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Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry

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International journal of Ophthalmology(English edition) 2010年第2期3卷 104-111页

作者： john j harding Nuffield Laboratory of Ophthalmology University of OxfordJohn Radcliffe HospitalHeadingtonOxfordUK

AIMTo attempt to identify the primary targets of carbamylation in bovine lenses incubated under physiological condition.

关键词： carbamylation cyanate cataract identification lens mass spectrometry post-translational modification ξ-crystallin

Speculations on the mechanisms for the formation and breakup of supercontinents

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Geoscience Frontiers 2013年第2期4卷 185-194页

作者： j.Brendan Murphy R.damian Nance Department of Earth Sciences.St.Francis Xavier University Antigonish.Nova Scotia B2G 2W5Canada Department of Geological Sciences Ohio UniversityAthensOH 45701USA

The supercontinent cycle has had a profound effect on the Earth＇s evolution since the Late Archean but our understanding of the forces responsible for its operation remains *** appear to form by two end-member processes：extroversion,in which the oceanic lithosphere surrounding the supercontinent（exterior ocean） is preferentially subducted（***）,and introversion in which the oceanic lithosphere formed between dispersing fragments of the previous supercontinent（interior ocean） is preferentially subducted（***）.Extroversion can be explained by ＂top-down＂ geodynamics, in which a supercontinent breaks up over a geoid high and amalgamates above a geoid low. Introversion,on the other hand,requires that the combined forces of slab-pull and ridge push（which operate in concert after supercontinent break-up） must be overcome in order to enable the previously dispersing continents to turn *** may begin when subduction zones are initiated along boundaries between the interior and exterior oceans and become trapped within the interior *** speculate that the reversal in continental motion required for introversion may be induced by slab avalanche events that trigger the rise of superplumes from the core-mantle boundary.

关键词： Supercontinent cycle Introversion Extroversion Pangea Rodinia Pannotia

Origins of the supercontinent cycle

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Geoscience Frontiers 2013年第4期4卷 439-448页

作者： R.damian Nance j.Brendan Murphy Department of Geological Sciences.316 Clippinger Laboratories.Ohio University.Athens.OH 45701.USA Department of Earth Sciences st.Francis Xavier UniversityAntigonishNova Scotia B2G 2W5.Canada

The supercontinent cycle, by which Earth history is seen as having been punctuated by the episodic assembly and breakup of supercontinents, has influenced the rock record more than any other geologic phenomena, and its recognition is arguably the most important advance in Earth Science since plate tectonics. It documents fundamental aspects of the planet＇s interior dynamics and has charted the course of Earth＇s tectonic, climatic and biogeochemical evolution for billions of years. But while the widespread realization of the importance of supercontinents in Earth history is a relatively recent development, the supercontinent cycle was first proposed thirty years ago and episodicity in tectonic processes was recognized long before plate tectonics provided a potential explanation for its occurrence. With interest in the supercontinent cycle gaining momentum and the literature expanding rapidly, it is instructive to recall the historical context from which the concept developed. Here we examine the supercontinent cycle from this perspective by tracing its development from the early recognition of long-term epi- sodicity in tectonic processes, through the identification of tectonic cycles following the advent of plate tectonics, to the first realization that these phenomena were the manifestation of episodic superconti- nent assembly and breakup.

关键词： Supercontinent cyclePlate tectonicsTectonic episodicitySecular trends

Surgical resection of rectal adenoma:A rapid review

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World journal of Gastroenterology 2009年第31期15卷 3851-3854页

作者： damian Casadesus Calixto Garcia Hospital J and University

Transanal excision （TE）, endoscopic transanal resection （ETAR） and transanal endoscopic microsurgery （TEN） can be used to remove adenomatous polyps. However, their use is limited by the size or location of the tumor. TE is limited to the lower rectum, TEN offers better access to lesions in the middle and upper rectum, and ETAR is used less frequently than it deserves for resection of rectal lesions.

关键词： Adenoma Colorectal surgery Endoscopy Gastrointestinal Microsurgery Rectal neoplasms

Estrogen,male dominance and esophageal adenocarcinoma:Is there a link?

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World journal of Gastroenterology 2012年第5期18卷 393-400页

作者： Huiqi Yang Olga A Sukocheva damian j Hussey David I Watson Huiqi Yang Olga A Sukocheva Damian Hussey DavidI Watson Department of Surgery Flinders Medical CentreFlinders University Bedford Park South Australia 5042 Australia Flinders Centre for Cancer Prevention and Control FlindersMedical Centre Bedford Park South Australia 5042

Esophageal adenocarcinoma is a cancer with poor prognosis, and its incidence has risen sharply over recent decades. Obesity is a major risk factor for developing this cancer and there is a clear male gender bias in the incidence that cannot be fully explained by known risk factors. It is possible that a difference in the expression of estrogen, or its signaling axes, may contribute to this gender bias. We undertook a com- prehensive literature search and analyzed the available data regarding estrogen and estrogen receptor expres- sion, and the possible sex-specific links with esopha- geal adenocarcinoma development. Potentially relevant associations between visceral vs subcutaneous fat deposition and estrogen expression, and the effect of crosstalk between estrogen and leptin signaling were identified. We also found limited studies suggesting a role for estrogen receptor 13 expression in esophageal adenocarcinoma development. The current literature supports speculation on an etiological role for estrogen in the male gender bias in esophageal adenocarcino- ma, but further studies are required.

