检索结果-南通市图书馆

Factors contributing to clinical picture and progression of Huntington's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第8期13卷 1364-1365页

作者： daniel Zielonka department of Epidemiology of Rare disorders and Neuroepidemiology Poznan University of Medical Sciences

Huntington’s disease（Hd）is an autosomal dominant,monogenic,progressive,neurodegenerative and rare disease with a frequency of10 per 100,000 in the caucasian population and occurring more rarely in other races（Squitieri et al.,1994）.Hd is,nevertheless,one of the most frequently and extensively studied diseases of those caused by a dynamic *** Hd mutation is located on the short arm of the 4th chromosome within the HTT gene.

关键词： Hd Factors contributing to clinical picture and progression of Huntington’s disease

The role of fluids in the lower crust and upper mantle:A tribute to Jacques Touret

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2014年第5期5卷 621-625页

作者： daniel Harlov GeoForschungsZentrum Potsdam TelegrafenbergD-14473 PotsdamGermany department of Geology University of Johannesburg P.O.Box 524Auckland Park2006South Africa

This special issue of Geoscience Frontiers is a tribute volume honoring the life and career of Jacques Touret. A set of research papers has been assembled, which broadly reflect his research interests over his 50 plus year career. These papers Focus on the role that fluids play during the Formation and evolution of the Earth＇s crust. Below I provide a brief summary of the life of Jacques Touret, along with a select bibliography of his more important papers. This is then followed by a brief introduction to the papers assembled for this special issue.

关键词： The role of fluids in the lower crust and upper mantle

Perspective: Limiting Antimicrobial Resistance with Artificial Intelligence/Machine Learning

在线全文

学校读者我要写书评

暂无评论

Biomedical Engineering Frontiers 2023年第1期4卷 1-2页

作者： daniel Amsterdam Jacobs School of Medicine&Biomedical Sciences State University of New YorkBuffaloNYUSA.Departments of Microbiology and ImmunologyMedicineand Pathology at the Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA.Department of Laboratory MedicineECMCBuffaloNYUSA

The author traces his experience with the application of computers in clinical microbiology over the past 60 years,specifically in directing clinicians to treat bacterial infections diagnosed by the laboratory and the antibacterial agent(s)that could be used to treat those *** use of antibiotics will result in reduced antimicrobial resistance,which is increasing *** early form of AI,Mycin(1976),a system based on rules provided by experts designed to propose antibiotic regimens for central nervous system infections,was never applied due to the limitations in the number of rules that could be incorporated into the clinical *** learning(ML)was developed to overcome the limitations of expert *** variables that influence the outcome bacteria/drug interaction,such as the source of the infection,absence of antimicrobial resistance markers,patients’health profile,and the historical susceptibility within the hospital and the local area are incorporated in the proposed comprehensive AI/ML *** role of AI in the discovery of new antimicrobial agents is also addressed.

关键词： computer agent limitations

Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2020年第4期8卷 447-457页

作者： Stephen d.Zoller Vishal Hegde Zachary d.c.Burke Howard y.Park chad R.Ishmael Gideon W.Blumstein William Sheppard christopher Hamad Amanda H.Loftin daniel O.Johansen Ryan A.Smith Marina M.Sprague Kellyn R.Hori Samuel J.clarkson Rachel Borthwell Scott I.Simon Jeff F.Miller Scott d.Nelson Nicholas M.Bernthal department of Orthopedic Surgery University of CaliforniaLos Angeles125016th St Suite 2100Santa MonicaCA 90404USA david Geffen School of Medicine University of CaliforniaLos Angeles10833 Le Conte AveLos AngelesCA 90095USA department of Internal Medicine University of CaliforniaLos Angeles757 Westwood PlazaSuite 7501Los AngelesCA 90095USA department of Biomedical Engineering University of CaliforniaDavisDavisCA 95616USA california NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA department of Microbiology Immunologyand Molecular GeneticsDavid Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA department of Pathology University of CaliforniaLos Angeles125016th St Suite 3450Santa MonicaCA 90404USA

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone *** persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft *** focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant *** insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over *** current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and ***-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were *** orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous *** establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone *** study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical *** presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment.

