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An electropenetrography waveform library for the probing and ingestion behaviors of Culex tarsalis on human hands

Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia M.W.Cooper Samuel b.Jameson Victoria Pickens Cameron Osborne Elaine A.backus Kristopher Silver dana N.Mitzel Department of Entomology Kansas State UniversityManhattanKansasUSA Department of Tropical Medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National bio and Agro-Defense Facility USDA Agricultural Research ServiceManhattanKansasUSA

Culex tarsalis Coquillett(Diptera:Culicidae)mosquitoes are capable of vectoring numerous pathogens affecting public and animal ***,the probing behaviors of mosquitoes are poorly understood because they occur in opaque ***(EPG)has the potential to elucidate these behaviors by recording the electrical signals generated during *** used an AC–DC EPG with variable input resistors(Ri levels)to construct a waveform library for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri levels and with two electrical current *** optimal settings for EPG recordings of *** probing on human hands was an Ri level of 10^(7)Ohms using an applied signal of 150 millivolts alternating *** for *** included those previously observed and associated with probing behaviors in Aedes aegypti L.(Diptera:Culicidae):waveform families J(surface salivation),K(stylet penetration through the skin),L(types 1 and 2,search for a blood vessel/ingestion site),M(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal).However,we also observed variations in the waveforms not described in ***,which we named types L3,M3,M4,and *** investigation enhances our understanding of mosquito probing *** also provides a new tool for the automated calculation of peak *** work will facilitate future pathogen acquisition and transmission studies and help identify new pest and disease management targets.

关键词： AC-DC blood feeders electrical penetration graph EPG human hands mosquitoes waveform library

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持久性环境污染物与夫妇生殖力:LIFE研究

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环境与职业医学 2013年第5期30卷 327-327页

作者： Germaine M.buck Louis Rajeshwari Sundaram Enrique F.Schisterman Anne M.Sweeney Courtney D.Lynch Robert E.Gore-Langton José Maisog Sungduk Kim Zhen Chen dana b.barr

[背景]证据表明，持久性环境污染物可能具有生殖毒性，因此对那些可测定污染暴露的夫妇需要进行前瞻性研究。[目的]在受孕时间进行检测，探讨选定的持久性污染物与夫妇生殖力的关系。[方法]前瞻性随访一个含501对夫妇的队列，参加者终... 详细信息

[背景]证据表明，持久性环境污染物可能具有生殖毒性，因此对那些可测定污染暴露的夫妇需要进行前瞻性研究。[目的]在受孕时间进行检测，探讨选定的持久性污染物与夫妇生殖力的关系。[方法]前瞻性随访一个含501对夫妇的队列，参加者终止避孕以受孕。随访为期12个月或直到一次绒毛膜促性腺激素（hCG）测试证实怀孕。

关键词：怀孕可铁宁生殖能力有机氯农药多溴联苯醚多氯联苯全氟化合物受孕时间

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Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

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World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares Helene boeuf Wassim Abou-Kheir dana Zeineddine Ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

bACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage *** exhibit a unique combination of self-renewal potency,unlimited proliferation,and *** latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ *** regulatory networks guide ESCs,directing their self-renewal and lineage-specific ***,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic ***-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly *** To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-b-cell lym-phoma 2(bCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes bcl-2,Pim-2,and Met-1,*** mESC-T2(wild-type),mESC-bCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac *** hanging drop method was adopted to generate embryoid bodies(Ebs)and induce terminal differentiation of *** size of the generated Ebs was measured in each condition compared to the wild *** the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the *** the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and ***,troponin T protein expression was evaluated through immunofluorescence and western blot *** Our findings showed that the upregulation of bcl-

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation b-cell lymphoma 2 PIM-2 Metallothionein-1

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Model Identification and Control of Electromagnetic Actuation in Continuous Casting Process With Improved Quality

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 203-215页

作者： Isabela birs Cristina Muresan dana Copot Clara Ionescu Research Group of Dynamical Systems and Control Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation Department Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presents an original theoretical framework to model steel material properties in continuous casting line process. Specific properties arising from non-Newtonian dynamics are herein used to indicate the natural convergence of distributed parameter systems to fractional order transfer function models. Data driven identification from a real continuous casting line is used to identify model of the electromagnetic actuator device to control flow velocity of liquid steel. To ensure product specifications, a fractional order control is designed and validated on the system. A projection of the closed loop performance onto the quality assessment at end production line is also given in this paper.

