检索结果-南通市图书馆

pharmacotechnical and Chemical Study of paracetamol Sold in Kinshasa-DR Congo: Comparative Quality Assessment of Five Brands

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Applied Sciences 2022年第4期12卷 501-516页

作者： Jocelyn K. Mankulu Eben-Ezer K. Ive Eugene M. Kagheni Timothy M. Mavanga daniel O. Opota Didi K. Mana Laboratory of Drugs Analysis and Quality Control and Diets Survey (LACOMEDA) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo Central Research Laboratory Catholic University of Graben Butembo Democratic Republic of the Congo Laboratory pharmaceutics and Solid Forms (Tests Division) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo

paracetamol/Acetaminophen was assessed in different 5 brands comparatively to study its physicochemical and pharmaceutical parameters. We also evaluated the similarity among those brands. Widely used as an antipyretic and analgesic agent to cure fever and pain, the therapeutic efficacy of this product depends on both physicochemical and pharmaceutical qualities which include its conformity to standard specifications according to the active ingredient dosage in the formulation. This research work aimed to assess comparatively 5 paracetamol brands tablet form sold in the Democratic Republic of the Congo (particularly in Kinshasa), on their physicochemical and pharmaceutical tests conformities compared to the standard specifications. Based on tests, we evaluated the uniformity of weight, disintegration time, friability, crushing strength (hardness), and the active ingredient dosage per brand. The tests were performed using the Sotaxp>TMp> apparatus according to standard methods following the pharmacopoeia protocols. And according to the performed tests, only the fifth brand of paracetamol coded p5 did not satisfy the friability test. About the hardness test, we have also observed the unconformity of three brands (p1, p2, and p3) while both p4 and p5 satisfied the test. This leads us to conclude that among all the studied brands, only p5 satisfy to all the tests either pharmacotechnically or chemically (identification and dosage). And this study allowed us to re-examine the equivalence concept between several princeps (original brand) with their generics since that similarity depends on many parameters that need to be improved during the manufacturing process including in-process analysis in all the phases of preparation to evaluate the rate of either active ingredient or inactive ingredient because each component can affect seriously the final pharmaceutical formulation quality.

关键词： Quality Control paracetamol pharmacotechnical Chemical Study

Induced Hall-Like Current by Acoustic phonons in Semiconductor Fluorinated Carbon Nanotube

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Condensed Matter physics 2020年第2期10卷 71-87页

作者： daniel Sakyi-Arthur Samuel Y. Mensah Kofi W. Adu Kwadwo A. Dompreh Raymond Edziah Natalia G. Mensah Cynthia Jebuni-Adanu Department of physics College of Agriculture and Natural Sciences U.C.C Ghana Department of Mathematics College of Agriculture and Natural Sciences U.C.C Ghana Department of physics Pennsylvania State University-Altoona College Altoona Pennsylvania USA Material Research Institute Pennsylvania State University University Park Pennsylvania USA St. Francis College of Education Hohoe Volta Region Ghana

We show that Hall-like current can be induced by acoustic phonons in a nondegenerate, semiconductor fluorine-doped single-walled carbon nanotube (FSWCNT) using a tractable analytical approach in the hypersound regime ?(q is the modulus of the acoustic wavevector and is the electron mean free path). We observed a strong dependence of the Hall-like current on the magnetic field, H, the acoustic wave frequency, , the temperature, T, the overlapping integral, , and the acoustic wavenumber, q. Qualitatively, the Hall-like current exists even if the relaxation time does not depend on the carrier energy but has a strong spatial dispersion, and gives different results compared to that obtained in bulk semiconductors. For and , the Hall-like current is in the absence of an electric field and in the presence of an electric field at 300 K. Similarly, the surface electric field due to the Hall-like current is in the absence of an external electric field. In the presence of an external electric field, and for at 300 K. q and can be used to tune the Hall-like current and of the FSWCNT. This offers the potential for room temperature application as an acoustic switch or transistor, as well as a material for ultrasound current source density imaging (UCSDI) and AE hydrophone device in biomedical engineering.

