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Long-Term Survival Trend of Gynecological Cancer:A Systematic Review of Population-Based Cancer Registration Data

Biomedical and Environmental Sciences 2024年第8期37卷 897-921页

作者： Xiaohui Zhou Danni Yang Yixin Zou dandan Tang Jun Chen Zhuoying Li Qiuming Shen Qun Xu Yongbing Xiang Department of Epidemiology&State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China School of Public Health Fudan UniversityShanghai 200025China Health Management Center Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Gynecological cancer significantly affect the health of *** review aimed to describe the global patterns and trends in the survival of patients with gynecological *** searched PubMed,Embase,Web of Science,SinoMed,and SEER for survival analyses of cancer registration data of cervical,endometrial,and ovarian cancers published between 1980 and ***,the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan,Liaoning,China(2008-2017).The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland(1995-1999,82.5%)and Singapore(1988-1992,62.0%).The 5-year relative survival rate of cervical cancer patients was higher in Haining,Zhejiang,China(2011-2014,85.8%).Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers,*** rates have improved for cervical,endometrial,and ovarian *** aged≥75 years and those with advancedstage disease had the worst 5-year survival *** rates were better for squamous cell carcinoma in cervical cancer,for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer,and for germ cell and sex-cord stromal tumors in ovarian *** the past four decades,the survival rates of gynecological cancers have increased globally,with notable increases in cervical and endometrial *** rates are higher in developed countries,with a slow-growing *** studies should focus on improving survival,especially in ovarian cancer patients.

关键词： Survival Cancer globally

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The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： Tongyu Zhang Yingxi Zhu Xiaochen Wang Danyang Chong Haiquan Wang dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring Health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

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Efficient Polytelluride Anchoring for Ultralong-Life Potassium Storage: Combined Physical Barrier and Chemisorption in Nanogrid-in-Nanofiber

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Nano-Micro Letters 2024年第4期16卷 364-378页

作者： Qinghua Li dandan Yu Jian Peng Wei Zhang Jianlian Huang Zhixin Liang Junling Wang Zeyu Lin Shiyun Xiong Jiazhao Wang Shaoming Huang Guangzhou Key Laboratory of Low‑Dimensional Materials and Energy Storage Devices School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006People’s Republic of China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018People’s Republic of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW 2522Australia

Metal tellurides(MTes) are highly attractive as promising anodes for high-performance potassium-ion batteries. The capacity attenuation of most reported MTe anodes is attributed to their poor electrical conductivity and large volume variation. The evolution mechanisms, dissolution properties, and corresponding manipulation strategies of intermediates(K-polytellurides, K-pTe_(x)) are rarely mentioned. Herein,we propose a novel structural engineering strategy to confine ultrafine CoTe_(2) nanodots in hierarchical nanogrid-in-nanofiber carbon substrates(CoTe_(2)@NC@NSPCNFs) for smooth immobilization of K-pTe_(x) and highly reversible conversion of CoTe_(2) by manipulating the intense electrochemical reaction process. Various in situ/ex situ techniques and density functional theory calculations have been performed to clarify the formation, transformation, and dissolution of K-pTe_(x)(K_(5)Te_(3) and K_(2)Te), as well as verifying the robust physical barrier and the strong chemisorption of K_(5)Te_(3) and K_(2)Te on S, N co-doped dual-type carbon substrates. Additionally, the hierarchical nanogrid-in-nanofiber nanostructure increases the chemical anchoring sites for K-pTe_(x), provides sufficient volume buffer space, and constructs highly interconnected conductive microcircuits, further propelling the battery reaction to new heights(3500 cycles at 2.0 A g^(-1)). Furthermore, the full cells further demonstrate the potential for practical applications. This work provides new insights into manipulating K-pTe_(x) in the design of ultralong-cycling MTe anodes for advanced PIBs.

关键词： Polytelluride dissolution Nanogrid-in-nanofiber structure Physicochemical adsorption Reaction mechanism Ultralonglife potassium storage

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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

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Promotion effect of epoxy group neighboring single-atom Cu site on acetylene hydrochlorination

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Chinese Chemical Letters 2024年第6期35卷 258-262页

作者： Junchen Peng Xue Yin dandan Dong Zhongyuan Guo Qinqin Wang Minmin Liu Fei He Bin Dai Chaofeng Huang School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi UniversityShihezi 832000China College of Chemistry&Chemical Engineering Yantai UniversityYantai 264010China School of Material Science and Engineering University of JinanJi’nan 250022China

