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Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6

Bone Research 2015年第4期3卷 235-245页

作者： Cassie A Schumacher danese m joiner Kennen D Less melissa Oosterhouse Drewry Bart O Williams Center for Cancer and Cell Biology Program in Skeletal Disease and Tumor MicroenvironmentVan Andel Research Institute

mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and *** lacking either gene alone were viable and fertile with normal knee *** in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during *** addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre transgene was active in cells that subsequently differentiated into *** both embryonic skeletal development and establishment of adult bone mass,Lrp5 and Lrp6 carry out redundant functions.

关键词： carrying Collagen displayed deletion engineered transgene viable embryogenesis redundant embryonic

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Familial aggregation in inflammatory bowel disease:Is it genes or environment?

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World Journal of Gastroenterology 2011年第22期17卷 2715-2722页

作者： Tiago Nunes Gionata Fiorino Silvio danese miquel Sans Department of Gastroenterology Hospital Clinic i Provincial/IDIBAPS CIBER EHD 08036 Barcelona Spain Division of Gastroenterology IRCCS Istituto Clinico Humanitas Rozzano Milan 20089 Italy

Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.

关键词： Inflammatory bowel disease Familial aggregation Familial clustering Environmental factors Genetics Genome wide association studies

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The star formation history of redshift z^2 galaxies:the role of the infrared prior

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Research in Astronomy and Astrophysics 2014年第1期14卷 15-34页

作者： Lu-Lu Fan Andrea Lapi Alessandro Bressan mario Nonino Gianfranco De Zotti Luigi danese Center for Astrophysics University of Science and Technology of China Key Laboratory for Research in Galaxies and Cosmology Chinese Academy of Sciences Astrophysics Sector SISSA Dip.Fisica Univ.‘Tor Vergata’Via Ricerca Scientifica 100133 Roma INAF-Osservatorio Astronomico di Trieste

We build a sample of 298 spectroscopically-confirmed galaxies at redshift z - 2, selected in the z850-band from the GOODS-mUSIC catalog. By utilizing the rest frame 8 p.m luminosity as a proxy of the star formation rate （SFR）, we check the accuracy of the standard SED-fitting technique, finding it is not accurate enough to provide reliable estimates of the physical parameters of galaxies. We then develop a new SED-fitting method that includes the IR luminosity as a prior and a generalized Calzetti law with a variable Rv. Then we exploit the new method to re-analyze our galaxy sample, and to robustly determine SFRs, stellar masses and ages. We find that there is a general trend of increasing attenuation with the SFR. moreover, we find that the SFRs range between a few to 103 m~ yr-1, the masses from 109 to 4 ~ 1011 mo, and the ages from a few tens of myr to more than 1 Gyr. We discuss how individual age measurements of highly attenuated objects indicate that dust must have formed within a few tens of myr and already been copious at 〈 100 myr. In addition, we find that low luminosity galaxies harbor, on average, significantly older stellar populations and are also less massive than brighter ones; we discuss how these findings and the well known ＇downsizing＇ scenario are consistent in a framework where less massive galaxies form first, but their star formation lasts longer. Finally, we find that the near-IR attenuation is not scarce for luminous objects, contrary to what is customarily assumed; we discuss how this affects the interpretation of the observed m,/L ratios.

关键词： cosmology: observations- galaxies: evolution- galaxies: high redshift-- galaxies: stellar content -- dust extinction

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一项关于社会经济地位较差的学龄前儿童血管功能评估的初步研究

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中华高血压杂志 2017年第3期25卷 283-284页

作者： Ghazi L Dudenbostel T Xing D Ejem D Turner-Henson A joiner CI Affuso O Azuero A Oparil S Calhoun DA Rice m Hage FG 曲浥晨机构不详

Ghazi L, Dudenbostel T, Xing D, Ejem D, Turner-Henson A, joiner CI, Affuso O, Azuero A, Oparil S, Calhoun DA, Rice m, Hage FG. Assessment of vascular function in low socioeconomic status preschool children： a pilot study. J Am Soc Hypertens ,2016 ： 1-9. 全球高血压患者〉10亿例，每年造成710万人死亡。在美国，〉8000万例成人及200万～300万例儿童患高血压。按当前趋势预计到2030年，美国高血压成年患者将增加2700万。越来越多的证据表明，包括高血压在内的心血管病危险因素在童年时期即出现并持续至成人后。因此，对日后可能出现心血管病高危因素的儿童，在早期予以干预十分重要。

关键词：学龄前儿童血管功能评估社会经济地位心血管病危险因素高血压患者成年患者高危因素 low

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儿童暴露于创伤所致的精神病理学改变:需要检测和干预以减少下游负担

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英国医学杂志中文版 2021年第7期24卷 365-369页

作者： Andrea danese Katie A mcLaughlin muthanna Samara Carla S Stover 韩彤妍(译) King′s College London Department of Child and Adolescent PsychiatryInstitute of PsychiatryPsychology&NeuroscienceLondonUK King′s College London SocialGenetic and Developmental Psychiatry CentreInstitute of PsychiatryPsychology&NeuroscienceLondonUK South London and maudsley NHS Foundation Trust National and Specialist CAMHS Clinic for TraumaAnxietyand DepressionLondonUK Department of Psychology Harvard UniversityCambridge MAUSA Department of Psychology Kingston UniversityLondonUK Yale Early Stress and Adversity Consortium Yale University Child Study CenterNew Haven CTUSA 北京大学第三医院儿科

Andrea danese及其同事认为,临床评估和循证干预滞后于研究,给个人和社会带来了巨大的花费。为了向一些最脆弱的儿童提供尽可能好的照护,必须加强专家培训、提高临床能力和增加儿童获得照护的机会。

关键词：临床能力临床评估循证干预病理学改变照护儿童

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