traits were positively correlated with soil water gradient for the shade intolerant species but negatively correlated in the shade tolerant *** economic traits were positively correlated with soil nitrogen gradient in shade intolerant species but not correlated in shade tolerant species,vein traits were negatively correlated with soil nitrogen gradient in shade tolerant species but not correlated in shade intolerant *** study provides evidence for distinct correlations between leaf economics and vein traits and local abiotic factors of species differing in light *** recommend that the ecological significance of shade tolerance be considered for species when evaluating ecosystem functions and predicting plant responses to environmental changes.

关键词： Leaf trait multidimensionality Economics traits Vein traits Soil water content Soil total nitrogen Shade tolerance

Modelling the potential consequences of adaptive closure management in a penaeid trawl fishery

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Aquaculture and Fisheries 2023年第2期8卷 190-201页

作者： Edward V.Camp daniel D.johnson Matthew D.Taylor Fisheries and Aquatic Sciences School of ForestFisheriesand Geomatics SciencesUniversity of FloridaGainesville32611FLUSA port Stephens Fisheries Institute New South Wales Department of Primary IndustriesTaylors Beach RdTaylors BeachNew South Wales2315Australia School of Environmental and Life Sciences University of NewcastleNew South Wales2308Australia

Spatial management of fishing effort can be used to avoid catching undesirable size classes for target species,and improve yield-per-recruit for the exploited *** closure management has been proposed as a means to more effectively utilise spatial management,however these management provisions often lack quantitative evaluation which constrains the information available to inform *** demonstrate the use of a spatially and size structured population dynamics model to evaluate the potential impact of spatial management on a multijurisdictional fishery for a highly migratory species(eastern king prawn,penaeus[Melicertus]plebejus).Under current conditions in the fishery,the overall effect of closures on harvest was estimated to be comparatively minor,regardless of assumptions about how effort or fisher behavior are affected by spatial *** assumptions about the movement patterns of eastern king prawn had little influence on the impact of closures on overall ***,when effort was increased to historic levels similar to those observed when the closures were implemented,a much greater impact on overall harvest was *** approach taken and simulation outcomes are discussed in the context of spatial management for both eastern king prawn,and penaeid fisheries more broadly.

关键词： penaeidae Trawl Management strategy evaluation Closures Adaptive management

Trees species’ dispersal mode and habitat heterogeneity shape negative density dependence in a temperate forest

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森林生态系统:英文版 2023年第5期10卷 589-596页

作者： Lishunan Yang daniel J.johnson Zhichun Yang Xiaochao Yang Qiulong Yin Ying Luo Zhanqing Hao Shihong Jia School of Ecology and Environment Northwestern Polytechnical UniversityXi’anShaanxi710072China Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and protection Northwestern Polytechnical UniversityXi’anShaanxi710072China School of Forest Fisheriesand Geomatics SciencesUniversity of FloridaGainesvilleFLUSA School of Geography and Tourism Shaanxi Normal UniversityXi’anShaanxi710062China

Conspecific negative density dependence(CNDD)is a potentially important mechanism in maintaining species *** previous evidence showed habitat heterogeneity and species’dispersal modes affect the strength of CNDD at early life stages of trees(e.g.,seedlings),it remains unclear how they affect the strength of CNDD at later life *** examined the degree of spatial aggregation between saplings and trees for species dispersed by wind and gravity in four topographic habitats within a 25-ha temperate forest dynamic plot in the Qinling Mountains of central *** used the replicated spatial point pattern(RSpp)analysis and bivariate paircorrelation function(pCF)to detect the spatial distribution of saplings around trees at two scales,15 and 50 m,*** the signal was not apparent across the whole study region(or 25-ha),it is distinct on isolated areas with specific characteristics,suggesting that these characteristics could be important factors in ***,we found that the gravity-dispersed tree species experienced CNDD across habitats,while for wind-dispersed species CNDD was found in gully,terrace and low-ridge *** study suggests that neglecting the habitat heterogeneity and dispersal mode can distort the signal of CNDD and community assembly in temperate forests.

关键词： Biodiversity Conspecific negative density dependence Dispersal Replicated point patterns Temperate forest Topographic habitat

Recurrent cyclops lesion after primary anterior cruciate ligament reconstruction using bone tendon bone allograft:A case report

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World Journal of Orthopedics 2023年第11期14卷 836-842页

作者： Grayson Kelmer Andrea H johnson Justin J Turcotte daniel E Redziniak Orthopedic Research Anne Arundel Medical CenterAnnapolisMD 21401United States Medical School Campbell University School of Osteopathic MedicineLillingtonNC 27546United States Orthopedic Surgery Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Cyclops lesions are a known complication of anterior cruciate ligament(ACL)reconstruction,with symptomatic cyclops syndrome occurring in up to 11%of *** cyclops lesions have been rarely documented;this case study documents the successful treatment of a recurrent cyclops *** SUMMARY A 28-year-old female presented following a non-contact injury to the right *** and clinical exam revealed an ACL tear,and arthroscopic reconstruction was *** years later a cyclops lesion was discovered and removed via arthroscopic *** months postoperatively,the patient presented with pain,stiffness,and difficulty achieving terminal extension.A smaller recurrent cyclops lesion was diagnosed,and a repeat synovectomy was *** patient recovered *** To the best of our knowledge,this is the first documented case of recurrent cyclops lesion after bone-patellar tendon-bone allograft ACL reconstruction presenting as cyclops syndrome.

关键词： Anterior cruciate ligament Cyclops lesion Cyclops syndrome Knee arthroscopy Anterior cruciate ligament reconstruction Case report

Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit

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Chinese Journal of Cancer 2012年第7期31卷 319-326页

作者： daniel E. johnson Departments of Medicine and pharmacology & Chemical Biology University of Pittsburgh Cancer InstitutePittsburgh Pennsylvania 15213 USA

Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC have not changed appreciably in the past few decades, underscoring a dire need for improved therapeutic options. Recent studies have elucidated a key signaling axis, the EGFR-STAT3-Bcl-XL signaling axis, that is aberrantly activated in a majority of HNSCC and contributes to the proliferation and survival of malignant cells. Considerable effort is being placed on developing highly specific inhibitors of different components of this pathway. This review highlights the progress that is being made towards achieving potent inhibition of the EGFR-STAT3-Bcl-XL signaling axis in HNSCC and the promising therapeutic strategies that are currently under development for this disease.

关键词：治疗效果头颈部癌症存活增殖鳞状细胞癌头部恶性肿瘤