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Effects of Navier slip on unsteady flow of a reactive variable viscosity non-Newtonian fluid through a porous saturated medium with asymmetric convective boundary conditions

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Journal of Hydrodynamics 2015年第6期27卷 934-944页

作者： RUNDORA Lazarus MAKINDE Oluwole daniel Department of Mathematics and Applied Mathematics University of LimpopoTurfloop Campus Faculty of Military Science Stellenbosch University

A study on the effects of Navier slip, in conjunction with other flow parameters, on unsteady flow of reactive variable viscosity third-grade fluid through a porous saturated medium with asymmetric convective boundary conditions is presented. The channel walls are assumed to be subjected to asymmetric convective heat exchange with the ambient, and exothermic chemical reactions take place within the flow system. The heat exchange with the ambient obeys Newton＇s law of cooling. The coupled equations, arising from the law of conservation of momentum and the first law of thermodynamics, then the derived system are non- dimensionalised and solved using a semi-implicit finite difference scheme. The lower wall slip parameter is observed to increase the fluid velocity profiles, whereas the upper wall slip parameter retards them because of backflow at the upper channel wall. Heat pro- duction in the fluid is seen to increase with the slip parameters. The wall shear stress increases with the slip parameters while the wall heat transfer rate is largely unaltered by the lower wall slip parameter but marginally increased by the upper wall slip parameter.

关键词： Navier slip saturated porous medium third-grade fluid temperature dependent viscosity convective boundary condi-tions

Identification of four novel DC-SIGN ligands on Mycobacterium bovis bCG

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Protein & Cell 2010年第9期1卷 859-870页

作者： Maria V.Carroll Robert b.Sim Fabiana bigi Anne Jäkel Robin Antrobus daniel A.Mitchell Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK Institute of biotechnology CICVyA-INTALos Reseros y Las Cabañas1712 CastelarArgentina Cambridge Institute of Medical Research Addenbrooke’s HospitalHills RoadCambridge CB20XYUK CSRI-UHCW Walsgrave Campus University of WarwickCoventryCV22DXUK

Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN;CD209)has an important role in mediating adherence of Mycobacteria species,including *** and *** bCG to human dendritic cells and macrophages,in which these bacteria can survive ***-SIGN is a C-type lectin,and interactions with mycobacterial cells are believed to occur via mannosylated structures on the mycobacterial *** studies suggest more varied modes of binding to multiple mycobacterial *** we identify,by affinity chromatography and mass-spectrometry,four novel ligands of *** bCG that bind to *** novel ligands are chaperone protein DnaK,60 kDa chaperonin-1(Cpn60.1),glyceraldehyde-3 phosphate dehydrogenase(GAPDH)and lipoprotein *** published work strongly suggests that these are on the cell *** these ligands,lprG appears to bind DC-SIGN via typical proteinglycan interactions,but DnaK and Cpn60.1 binding do not show evidence of carbohydrate-dependent *** was also identified as a ligand for DC-SIGNR(L-SIGN;CD299)and the *** orthologue of lprG has been found previously to interact with human toll-like receptor ***,these findings offer new targets for combating mycobacterial adhesion and within-host survival,and reinforce the role of DCSIGN as an important host ligand in mycobacterial infection.

关键词： DC-SIGN Mycobacteria lectins

Study of the Superficial Modification of Sisal Fibres with Lignin, and Its Use As a Reinforcement Agent in Cementitious Composites

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Journal of Renewable Materials 2020年第8期8卷 891-903页

作者： Plínio b.Mundim Rondinele A.R.Ferreira Leila A.C.Motta Mariana A.Henrique daniel Pasquini College of Civil Engineering Federal University of UberlândiaUberlândia38400-902Brazil Chemistry Institute Federal University of UberlândiaUberlândia38400-902Brazil