关键词： immunity insight reservoir

在线全文

学校读者我要写书评

暂无评论

自养型生物过滤器硝化氧化一氧化氮

环境科学 2003年第2期24卷 1-6页

作者：陈建孟 Lance Hershman 陈浚 daniel P.y.chang 浙江工业大学生物与环境工程学院杭州310032 department of civil&Environmental Engineering

采用一种新的工程材料多孔碳作为填料 ,在 3个5 0 8mm填充着不同孔径多孔碳和驯化培养好的自养型亚硝酸盐硝化菌的生物过滤器中 ,进行了净化气体中NO的探索性研究 .实验采用亚硝酸盐为唯一氮源 ,在多孔碳的表面培养生物膜 ,采用超声... 详细信息

采用一种新的工程材料多孔碳作为填料 ,在 3个5 0 8mm填充着不同孔径多孔碳和驯化培养好的自养型亚硝酸盐硝化菌的生物过滤器中 ,进行了净化气体中NO的探索性研究 .实验采用亚硝酸盐为唯一氮源 ,在多孔碳的表面培养生物膜 ,采用超声波气溶胶发生器来维持过滤器内的湿度并保持多孔碳表面液膜的厚度较小 .液相硝化试验用来比较 3种不同孔径的多孔碳之间硝化性能的潜力和差异 .结果表明 ,在亚氮 (NO- 2 N)进口负荷约2 0 0～ 80 0g/(L·min)的范围内 ,2 4孔 /cm(PoresPercentimeter,PPc)多孔碳过滤器的硝化速率最大 ,达到 94%～98%;8PPc和 1 8PPc多孔碳过滤器的硝化速率分别达到 1 5 %～ 2 1 %和 3 0 %～ 40 %.气相试验表明 ,在NO空床停留时间 3 5min、进口浓度 66 97～ 2 67 86mg/m3的范围内 ,2 4PPc多孔碳过滤器对NO的去除效率为 41 %～5 2 %左右。

关键词：硝化生物过滤器多孔碳填料氮氧化物净化空气污染控制

current aspects of renal dysfunction after liver transplantation

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第1期14卷 45-61页

作者： Mariana P Pacheco Luiz Augusto carneiro-d'Albuquerque daniel F Mazo division of clinical Gastroenterology and Hepatology Department of GastroenterologyUniversity of São Paulo School of MedicineSao Paulo 05403-900Sao PauloBrazil division of digestive Organs Transplant Department of GastroenterologyUniversity of São Paulo School of MedicineSao Paulo 05403-900Sao PauloBrazil division of Gastroenterology Department of Internal MedicineSchool of Medical Sciences of University of CampinasCampinas 13083-878Sao PauloBrazil

The development of chronic kidney disease(cKd)after liver transplantation(LT)exerts a severe effect on the survival of *** widespread adoption of the model for end-stage liver disease score strongly impacted cKd incidence after the procedure,as several patients are transplanted with previously deteriorated renal *** to its multifactorial nature,encompassing pre-transplantation conditions,perioperative events,and nephrotoxic immunosuppressor therapies,the accurate identification of patients under risk of renal disease,and the implementation of preventive approaches,are extremely *** for the evaluation of renal function in this setting range from formulas that estimate the glomerular filtration rate,to non-invasive markers,although no option has yet proved efficient in early detection of kidney *** the nephrotoxicity of calcineurin inhibitors(cNI)as a factor of utmost importance after LT,early nephroprotective strategies are highly *** are based mainly on delaying the application of cNI during the immediate postoperativeperiod,reducing their dosage,and associating them with other less nephrotoxic drugs,such as mycophenolate mofetil and *** review provides a critical assessment of the causes of renal dysfunction after LT,the methods of its evaluation,and the interventions aimed at preserving renal function early and belatedly after LT.

关键词： Liver transplantation Acute kidney injury chronic kidney disease calcineurin inhibitor Mycophenolic acid Everolimus

Respiratory plasticity following spinal cord injury:perspectives from mouse to man

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第10期17卷 2141-2148页

作者： Katherine c.Locke Margo L.Randelman daniel J.Hoh Lyandysha V.Zholudeva Michael A.Lane department of Neurobiology&Anatomy Drexel UniversityPhiladelphiaPAUSA Marion Murray Spinal cord Research center PhiladelphiaPAUSA Lillian S.Wells department of Neurosurgery University of FloridaGainesvilleFLUSA cardiovascular disease Gladstone InstitutesSan FranciscoCAUSA

The study of respiratory plasticity in animal models spans *** the bench,researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord *** field of research is highly clinically *** living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels c3-c5 typically have significant impairments in breathing which may require assisted *** who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life ***-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical *** how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical *** three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury,discuss plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical *** investigating current targets of respiratory plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.