关键词： Carbon Nanotube Fluorinated Hall-Like Current Cyclotron

Are Tuberculosis patients Managed According to the National Guidelines in Lagos State Nigeria?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2016年第1期7卷 16-24页

作者： Olusola Adedeji Adejumo Olusoji James daniel Mustapha Gidado Andrew Folarin Otesanya Esther Ngozi Adejumo Ebunoluwa O. Jaiyesimi Oluwatoyin Esther Idowu Olumuyiwa O. Odusanya Department of Community Health and primary Health Care Lagos State University Teaching Hospital Ikeja Lagos Nigeria Department of Community Medicine and primary Care Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria KNCV Tuberculosis Foundation/TB CARE I project Abuja Nigeria Medical Services Department Central Bank of Nigeria Lagos Nigeria Department of Medical Laboratory Science Babcock University Ilisan-Remo Nigeria Department of Community Health and primary Health Care College of Medicine Lagos Lagos State University Lagos Nigeria

Setting: private and public tuberculosis (TB) treatment centers in Lagos State, Nigeria. Objective: To compare adherence of private and public providers of directly observed treatment short course (DOTS) in the Lagos State TB control program, Nigeria (LSTBLCp) with the national TB guidelines. Design: A retrospective review of treatment cards of TB patients managed within the first and second quarter of 2012 in 34 DOTS facilities {23 public, 7 private for profit (pFp), and 4 private not for profit (pNFp)} involved in the private public mix of the LSTBLCp. Results: Of the 1896 treatment cards reviewed, 1524 (80.4%), 132 (7.0%) and 240 (12.6%) were from public, pFp and pNFp DOTS facilities, respectively. About 19%, 25% and none of the patients managed at the public, pNFp, and pFp DOTS facilities were treated in full adherence with the national guidelines respectively. A significantly higher proportion of adults and sputum smear positive TB patients were treated in full adherence with the national guidelines (p providers in public and private health facilities in Lagos State Nigeria to ensure full adherence with the national TB guidelines.

关键词： Adherence National Guidelines Health Workers DOTS Facilities

微生物和3-D地震测量的综合可以发现砾岩油田并追索微油气苗的减弱

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石油地质科技动态 2005年第6期 38-44页

作者： daniel C. Hitzman 吕娟（译）李大荣（校）白振瑞（校）

通过微生物微油气苗特征和3-D地震资料的综合研究，勘探工作者提出了一种新的成藏层带研究思路，并在得克萨斯州蒙塔古县发现了帕克斯普林斯（park Springs）（砾岩）油田。开展了5．6km^-2的标准3-D地球物理测量，在工区北部大约2200m... 详细信息

通过微生物微油气苗特征和3-D地震资料的综合研究，勘探工作者提出了一种新的成藏层带研究思路，并在得克萨斯州蒙塔古县发现了帕克斯普林斯（park Springs）（砾岩）油田。开展了5．6km^-2的标准3-D地球物理测量，在工区北部大约2200m深处发现了埃伦博格远景构造。1995年12月。利用微生物石油勘探技术（MOST）对该地区的微油气苗进行了普查。在埃伦博格构造区发现了正的但规模较小的微油气苗异常特征。在位于其南面1.6km远处的构造地堑的上方发现了更强且更大的微生物异常。1996年2月，在研究区又采集了更多的MOST样品。新的测量结果证实了与地震远景构造有关的小规模烃类异常，同时也证实了与1．6km以南的构造地堑有关的大规模烃类异常。对得克萨斯北部类似的地质远景区进行对比研究发现，这个地堑可能合有阿托坎（Atokan）统砾岩（沃思堡盆地的一个风险勘探目标），但主要的勘探目标仍然是埃伦博格构造以及与其有关的小规模微油气苗异常区。1996年3月，在构造顶部对这个由地震圈定的远景构造进行了钻探。Silver 1井揭穿了埃伦博格群中1．8m厚的Salona组致密砂岩。完井后只获得了边际石油产量，3年内生产了约340桶石油。研究人员加强了寻找可能的砾岩油藏的研究。1996年10月，***石油公司在地堑的地球化学异常区钻探了Sutherland Unit]井，该井钻遇了2套独立的砾岩层，每套砾岩层的产层厚度都在3m。下部砾岩层的初始日产量是气50万立方英尺、油5桶。第二口井发现了3套舍油气砾岩层，其中包括底部厚6．7m的产层，天然气初始日产量接近100万立方英尺。在地堑内及附近的砾岩层中共钻了14口生产井。另外，该地堑中还有4口干井，但均位于微生物微油气苗异常区以外。1997年10月，为了研究这个新油气发现区内微油气苗特征随时间的变化，重新进行了一次微生物测量。总体上看，经过一年的开采之后，对比区的微生物背景值保持稳定，而两个开采区的微油气苗特征值下降了50％。研究认为，正在开采的油田上方的微油气苗明显减少，是油藏压力下降以及控制微油气苗的驱动机理发生变化所致。