The objective of this work was to evaluate different superficial treatments of sisal fibres employing lignin,and their use as a reinforcement agent in cementitious *** treatments consisted of superficially impregnating sisal fibres(S)with organosolv lignin(LO),organosolv lignin and glutaraldehyde(LOG),Kraft lignin(LK)and Kraft lignin and glutaraldehyde(LKG).The fibre modifications were verified by FTIR-ATR and SEM analyzes,and the presence of lignin on the surface of the fibres was evidenced,confirming the effectiveness of the *** mechanical,thermal(by TGA)and water absorption properties of the fibres before and after the modifications were also *** treatment,the modified fibres presented an expressive reduction of the water absorption and did not show significant changes in the mechanical properties when compared with the natural unmodified sisal fibre(SNAT).It was verified an increase in the thermal stability of the treated fibres which can be attributed to the insertion of lignin on the *** evaluate the performance of the fibres in the cementitious composites,cement plates(CP)were produced with different treated fibres(CP-SLOG,CP-SLO,CP-SLKG,CP-SLK)and fibres without treatment(CP-SNAT).The composites were evaluated concerning to the water absorption,porosity and mechanical *** fractured regions were also investigated by *** composites prepared showed similar values of absorption and porosity *** the mechanical properties,the composites prepared with modified fibres showed a significant increase in the modulus of rupture and modulus of elasticity compared with CP-SNAT,while toughness was similar to all *** the SEM images,it was observed that the modified fibres immersed in the cementitious plates showed no degradation,indicating that the impregnation of lignin acted as a protective agent of the ***,the treatments of the fibres with lignin led to a significant improvement in th

关键词： Cementitious composites sisal lignin surface modification

Operative complications and economic outcomes of cholecystectomy for acute cholecystitis

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World Journal of Gastroenterology 2019年第48期25卷 6916-6927页

作者： Christopher P Rice Krishnamurthy b Vaishnavi Celia Chao daniel Jupiter August b Schaeffer Whitney R Jenson Lance W Griffin William J Mileski School of Medicine University of Texas Medical BranchGalvestonTX 77555United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Department of biostatistics University of Texas Medical BranchGalvestonTX 77555United States

bACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost *** adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this *** hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost *** To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute *** Under an IRb-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year *** were identified using the acute care surgery registry and billing *** was retrieved via EMR,operative logs,and Revenue Cycle *** severity of acute cholecystitis was graded according to the Tokyo ***18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,*** were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<*** Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed *** rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs *** with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=

关键词： Acute cholecystitis Tokyo guidelines Cholecystectomy Complications Delayed cholecystectomy

Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation

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bone Research 2015年第3期3卷 173-181页

作者： Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He daniel J Leong Hui b Sun Leni and Peter W.May Department of Orthopedics Icahn School of Medicine at Mount Sinai Departments of Orthopedic Surgery Albert Einstein College of Medicine Radiation Oncology Albert Einstein College of Medicine

Mesenchymal stem cell （MSC）-based treatments have shown promise for improving tendon healing and repair. MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK, actin and myosin （two other components of the pathway） using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds.

关键词： MSCs Figure Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation

Anchoring of 10-phenylphenothiazine to mesoporous silica materials:A water compatible organic photocatalyst for the degradation of pollutants

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Journal of Materials Science & Technology 2022年第8期103卷 134-143页

作者： daniel González-Muñoz Almudena Gómez-Avilés Carmen b.Molina Jorge bedia Carolina belver Jose Alemán Silvia Cabrera Organic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Chemical Engineering Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de Madrid28049 MadridSpain Inorganic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain

The application of organic photocatalysts towards the oxidation of pollutants in water is hampered by different limitations such as their insolubility in the ***,we report that the grafting of a photoorganocatalyst into mesoporous silica materials is an ideal approach to obtain effective ***,the photocatalyst 10-phenylphenothiazine(PTH)was easily anchored into three different mesoporous silica-based materials(MSN,MSU-2 and SbA-15)with different particle sizes and pore sizes through an amide bond *** materials were characterized using IR analysis,solid-state X-ray diffraction,porosity and microscopy(SEM and TEM)techniques,showing that PTH is immobilized inside the pores of the materials and its optical properties are maintained after the *** homogeneous PTH was inactive in water media,the three photocatalytic materials were active for the degradation of ***-15-AP-PTH exhibited the highest catalytic performance towards the degradation of acetaminophen and diclofenac under solar irradiation,finding in this manner a new strategy for the decontamination of pollutants.