关键词： Estrogen Estrogen receptors Male domi-nance Esophageal adenocarcinoma

Can active late-type stars contribute to the Galactic lithium abundance?

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Research in Astronomy and Astrophysics 2020年第7期20卷 127-133页

作者： Darnell E.Kelly damian j.Christian Mihalis Mathioudakis Darko jevremovi′c Department of Physics and Astronomy California State UniversityNorthridgeCA 91330-8268USA Astrophysics Research Centre School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUK Astronomical Observatory Volgina 711060 BelgradeSerbia

Lithium abundances in our Galaxy and especially 6 Li abundances provide important constraints on our understanding of Big Bang Nucleosynthesis(BBNS),stellar evolution and the creation of light elements by cosmic rays in the ISM.~6 Li has been detected in energetic solar events,one chromospherically active binary and several dwarf halo *** our work on active late-type stars with high lithium abundances,we expand our study to consider if the flare origin of lithium created by spallation can contribute significantly to the Galactic abundance of *** previously derived ~6 Li/~7 Li=0.030 ± 0.010 for active K dwarf Gj 117 using VLT UVES *** find^6 Li/~7 Li ratios of 0.02 and 0.10 for two other stars in our sample,Gj 182 and EUVE j1145-55.3 A,*** that these later type,active stars have significant flare rates and stellar winds,we have estimated the contribution of these stars to the Galactic lithium *** that K and M stars comprise over 84% of our Galaxy and that many of these can have significant stellar winds,we conclude that spallation in stellar flares can contribute 1% and up to 5% of the Galactic lithium abundance.

关键词： stars:abundances stars:activity Galaxy:abundances

MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

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World journal of Gastroenterology 2010年第5期16卷 531-537页

作者： Cameron M Smith David I Watson Michael Z Michael damian j Hussey Department of Surgery Flinders University Room 3D211 Flinders Medical Centre Bedford Park South Australia 5042 Australia Department of Gastroenterology & Hepatology Flinders University Bedford Park South Australia 5042 Australia

Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.

关键词： Barrett’s esophagus MicroRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor

G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

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World journal of Gastroenterology 2019年第30期25卷 4092-4104页

作者： damian jacenik Ellen j Beswick Wanda M Krajewska Eric R Prossnitz Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Internal Medicine School of Medicineand UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueNM 87131United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineUniversity of UtahSalt Lake CityUT 84132United States

Estrogens play important roles in the development and progression of multiple tumor *** evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly *** on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative *** is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC ***,multiple lines of evidence suggest that GPER may play an important role in colorectal *** this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC.

关键词： G protein-coupled estrogen receptor Colorectal cancer Proliferation Migration Colonic motility Inflammatory bowel disease

Multi-wavelength observations of the 2014 june 11 M3.9 flare: temporal and spatial characteristics

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Research in Astronomy and Astrophysics 2019年第7期19卷 123-132页

作者： damian j.Christian David Kuridze David B.jess Menoa Yousefi Mihalis Mathioudakis Department of Physics and Astronomy California State University NorthridgeNorthridgeCA 91330USA Institute of Mathematics Physics and Computer ScienceAberystwyth UniversityCeredigionCymruSY23 3UK Astrophysics Research Center School of Mathematics and PhysicsQueen's University BelfastBelfast BT7 INNUK

We present multi-wavelength observations of an M-class flare(M3.9) that occurred on 2014 june *** observations were conducted with the Dunn Solar Telescope(DST),employing adaptive optics,the multi-camera system Rapid Oscillations in Solar Atmosphere(ROSA),the new Hydrogen-Alpha Rapid Dynamics camera(HARDcam) in various wavelengths,such as Ca II K,Mg I b2(at 5172.7 A),and Hα narrow band and G-band continuum *** were re-constructed using the Kiepenheuer-Institut Speckle Interferometry Package(KISIP) code,to improve our image *** observed intensity increases of ≈120%–150% in the Mg,Ca K and Hα narrow band filters during the *** increases for the flare observed in the SDO EUV channels were several times larger,and the X-rays,as recorded by GOES,increased over a factor of 30 for the harder *** a modest delay was found between the onset of flare ribbons of a nearby sympathetic flare and the main flare ribbons observed in these narrow band *** peak flare emission occurred within a few seconds for the Ca K,Mg and Hα *** techniques indicate propagation velocities of ≈60 km s^-1 for the main flare ribbon and as high as300 km s^-1 for smaller regions,which we attribute to filament *** result and delays and velocities observed with SDO(≈100 km s^-1) for different coronal heights agree well with the simple model of energy propagation versus height,although a more detailed model for the flaring solar atmosphere is ***,we detected marginal quasi-periodic pulsations(QPPs) in the 40–60 s range for the Ca K,Mg and Hα bands,and such measurements are important for disentangling the detailed flare-physics.

关键词： magnetic reconnection-Sun flares-Sun atmosphere