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Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3771-3780页

作者： Su-Ting Qian Hao-Yu Zhao Fei-Fei Xie Qing-Sheng liu dan-li cai Department of Digestive Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina Science and Education Section Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 311122Zhejiang ProvinceChina

The microbiota is strongly association with *** have shown significant differences in the gastric microbiota between patients with gastric cancer(GC)patients and noncancer patients,suggesting that the microbiota may play a role in the development of *** Helicobacter pylori(***)infection is widely recognized as a primary risk factor for GC,recent studies based on microbiota sequencing technology have revealed that *** microbes also have a significant impact on GC.A recent study discovered that Streptococcus anginosus(***)is more prevalent in the gastric mucosa of patients with GC than in that of those without *** infection can spontaneously induce chronic gastritis,mural cell atrophy,mucoid chemotaxis,and heterotrophic hyperplasia,which promote the development of precancerous lesions of GC(PLGC).*** also disrupts the gastric barrier function,promotes the proliferation of GC cells,and inhibits ***,*** is underrepresented in the *** reports suggest that it may cause precancerous lesions,indicating its emerging *** novel molecular diagnostic techniques,such as polymerase chain reaction,genetic testing,and Ultrasensitive Chromosomal Aneuploidy Detection,can be used to gastric precancerous lesions via microbial ***,we present a concise summary of the relationship between *** and *** aim was to further investigate new methods of preventing and treating PLGC by exploring the pathogenicity of *** on PLGC.

关键词： Streptococcus anginosus Gastric cancer Precancerous lesions of gastric cancer Microbiota Microbiota sequencing technology

Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 6-12页

作者： Su-Ting Qian Fei-Fei Xie Hao-Yu Zhao Qing-Sheng liu dan-li cai Department of Digestive Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Science and Education Section Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 311122Zhejiang ProvinceChina

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in *** advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains *** targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been *** have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and ***,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these *** these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal *** editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

关键词： Gastric cancer Precancerous lesions of gastric cancer Molecular typing Ultrasensitive chromosomal aneuploidy detection Adjuvant therapy Application prospects

Single-cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever

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Animal Models and Experimental Medicine 2025年第1期8卷 30-43页

作者： Yizhen Yuan Qian Chen Zhe li Fangzhou cai dan li Wei Wang National Center of Technology Innovation for Animal Model State Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationNHC Key Laboratory of Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC)BeijingChina

Background:Dengue fever,an acute insect-borne infectious disease caused by the dengue virus(DENV),poses a great challenge to global public *** involve-ment is the most common complication of severe dengue and is closely related to the occurrence and development of ***,the features of adaptive immune responses associated with liver injury in severe dengue are not ***:We used single-cell sequencing to examine the liver tissues of mild or se-vere dengue mice model to analyze the changes in immune response of T cells in the liver after dengue virus infection,and the immune interaction between macrophages and T *** cytometry was used to detect T cells and macrophages in mouse liver and blood to verify the single-cell sequencing ***:Our result showed CTLs were significantly activated in the severe liver injury group but the immune function-related signal pathway was *** rea-son may be that the excessive immune response in the severe group at the late stage of DENV infection induces the polarization of macrophages into M2 type,and the macrophages then inhibit T cell immunity through the TGF-βsignaling *** ad-dition,the increased proportion of Treg cells suggested that Th17/Treg homeostasis was disrupted in the livers of severe liver injury ***:In this study,single-cell sequencing and flow cytometry revealed the characteristic changes of T cell immune response and the role of macrophages in the liver of severe dengue fever *** study provides a better understanding of the pathogenesis of liver injury in dengue fever patients.

关键词： adaptive immunity dengue fever model liver injury single-cell sequencing

Toward long-life Zn anode using highly polar electrolyte additives

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Journal of Energy Chemistry 2025年第2期101卷 651-660页

作者： Nengbin cai Hongming Chen Busheng Zhang Zijing liu Xinbo He dan Zhou Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Shunde Innovation School University of Science and Technology Beijing School of Textile Science and Engineering Wuyi University

Unstable Zn interface caused by rampant dendrite growth and parasitic side reactions always hinders the practical application of aqueous zinc metal batteries（AZMBs）,Herein,tyrosine（Tyr） with high molecular polarity was introduced into aqueous electrolyte to modulate the interfacial electrochemistry of Zn *** AZMBs,the positively charged side of Tyr can be well adsorbed on the surface of Zn anode to form a water-poor layer,and the exposed carboxylate side can be easily coordinated with Zn2+,favoring inducing uniform plating of Zn2+and inhibiting the occurrence of water-induced side *** in turn enable the achievement of highly stable Zn ***,the Zn anodes achieve outstanding cyclic stability(3000 h at 2 mA cm-2,2 mA h cm-2and 1300 h at 5 mA cm-2,5 mA h cm-2),high average Coulombic efficiency（99.4% over 3200 cycles）,and high depth of discharge（80% for 500 h）.Besides,the assembled Zn‖NaV3O8·1.5H2O full cells deliver remarkable capacity retention and ultra-long lifetime(61.8% over 6650 cycles at 5 A g-1) and enhanced rate capability(169 mA h g-1at 5 A g-1).The work may promote the design and deep understanding of electrolyte additives with high molecular polarity for high-performance AZMBs.