关键词：地震测量砾岩油藏油气苗微生物 3-D 油田石油勘探技术得克萨斯州减弱地球物理测量

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

垄断地位的维持:美国政府控微软案

山东大学学报（哲学社会科学版） 2008年第3期 15-27页

作者：丹尼尔.L.鲁宾费尔德美国司法部

微软案的核心是美国政府声称微软采取了一系列反竞争行为,其目的是保持其在操作系统(OS)市场上的垄断。美国政府并没有质疑微软历史上成功的根源,但是声称,微软的行为使消费者受到了损害,部分原因是因为消费者需要为操作系统支付更高的... 详细信息

微软案的核心是美国政府声称微软采取了一系列反竞争行为,其目的是保持其在操作系统(OS)市场上的垄断。美国政府并没有质疑微软历史上成功的根源,但是声称,微软的行为使消费者受到了损害,部分原因是因为消费者需要为操作系统支付更高的价钱,部分原因是因为微软的行为减少了软件行业的创新。而作为回应,微软则辩解道,在一个高速发展的产业中,它面临的是十分严峻的竞争威胁,因此并不存在垄断。它进一步辩解道,微软的成功应被视为是促进竞争的,因为从它的高质量创新型软件分销中,消费者得到了利益。如果法院强行实施反托拉斯纠正,微软相信,竞争的激励将会减少,并会导致更少的而不是更多的创新。

关键词：反垄断美国司法部微软

Evaluation of Stress Corrosion Cracking Damage to an ApI 5L X52 pipeline Transporting Ammonia: A Case Study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Materials Sciences and Applications 2016年第10期7卷 610-622页

作者： José Luis Mora-Mendoza Mónica Jazmín Hernández-Gayosso daniel Antonio Morales-Serrat Octaviano Roque-Oms Digna Alejandra Del Angel Gerardo Zavala-Olivares petróleos Mexicanos Marina Nacional 329 Col. Petróleos Mexicanos CDMX Ciudad de México México Instituto Mexicano del petróleo Eje Central Lázaro Cárdenas Norte 152 Col. San Bartolo Atepehuacan CDMX Ciudad de México México

The high number of leak events that took place in recent years at a 25.4 cm (10”)Øpipeline transporting anhydrous liquid ammonia, located in the Southeast of Mexico, was the main reason to carry out a number of field studies and laboratory tests that helped establish not only the failure causes but also mitigation and control solutions. The performed activities included direct evaluation at failure sites, total repair programs, metallographic studies and pipeline flexibility analyses. The obtained results were useful to conclude that the failures obeyed a cracking mechanism by Stress Corrosion Cracking (SCC) which was caused by the combined effect of different factors: high stress resistance, high hardness of the base metal with a microstructure prone to brittleness and residual strains originated during the pipeline construction. From the operative, logistic and financial standpoints, it is not feasible to release the stress of approximately 22 km of pipeline. Therefore, the only viable solution is to install a new pipeline with suitable fabrication, construction and installation specifications aimed at preventing the SCC phenomenon.

关键词： Stress Corrosion Cracking Residual Stress Ammonia Transporting pipeline

Controlling the gelation temperature of biomimetic polyisocyanides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第2期29卷 281-284页

作者： paul H.J. Kouwer paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage daniel C. Schoenmakers Chengfen Xing Jialiang xu Institute for Molecules and Materials Radboud University Nijmegen 6525 A J The Netherlands

Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature（LCST） is often sharp, which allows for a wide range of smart material *** the LCST, oligo（ethylene glycol）-substituted polyisocyanides（pICs） form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of pICs strongly depends linearly on the length of the ethylene glycol（EG） tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the pIC gels.