关键词： Electromagnetic actuator fractional order control fractional order system model non-Newtonian material

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Electro–optic response in thin smectic C* film with chevron structures

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Chinese Physics b 2016年第12期25卷 337-343页

作者： Aleksey A Kudreyko Nail G Migranov dana N Migranova Ufa State Petroleum Technological University Department of Physics bashkir State Pedagogical University Department of General and Theoretical Physics

The effects in electrostatic models of chevron surface-stabilized ferroelectric liquid crystals are investigated through numerical modeling. To study smectic C＊ director distribution within the cell, we consider two nonlinear approaches： the chevron interface does not interplay with the electric field; the electric field interplays with the chevron interface. The obtained results of the director field distribution are compared with the earlier linearized studies. We find that whether or not the electric field interplays with the chevron interface, the electro-optic response requires a generalized approach for its description. The threshold electric field, which is necessary for switching between two stable director states in the chevron cell is evaluated. This study suggests that, in many cases of practical interest, electro-optic response to the electric field and the threshold electric field can be precisely estimated. We argue that, beside being numerically efficient, our approach provides a convenient and a novel standpoint for looking at the electro-optic response problem.

关键词： surface-stabilized ferroelectric liquid crystal chevron structure thin films bistability Euler'sequation

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APIR:Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control

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Genomics, Proteomics & bioinformatics 2024年第2期22卷 171-187页

作者： Yiling Elaine Chen Xinzhou Ge Kyla Woyshner MeiLu McDermott Antigoni Manousopoulou Scott b.Ficarro Jarrod A.Marto Kexin Li Leo David Wang Jingyi Jessica Li Department of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Quantitative and Computational biology University of Southern CaliforniaLos AngelesCA 90089USA Department of Cancer biology and blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Department of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA bioinformatics Interdepartmental Program University of CaliforniaLos AngelesCA 90095USA Department of Human Genetics University of CaliforniaLos AngelesCA 90095USA Department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA Department of biostatistics University of CaliforniaLos AngelesCA 90095USA

Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide–spectrum matches(PSMs),which convert mass spectra to peptide *** database search algorithms use distinct search strategies and thus may identify unique ***,no existing approaches can aggregate all user-specified database search algorithms with a guaranteed increase in the number of identified peptides and a control on the false discovery rate(FDR).To fill in this gap,we proposed a statistical framework,Aggregation of Peptide Identification Results(APIR),that is universally compatible with all database search ***,under an FDR threshold,APIR is guaranteed to identify at least as many,if not more,peptides as individual database search algorithms *** of APIR on a complex proteomics standard dataset showed that APIR outpowers individual database search algorithms and empirically controls the *** data studies showed that APIR can identify disease-related proteins and post-translational modifications missed by some individual database search *** APIR framework is easily extendable to aggregating discoveries made by multiple algorithms in other high-throughput biomedical data analysis,e.g.,differential gene expression analysis on RNA sequencing *** APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteomics Peptide–spectrum match Peptide identification Aggregation of lists FDR control

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Ru/C催化剂上香豆素加氢制八氢香豆素（英文）

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催化学报 2015年第7期36卷 957-960页

作者： dana bílková Petr Jansa Iva Paterová Libor erveny DepartmentofOrganicTechnology InstituteofChemicalTechnologyPragueTechnickd516628Praha6CzechRepublic AromaPrahaa.s. Zidovice6441183HrobceCzechRepublic

The production of octahydrocoumarin,which can serve as a replacement for toxic coumarin,was investigated using 5% Ru on active carbon(Ru/C) as the catalyst for the hydrogenation of coumarin. The hydrogenation was studied by optimizing the reaction conditions(pressure,solvent and coumarin concentration). The activity and selectivity of the Ru/C catalyst were compared for different solvents. The mechanism of coumarin hydrogenation was deduced. The formation of side products was explained. The optimal hydrogenation reaction conditions were: 130 °C,10 MPa,60 wt% coumarin in methanol,and 0.5 wt%(based on coumarin) of Ru/C catalyst. At the complete conversion of coumarin,the selectivity to the desired product was 90%.