关键词： Organic semiconductors Silica support Solar photocatalysis Water treatment Pharmaceuticals

Modified combustion synthesis of g-LiAlO_2 using metal oxides

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1793-1800页

作者： daniel CRUZ H.b.ORTIZ-OLIVEROS L.M.PéREZ-DíAZ R.M.FLORES-ESPINOSA G.ROSANO-ORTEGA Facultad de Ingeniería Química Benemérita Universidad Autónoma de Puebla14 Sur y San ClaudioCiudad UniversitariaC.P.72570Cd.PueblaMéxico Instituto Nacional de Investigaciones Nucleares Dirección de Investigación TecnológicaApartado Postal 18-102711801 MéxicoDFMéxico Universidad Popular Autónoma del Estado de Puebla 21 Sur no.1103Colonia SantiagoC.P.72410PueblaMéxico

An alternative solution for the direct formation of?-LiAlO2 was presented by a modified combustion method,to apply it to rather simple systems,utilizing non-oxidizer compounds such as Al2O3 and LiOH,and urea as ***2 was prepared via non-stoichiometric 1:1,1.5:1 and 2:1 of Li/Al molar ratios at 900 and 1000°C for 5 *** and structural characterization ofγ-LiAlO2 was ***,the effect of different Li/Al molar ratios on material morphology and its stability before high gamma radiation gradients was *** results showed that the crystal structures of the obtained powders wereγ-LiAlO2 and?-LiAlO2,depending on the Li/Al molar *** results obtained demonstrate that?-LiAlO2 microbricks,polyhedral and laminar shapes can be successfully synthesized with the proposed method and without any subsequent ***,gamma irradiation showed that the?-LiAlO2 obtained does not decompose,forming only small amounts of *** can be established that the irradiation produces consolidation,which is not favourable for an efficient extraction of ***,it could be demonstrated that nitrate precursors are not necessary in the combustion method to produceγ-LiAlO2 with high purity.

关键词： urea oxide combustion lithium aluminate ceramic

Takotsubo cardiomyopathy:A comprehensive review

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World Journal of Cardiology 2022年第6期14卷 355-362页

作者： Walker barmore Himax Patel Sean Harrell daniel Garcia Joe b Calkins Jr Department of Internal Medicine Augusta University Medical CenterAugustaGA 30912United States Department of Cardiovascular Medicine Augusta University Medical CenterAugustaGA 30912United States

Takotsubo cardiomyopathy(TCM),also known as stress cardiomyopathy,occurs in the setting of catecholamine surge from an acute *** cardiomyopathy mimics acute myocardial infarction in the absence of coronary *** classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left *** etiology of the stressor is often physical or emotional stress,however iatrogenic causes of TCM have been reported in the *** our review,we discuss medications,primarily the exogenous administration of catecholamines,and a wide array of procedures with subsequent development of iatrogenic *** is unique in that it is transient and has favorable outcomes in most ***,beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy;however,unique to TCM,no specific treatment is required other than temporary supportive measures as this process is ***,no improvement in mortality or recurrence have been reported in patients on these *** aim of this review is to elucidate on the iatrogenic causes of TCM,allowing for prompt recognition and management by clinicians.

关键词： Takotsubo Cardiomyopathy Iatrogenic Heart Failure Myocardial Infarction

The effect of wilderness and medical training on injury and altitude preparedness among backcountry hikers in Rocky Mountain National Park

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World Journal of Emergency Medicine 2018年第3期9卷 172-177页

作者： Michael D.T.Yue David W.Spivey daniel b.Gingold Douglas G.Sward University of Maryland School of Medicine BaltimoreMarylandUSA Department of Emergency Medicine University of Maryland School of MedicineBaltimoreMarylandUSA Division of Hyperbaric Medicine Program in TraumaUniversity of Maryland Medical CenterBaltimoreMarylandUSA

bACKGROUND:The purpose of this study was to document the correlation between medical and wilderness training with levels of preparedness for acute mountain sickness(AMS),illness,and injury among backcountry ***:We conducted a cross-sectional,convenience survey in Rocky Mountain National Park in July and August *** study group consisted of 380 hikers who completed a written survey that collected information about demographics,wilderness experience,altitude experience,hiking equipment,communications devices,and trip ***:Factors such as wilderness training(wilderness first aid[WFA],wilderness first responder[WFR],or wilderness emergency medical technician[WEMT]),wilderness experience,and altitude experience all affected hikers’emergency *** with medical training were more prepared to avoid or respond to AMS(62.3%vs.34.3%[Pbe prepared to avoid or respond to AMS(52.3%vs.36.8%[P=0.025])but not significantly more likely to be prepared to manage illness/injury(31.8%vs.22.0%[Pbe prepared to avoid or manage AMS,medical emergencies,and injuries than their non-medically trained *** training increased hikers’preparedness for AMS but did not significantly alter preparedness for illness/injury.

关键词： Hiking wilderness Acute mountain illness Injury Training