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Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

Nano-Micro Letters 2024年第10期16卷 403-434页

作者： Yilin Sun Huaipeng Wang dan xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing

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Variational quantum algorithms for scanning the complex spectrum of non-Hermitian systems

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Frontiers of physics 2024年第4期19卷 275-285页

作者： Xu-dan xie Zheng-Yuan Xue dan-Bo Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(Ministry of Education) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matterand School of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials Guangdong–Hong Kong Joint Laboratory of Quantum Matterand Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China

Solving non-Hermitian quantum many-body systems on a quantum computer by minimizing the variational energy is challenging as the energy can be ***,we propose a variational quantum algorithm for solving the non-Hermitian Hamiltonian by minimizing a type of energy variance,where zero variance can naturally determine the eigenvalues and the associated left and right ***,the energy is set as a parameter in the cost function and can be tuned to scan the whole spectrum efficiently by using a two-step optimization *** numerical simulations,we demonstrate the algorithm for preparing the left and right eigenstates,verifying the biorthogonal relations,as well as evaluating the *** also investigate the impact of quantum noise on our algorithm and show that its performance can be largely improved using error mitigation ***,our work suggests an avenue for solving non-Hermitian quantum many-body systems with variational quantum algorithms on near-term noisy quantum computers.

关键词： quantum algorithm non-Hermitian physics quantum manybody systems

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Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU Jun REN Yu-Ang CHEN Xiangshun GENG dan xie Tian-Ling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

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Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1213-1226页

作者： Guo-Le Nie Jun Yan Ying Li Hong-Long Zhang dan-Na xie Xing-Wang Zhu Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT),a complication of liver cirrhosis,is a major public health *** prediction is the most effective method for PVT diagnosis and *** To develop and validate a nomogram and network calculator based on clinical indicators to predict PVT in patients with *** Patients with cirrhosis hospitalized between January 2016 and December 2021 at the First Hospital of Lanzhou University were screened and 643 patients with cirrhosis who met the eligibility criteria were *** a 1:1 propensity score matching 572 patients with cirrhosis were screened,and relevant clinical data were *** risk factors were identified using the least absolute shrinkage and selection operator(LASSO)and multivariate logistic regression *** inflation factors and correlation matrix plots were used to analyze multicollinearity among the variables.A nomogram was constructed to predict the probability of PVT based on independent risk factors for PVT,and its predictive performance was verified using a receiver operating characteristic curve(ROC),calibration curves,and decision curve analysis(DCA).Finally,a network calculator was constructed based on the *** This study enrolled 286 cirrhosis patients with PVT and 286 without *** analysis revealed 13 variables as strongly associated with PVT *** logistic regression analysis revealed nine indicators as independent PVT risk factors,including etiology,ascites,gastroesophageal varices,platelet count,D-dimer,portal vein diameter,portal vein velocity,aspartate transaminase to neutrophil ratio index,and platelet-to-lymphocyte *** and correlation matrix plot results revealed no significant multicollinearity or correlation among the variables.A nomogram was constructed based on the screened independent risk *** nomogram had excellent predictive performance,with an area under the ROC curve of 0.821 and 0.829 in the

关键词： Portal vein thrombosis Liver cirrhosis Nomogram Inflammatory markers Aspartate aminotransferase to neutrophil ratio index Platelet-to-lymphocyte ratio

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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao dan xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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家文化的克里斯玛特质:建设中华民族现代文明的元逻辑

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贵州民族研究 2024年第1期45卷 165-171页

作者：谢丹凤贵州师范大学马克思主义学院贵州贵阳550025

近代以来,在现代化的探寻中,中华民族开启了对现代文明的追寻,建设中华民族现代文明是中国式现代化新的文化使命。中华优秀传统文化是建设中华民族现代文明的文化源泉和精神动力。中华优秀传统文化的传承是建设中华民族现代文明形态的... 详细信息

近代以来,在现代化的探寻中,中华民族开启了对现代文明的追寻,建设中华民族现代文明是中国式现代化新的文化使命。中华优秀传统文化是建设中华民族现代文明的文化源泉和精神动力。中华优秀传统文化的传承是建设中华民族现代文明形态的根本路径。中华优秀传统文化的传承过程中,家是基石和载体,家文化是文化源泉和逻辑起点。家和家文化的克里斯玛特质的“附魅—祛魅—复魅”的文明生成逻辑,是中华民族现代文明建设的元逻辑。