关键词： AZMBs Electrolyte additives Highly stable Zn anode Interfacial electrochemistry Tyr

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng cai Shengjun Miao Yuan li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

Statistical Research on Megahertz-peaked Spectra Pulsars

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Research in Astronomy and Astrophysics 2025年第1期25卷 116-134页

作者： Hong-Bing cai li Chen Shi-dang li Kai Wang Hang liu JSNU SPBPU Institute of Engineering & SINO RUSSIAN Institute Jiangsu Normal University School of Physics and Electronic Engineering Jiangsu Normal University

Megahertz-peaked spectra(MPS) pulsars are referred as cases whose radio spectra turn over around 100 MHz. We identified 53 MPS pulsars based on the spectral data from the literature, and statistically analyzed the spatial location distribution, the magnetic field-period distribution, peak frequencies, spectral indices, and dispersion measures of these MPS pulsars. We found that there is a strong positive correlation between the dispersion measures and the peak frequencies of MPS pulsars, and negative correlations of the dispersion measures with spectral indices and the ages are also found. Such correlations suggest that the interstellar medium is an important factor that affects observational properties of MPS pulsars.

关键词： (stars:) pulsars: general ISM: general radio continuum: general

Experimental Research on a Feasible Building Insulation Material Based Reed in China

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Journal of Thermal Science 2025年第1期34卷 176-187页

作者： liU Tiantian PENG Yizhe liU lifang cai Chenghan WANG Shuang li Hongqiang College of Civil Engineering Hunan UniversityChangsha 410082China College of Civil Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China National Center for International Research Collaboration in Building Safety and Environment(NCIRCBSE) Hunan UniversityChangsha 410082China Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China

The seemingly useless reeds are prepared as thermal insulation materials,which not only meet the requirements of environmental sustainability but also enhance the added value of reeds,creating new economic *** hydrophobicity of raw biomass surfaces leads to problems such as weak bonding strength and non-dense structure in the formed materials,as well as issues related to the residual insect infestations on the *** this study,reed straw was used as the raw material,and foamed geopolymer was used as the binder to prepare building insulation materials based *** improve the interfacial adhesion performance between reed straw and foamed geopolymer,a thermochemical modification method-thermal carbonization,was *** this study,the mechanical properties and hydraulic properties of the studied materials with different degrees of surface thermal modification were tested,especially the fire resistance performance,and weathering resistance performance rarely found in published *** the surface thermal modification condition of reed straw was 250℃(30 min),the comprehensive performance of reed-based building insulation materials was the best,when the studied material density was 321.3 kg/m^(3);the compressive strength was 0.59 MPa;the thermal conductivity was 0.101 W/(m·K);the pH was 11.27;the moisture absorption rate was 25.1%,and the compressive strength loss rate in wet-dry cycles was 18.5%.In addition,it had excellent fire resistance performance and weathering resistance *** new material can be widely used to improve the thermal insulation of traditional buildings and as sandwich filler in prefabricated buildings,such as preparing insulating walls.

关键词： pre-treatment of reeds interface adhesion properties building insulation material based reed fire resistance performance weathering resistance performance

Phase-matching enhanced quantum phase and amplitude estimation of a two-level system in a squeezed reservoir

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Chinese Physics B 2025年第1期34卷 257-263页

作者： Yan-ling li cai-Hong liao Xing Xiao School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China

Squeezed reservoir engineering is a powerful technique in quantum information that combines the features of squeezing and reservoir engineering to create and stabilize non-classical quantum states. In this paper, we focus on the previously neglected aspect of the impact of the squeezing phase on the precision of quantum phase and amplitude estimation based on a simple model of a two-level system(TLS) interacting with a squeezed reservoir. We derive the optimal squeezed phase-matching conditions for phase φ and amplitude θ parameters, which are crucial for enhancing the precision of quantum parameter estimation. The robustness of the squeezing-enhanced quantum Fisher information against departures from these conditions is examined, demonstrating that minor deviations from phase-matching can still result in remarkable precision of estimation. Additionally, we provide a geometric interpretation of the squeezed phase-matching conditions from the classical motion of a TLS on the Bloch sphere. Our research contributes to a deeper understanding of the operational requirements for employing squeezed reservoir engineering to advance quantum parameter estimation.

关键词： quantum parameter estimation squeezed reservoir phase-matching conditions quantum Fisher information

Streamlined photonic reservoir computer with augmented memory capabilities

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Opto-Electronic Advances 2025年第1期8卷 45-57页

作者： Changdi Zhou Yu Huang Yigong Yang Deyu cai Pei Zhou Kuenyao Lau Nianqiang li Xiaofeng li School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of China Soochow UniversitySuzhou 215006China

Photonic platforms are gradually emerging as a promising option to encounter the ever-growing demand for artificial intelligence,among which photonic time-delay reservoir computing(TDRC)is widely *** such a computing paradigm can only employ a single photonic device as the nonlinear node for data processing,the performance highly relies on the fading memory provided by the delay feedback loop(FL),which sets a restriction on the extensibility of physical implementation,especially for highly integrated ***,we present a simplified photonic scheme for more flexible parameter configurations leveraging the designed quasi-convolution coding(QC),which completely gets rid of the dependence on *** delay-based TDRC,encoded data in QC-based RC(QRC)enables temporal feature extraction,facilitating augmented memory ***,our proposed QRC is enabled to deal with time-related tasks or sequential data without the implementation of ***,we can implement this hardware with a low-power,easily integrable vertical-cavity surface-emitting laser for high-performance parallel *** illustrate the concept validation through simulation and experimental comparison of QRC and TDRC,wherein the simpler-structured QRC outperforms across various benchmark *** results may underscore an auspicious solution for the hardware implementation of deep neural networks.

关键词： photonic reservoir computing machine learning vertical-cavity surface-emitting laser quasi-convolution coding augmented memory capabilities