关键词： breathing phrenic plasticity rehabilitation respiration spinal cord injury translation

Engineering and microstructure properties of contaminated marine sediments solidified by high content of incinerated sewage sludge ash

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 643-652页

作者： Jiang-Shan Li yifan Zhou Xin chen Qiming Wang Qiang Xue daniel c.W.Tsang chi Sun Poon State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China IRSM-cAS/HK PolyU Joint Laboratory on Solid Waste Science Hung HomKowloonHong KongChina Hubei Province Key Laboratory of contaminated Sludge and Soil Science and Engineering Wuhan430071China department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Management of incinerated sewage sludge ash(ISSA)and dredged contaminated marine sediments(cMSs)is a great challenge for Hong Kong and other coastal cities due to limited landfilling *** present study investigates the use of high content(20%of sediment by mass)of ISSA in combination with cement/lime for solidification/stabilization(S/S)treatment of cMSs to provide a way to reuse the wastes as construction *** results showed that ISSA being a porous material was able to absorb a large amount of water rendering a more efficient solidification process of the marine sediment which normally had a very high water content(w80%).The S/S treatment improved the engineering properties of the sediment,but reduced the workability,especially for the lime-treated *** can be used to replace ordinary Portland cement(OPc)for better heavy metal immobilization and carbon emission *** hardened sediment samples prepared with 10%of lime and 20%of ISSA could attain a strength of 1.6 MPa after 28 d of *** addition,leaching tests confirmed that there was no environmental risk induced by these stabilized *** formation of hydrated cementitious compounds including calcium silicate hydrate(ceSeH)/calcium aluminate silicate hydrate(c-A-S-H)/hydrocalumite/calcite was mainly responsible for the strength development in the ISSA/lime-treated sediments.

关键词： contaminated marine sediment(cMS) Incinerated sewage sludge ash(ISSA) Solidification/stabilization(S/S) Heavy metals construction material

Round Top Mountain rhyolite(Texas, USA), a massive, unique y-bearing-fluorite-hosted heavy rare earth element(HREE) deposit

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2014年第1期32卷 90-96页

作者： PINGITORE Nicholas cLAGUE Juan GORSKI daniel department of Geological Sciences The University of Texas at El Paso Texas Rare Earth Resources

Round Top Mountain in Hudspeth county, west Texas, USA is a surface-exposed rhyolite intrusion enriched in y and heavy rare earth elements （HREEs）, as well as Nb, Ta, Be, Li, F, Sn, Rb, Th, and U. The massive tonnage, estimated at well over 1 billion tons, of the deposit makes it a target for recovery of valuable yttrium and HREEs （yHREEs）, and possibly other scarce ele-ments. Because of the extremely fine grain size of the mineralized rhyolite matrix, it has not been clear which minerals host the yHREEs and in what proportions. REE-bearing minerals reported in the deposit included bastn？site-ce, y-bearing fluorite, xeno-time-y, zircon, aeschynite-ce, a ca-Th-Pb fluoride, and possibly ancylite-La and cerianite-ce. Extended X-ray absorption fine struc-ture （EXAFS） indicated that virtually all of the yttrium, a proxy for the HREEs, resided in a coordination in the fluorite-type crystal structure, rather than those in the structures of bastn？site-ce and xenotime-y. The yREE grade of the Round Top deposit was just over 0.05%, with 72%of this consisting of yHREEs. This grade was in the range of the South china ionic clay deposits that supply essentially all of the world’s yHREEs. Because the host y-bearing fluorite is soluble in dilute sulfuric acid at room temperature, a heap leaching of the deposit appeared feasible, aided by the fact that 90%-95%of the rock consists of unreactive and insoluble feld-spars and quartz. The absence of overburden, remarkable consistency of mineralization grade throughout the massive rhyolite, prox-imity （a few km） to a US interstate highway, major rail systems and gas and electricity, temperate climate, and stable political location in the world’s largest economy all enhanced the potential economic appeal of Round Top.

关键词： heavy rare earth elements yttrium-beating fluorite yttrofluorite heap leaching rhyolite Round Top deposit