关键词：钌/碳催化剂加氢反应条件香豆素 RU 活性炭副产物氢化转化率

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环氧树脂-聚氨酯含砂抗滑封层设计及性能研究

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热固性树脂 2024年第3期39卷 52-56页

作者：达娜·塔布斯叶奋新疆大学建筑工程学院新疆乌鲁木齐830017 同济大学交通运输工程学院上海200092

为提高水泥路面耐久性及抗滑性,设计了多层结构含砂封层,即先喷涂无溶剂环氧树脂胶结料和抗滑颗粒组成的含砂雾封层,待其常温固化后,再用双组分无溶剂聚氨酯进行封层。通过材料性能试验及路用性能试验对封层材料的各组分进行确定及评价... 详细信息

为提高水泥路面耐久性及抗滑性,设计了多层结构含砂封层,即先喷涂无溶剂环氧树脂胶结料和抗滑颗粒组成的含砂雾封层,待其常温固化后,再用双组分无溶剂聚氨酯进行封层。通过材料性能试验及路用性能试验对封层材料的各组分进行确定及评价。结果表明:环氧树脂胶结料的A、b组分质量比为2∶1,聚氨酯胶结料的A、b组分质量比为5∶1时,封层表干时间符合施工和易性,效果最佳。粘结强度试验结果表明,当稀释剂质量分数为3%时,环氧树脂胶结料的粘结强度比未添加稀释剂时仅降低23%,且起到了降粘作用。聚氨酯不含稀释剂时,粘结性能最优。对优选配比后的封层试件进行7200次磨耗试验,结果表明:抗滑颗粒类型对封层试件磨耗前后的bPN变化值及质量损失率影响最大。确定环氧树脂胶结料涂布量为0.6 kg/m^(2),抗滑颗粒为金刚砂,洒布量为0.5~0.7 kg/m^(2),长期磨耗测试表明所设计的雾封层具有更好的耐久性,有利于延长水泥路面的使用寿命。

关键词：环氧树脂聚氨酯含砂雾封层水泥路面防滑磨耗试验耐久性

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Ultrafast plasmon dynamics in asymmetric gold nanodimers

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Chinese Physics b 2022年第6期31卷 387-395页

作者： bereket Dalga dana Alemayehu Nana Koya Xiaowei Song Jingquan Lin School of Science Changchun University of Science and TechnologyChangchun 130022China Department of Physics College of Natural and Computational SciencesWolaita Sodo UniversityP.O.Box 138Wlaita SodoEthiopia

We theoretically investigate the effect of symmetry breaking on the ultrafast plasmon responses of Au nanodisk(ND)dimers by varying the diameter of one of the constituent *** the case of a single ultrafast laser pulse,we demonstrate that the ultrafast responses of Au ND homodimer can be significantly modified due to the effect of symmetry *** symmetric dimer shows a single broad spectral peak,whereas the size-asymmetric dimer shows three spectral *** first system displays at most one temporal maximum and no beats in ultrafast temporal,whereas the second system may have three temporal maxima and two beats due to a combination of broken symmetry and the coherent superposition between various plasmon modes induced by the ultra-short laser ***,the shape of temporal dynamics of the size-asymmetric dimer is significantly deformed due to the excitation of local plasmon modes with different wavelength ***,the decay time of the amplitude of the local field is longer and oscillates with a high frequency due to the narrower linewidth and red-shifted spectral *** show that the ultrafast plasmon responses of both dimers can be controlled by varying the relative phase and time delays between a pair of two *** results will open new paths to understanding ultrafast plasmon responses in asymmetric heterodimers with suitable properties for different applications.

关键词： ultrafast plasmon dynamics coherent control spectral intensity temporal maximum

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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

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生物活性材料(英文) 2023年第1期19卷 642-652页

作者： Michaela b.Cooley Eric C.Abenojar dana Wegierak Anirban Sen Gupta Michael C.Kolios Agata A.Exner Department of biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PbS),plasma,or red blood cell solutions(RbCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak intensity reached within 145 *** contrast,nanobubbles in PbS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RbCs,suggesting that direct interactions,or hitchhiking,of nanobubbles on RbCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be key to extending nanobubble circulation time and has broad implications in drug delivery,where RbC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhiking Ultrasound Drug delivery

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