Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer
作者机构：Department of DigestiveHangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina Science and Education SectionHangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina Intensive Care UnitThe First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 311122Zhejiang ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第9期
页 面：3771-3780页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Streptococcus anginosus Gastric cancer Precancerous lesions of gastric cancer Microbiota Microbiota sequencing technology
摘 要：The microbiota is strongly association with *** have shown significant differences in the gastric microbiota between patients with gastric cancer(GC)patients and noncancer patients,suggesting that the microbiota may play a role in the development of *** Helicobacter pylori(***)infection is widely recognized as a primary risk factor for GC,recent studies based on microbiota sequencing technology have revealed that *** microbes also have a significant impact on GC.A recent study discovered that Streptococcus anginosus(***)is more prevalent in the gastric mucosa of patients with GC than in that of those without *** infection can spontaneously induce chronic gastritis,mural cell atrophy,mucoid chemotaxis,and heterotrophic hyperplasia,which promote the development of precancerous lesions of GC(PLGC).*** also disrupts the gastric barrier function,promotes the proliferation of GC cells,and inhibits ***,*** is underrepresented in the *** reports suggest that it may cause precancerous lesions,indicating its emerging *** novel molecular diagnostic techniques,such as polymerase chain reaction,genetic testing,and Ultrasensitive Chromosomal Aneuploidy Detection,can be used to gastric precancerous lesions via microbial ***,we present a concise summary of the relationship between *** and *** aim was to further investigate new methods of preventing and treating PLGC by exploring the pathogenicity of *** on PLGC.
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