Carbon materials have been used as the support for catalysts in the field of acetylene hydrochlorination,the influence of inevitable oxygen-containing moieties on the reaction is often ignored and the mechanism of the oxygen-doping structure remains ***,we explored the effect of the oxygen-containing group(C-O-C)in the support on the activity of single-atom dispersed Cu *** immersing the Cu single-atom catalyst in an alkaline solution,the epoxy species on the carbon support was cleaved to obtain a pure ether species while the Cu site was modified to a more electron-deficient *** turnover frequency value of Cu/O-FLP catalyst with epoxy groups was 1.6-fold higher than that of alkaline treated *** result indicated that the epoxy groups could assist adjacent single-atom Cu sites to synergistically promote the adsorption and cleavage of the reactant hydrogen chloride toward form C-OH and Cu-Cl bonds,and reduce the reaction energy *** presence of electron deficient Cu sites and ether species could induce competitive adsorption of the acetylene and hydrogen chloride,thereby reducing the activity of the *** study highlights the influence of surface oxygen species and the tunability of the support,providing the foundation for the fabrication of higher-activity Cu catalysts for acetylene hydrochlorination.

关键词： Epoxy group Acetylene hydrochlorination Single-atom Cu catalyst Synergistic dissociation

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Mg(NO_(3))_(2)·6H_(2O)-Assisted insitu-Fabrication of Tea Residual Biochar for Ultra-Fast and High Adsorption of Rhodamine B

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 165-176页

作者： HU dandan XUE Yangfan LIU Bo WU Yongjuan LI Zichen School of Chemistry&Chemical Engineering Shaanxi Xueqian Normal UniversityXi'an 710100ShaanxiChina Safe College Xi􀆳an University of Science and TechnologyXi'an 710054ShaanxiChina

In this work,porous biochar(MN-TRB_(750))was fabricated via direct pyrolysis of tea residue(TR)and Mg(NO_(3))_(2)·6H_(2)O(MN).The as-synthesized MN-TRB_(750) reached a specific surface area of 839.54 m^(2)·g^(-1)and an average pore size of 3.75 nm with multi-level pore *** decreased TR's carbonization temperature and promoted the aromatics extent,pore structure for the frizzly flake-like *** B(RhB)was chosen as the adsorbate to explore the removal performance of organic dyes in this *** results indicated that the maximum adsorption capacity of RhB on MN-TRB_(750) at 20℃ is up to 809.0 mg·g^(-1)with isotherms fitted well to Freundlich and Dubinin-Radushkevic *** adsorption kinetics followed pseudo-second-order and Elovich models with an equilibrium adsorption capacity of 757.6 mg·g^(-1)as the initial concentration of RhB is 260 mg·L^(-1).High pore filling,hydrogen bond,π-πinteraction determined the adsorption of RhB onto MN-TRB850 through a multi-active center and exothermic chemical sorption process.

关键词： Mg(NO_(3))_(2)·6H_(2)O porous biochar mechanism rhodamine B adsorption

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Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration

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Bone Research 2024年第2期12卷 361-371页

作者： dandan Wang Yaru Guo Boon Chin Heng Xuehui Zhang Yan Wei Ying He Mingming Xu Bin Xia Xuliang Deng Department of Pediatric Dentistry Peking University School and Hospital of StomatologyBeijing 100081P.R.China Department of Geriatric Dentistry Peking University School and Hospital of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China

Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells(BMSCs)and vascular endothelial cells(ECs).However,there are apparent limitations in stem cell-based therapy which hinder its clinic ***,we investigated the potential of alternative stem cell substitutes for facilitating bone *** this study,we successfully prepared cell membrane vesicles(CMVs)from BMSCs and *** results showed that BMSC-derived cell membrane vesicles(BMSC-CMVs)possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental ***-derived cell membrane vesicles(EC-CMVs)also contained BMP2 and VEGF derived from their parental ***-CMVs enhanced tube formation and migration ability of hUVECs,while EC-CMVs promoted the osteogenic differentiation of hBMSCs in *** a rat skull defect model,we found that co-transplantation of BMSC-CMVs and EC-CMVs could stimulate angiogenesis and bone formation in ***,our research might provide an innovative and feasible approach for cell-free therapy in bone tissue regeneration.

关键词： hinder apparent vesicles

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西藏墨脱县4个茶树良种叶片表型及光合特性分析

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分子植物育种 2023年第17期21卷 5794-5801页

作者：游丹丹张子威王贞红西藏农牧学院资源与环境学院林芝860000

为了研究西藏茶树的光合特性及其对环境的适应能力,以4个茶树良种(‘福鼎大白’,‘名山特早212’,‘名毫131’和’梅占’)为研究对象,测定其叶片表型性状及光合参数日变化,分析了影响光合参数的主要因子。结果表明:‘福鼎大白’和‘梅... 详细信息