关键词：家文化克里斯玛特质中华民族现代文明

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写意木刻——康宁版画中灰色调的拓展与观念重构

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美术 2024年第8期 56-59页

作者：解丹梁冰四川美术学院造型艺术学院

本文围绕康宁20世纪80年代以来在黑白木刻中对灰色调的实践和探索展开,剖析其不同创作阶段对灰色调的视觉转向、观念与象征意义的建构,以及伴随着对“原木”材料属性的挖掘,康宁进一步将灰色调构成中刀痕的书写性与写实性相融合,探寻“... 详细信息

本文围绕康宁20世纪80年代以来在黑白木刻中对灰色调的实践和探索展开,剖析其不同创作阶段对灰色调的视觉转向、观念与象征意义的建构,以及伴随着对“原木”材料属性的挖掘,康宁进一步将灰色调构成中刀痕的书写性与写实性相融合,探寻“超以象外”的意象精神,进而折射出艺术家对版画中最具人文价值的部分。

关键词：灰色调写意版画黑白木刻

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微反应器内阳离子聚合研究进展

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化工学报 2024年第4期75卷 1302-1316页

作者：何宇航谢丹吕阳成清华大学化学工程系化学工程联合国家重点实验室北京100084

阳离子聚合是制备高分子材料的重要方法之一。因阳离子聚合反应活性高、可控性差,采用传统的方式对其进行深入研究难度往往很大。微反应器技术因其优异的过程控制能力在阳离子聚合研究中表现出得天独厚的优势。本文介绍了微反应器内传... 详细信息

阳离子聚合是制备高分子材料的重要方法之一。因阳离子聚合反应活性高、可控性差,采用传统的方式对其进行深入研究难度往往很大。微反应器技术因其优异的过程控制能力在阳离子聚合研究中表现出得天独厚的优势。本文介绍了微反应器内传统阳离子聚合和活性阳离子聚合的研究进展,论述了微反应器对提高异丁烯、乙烯基醚类单体阳离子聚合反应可控性、反应效率以及机理研究的重要作用,探讨了阳离子聚合体系和装备理性设计的方向。

关键词：微反应器过程控制阳离子聚合活性聚合理性设计

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地方志对马可·波罗记载问题的再考证——兼论方志解决历史疑难问题的研究空间

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中国地方志 2024年第3期 84-88,M0005,M0006页

作者：谢丹浙江师范大学人文学院

马可·波罗曾在扬州做官3年,此为其重要经历。通过对扬州方志史料全面考索,可订正所载“忽都火者”乃马可·波罗的讹误,并考察“火者”一词历时义项变化,对照马可·波罗笔下的扬州空间书写,发现曾任江都达鲁花赤的“马马火者”是马可·... 详细信息

马可·波罗曾在扬州做官3年,此为其重要经历。通过对扬州方志史料全面考索,可订正所载“忽都火者”乃马可·波罗的讹误,并考察“火者”一词历时义项变化,对照马可·波罗笔下的扬州空间书写,发现曾任江都达鲁花赤的“马马火者”是马可·波罗。同时亦可推断元代马可·波罗到扬州后政绩不彰,此可能是其在史志中“不载”的主要原因。马可·波罗宦迹问题对于百年来“马可·波罗到华”争议颇有助益,为解读马可·波罗提供方志新线索。

关键词：马可·波罗扬州地方志

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悬索跨越管桥结构的静力及动力特性分析

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山西建筑 2024年第3期50卷 155-157,198页

作者：谢丹抚州市国防动员事务中心江西抚州344000

在油气长输管道建设和水利工程中经常采用跨越管桥结构。以渭惠渠跨越段工程中某悬索跨越管桥结构为实例,利用有限元软件ANSYS建立悬索跨越管桥结构三维有限元分析模型,通过三种工况下的静力性能分析,获得节点的位移及单元的最大应力值... 详细信息

在油气长输管道建设和水利工程中经常采用跨越管桥结构。以渭惠渠跨越段工程中某悬索跨越管桥结构为实例,利用有限元软件ANSYS建立悬索跨越管桥结构三维有限元分析模型,通过三种工况下的静力性能分析,获得节点的位移及单元的最大应力值,结果表明该悬索跨越管桥结构在静力作用下是安全的。通过动力特性分析得到悬索跨越管桥结构的各阶自振频率和振型,有利于同类结构的设计。

关键词：悬索跨越管桥静力作用动力特性有限元分析

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