关键词： Smart materials Lower critical solution temperature polyisocyanides Mechanical properties Biomimetic polymers

prolapsed Juvenile polyp of the Anus in 2 Cases

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of pediatrics 2023年第6期13卷 785-790页

作者： Mohamed Lamine Sadou Sacko Balla Keita Thierno Saidou Barry Mory Sangare Mamadou Madiou Barry Moussa Conde Seydou Keita Salif Mariértou Sylla daniel Agbo-panzo Department of pediatric Surgery CHU de Donka Conakry Guinea Gamal Abdel Nasser University Conakry Guinea General Surgery Department Ignace Deen University Hospital Conakry Guinea Gastroenterology Department Conakry Military Hospital Conakry Guinea

Introduction :Rectal polyps are well-circumscribed, sessile or pedunculated formations that develop on the digestive mucosa. Juvenile polyps are seen in 4% - 12% of cases during pediatric colonoscopies. In children, rectal bleeding is a frequent warning sign, often a recurrent bleed with no impact on general condition. Diagnosis is based on clinical, imaging and digestive investigations, but anatomopathological examination remains the only means of confirmation. There are a number of treatment options, ranging from abstention to surgical excision. We report two (2) cases of isolated hemorrhagic juvenile polyp prolapsed to the anus in order to analyze the diagnostic and therapeutic features of this pathology. patients and observations: A 7-year-old female patient presented to the pediatric emergency department of the Donka National Hospital with a hemorrhagic anal mass. On clinical examination, the patient was found to be in satisfactory general condition, with a hemorrhagic pedicle mass prolapsed to the anus. The mass was removed under general anesthesia. postoperative management was straightforward. Conclusion: Juvenile polyps are the most common proctological condition in this age group. Clinical examination must be meticulous, as certain signs may point to a particular pathology. Colonoscopy is the diagnostic test of choice, and can also be used as a therapeutic tool.

关键词： polyp Juvenile prolapse Child

低温和酸中毒对人全血凝血功能损害的协同作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2009年第3期5卷 28-34页

作者： daniel Dirkmann Alexander A. Klaus Gorlinger Jurgen peters 张昕(译) Klinik fur Anasthesiologie und Intensivmedizin Universitat Duisburg-Essen Universi~tsklinikum Essen Essen Germany 不详

背景低温和酸中毒对不同临床状态下凝血疾患的影响已有报道。本研究中，我们对全血的凝血功能进行评估，以探讨低温和酸中毒对凝血的影响。方法采自10名健康志愿者（2女，8男）的全血样本（3．000μl），加入40μl摩尔浓度递加的盐酸，... 详细信息

背景低温和酸中毒对不同临床状态下凝血疾患的影响已有报道。本研究中，我们对全血的凝血功能进行评估，以探讨低温和酸中毒对凝血的影响。方法采自10名健康志愿者（2女，8男）的全血样本（3．000μl），加入40μl摩尔浓度递加的盐酸，使血液酸化至pH（α-pH固定计）介于7．0和7．37之间。用内源性（InTEM^TM）和外源性（ExTEM^TM）活化方法孵化30分钟后，再用旋转血栓弹性测定法分析凝血功能。为了评估凝血功能对温度的依赖性，所有试验均在血液／血栓弹性测定仪的温度30、33、36和39℃下分别进行。此外，通过添加细胞松弛素D进行了另一项外源性激活方法，以此来检测在无血小板作用时，血凝块的形成情况。结果正常pH下低温导致了凝血时间延长[ExTEM：65秒±3．6（36℃）vs85±4（30℃），p〈0．001；InTEM：181秒±10（36℃）vs226±9，p〈0．001]，血凝块形成时间延长[ExTEM：105秒±5（36℃）vs 187±6（30℃），p〈0．001；InTEM：101秒±5（36℃）vs175±7，p〈0．001]，并且伴有α角的缩小，[ExTEM：65．6±1．8（36℃）vs 58±1．1，p〈0．01；InTEM：70．5±1．8（36℃）vs 60．2±1．5，p〈0．001]。最大血栓弹力仅在InTEM测定法中显著受损[56．9mm±0．9（36℃）vs 52．7±0．9，p〈0．05]。相反，正常体温下酸中毒本身无明显作用。酸中毒放大了低温的作用，并在内源性和外源性激活实验中，两者对凝血时间、d角、最大血栓弹力的影响有协同作用。用细胞松弛素D消除血小板功能后进行的纤维蛋白凝块形成试验显示，凝血功能并没有受损。血凝块溶解在低温和（或）酸中毒环境下减少，而在体温升高的情况下增加。结论在此体外研究中，血栓弹性测定法显示：酸中毒使低温引起的凝血功能改变恶化，而不伴低温的酸中毒对凝血功能无显著影响。这种情况是由于凝血因子和血小板功能受到抑制引起的。因此，在37℃下进行的血栓弹性测定法高估了低温尤其伴酸中毒时凝血功能的完整性。

关键词：凝血功能改变酸中毒协同作用人全血低温功能损害凝血时间延长细胞松弛素D