为了研究西藏茶树的光合特性及其对环境的适应能力,以4个茶树良种(‘福鼎大白’,‘名山特早212’,‘名毫131’和’梅占’)为研究对象,测定其叶片表型性状及光合参数日变化,分析了影响光合参数的主要因子。结果表明:‘福鼎大白’和‘梅占’叶型指数、叶面积和比叶重均较大,且‘梅占’叶片厚度和叶绿素相对含量也较高,而‘名山特早212’和‘名毫131’叶片相对含水量较高。日变化中,净光合速率为‘福鼎大白’和‘梅占’较高且呈双峰曲线,而‘名山特早212’和‘名毫131’较低为单峰曲线;气孔导度和蒸腾速率也是‘福鼎大白’和‘梅占’较高。相关分析表明,光照和空气温度与‘福鼎大白’的蒸腾速率呈正相关,但与‘名山特早212’的胞间CO_(2)浓度呈负相关;空气中CO_(2)浓度与‘名山特早212’、‘名毫131’和‘梅占’的胞间CO_(2)浓度均呈正相关关系;叶绿素相对含量与4个茶树良种净光合速率均呈正相关关系。总体上,‘福鼎大白’光合碳同化能力强,喜光且耐高温;‘名山特早212’和‘名毫131’较耐旱;‘梅占’也具有较高的净光合速率但不耐旱。结合4种茶树的光合特性,根据每种茶树对光照的需求不同采取适当遮阴,进一步提高其光合利用效率和增加产量。上述结论可为墨脱县茶树科学种植提供可靠依据。

关键词：西藏墨脱县茶树叶片表型光合特性

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Clinical analysis of patients with deep sternal wound infection-induced sepsis:a retrospective cohort study

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Emergency and Critical Care Medicine 2024年第2期4卷 67-73页

作者： Bin Song Zhentian Cui Hongyan Ju Yue Sun dandan Liu Guanggang Li Department of Critical Care 7th Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiac and Macrovascular Surgery 7th Medical Center of Chinese PLA General HospitalBeijingChina

Background:This study aimed to summarize the clinical characteristics of patients with deep sternal wound infection-induced sepsis after median sternotomy and improve the treatment outcomes of infection-related ***:A retrospective cohort study was conducted on 21 patients with deep sternal wound infection-induced sepsis after median sternotomy who were admitted to the Department of Critical *** clinical manifestations,laboratory test results,infection control,and organ and nutritional support of the patients were summarized,and the follow-up data were ***:The primary symptoms of deep sternal wound infection-induced sepsis included dyspnea,high fever,chills,and altered state of *** test results revealed increased inflammatory markers and decreased oxygenation *** and liver function injury were observed in 8 and 4 patients,respectively;18 and 12 patients demonstrated elevated D-dimer and N-terminal Pro B type natriuretic peptide levels,*** the 8 patients whose wound secretions tested positive for bacteria,Acinetobacter baumannii and Staphylococcus aureus infections were present in 6 and 2 patients,*** of the 6 patients whose blood cultures tested positive for bacteria demonstrated Candida albicans *** patients received ventilator-assisted ventilation and 2 patients received renal replacement *** all the 21 patients,17 were cured,2 died,and 2 were ***:Postmedian sternotomy sepsis attributed to a deep sternal wound infection usually results from a preexisting *** most prominent clinical manifestation is dyspnea,which is sometimes accompanied by the impairment of organ *** prevention,proper nutrition support,and maintenance of healthy organ function are the cornerstones for successful treatment outcomes.

关键词： Clinical analysis Deep sternal wound infection Sepsis

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Fermi level tuning in Sn_(1-x)Pb_(x)Te/Pb heterostructure via changing interface roughness

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 118-125页

作者： Tengteng Liu Zhaoxia Yi Bangjin Xie Weiyan Zheng dandan Guan Shiyong Wang Hao Zheng Canhua Liu Hao Yang Yaoyi Li Jinfeng Jia Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) Tsung-Dao Lee InstituteSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Hefei National Laboratory Hefei 230088China

Superconducting SnTe-type topological crystalline insulators(TCIs)are predicted to host multiple Majorana zero modes(MZMs)which can coexist in a single *** level(FL)close to the Dirac points of topological surface states is helpful for detecting ***,the TCI SnTe is a heavily p-type semiconductor which is very difficult to modify to n-type via doping or *** this work,we fabricate the atomically flat Sn_(1-x)Pb_(x)Te/Pb heterostructure by molecular beam epitaxy,and make the p-type Sn_(1-x)Pb_(x)Te become n-type through changing the interface *** scanning tunnelling microscope,we find the Dirac points of Sn_(1-x)Pb_(x)Te/Pb heterostructure are always above the FL due to the Fermi level pinning(FLP)induced by topological surface states at atomically flat *** increasing the interface roughness,the FLP effect is suppressed and then the Dirac points of p-type Sn_(1-x)Pb_(x)Te can be tuned very close to or even below the *** work provides a new method for tuning the FL of SnTe-type TCI which has potential application in novel topological superconductor device.

关键词： topological crystalline insulator superconductor heterostructure Fermi level pinning interface roughness

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